{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T02:48:37Z","timestamp":1787971717400,"version":"build-2784847793"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,7,19]],"date-time":"2014-07-19T00:00:00Z","timestamp":1405728000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Urol"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/1471-2490-14-53","type":"journal-article","created":{"date-parts":[[2014,7,19]],"date-time":"2014-07-19T21:01:10Z","timestamp":1405803670000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Chronic bacterial prostatitis: efficacy of short-lasting antibiotic therapy with prulifloxacin (Unidrox\u00ae) in association with saw palmetto extract, lactobacillus sporogens and arbutin (Lactorepens\u00ae)"],"prefix":"10.1186","volume":"14","author":[{"given":"Gian Maria","family":"Busetto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Giovannone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Ferro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Tricarico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Del Giudice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deliu Victor","family":"Matei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ottavio","family":"De Cobelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Gentile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ettore","family":"De Berardinis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,7,19]]},"reference":[{"key":"347_CR1","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.ucl.2007.09.005","volume":"35","author":"MA Pontari","year":"2008","unstructured":"Pontari MA: Chronic prostatitis\/chronic pelvic pain syndrome. Urol Clin North Am. 2008, 35: 81-89. 10.1016\/j.ucl.2007.09.005.","journal-title":"Urol Clin North Am"},{"key":"347_CR2","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1016\/S0022-5347(01)66359-6","volume":"155","author":"K Wenninger","year":"1996","unstructured":"Wenninger K, Heiman JR, Rothman I, Berghuis JP, Berger RE: Sickness impact of chronic nonbacterial prostatitis and its correlates. J Urol. 1996, 155: 965-968. 10.1016\/S0022-5347(01)66359-6.","journal-title":"J Urol"},{"key":"347_CR3","doi-asserted-by":"publisher","first-page":"S61","DOI":"10.1016\/j.juro.2008.03.139","volume":"179","author":"MA Pontari","year":"2008","unstructured":"Pontari MA, Ruggieri MR: Mechanisms in prostatitis\/chronic pelvic pain syndrome. J Urol. 2008, 179: S61-S67. 10.1016\/j.juro.2008.03.139.","journal-title":"J Urol"},{"key":"347_CR4","first-page":"71","volume":"79","author":"S Mazzoli","year":"2007","unstructured":"Mazzoli S: Conventional bacteriology in prostatitis patients: microbiological bias, problems and epidemiology on 1686 microbial isolates. Arch Ital Urol Androl. 2007, 79: 71-75.","journal-title":"Arch Ital Urol Androl"},{"key":"347_CR5","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1016\/j.juro.2007.11.081","volume":"179","author":"JC Nickel","year":"2008","unstructured":"Nickel JC, Xiang J: Clinical significance of nontraditional bacterial uropathogens in the management of chronic prostatitis. J Urol. 2008, 179: 1391-1395. 10.1016\/j.juro.2007.11.081.","journal-title":"J Urol"},{"issue":"6","key":"347_CR6","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1159\/000019784","volume":"34","author":"TE Bjerklund Johansen","year":"1998","unstructured":"Bjerklund Johansen TE, Gr\u00fcneberg RN, Guibert J, Bjerklund Johansen TE, Gr\u00fcneberg RN, Guibert J, Hofstetter A, Lobel B, Naber KG, Palou Redorta J, van Cangh PJ: The role of antibiotics in the treatment of chronic prostatitis: a consensus statement. Eur Urol. 1998, 34 (6): 457-466. 10.1159\/000019784.","journal-title":"Eur Urol"},{"issue":"Suppl 2","key":"347_CR7","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/S1569-9056(02)00196-3","volume":"43","author":"KG Naber","year":"2003","unstructured":"Naber KG: Antimicrobial treatment of bacterial prostatitis. Eur Urol. 2003, 43 (Suppl 2): 23-26.","journal-title":"Eur Urol"},{"key":"347_CR8","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0022-5347(17)61919-0","volume":"103","author":"TA Stamey","year":"1970","unstructured":"Stamey TA, Meares EM, Winningham DG: Chronic bacterial prostatitis and diffusion of drugs into prostatic fluid. J Urol. 1970, 103: 187-194.","journal-title":"J Urol"},{"issue":"Suppl 6A","key":"347_CR9","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S0090-4295(02)02383-X","volume":"60","author":"DA Shoskes","year":"2002","unstructured":"Shoskes DA: Phytotherapy in chronic prostatitis. Urology. 