{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T01:56:01Z","timestamp":1771034161932,"version":"3.50.1"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2008,11,7]],"date-time":"2008-11-07T00:00:00Z","timestamp":1226016000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Musculoskelet Disord"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Individuals with osteoporosis and recent vertebral fractures suffer from pain and impaired health-related quality of life (HRQL). To determine whether patients with osteoporosis treated with teriparatide experienced improvement in HRQL and pain symptoms after several months of therapy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We retrospectively studied a sample of osteoporosis patients treated with teriparatide in a Canadian rheumatology practice. We included patients that received teriparatide therapy with baseline and follow-up Mini-Osteoporosis Quality of Life Questionnaire (OQLQ) data. Follow-up data was measured at three or six months. We used a paired Student's t-test to compare baseline and follow-up measurements for each of the questionnaire's ten questions (five domains). Statistical analysis was also repeated to only include patients who suffered a prior vertebral fracture.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>57 patients were included in the study, including 47 women. The mean age was 63.8 years (standard deviation 12.1 years). About sixty five percent (37\/57) had previously sustained one or more osteoporotic fractures and about 38.6% (22\/57) had suffered a prior vertebral fracture. About 44% (25\/57) of individuals were taking one or more types of pain medications regularly prior to starting therapy. At follow-up, significant improvements were observed in the OQLQ domains of pain symptoms. This was seen when all patients on teriparatide were included, and also when only patients with prior vertebral fractures were included. There was also an improvement in emotional functioning, relating to fear of falling at 3 months follow-up (p = 0.019). Respondents also reported improvement in the domain of activities of daily living, relating to vacuuming at 6 months follow-up (p = 0.036), and an improvement in the leisure domain, relating to ease of traveling in the prior vertebral fracture population at 3 months follow-up (p = 0.012). However, there was no significant improvement observed in the domains of physical functioning. Participants also reported a decrease in need for pain medications, with 26% (15\/57) requiring analgesics at the time of follow-up.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Teriparatide use may be associated with improvements in HRQL in osteoporosis patients, in particular alleviation of pain symptoms. These results were especially evident in patients with a history of vertebral fractures. These findings should be confirmed in larger prospective studies with a suitable control group.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2474-9-151","type":"journal-article","created":{"date-parts":[[2008,11,7]],"date-time":"2008-11-07T07:14:51Z","timestamp":1226042091000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Improvement in health-related quality of life in osteoporosis patients treated with teriparatide"],"prefix":"10.1186","volume":"9","author":[{"given":"Arthur N","family":"Lau","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sammy H","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna M","family":"Sawka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lehana","family":"Thabane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Papaioannou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amiram","family":"Gafni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan D","family":"Adachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,11,7]]},"reference":[{"key":"557_CR1","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1001\/jama.285.6.785","volume":"285","author":"NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis and Therapy","year":"2001","unstructured":"NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis and Therapy: Osteoporosis prevention, diagnosis and therapy. JAMA. 2001, 285: 785-795. 