{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T04:16:34Z","timestamp":1728360994611},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2005,8,7]],"date-time":"2005-08-07T00:00:00Z","timestamp":1123372800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2005,8,7]],"date-time":"2005-08-07T00:00:00Z","timestamp":1123372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Surg"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Background<\/jats:title>\n                        <jats:p>In vitro studies show that new miniature cryoprobes are suitable for cryoablation of bone tissue. The aim of this animal trial on 24 sheep was to examine the perioperative complications, particularly the danger of embolism, of cryoablation when using miniature cryoprobes.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>Cryoablations with 2 freeze-thaw cycles each were carried out in the epiphysis of the right tibia and the metaphysis of the left femur. Pulmonary artery pressure (PAP) and central venous pressure (CVP) were measured. Throughout the intra- and perioperative phase, heart rate and oxygen saturation by pulse oxymetry, blood gas and electrolytes were monitored regularly. Postoperative complications were examined up to 24 weeks postoperativ.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>As result, no significant increase of PAP, CVP or heart rate were observed. Blood gases were unremarkable, with pO<jats:sub>2<\/jats:sub> and pCO<jats:sub>2<\/jats:sub> remaining constant throughout the operation. Regarding pH, standard bicarbonate and base excess, only a non-significant shift towards a slight acidosis was seen. There was a mean hemoglobin decrease of 0.5 g\/dl. One animal showed postoperative wound infection and wound edge necrosis. No major peri- and postoperative complications associated with cryosurgery of bone were observed, especially regarding clinically relevant pulmonary embolism.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusion<\/jats:title>\n                        <jats:p>Surgery with new types of miniature cryoprobes appears to be a safe alternative to or a complement to conventional resection of abnormal bone tissue.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/1471-2482-5-17","type":"journal-article","created":{"date-parts":[[2005,8,9]],"date-time":"2005-08-09T18:14:00Z","timestamp":1123611240000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Complications after cryosurgery with new miniature cryoprobes in long hollow bones: An animal trial"],"prefix":"10.1186","volume":"5","author":[{"given":"Frank","family":"Popken","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Meschede","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heike","family":"Erberich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timmo","family":"Koy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marfalda","family":"Bosse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen H","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peer","family":"Eysel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2005,8,7]]},"reference":[{"key":"57_CR1","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1097\/00003086-199902000-00019","volume":"359","author":"MM Malawer","year":"1999","unstructured":"Malawer MM, Bickels J, Meller I, Buch RG, Henshaw RW, Kollender Y: Cryosurgery in the treatment of giant cell tumor. A long-term followup study. Clin Orthop. 1999, 359: 176-188. 10.1097\/00003086-199902000-00019.","journal-title":"Clin Orthop"},{"issue":"5","key":"57_CR2","first-page":"532","volume":"44","author":"RC Marcove","year":"1968","unstructured":"Marcove RC, Miller TR, Cahan WC: The treatment of primary and metastatic bone tumors by repetitive freezing. Bull N Y Acad Med. 1968, 44 (5): 532-544.","journal-title":"Bull N Y Acad Med"},{"issue":"10","key":"57_CR3","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.1001\/jama.1969.03150230104014","volume":"207","author":"RC Marcove","year":"1969","unstructured":"Marcove RC, Miller TR: Treatment of primary and metastatic bone tumors by cryosurgery. JAMA. 1969, 207 (10): 1890-1894. 10.1001\/jama.207.10.1890.","journal-title":"JAMA"},{"key":"57_CR4","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1002\/1097-0142(197803)41:3<957::AID-CNCR2820410325>3.0.CO;2-Y","volume":"41","author":"RC Marcove","year":"1978","unstructured":"Marcove RC, Weis LD, Vaghaiwalla MRT, Pearson R, Huvos AG: Cryosurgery in the Treatment of Giant Cell Tumors of the bone. Cancer. 1978, 41: 957-969.","journal-title":"Cancer"},{"key":"57_CR5","first-page":"275","volume":"134","author":"RC Marcove","year":"1978","unstructured":"Marcove RC, Weis LD, Vaghaiwalla MR, Pearson R: Cryosurgery in the treatment of giant cell tumors of bone: a report of 52 consecutive cases. Clin Orthop. 