{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T23:49:54Z","timestamp":1779148194077,"version":"3.51.4"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2004,9,24]],"date-time":"2004-09-24T00:00:00Z","timestamp":1095984000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Musculoskelet Disord"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Background<\/jats:title>\n                        <jats:p>We examined the time course of the functional alterations in two types of muscles following sciatic nerve crush in neonatal rats and the neuroprotective effect of Mg<jats:sup>2+<\/jats:sup>.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>The nerve crush was performed on the 2<jats:sup>nd<\/jats:sup> postnatal day. MgSO<jats:sub>4<\/jats:sub>*7H<jats:sub>2<\/jats:sub>O was administered daily for two weeks. Animals were examined for the contractile properties and for the number of motor units of extensor digitorum longus and soleus muscles at three postnatal stages and adulthood. Four experimental groups were included in this study: i) controls, ii) axotomized rats, iii) magnesium treated controls and iv) axotomized and Mg<jats:sup>2+<\/jats:sup>-treated rats.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>Axotomy resulted in 20% MU survival in EDL and 50% in soleus. In contrast, magnesium treatment resulted in a significant motor unit survival (40% survival in EDL and 80% in soleus). The neuroprotective effects of Mg<jats:sup>2+<\/jats:sup> were evident immediately after the Mg<jats:sup>2+<\/jats:sup>-treatment. Immature EDL and soleus muscles were slow and fatigueable. Soleus gradually became fatigue resistant, whereas, after axotomy, soleus remained fatigueable up to adulthood. EDL gradually became fastcontracting. Tetanic contraction in axotomized EDL was just 3,3% of the control side, compared to 15,2% in Mg<jats:sup>2+<\/jats:sup>-treated adult rats. The same parameter for axotomized soleus was 12% compared to 97% in Mg<jats:sup>2+<\/jats:sup>-treated adult rats.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusions<\/jats:title>\n                        <jats:p>These results demonstrate that motoneuron death occurs mostly within two weeks of axotomy. Magnesium administration rescues motoneurons and increases the number of motor units surviving into adulthood. Fast and slow muscles respond differently to axotomy and to subsequent Mg<jats:sup>2+<\/jats:sup> treatment in vivo.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/1471-2474-5-33","type":"journal-article","created":{"date-parts":[[2004,9,30]],"date-time":"2004-09-30T06:23:47Z","timestamp":1096525427000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Magnesium administration provokes motor unit survival, after sciatic nerve injury in neonatal rats"],"prefix":"10.1186","volume":"5","author":[{"given":"N","family":"Gougoulias","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Hatzisotiriou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Kapoukranidou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Albani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2004,9,24]]},"reference":[{"key":"97_CR1","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1113\/jphysiol.1960.sp006395","volume":"150","author":"AJ Buller","year":"1960","unstructured":"Buller AJ, Eccles JC and Eccles EM: Interactions between motoneurons and muscles in respect of the characteristic speeds of their responses. 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