10.1001\/jama.285.6.785.","journal-title":"JAMA"},{"key":"557_CR2","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/s00198-005-2013-2","volume":"17","author":"M Nevitt","year":"2006","unstructured":"Nevitt M, Chen P, Kiel DP, Reginster JY, Dore RK, Zanchetta JR, Glass EV, Krege JH: Reduced risk of back pain following teriparatide treatment: a meta-analysis. Osteoporos Int. 2006, 17: 273-280. 10.1007\/s00198-005-2013-2.","journal-title":"Osteoporos Int"},{"key":"557_CR3","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1093\/oxfordjournals.aje.a116756","volume":"137","author":"C Cooper","year":"1993","unstructured":"Cooper C, Atkinson EJ, Jacobsen SJ, O'Fallon WM, Melton LJ: Population-based study of survival after osteoporotic fractures. Am J Epidemiol. 1993, 137: 1001-1005.","journal-title":"Am J Epidemiol"},{"issue":"supplement","key":"557_CR4","doi-asserted-by":"publisher","first-page":"185S","DOI":"10.1016\/8756-3282(95)00500-5","volume":"18","author":"DT Gold","year":"1996","unstructured":"Gold DT: The clinical impact of vertebral fractures: quality of life in women with osteoporosis. Bone. 1996, 18 (supplement): 185S-189S. 10.1016\/8756-3282(95)00500-5.","journal-title":"Bone"},{"key":"557_CR5","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1007\/s001980050076","volume":"8","author":"C Matthis","year":"1998","unstructured":"Matthis C, Weber U, O'Neill TW, Raspe H: Health impact associated with vertebral deformities: results from the European Vertebral Osteoporosis Study (EVOS). Osteoporos Int. 1998, 8: 364-372. 10.1007\/s001980050076.","journal-title":"Osteoporos Int"},{"key":"557_CR6","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1093\/rheumatology\/40.1.7","volume":"40","author":"W Sedrine","year":"2001","unstructured":"Sedrine W, Radican L, Reginster JY: On conducting burden-of-osteoporosis studies: a review of the core concepts and practical issues. A study carried out under the auspices of a WHO Collaborating Center. Rheumatology. 2001, 40: 7-14. 10.1093\/rheumatology\/40.1.7.","journal-title":"Rheumatology"},{"key":"557_CR7","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.jbspin.2006.06.004","volume":"74","author":"CL Benhamou","year":"2007","unstructured":"Benhamou CL: Effects of osteoporosis medications on bone quality. Joint Bone Spine. 2007, 74: 39-47. 10.1016\/j.jbspin.2006.06.004.","journal-title":"Joint Bone Spine"},{"issue":"19","key":"557_CR8","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1056\/NEJM200105103441904","volume":"344","author":"RM Neer","year":"2001","unstructured":"Neer RM, Arnaud CD, Zanchetta JR, Prince R, Gaich GA, Reginster JY, Hodsman AB, Eriksen EF, Ish-Shalom S, Genant HK, Wang O, Mitlak BH: Effect of parathyroid hormone (1\u201334) on fractures and bone mineral density in postmenopausal women with osteoporosis. N Engl J Med. 2001, 344 (19): 1434-1441. 10.1056\/NEJM200105103441904.","journal-title":"N Engl J Med"},{"key":"557_CR9","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1359\/jbmr.060802","volume":"21","author":"P Chen","year":"2006","unstructured":"Chen P, Miller PD, Delmas P, Misurski DA, Krege JH: Changes in lumbar spine BMD and vertebral fracture risk reduction in teriparatide-treated postmenopausal women in osteoporosis. J Bone Miner Res. 2006, 21: 1785-1790. 10.1359\/jbmr.060802.","journal-title":"J Bone Miner Res"},{"key":"557_CR10","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/S0002-9343(02)01190-7","volume":"113","author":"A Papaioannou","year":"2002","unstructured":"Papaioannou A, Watts NB, Kendler DL, Yuen CK, Adachi JD, Ferko N: Diagnosis and management of vertebral fractures in elderly patients. Am J Med. 2002, 113: 220-228. 10.1016\/S0002-9343(02)01190-7.","journal-title":"Am J Med"},{"issue":"3","key":"557_CR11","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/s001980050217","volume":"10","author":"DJ Cook","year":"1999","unstructured":"Cook DJ, Guyatt GH, Adachi JD, Epstein RS, Juniper EF, Austin PA, Clifton J, Rosen CJ, Kessenich CR, Stock JL, Overdorf J, Miller PD, Erickson AL, McClung MR, McClung BL, Griffith LE, Ioannidis G: Development and validation of the mini-osteoporosis quality of life questionnaire (OQLQ) in osteoporotic women with back pain due to vertebral fractures. Osteoporosis Quality of Life Study Group. Osteoporos Int. 1999, 10 (3): 207-13. 