{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T15:49:46Z","timestamp":1777650586613,"version":"3.51.4"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2007,7,25]],"date-time":"2007-07-25T00:00:00Z","timestamp":1185321600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Musculoskelet Disord"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Malignant melanoma occurs infrequently in Taiwan. Once it has progressed into osseous metastases, the prognosis is poor. There are no reported clinical experiences of surgical management in this area.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>To improve our understanding of the rare clinical experiences, we retrospectively investigated clinical characteristics, radiological findings, treatment modalities, survival outcomes and prognoses of 11 Taiwanese patients with osseous metastasis of melanoma treated surgically at two national medical centers, National Taiwan University Hospital and National Cheng Kung University Hospital from January 1983 to December 2006.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Six patients suffered from acral-lentiginous melanoma. Nine patients sustained multiple osseous metastases and most lesions were osteolytic. Nine patients also had sustained metastases to other organs including liver, lungs, lymph nodes, brain and spleen. Second malignancies including lung cancer, thyroid papillary carcinoma, renal cell carcinoma and cervical cancer co-existed in four patients. The interval from the initial diagnosis of melanoma to the clinical detection of osseous metastases varied from 0\u201337.8 months (mean 9.75 months). Metastatic melanoma was invariably fatal; the mean survival time from bone metastases to death was 5.67 months.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Due to the high morbidity and poor survival of Taiwanese patients with osseous metastases of melanoma, surgical treatment should be directed towards pain relief and the prevention of skeletal debilitation in order to maintain their quality of life.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2474-8-70","type":"journal-article","created":{"date-parts":[[2007,7,25]],"date-time":"2007-07-25T06:13:37Z","timestamp":1185344017000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Rare clinical experiences for surgical treatment of melanoma with osseous metastases in Taiwan"],"prefix":"10.1186","volume":"8","author":[{"given":"Kuo-Yuan","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chrong-Reen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong-Sen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,7,25]]},"reference":[{"key":"347_CR1","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1097\/00001622-199703000-00016","volume":"9","author":"MB Atkins","year":"1997","unstructured":"Atkins MB: The treatment of metastatic melanoma with chemotherapy and biologics. Curr Opin Oncol. 1997, 9: 205-213.","journal-title":"Curr Opin Oncol"},{"key":"347_CR2","first-page":"193","volume":"181","author":"A Barth","year":"1995","unstructured":"Barth A, Wanek LA, Morton DL: Prognostic factors in 1,521 melanoma patients with distant metastases. J Am Coll Surg. 1995, 181: 193-201.","journal-title":"J Am Coll Surg"},{"key":"347_CR3","first-page":"71","volume":"10","author":"L Brochez","year":"2000","unstructured":"Brochez L, Naeyaert JM: Understanding the trends in melanoma incidence and mortality: where do we stand?. Eur J Dermatol. 2000, 10: 71-75.","journal-title":"Eur J Dermatol"},{"key":"347_CR4","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S0190-9622(99)70562-1","volume":"40","author":"HI Hall","year":"1999","unstructured":"Hall HI, Miller DR, Rogers JD, Bewerse B: Update on the incidence and mortality from melanoma in the United States. J Am Acad Dermatol. 1999, 40: 35-42. 10.1016\/S0190-9622(99)70562-1.","journal-title":"J Am Acad Dermatol"},{"key":"347_CR5","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3322\/canjclin.57.1.43","volume":"57","author":"A Jemal","year":"2007","unstructured":"Jemal A, Siegel R, Samuels A, Ward E, Murray T, Xu J, Thun MJ: Cancer statistics, 2007. CA Cancer J Clin. 2007, 57: 43-66.","journal-title":"CA Cancer J Clin"},{"key":"347_CR6","first-page":"139","volume":"19","author":"D Chatelain","year":"1999","unstructured":"Chatelain D, de Pinieux G, Guillemette J, Forest M: Bone metastasis of a clear cell tumor. Ann Pathol. 1999, 19: 139-140.","journal-title":"Ann Pathol"},{"key":"347_CR7","doi-asserted-by":"crossref","first-page":"657","DOI":"10.3928\/0147-7447-19920501-18","volume":"15","author":"NE Motzkin","year":"1992","unstructured":"Motzkin NE, Rock MG, Wold LE, Beabout JW: Malignant melanoma metastatic to bone. Orthopedics. 1992, 15: 657-659.","journal-title":"Orthopedics"},{"key":"347_CR8","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1177\/107327480200900105","volume":"9","author":"SJ O'Day","year":"2002","unstructured":"O'Day SJ, Kim CJ, Reintgen DS: Metastatic melanoma: chemotherapy to biochemotherapy. Cancer Control. 