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Our aim was to determine whether depletion or maintenance of intestinal glutathione changes susceptibility of rats to <jats:italic>Salmonella<\/jats:italic> infection and associated inflammation.<\/jats:p>\n            <jats:p>Rats were fed a control diet or the same diet supplemented with buthionine sulfoximine (BSO; glutathione depletion) or cystine (glutathione maintenance). Inert chromium ethylenediamine-tetraacetic acid (CrEDTA) was added to the diets to quantify intestinal permeability. At day 4 after oral gavage with <jats:italic>Salmonella<\/jats:italic>\n              <jats:italic>enteritidis<\/jats:italic> (or saline for non-infected controls), <jats:italic>Salmonella<\/jats:italic> translocation was determined by culturing extra-intestinal organs. Liver and ileal mucosa were collected for analyses of glutathione, inflammation markers and oxidative damage. Faeces was collected to quantify diarrhoea.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Glutathione depletion aggravated ileal inflammation after infection as indicated by increased levels of mucosal myeloperoxidase and interleukin-1\u03b2. Remarkably, intestinal permeability and <jats:italic>Salmonella<\/jats:italic> translocation were not increased. Cystine supplementation maintained glutathione in the intestinal mucosa but inflammation and oxidative damage were not diminished. Nevertheless, cystine reduced intestinal permeability and <jats:italic>Salmonella<\/jats:italic> translocation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Despite increased infection-induced mucosal inflammation upon glutathione depletion, this tripeptide does not play a role in intestinal permeability, bacterial translocation and diarrhoea. On the other hand, cystine enhances gut barrier function by a mechanism unlikely to be related to glutathione.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1472-6793-9-6","type":"journal-article","created":{"date-parts":[[2009,5,6]],"date-time":"2009-05-06T18:16:53Z","timestamp":1241633813000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Intestinal barrier function in response to abundant or depleted mucosal glutathione in Salmonella-infected rats"],"prefix":"10.1186","volume":"9","author":[{"given":"Marleen TJ","family":"van Ampting","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arjan J","family":"Schonewille","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolien","family":"Vink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert Jan","family":"Brummer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roelof vander","family":"Meer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingeborg MJ","family":"Bovee-Oudenhoven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,4,17]]},"reference":[{"issue":"1397","key":"129_CR1","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1098\/rstb.2000.0603","volume":"355","author":"BB Finlay","year":"2000","unstructured":"Finlay BB, Brumell JH: Salmonella interactions with host cells: in vitro to in vivo. 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