{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:10:17Z","timestamp":1790187017004,"version":"4.1.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2006,11,28]],"date-time":"2006-11-28T00:00:00Z","timestamp":1164672000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Surg"],"published-print":{"date-parts":[[2006,12]]},"DOI":"10.1186\/1471-2482-6-15","type":"journal-article","created":{"date-parts":[[2006,11,29]],"date-time":"2006-11-29T08:05:17Z","timestamp":1164787517000},"source":"Crossref","is-referenced-by-count":95,"title":["Diagnostic value of blood inflammatory markers for detection of acute appendicitis in children"],"prefix":"10.1186","volume":"6","author":[{"given":"Ulrich","family":"Sack","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Biereder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tino","family":"Elouahidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Keller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf-Bodo","family":"Tr\u00f6bs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,11,28]]},"reference":[{"key":"78_CR1","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1007\/s00268-005-0304-6","volume":"30","author":"J Styrud","year":"2006","unstructured":"Styrud J, Eriksson S, Nilsson I, Ahlberg G, Haapaniemi S, Neovius G, Rex L, Badume I, Granstrom L: Appendectomy versus antibiotic treatment in acute appendicitis. a prospective multicenter randomized controlled trial. World J Surg. 2006, 30: 1033-1037. 10.1007\/s00268-005-0304-6.","journal-title":"World J Surg"},{"key":"78_CR2","first-page":"37","volume":"158","author":"RE Andersson","year":"1992","unstructured":"Andersson RE, Hugander A, Thulin AJ: Diagnostic accuracy and perforation rate in appendicitis: association with age and sex of the patient and with appendicectomy rate. Eur J Surg. 1992, 158: 37-41.","journal-title":"Eur J Surg"},{"key":"78_CR3","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/S0002-9610(99)00002-1","volume":"177","author":"MS Lessin","year":"1999","unstructured":"Lessin MS, Chan M, Catallozzi M, Gilchrist MF, Richards C, Manera L, Wallach MT, Luks FI: Selective use of ultrasonography for acute appendicitis in children. Am J Surg. 1999, 177: 193-196. 10.1016\/S0002-9610(99)00002-1.","journal-title":"Am J Surg"},{"key":"78_CR4","first-page":"303","volume":"184","author":"H Paajanen","year":"1997","unstructured":"Paajanen H, Mansikka A, Laato M, Kettunen J, Kostiainen S: Are serum inflammatory markers age dependent in acute appendicitis?. J Am Coll Surg. 1997, 184: 303-308.","journal-title":"J Am Coll Surg"},{"key":"78_CR5","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1097\/00005176-199301000-00008","volume":"16","author":"M Tsuji","year":"1993","unstructured":"Tsuji M, Puri P, Reen DJ: Characterisation of the local inflammatory response in appendicitis. J Pediatr Gastroenterol Nutr. 1993, 16: 43-48.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"78_CR6","doi-asserted-by":"publisher","first-page":"837","DOI":"10.2307\/2531595","volume":"44","author":"ER DeLong","year":"1988","unstructured":"DeLong ER, DeLong DM, Clarke-Pearson DL: Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics. 1988, 44: 837-845. 10.2307\/2531595.","journal-title":"Biometrics"},{"key":"78_CR7","first-page":"137","volume-title":"Pathology of the appendix and its surgical treatment","author":"P Myers","year":"1984","unstructured":"Myers P: Surgical. Pathology of the appendix and its surgical treatment. Edited by: Williams RA, Myers P. 1984, London: Chapman and Hall Medical, 137-141."},{"key":"78_CR8","first-page":"53","volume-title":"Pathology of the appendix and its surgical treatment","author":"RA Williams","year":"1984","unstructured":"Williams RA: Inflammatory disorders of the appendix. Pathology of the appendix and its surgical treatment. Edited by: Williams RA, Myers P. 1984, London: Chapman and Hall Medical, 53-89."},{"key":"78_CR9","first-page":"13","volume":"110","author":"JR Beck","year":"1986","unstructured":"Beck JR, Shultz EK: The use of relative operating characteristic (ROC) curves in test performance evaluation. Arch Pathol Lab Med. 1986, 110: 13-20.","journal-title":"Arch Pathol Lab Med"},{"key":"78_CR10","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1042\/bj2650621","volume":"265","author":"PC Heinrich","year":"1990","unstructured":"Heinrich PC, Castell JV, Andus T: Interleukin-6 and the acute phase response. Biochem J. 1990, 265: 621-636.","journal-title":"Biochem J"},{"key":"78_CR11","first-page":"55","volume":"152","author":"H Peltola","year":"1986","unstructured":"Peltola H, Ahlqvist J, Rapola J, Rasanen J, Louhimo I, Saarinen M, Eskola J: C-reactive protein compared with white blood cell count and erythrocyte sedimentation rate in the diagnosis of acute appendicitis in children. Acta Chir Scand. 