2002, 60 (Suppl 6A): 35-37.","journal-title":"Urology"},{"key":"347_CR10","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1097\/01.ju.0000101487.83730.80","volume":"171","author":"SA Kaplan","year":"2004","unstructured":"Kaplan SA, Volpe MA, Te AE: A prospective, 1-year trial using saw palmetto versus finasteride in the treatment of category III prostatitis\/chronic pelvic pain syndrome. J Urol. 2004, 171: 284-288. 10.1097\/01.ju.0000101487.83730.80.","journal-title":"J Urol"},{"issue":"8","key":"347_CR11","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1007\/s00011-012-0474-2","volume":"61","author":"HJ Lee","year":"2012","unstructured":"Lee HJ, KIM KW: Anti-inflammatory effects of arbutin in lypopolysaccharide-stimulated BV2 microglial cells. Inflamm Res. 2012, 61 (8): 817-825. 10.1007\/s00011-012-0474-2.","journal-title":"Inflamm Res"},{"key":"347_CR12","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/j.mehy.2009.04.035","volume":"73","author":"L Liu","year":"2009","unstructured":"Liu L, Yang J, Lu F: Urethral dysbacteriosis as an underlying, primary cause of chronic prostatitis: potential implications for probiotic therapy. Med Hypotheses. 2009, 73: 741-743. 10.1016\/j.mehy.2009.04.035.","journal-title":"Med Hypotheses"},{"issue":"5","key":"347_CR13","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1007\/s00284-011-0006-2","volume":"63","author":"S Amdekar","year":"2011","unstructured":"Amdekar S, Singh V, Singh DD: Probiotic therapy: immunomodulating approach toward urinary tract infection. Curr Microbiol. 2011, 63 (5): 484-490. 10.1007\/s00284-011-0006-2.","journal-title":"Curr Microbiol"},{"issue":"6","key":"347_CR14","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1016\/S0090-4295(02)01601-1","volume":"59","author":"KJ Probert","year":"2002","unstructured":"Probert KJ, Alexander RB, Nickel JC, Kusek JW, Litwin MS, Landis JR, Nyberg LM, Schaeffer AJ, Chronic Prostatitis Collaborative Research Network: Design of a multicenter randomized clinical trial for chronic prostatitis\/chronic pelvic pain syndrome. Urology. 2002, 59 (6): 870-876. 10.1016\/S0090-4295(02)01601-1.","journal-title":"Urology"},{"issue":"3","key":"347_CR15","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1179\/joc.2007.19.3.304","volume":"19","author":"G Giannarini","year":"2007","unstructured":"Giannarini G, Mogorovich A, Valent F, Morelli G, De Maria M, Manassero F, Barbone F, Selli C: Prulifloxacin versul levofloxacin in the treatment of chronic bacterial prostatitis: a prospective, randomized, double-blind trial. J Chemother. 2007, 19 (3): 304-308. 10.1179\/joc.2007.19.3.304.","journal-title":"J Chemother"},{"key":"347_CR16","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.ijantimicag.2006.09.027","volume":"29","author":"V Magri","year":"2007","unstructured":"Magri V, Trinchieri A, Pozzi G, Restelli A, Garlaschi MC, Torresani E, Zirpoli P, Marras E, Perletti G: Efficacy of repeated cyclesnof combination therapy for the eradication of infecting organisms in chronic bacterial prostatitis. Int J Antimicrob Agents. 2007, 29: 549-556. 10.1016\/j.ijantimicag.2006.09.027.","journal-title":"Int J Antimicrob Agents"},{"issue":"6","key":"347_CR17","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.ijantimicag.2008.11.012","volume":"33","author":"T Cai","year":"2009","unstructured":"Cai T, Mazzoli S, Bechi A, Addonisio P, Mondaini N, Pagliai RC, Bartoletti R: Serenoa repens associated with Urtica dioica (ProstaMEV) and curcumin and quercitin (FlogMEV) extracts are able to improve the efficacy of prulifloxacin in bacterial prostatitis patients: results from a prospective randomised study. Int J Antimicrob Agents. 2009, 33 (6): 549-553. 10.1016\/j.ijantimicag.2008.11.012.","journal-title":"Int J Antimicrob Agents"},{"issue":"Suppl 2","key":"347_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S1569-9056(02)00191-4","volume":"3","author":"AJ Schaeffer","year":"2003","unstructured":"Schaeffer AJ, Weidner W, Barbalias GA: Summary consensus statement: diagnosis and management of chronic prostatitis\/chronic pelvic pain syndrome. Eur Urol. 2003, 3 (Suppl 2): 1-4.","journal-title":"Eur Urol"},{"issue":"7","key":"347_CR19","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1111\/j.1464-410X.2012.11088.x","volume":"110","author":"A Thakkinstian","year":"2012","unstructured":"Thakkinstian A, Attia J, Anothaisintawee T, Nickel JC: \u03b1-blockers, antibiotics and anti-inflammatories have a role in the management of chronic prostatitis\/chronic pelvic pain syndrome. BJU Int. 2012, 110 (7): 1014-1022. 