10.1007\/s001980050217.","journal-title":"Osteoporos Int"},{"key":"557_CR12","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/0021-9681(87)90069-5","volume":"40","author":"G Guyatt","year":"1987","unstructured":"Guyatt G, Walter S, Norman G: Measuring change over time: assessing the usefulness of evaluative instruments. J Chronic Dis. 1987, 40: 171-178. 10.1016\/0021-9681(87)90069-5.","journal-title":"J Chronic Dis"},{"key":"557_CR13","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/0895-4356(94)90036-1","volume":"47","author":"EF Juniper","year":"1994","unstructured":"Juniper EF, Guyatt GH, Willan A, Griffith LE: Determining a minimal important change in a disease-specific Quality of Life Questionnaire. J Clin Epidemiol. 1994, 47: 81-87. 10.1016\/0895-4356(94)90036-1.","journal-title":"J Clin Epidemiol"},{"key":"557_CR14","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1471-2474-3-11","volume":"3","author":"JD Adachi","year":"2002","unstructured":"Adachi JD, Ioannidis G, Olszynski WP, Brown JP, Hanley DA, Sebaldt RJ, Petrie A, Tenenhouse A, Stephenson GF, Papaioannou A, Guyatt GH, Goldsmith CH: The impact of incident vertebral and non-vertebral fractures on health related quality of life in postmenopausal women. BMC Musculoskelet Disord. 2002, 3: 11-10.1186\/1471-2474-3-11.","journal-title":"BMC Musculoskelet Disord"},{"key":"557_CR15","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/BF01623271","volume":"3","author":"LJ Melton","year":"1993","unstructured":"Melton LJ, Lane AW, Cooper C, Eastell R, O'Fallon WM, Riggs BL: Prevelance and incidence of vertebral deformities. Osteoporos Int. 1993, 3: 113-119. 10.1007\/BF01623271.","journal-title":"Osteoporos Int"},{"key":"557_CR16","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1007\/s001980170039","volume":"12","author":"A Papaioannou","year":"2001","unstructured":"Papaioannou A, Adachi JD, Parkinson W, Stephenson G, Bedard M: Lengthy hospitalization associated with vertebral fractures despite control for comorbid conditions. Osteoporos Int. 2001, 12: 870-874. 10.1007\/s001980170039.","journal-title":"Osteoporos Int"},{"issue":"8","key":"557_CR17","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1007\/s00198-004-1774-3","volume":"16","author":"AM Oleksik","year":"2005","unstructured":"Oleksik AM, Ewing S, Shen W, van Schoor NM, Lips P: Impact of incident vertebral fractures on health related quality of life (HRQOL) in postmenopausal women with prevalent vertebral fractures. Osteoporos Int. 2005, 16 (8): 861-870. 10.1007\/s00198-004-1774-3.","journal-title":"Osteoporos Int"},{"key":"557_CR18","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1002\/hep.21404","volume":"44","author":"H Toft Sorensen","year":"2006","unstructured":"Toft Sorensen H, Lash T, Rothman K: Beyond randomized control trials: A critical comparison of trials with non-randomized studies. Hepatology. 2006, 44: 1075-1082. 10.1002\/hep.21404.","journal-title":"Hepatology"}],"container-title":["BMC Musculoskeletal Disorders"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2474-9-151.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2474-9-151\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2474-9-151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2474-9-151.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T01:11:36Z","timestamp":1630458696000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmusculoskeletdisord.biomedcentral.com\/articles\/10.1186\/1471-2474-9-151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,7]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["557"],"URL":"https:\/\/doi.org\/10.1186\/1471-2474-9-151","relation":{},"ISSN":["1471-2474"],"issn-type":[{"value":"1471-2474","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,7]]},"assertion":[{"value":"3 March 2008","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2008","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2008","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"151"}}