1986, 152: 55-58.","journal-title":"Acta Chir Scand"},{"key":"78_CR12","first-page":"533","volume":"163","author":"S Hallan","year":"1997","unstructured":"Hallan S, Asberg A, Edna TH: Additional value of biochemical tests in suspected acute appendicitis. Eur J Surg. 1997, 163: 533-538.","journal-title":"Eur J Surg"},{"key":"78_CR13","first-page":"41","volume":"161","author":"S Eriksson","year":"1995","unstructured":"Eriksson S, Granstrom L, Olander B, Wretlind B: Sensitivity of interleukin-6 and C-reactive protein concentrations in the diagnosis of acute appendicitis. Eur J Surg. 1995, 161: 41-45.","journal-title":"Eur J Surg"},{"key":"78_CR14","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1007\/BF01957898","volume":"155","author":"JL Chung","year":"1996","unstructured":"Chung JL, Kong MS, Lin SL, Lin TY, Huang CS, Lou CC, Lin JN: Diagnostic value of C-reactive protein in children with perforated appendicitis. Eur J Pediatr. 1996, 155: 529-531. 10.1007\/BF01957898.","journal-title":"Eur J Pediatr"},{"key":"78_CR15","first-page":"21","volume":"45","author":"S Asfar","year":"2000","unstructured":"Asfar S, Safar H, Khoursheed M, Dashti H, al Bader A: Would measurement of C-reactive protein reduce the rate of negative exploration for acute appendicitis?. J R Coll Surg Edinb. 2000, 45: 21-24.","journal-title":"J R Coll Surg Edinb"},{"key":"78_CR16","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1177\/000313480206801201","volume":"68","author":"DY Yoon","year":"2002","unstructured":"Yoon DY, Chu J, Chandler C, Hiyama S, Thompson JE, Hines OJ: Human cytokine levels in nonperforated versus perforated appendicitis: molecular serum markers for extent of disease?. Am Surg. 2002, 68: 1033-1037.","journal-title":"Am Surg"},{"key":"78_CR17","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1024\/1023-9332.6.4.169","volume":"6","author":"S Erkasap","year":"2000","unstructured":"Erkasap S, Ates E, Ustuner Z, Sahin A, Yilmaz S, Yasar B, Kiper H: Diagnostic value of interleukin-6 and C-reactive protein in acute appendicitis. Swiss Surg. 2000, 6: 169-172. 10.1024\/1023-9332.6.4.169.","journal-title":"Swiss Surg"},{"key":"78_CR18","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1046\/j.1445-2197.2002.02516.x","volume":"72","author":"G Gurleyik","year":"2002","unstructured":"Gurleyik G, Gurleyik E, Cetinkaya F, Unalmiser S: Serum interleukin-6 measurement in the diagnosis of acute appendicitis. ANZ J Surg. 2002, 72: 665-667. 10.1046\/j.1445-2197.2002.02516.x.","journal-title":"ANZ J Surg"},{"key":"78_CR19","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1080\/003655102764654312","volume":"62","author":"H Paajanen","year":"2002","unstructured":"Paajanen H, Mansikka A, Laato M, Ristamaki R, Pulkki K, Kostiainen S: Novel serum inflammatory markers in acute appendicitis. Scand J Clin Lab Invest. 2002, 62: 579-584. 10.1080\/003655102764654312.","journal-title":"Scand J Clin Lab Invest"},{"key":"78_CR20","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1007\/s002689910076","volume":"24","author":"RE Andersson","year":"2000","unstructured":"Andersson RE, Hugander A, Ravn H, Offenbartl K, Ghazi SH, Nystrom PO, Olaison G: Repeated clinical and laboratory examinations in patients with an equivocal diagnosis of appendicitis. World J Surg. 2000, 24: 479-485. 10.1007\/s002689910076.","journal-title":"World J Surg"},{"key":"78_CR21","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1080\/11024159950189744","volume":"165","author":"H Korner","year":"1999","unstructured":"Korner H, Soreide JA, Sondenaa K: Diagnostic accuracy of inflammatory markers in patients operated on for suspected acute appendicitis: a receiver operating characteristic curve analysis. Eur J Surg. 1999, 165: 679-685. 10.1080\/11024159950189744.","journal-title":"Eur J Surg"},{"key":"78_CR22","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1001\/archsurg.140.2.169","volume":"140","author":"I Dalal","year":"2005","unstructured":"Dalal I, Somekh E, Bilker-Reich A, Boaz M, Gorenstein A, Serour F: Serum and peritoneal inflammatory mediators in children with suspected acute appendicitis. Arch Surg. 2005, 140: 169-173. 10.1001\/archsurg.140.2.169.","journal-title":"Arch Surg"},{"key":"78_CR23","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1515\/CCLM.2005.007","volume":"43","author":"L Lycopoulou","year":"2005","unstructured":"Lycopoulou L, Mamoulakis C, Hantzi E, Demetriadis D, Antypas S, Giannaki M, Bakoula C, Chrousos G, Papassotiriou I: Serum amyloid A protein levels as a possible aid in the diagnosis of acute appendicitis in children. Clin Chem Lab Med. 2005, 43: 49-53. 10.1515\/CCLM.2005.007.","journal-title":"Clin Chem Lab Med"}],"container-title":["BMC Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2482-6-15.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2482-6-15\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2482-6-15","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T15:45:07Z","timestamp":1707407107000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmcsurg.biomedcentral.com\/articles\/10.1186\/1471-2482-6-15"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,28]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["78"],"URL":"https:\/\/doi.org\/10.1186\/1471-2482-6-15","relation":{},"ISSN":["1471-2482"],"issn-type":[{"value":"1471-2482","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,28]]},"article-number":"15"}}