10.1111\/j.1464-410X.2012.11088.x.","journal-title":"BJU Int"},{"key":"347_CR20","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1007\/s11934-002-0059-7","volume":"3","author":"DA Shoskes","year":"2002","unstructured":"Shoskes DA: Phytotherapy and other alternative forms of care for the patients with prostatitis. Curr Urol Rep. 2002, 3: 330-10.1007\/s11934-002-0059-7.","journal-title":"Curr Urol Rep"},{"issue":"1","key":"347_CR21","doi-asserted-by":"publisher","first-page":"27","DOI":"10.2165\/0044011-200929010-00003","volume":"29","author":"C Giberti","year":"2009","unstructured":"Giberti C, Gallo F, Rosignoli MT, Ruggieri A, Baratt\u00e8 S, Picollo R, Dionisio P: Penetration of orally administered prulifloxacin into human prostate tissue. Clin Drug Investig. 2009, 29 (1): 27-34. 10.2165\/0044011-200929010-00003.","journal-title":"Clin Drug Investig"},{"issue":"18","key":"347_CR22","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1001\/jama.280.18.1604","volume":"280","author":"TJ Wilt","year":"1998","unstructured":"Wilt TJ, Ishani A, Stark G, MacDonald R, Lau J, Mulrow C: Saw palmetto extracts for treatment of benign prostatic hyperplasia: a systematic review. JAMA. 1998, 280 (18): 1604-1609. 10.1001\/jama.280.18.1604.","journal-title":"JAMA"},{"issue":"2","key":"347_CR23","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1002\/(SICI)1097-0045(19981001)37:2<77::AID-PROS3>3.0.CO;2-I","volume":"37","author":"F Di Silverio","year":"1998","unstructured":"Di Silverio F, Monti S, Sciarra A, Varasano PA, Martini C, Lanzara S, D\u2019Eramo G, Di Nicola S, Toscano V: Effects of long-term treatment with Serenoa repens (Permixon) on the concentrations and regional distribution of androgens and epidermal growth factor in benign prostatic hyperplasia. Prostate. 1998, 37 (2): 77-83. 10.1002\/(SICI)1097-0045(19981001)37:2<77::AID-PROS3>3.0.CO;2-I.","journal-title":"Prostate"},{"issue":"4","key":"347_CR24","first-page":"5826","volume":"18","author":"LB Weinstock","year":"2011","unstructured":"Weinstock LB, Geng B, Brandes SB: Chronic prostatitis and small intestinal bacterial overgrowth: effect of rifaximin. Can J Urol. 2011, 18 (4): 5826-5830.","journal-title":"Can J Urol"},{"key":"347_CR25","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1111\/j.1464-410X.1982.tb13635.x","volume":"54","author":"RS Kirby","year":"1982","unstructured":"Kirby RS, Lowe D, Bultitude MI, Shuttleworth KE: Intra-prostatic urinary reflux: an aetiological factor in abacterial prostatitis. Br J Urol. 1982, 54: 729-731. 10.1111\/j.1464-410X.1982.tb13635.x.","journal-title":"Br J Urol"},{"key":"347_CR26","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s10482-004-5475-x","volume":"88","author":"M Fraga","year":"2005","unstructured":"Fraga M, Scavone P, Zunino P: Preventive and therapeutic administration of an indigenous Lactobacillus sp. Strain against Proteus mirabilis ascending urinary tract infection in a mouse model. Antoine Ven Leeuwenhoek. 2005, 88: 25-34. 10.1007\/s10482-004-5475-x.","journal-title":"Antoine Ven Leeuwenhoek"},{"issue":"4","key":"347_CR27","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1097\/01.ju.0000055549.95490.3c","volume":"169","author":"DA Shoskes","year":"2003","unstructured":"Shoskes DA, Hakim L, Ghoniem G, Jackson CL: Long-term results of multimodal therapy for chronic prostatitis\/chronic pelvic pain syndrome. J Urol. 2003, 169 (4): 1406-1410. 10.1097\/01.ju.0000055549.95490.3c.","journal-title":"J Urol"},{"issue":"16","key":"347_CR28","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1016\/j.purol.2013.05.009","volume":"23","author":"F Bruyere","year":"2013","unstructured":"Bruyere F, Amine LM: PSA interest and prostatitis: literature review. Prog Urol. 2013, 23 (16): 1377-1381. 10.1016\/j.purol.2013.05.009.","journal-title":"Prog Urol"},{"key":"347_CR29","first-page":"93","volume":"79","author":"V Magri","year":"2007","unstructured":"Magri V, Trinchieri A, Ceriani I, Marras E, Perletti G: Eradication of unusual pathogens by combination pharmacological tharapy is parallel by improvement of signs and symptoms of chronic prostatitis syndrome. Arch Ital Urol Androl. 2007, 79: 93-98.","journal-title":"Arch Ital Urol Androl"}],"container-title":["BMC Urology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2490-14-53.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2490-14-53\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2490-14-53","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2490-14-53.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T20:18:24Z","timestamp":1548101904000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcurol.biomedcentral.com\/articles\/10.1186\/1471-2490-14-53"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,19]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["347"],"URL":"https:\/\/doi.org\/10.1186\/1471-2490-14-53","relation":{},"ISSN":["1471-2490"],"issn-type":[{"value":"1471-2490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,19]]},"assertion":[{"value":"27 October 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 July 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"53"}}