1978, 134: 275-289.","journal-title":"Clin Orthop"},{"issue":"4","key":"57_CR6","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1002\/1097-0142(19940815)74:4<1253::AID-CNCR2820740412>3.0.CO;2-9","volume":"74","author":"RC Marcove","year":"1994","unstructured":"Marcove RC, Sheth DS, Brien EW, Huvos AG, Healey JH: Conservative surgery for giant cell tumors of the sacrum. The role of cryosurgery as a supplement to curettage and partial excision. Cancer. 1994, 74 (4): 1253-60.","journal-title":"Cancer"},{"issue":"6","key":"57_CR7","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1097\/00004694-199711000-00022","volume":"17","author":"HW Schreuder","year":"1997","unstructured":"Schreuder HW, Conrad EU, Bruckner JD, Howlett AT, Sorensen LS: Treatment of simple bone cysts in children with curettage and cryosurgery. J Pediatr Orthop. 1997, 17 (6): 814-820. 10.1097\/00004694-199711000-00022.","journal-title":"J Pediatr Orthop"},{"issue":"1","key":"57_CR8","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1002\/(SICI)1096-9098(199705)65:1<40::AID-JSO8>3.0.CO;2-O","volume":"65","author":"HW Schreuder","year":"1997","unstructured":"Schreuder HW, van Egmond J, van Beem HB, Veth RP: Monitoring during cryosurgery of bone tumors. J Surg Oncol. 1997, 65 (1): 40-45. 10.1002\/(SICI)1096-9098(199705)65:1<40::AID-JSO8>3.0.CO;2-O.","journal-title":"J Surg Oncol"},{"issue":"2","key":"57_CR9","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/S0748-7983(98)91459-7","volume":"24","author":"HW Schreuder","year":"1998","unstructured":"Schreuder HW, Pruszczynski M, Veth RP, Lemmens JA: Treatment of benign and low-grade malignant intramedullary chondroid tumours with curettage and cryosurgery. Eur J Surg Oncol. 1998, 24 (2): 120-6. 10.1016\/S0748-7983(98)91459-7.","journal-title":"Eur J Surg Oncol"},{"key":"57_CR10","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1001\/jama.1966.03100220062020","volume":"196","author":"AA Gage","year":"1966","unstructured":"Gage AA, Greene GW, Neiders ME, Emmings FG: Freezing bone without excision. An experimental study of bone-cell destruction and manner of regrowth in dogs. JAMA. 1966, 196: 770-774. 10.1001\/jama.196.9.770.","journal-title":"JAMA"},{"issue":"5","key":"57_CR11","first-page":"532","volume":"44","author":"RC Marcove","year":"1968","unstructured":"Marcove RC, Miller TR, Cahan WC: The treatment of primary and metastatic bone tumors by repetitive freezing. Bull N Y Acad Med. 1968, 44 (5): 532-544.","journal-title":"Bull N Y Acad Med"},{"key":"57_CR12","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1002\/1097-0142(197803)41:3<957::AID-CNCR2820410325>3.0.CO;2-Y","volume":"41","author":"RC Marcove","year":"1978","unstructured":"Marcove RC, Weis LD, Vaghaiwalla MRT, Pearson R, Huvos AG: Cryosurgery in the Treatment of Giant Cell Tumors of the bone. Cancer. 1978, 41: 957-969.","journal-title":"Cancer"},{"issue":"3","key":"57_CR13","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1002\/jso.2930600311","volume":"60","author":"HW Schreuder","year":"1995","unstructured":"Schreuder HW, van Beem HB, Veth RP: Venous gas embolism during cryosurgery for bone tumors. J Surg Oncol. 1995, 60 (3): 196-200.","journal-title":"J Surg Oncol"},{"issue":"2","key":"57_CR14","first-page":"142","volume":"13","author":"W Russe","year":"1984","unstructured":"Russe W, Kerschbaumer F, Bauer R: Kryochirurgie in der Orthop\u00e4die. Orthop\u00e4de. 1984, 13 (2): 142-150.","journal-title":"Orthop\u00e4de"},{"key":"57_CR15","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1006\/cryo.1997.2039","volume":"35","author":"PM Hewitt","year":"1997","unstructured":"Hewitt PM, Zhao J, Akhter J, Morris DL: A Comparative Laboratory Study of Liquid Nitrogen and Argon Gas Cryosurgery Systems. Cryobiology. 1997, 35: 303-308. 10.1006\/cryo.1997.2039.","journal-title":"Cryobiology"},{"issue":"5","key":"57_CR16","first-page":"532","volume":"44","author":"RC Marcove","year":"1968","unstructured":"Marcove RC, Miller TR, Cahan WC: The treatment of primary and metastatic bone tumors by repetitive freezing. Bull N Y Acad Med. 1968, 44 (5): 532-544.","journal-title":"Bull N Y Acad Med"},{"key":"57_CR17","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1055\/s-2001-11872","volume":"139","author":"F Popken","year":"2001","unstructured":"Popken F, Bertram C, Land M, K\u00f6nig DP, Bilgic M, Jeschkeit S, Hackenbroch MH, Fischer JH: The cryosurgical ablation of bone tissue by means of a new miniature cryoprobe \u2013 adaption of the method for an in-vitro and in-vivo application to bone. Z Orthop Ihre Grenzgeb. 2001, 139: 64-69. 