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Death from colonic disease in epidermolysis bullosa (EB) is never reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>We demonstrate a male patient with RDEB. He suffered megacolon due to fecal impaction and died from sigmoid colon perforation with peritonitis at age 35 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Constipation is a common clinical feature of RDEB, but fetal complications of chronic constipation are rarely reported. To the author's best knowledge, it has not been reported or recognized in the English literature previously. The aggressive assessment of constipation with fecal impaction is recommended in patients with RDEB.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1471-5945-6-2","type":"journal-article","created":{"date-parts":[[2006,2,17]],"date-time":"2006-02-17T07:45:28Z","timestamp":1140162328000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Death from colonic disease in epidermolysis bullosa dystrophica"],"prefix":"10.1186","volume":"6","author":[{"given":"Chih-Hsin","family":"Hsieh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Che-Jen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gau-Tyan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,2,15]]},"reference":[{"key":"62_CR1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2340\/00015555645762","volume":"64","author":"M Kero","year":"1984","unstructured":"Kero M: Occurrence of epidermolysis bullosa in Finland. 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