2002, 9: 31-38.","journal-title":"Cancer Control"},{"key":"347_CR9","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1111\/j.1346-8138.2000.tb02279.x","volume":"27","author":"N Kato","year":"2000","unstructured":"Kato N, Kimura K, Sugawara H, Aoyagi S, Kondo K, Yamashiro K: Pedunculated melanoma with pulmonary and bony metastases. J Dermatol. 2000, 27: 769-773.","journal-title":"J Dermatol"},{"key":"347_CR10","first-page":"1561","volume-title":"Clinical Oncology","author":"JR Lange","year":"2004","unstructured":"Lange JR, Sharfman WH, Alani RM, Balch CM: melanoma. Clinical Oncology. 2004, Churchill Livingstone, 1561-1583. 3","edition":"3"},{"key":"347_CR11","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1016\/S0190-9622(99)70251-3","volume":"41","author":"YJ Chen","year":"1999","unstructured":"Chen YJ, Wu CY, Chen JT, Shen JL, Chen CC, Wang HC: Clincopathologic analysis of malignant melanoma in Taiwan. J Am Acad Dermatol. 1999, 41: 945-9. 10.1016\/S0190-9622(99)70251-3.","journal-title":"J Am Acad Dermatol"},{"key":"347_CR12","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1259\/0007-1285-62-744-1095","volume":"62","author":"ME O'Connell","year":"1989","unstructured":"O'Connell ME, Powell BW, O'Connell JM, Harmer CL: Spontaneous regression of multiple bone metastases in malignant melanoma. Br J Radiol. 1989, 62: 1095-1100.","journal-title":"Br J Radiol"},{"issue":"6","key":"347_CR13","first-page":"741","volume":"87","author":"P Potepan","year":"1994","unstructured":"Potepan P, Spagnoli I, Danesini GM, Laffranchi A, Gadda D, Mascheroni L, Guzzon A: The radiodiagnosis of bone metastases from melanoma. Radiol Med. 1994, 87 (6): 741-746.","journal-title":"Radiol Med"},{"key":"347_CR14","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1002\/jso.2930420405","volume":"42","author":"WA Salwen","year":"1989","unstructured":"Salwen WA, Krementz ET, Campeau RJ: Bone and liver imaging in regionally advanced melanoma. J Surg Oncol. 1989, 42: 225-228. 10.1002\/jso.2930420405.","journal-title":"J Surg Oncol"},{"key":"347_CR15","first-page":"209","volume":"35","author":"EN Brountzos","year":"2001","unstructured":"Brountzos EN, Panagiotou IE, Bafaloukos D, Kelekis DA: Bone metastases from malignant melanoma: a retrospective review and analysis of 28 cases. Radiol Oncol. 2001, 35: 209-214.","journal-title":"Radiol Oncol"},{"key":"347_CR16","doi-asserted-by":"publisher","first-page":"2471","DOI":"10.1002\/(SICI)1097-0142(19960615)77:12<2471::AID-CNCR9>3.0.CO;2-P","volume":"77","author":"R Yokoyama","year":"1996","unstructured":"Yokoyama R, Mukai K, Hirota T, Beppu Y, Fukuma H: Primary malignant melanoma (clear cell sarcoma) of bone: report of a case arising in the ulna. Cancer. 1996, 77: 2471-2475. 10.1002\/(SICI)1097-0142(19960615)77:12<2471::AID-CNCR9>3.0.CO;2-P.","journal-title":"Cancer"},{"key":"347_CR17","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1097\/00003086-199602000-00038","volume":"323","author":"DK DeBoer","year":"1996","unstructured":"DeBoer DK, Schwartz HS, Thelman S, Reynolds VH: Heterogeneous survival rates for isolated skeletal metastases from melanoma. Clin Orthop. 1996, 323: 277-283. 10.1097\/00003086-199602000-00038.","journal-title":"Clin Orthop"},{"key":"347_CR18","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/S1067-2516(00)80076-9","volume":"39","author":"MS Downey","year":"2000","unstructured":"Downey MS, Lamm BM: Metastatic malignant melanoma to the foot and ankle: a review of the literature and case report. J Foot Ankle Surg. 2000, 39: 392-401.","journal-title":"J Foot Ankle Surg"},{"key":"347_CR19","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1007\/BF00182712","volume":"16","author":"HJ Jaeger","year":"1992","unstructured":"Jaeger HJ, Kruegener GH, Donovan AG: Patellar metastasis from a malignant melanoma. Int Orthop. 1992, 16: 282-284. 10.1007\/BF00182712.","journal-title":"Int Orthop"},{"key":"347_CR20","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/S1010-7940(98)00248-6","volume":"14","author":"J Laredo","year":"1998","unstructured":"Laredo J, Morris DJ, Thurer RL: Metastatic melanoma to the manubrium sternum. Eur J Cardiothorac Surg. 1998, 14: 629-630. 10.1016\/S1010-7940(98)00248-6.","journal-title":"Eur J Cardiothorac Surg"},{"key":"347_CR21","first-page":"368","volume":"33","author":"SA Tamburri","year":"1994","unstructured":"Tamburri SA, Boberg JS: Skeletally metastatic malignant melanoma of the foot. J Foot Ankle Surg. 1994, 33: 368-372.","journal-title":"J Foot Ankle Surg"},{"key":"347_CR22","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1053\/ar.1999.v15.0150091","volume":"15","author":"RN Tandogan","year":"1999","unstructured":"Tandogan RN, Aydogan U, Demirhan B, Arican A, Yuceturk A: Intra-articular metastatic melanoma of the right knee. Arthroscopy. 