{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:44:59Z","timestamp":1763685899090},"reference-count":4,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2005,8,18]],"date-time":"2005-08-18T00:00:00Z","timestamp":1124323200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Dermatol"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Severe psoriasis vulgaris can be extremely difficult to treat in some patients, even with the newer biological therapies available today.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Case presentations<\/jats:title>\n            <jats:p>We present two patients with severe chronic plaque psoriasis who received numerous systemic anti-psoriatic therapies with varied results. Both responded well to initial treatment with efalizumab (anti-CD11a), but then experienced a flare of their disease after missing a dose. However, after disease stablization, both patients responded well to re-introduction of efalizumab, one patient requiring concurrent treatment with infliximab (anti-TNF-\u03b1).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>These cases are presented to characterize this \"flare\" reaction, and to inform health care providers that efalizumab can still be administered after disease flare, and again may be a successful therapy.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-5945-5-9","type":"journal-article","created":{"date-parts":[[2005,8,23]],"date-time":"2005-08-23T18:13:42Z","timestamp":1124820822000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Psoriasis vulgaris flare during efalizumab therapy does not preclude future use: a case series"],"prefix":"10.1186","volume":"5","author":[{"given":"Michelle A","family":"Lowes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A","family":"Turton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James G","family":"Krueger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross StC","family":"Barnetson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2005,8,18]]},"reference":[{"key":"56_CR1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/j.1365-2133.2004.06009.x","volume":"151","author":"T Kormeili","year":"2004","unstructured":"Kormeili T, Lowe NJ, Yamauchi PS: Psoriasis: immunopathogenesis and evolving immunomodulators and systemic therapies; U.S. experiences. Br J Dermatol 2004, 151: 3\u201315. 10.1111\/j.1365-2133.2004.06009.x","journal-title":"Br J Dermatol"},{"key":"56_CR2","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.clim.2004.06.001","volume":"113","author":"Y Vugmeyster","year":"2004","unstructured":"Vugmeyster Y, Kikuchi T, Lowes MA, Howell K, Chamian F, Kagen MH, Gilleaudeau P, Lee E, Dummer W, Pippig S, Hunte B, Bodary S, Krueger JG: Efalizumab (anti-CD11a)-induced increase in leukocyte numbers in psoriasis patients is preferentially mediated by blocked entry of memory CD8+ T cells into the skin. Clin Immunol 2004, 113: 38\u201346. 10.1016\/j.clim.2004.06.001","journal-title":"Clin Immunol"},{"key":"56_CR3","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1517\/14712598.3.2.361","volume":"3","author":"JC Cather","year":"2003","unstructured":"Cather JC, Menter A: Modulating T cell responses for the treatment of psoriasis: a focus on efalizumab. Expert Opin Biol Ther 2003, 3: 361\u2013370. 10.1517\/14712598.3.2.361","journal-title":"Expert Opin Biol Ther"},{"key":"56_CR4","doi-asserted-by":"publisher","first-page":"ii87","DOI":"10.1136\/ard.2004.032276","volume":"64 Suppl 2","author":"LS Winterfield","year":"2005","unstructured":"Winterfield LS, Menter A, Gordon K, Gottlieb A: Psoriasis treatment: current and emerging directed therapies. Ann Rheum Dis 2005, 64 Suppl 2: ii87\u201390; discussion ii91\u20132. 10.1136\/ard.2004.032276","journal-title":"Ann Rheum Dis"}],"container-title":["BMC Dermatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-5945-5-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-5945-5-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-5945-5-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-5945-5-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T21:17:25Z","timestamp":1630444645000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcdermatol.biomedcentral.com\/articles\/10.1186\/1471-5945-5-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8,18]]},"references-count":4,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["56"],"URL":"https:\/\/doi.org\/10.1186\/1471-5945-5-9","relation":{},"ISSN":["1471-5945"],"issn-type":[{"value":"1471-5945","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,8,18]]},"assertion":[{"value":"2 May 2005","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2005","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2005","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"9"}}