10.1055\/s-2001-11872.","journal-title":"Z Orthop Ihre Grenzgeb"},{"issue":"3","key":"57_CR18","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s00402-001-0371-6","volume":"122","author":"F Popken","year":"2002","unstructured":"Popken F, Bertram C, K\u00f6nig DP, R\u00fctt J, Land M, Hackenbroch MH: The cryosurgical ablation of bone tissue by means of a new miniture cryoprobe \u2013 adaption of the method for an in-vitro and in-vivo application to bone. Arch Orthop Trauma Surg. 2002, 122 (3): 129-133. 10.1007\/s00402-001-0371-6.","journal-title":"Arch Orthop Trauma Surg"},{"issue":"6","key":"57_CR19","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/S0748-7983(03)00069-6","volume":"29","author":"F Popken","year":"2003","unstructured":"Popken F, Land M, Bosse M, Erberich H, Meschede P, K\u00f6nig DP, Fischer JH, Eysel P: Cryosurgery in long bones by means of a new miniature cryoprobe: An experimental in vivo study of the cryosurgical temperature field in sheep. Eur J Surg Oncol. 2003, 29 (6): 542-547. 10.1016\/S0748-7983(03)00069-6.","journal-title":"Eur J Surg Oncol"},{"key":"57_CR20","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/BF01246134","volume":"96","author":"F Kerschbaumer","year":"1980","unstructured":"Kerschbaumer F, Weiser G, Neuerer G, Russe W, Bauer R: Cryolesions of Bone. An Experimental Study. Part I: Examinations in technique of controlled cryolesion in bone. Arch Orthop Traumat Surg. 1980, 96: 5-9. 10.1007\/BF01246134.","journal-title":"Arch Orthop Traumat Surg"},{"key":"57_CR21","volume-title":"Proschrift","author":"HB Oeseburg","year":"1977","unstructured":"Oeseburg HB: Cryochirurgische behandeling van enkele beentumoren. Proschrift. 1977, Groningen"},{"issue":"2","key":"57_CR22","first-page":"60","volume":"25","author":"G Schlag","year":"1976","unstructured":"Schlag G, Schliep HJ, Dingeldein E, Grieben A, Ringsdorf W: Does methylmethacrylate induce cardiovascular complications during alloarthroplastic surgery of the hip joint?. Anaesthesist. 1976, 25 (2): 60-7.","journal-title":"Anaesthesist"},{"key":"57_CR23","first-page":"134","volume":"29","author":"F Kerschbaumer","year":"1982","unstructured":"Kerschbaumer F, Kr\u00f6sel P, Schlag G: Cryogenic surgery of the bone \u2013 examinations of hemodynamics and tissue. Beitr Orthop u Traumatol. 1982, 29: 134-139.","journal-title":"Beitr Orthop u Traumatol"},{"issue":"2","key":"57_CR24","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1159\/000174985","volume":"80","author":"AD Popovic","year":"1992","unstructured":"Popovic AD, Milovanovic B, Neskovic AN, Pavlovski K, Putnikovic B, Hadzagic I: Detection of massive pulmonary embolism by transesophageal echocardiography. Cardiology. 1992, 80 (2): 94-99.","journal-title":"Cardiology"},{"issue":"6","key":"57_CR25","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1056\/NEJM199702063360605","volume":"6, 336","author":"PA van der Wouw","year":"1997","unstructured":"van der Wouw PA, Bax M: Images in clinical medicine. Massive pulmonary embolism. N Engl J Med. 1997, 6, 336 (6): 416-10.1056\/NEJM199702063360605.","journal-title":"N Engl J Med"},{"issue":"3","key":"57_CR26","first-page":"232","volume":"52","author":"RS Myers","year":"1969","unstructured":"Myers RS, Hammond WG, Ketcham AS: A method for cryosurgical investigation of mouse tumors. Int Surg. 1969, 52 (3): 232-233.","journal-title":"Int Surg"},{"key":"57_CR27","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/0007-117X(78)90003-3","volume":"15","author":"AD Fisher","year":"1978","unstructured":"Fisher AD, Williams DF, Bradley PF: The effect of cryosurgery on the strength of bone. Br J Oral Surg. 1978, 15: 215-222. 10.1016\/0007-117X(78)90003-3.","journal-title":"Br J Oral Surg"}],"container-title":["BMC Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2482-5-17.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/1471-2482-5-17\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2482-5-17","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2482-5-17.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T12:50:09Z","timestamp":1728305409000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcsurg.biomedcentral.com\/articles\/10.1186\/1471-2482-5-17"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8,7]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2005,12]]}},"alternative-id":["57"],"URL":"https:\/\/doi.org\/10.1186\/1471-2482-5-17","relation":{},"ISSN":["1471-2482"],"issn-type":[{"type":"electronic","value":"1471-2482"}],"subject":[],"published":{"date-parts":[[2005,8,7]]},"assertion":[{"value":"29 June 2004","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2005","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2005","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"17"}}