1999, 15: 98-102.","journal-title":"Arthroscopy"},{"key":"347_CR23","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/S0360-3016(99)00066-8","volume":"44","author":"MH Seegenschmiedt","year":"1999","unstructured":"Seegenschmiedt MH, Keilholz L, Altendorf-Hofmann A, Urban A, Schell H, Hohenberger W, Sauer R: Palliative radiotherapy for recurrent and metastatic malignant melanoma: prognostic factors for tumor response and long-term outcome: a 20-year experience. Int J Radiat Oncol Biol Phys. 1999, 44: 607-18. 10.1016\/S0360-3016(99)00066-8.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"347_CR24","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/sj.bjc.6600717","volume":"88","author":"GC de Gast","year":"2003","unstructured":"de Gast GC, Batchelor D, Kersten MJ, Vyth-Dreese FA, Sein J, van de Kasteele WF, Nooijen WJ, Nieweg OE, de Waal MA, Boogerd W: Temozolomide followed by combined immunotherapy with GM-CSF, low-dose IL2 and IFN alpha in patients with metastatic melanoma. Br J Cancer. 2003, 88: 175-180. 10.1038\/sj.bjc.6600717.","journal-title":"Br J Cancer"},{"key":"347_CR25","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1002\/jso.20303","volume":"94","author":"SE Young","year":"2006","unstructured":"Young SE, Martinez SR, Essner R: The role of surgery in treatment of stage IV melanoma. J Surg Oncol. 2006, 94: 344-51. 10.1002\/jso.20303.","journal-title":"J Surg Oncol"},{"key":"347_CR26","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1634\/theoncologist.10-1-52","volume":"10","author":"JR Berenson","year":"2005","unstructured":"Berenson JR: Recommendations for zoledronic acid treatment of patients with bone metastases. Oncologist. 2005, 10: 52-62. 10.1634\/theoncologist.10-1-52.","journal-title":"Oncologist"},{"key":"347_CR27","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1002\/(SICI)1097-0142(20000301)88:5<1082::AID-CNCR20>3.0.CO;2-Z","volume":"88","author":"A Lipton","year":"2000","unstructured":"Lipton A, Theriault RL, Hortobagyi GN, Simeone J, Knight RD, Mellars K, Reitsma DJ, Heffernan M, Seaman JJ: Pamidronate prevents skeletal complications and is effective palliative treatment in women with breast carcinoma and osteolytic bone metastases: long term follow-up of two randomized, placebo-controlled trials. Cancer. 2000, 88: 1082-90. 10.1002\/(SICI)1097-0142(20000301)88:5<1082::AID-CNCR20>3.0.CO;2-Z.","journal-title":"Cancer"},{"key":"347_CR28","first-page":"CD002068","volume-title":"Cochrane Database Syst Rev","author":"R Wong","year":"2002","unstructured":"Wong R, Wiffen PJ: Bisphosphonates for the relief of pain secondary to bone metastases. Cochrane Database Syst Rev. 2002, CD002068-"},{"key":"347_CR29","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1038\/sj.bjc.6600476","volume":"87","author":"C Riebeling","year":"2002","unstructured":"Riebeling C, Forsea AM, Raisova M, Orfanos CE, Geilen CC: The bisphosphonate pamidronate induces apoptosis in human melanoma cells in vitro. Br J Cancer. 2002, 87: 366-71. 10.1038\/sj.bjc.6600476.","journal-title":"Br J Cancer"},{"key":"347_CR30","first-page":"211","volume":"13","author":"Y Kitagawa","year":"2005","unstructured":"Kitagawa Y, Hiraga T, Yura Y, Yoneda T: Suppression by incadronate of invasion and growth of A-375 human melanoma in mandible in nude mice. Oncol Rep. 2005, 13: 211-6.","journal-title":"Oncol Rep"},{"key":"347_CR31","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1097\/00000637-199201000-00013","volume":"28","author":"DS Reintgen","year":"1992","unstructured":"Reintgen DS, Cox C, Slingluff CJ, Seigler HF: Recurrent malignant melanoma: the identification of prognostic factors to predict survival. Ann Plast Surg. 1992, 28: 45-49. 10.1097\/00000637-199201000-00013.","journal-title":"Ann Plast Surg"}],"container-title":["BMC Musculoskeletal Disorders"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2474-8-70.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2474-8-70\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2474-8-70","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2474-8-70.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T22:21:27Z","timestamp":1630448487000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmusculoskeletdisord.biomedcentral.com\/articles\/10.1186\/1471-2474-8-70"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7,25]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["347"],"URL":"https:\/\/doi.org\/10.1186\/1471-2474-8-70","relation":{},"ISSN":["1471-2474"],"issn-type":[{"value":"1471-2474","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7,25]]},"assertion":[{"value":"11 July 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 July 2007","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 July 2007","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"70"}}