{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:05:24Z","timestamp":1793070324043,"version":"4.5.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,6,13]],"date-time":"2012-06-13T00:00:00Z","timestamp":1339545600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Endocr Disord"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1186\/1472-6823-12-8","type":"journal-article","created":{"date-parts":[[2012,6,25]],"date-time":"2012-06-25T10:14:10Z","timestamp":1340619250000},"source":"Crossref","is-referenced-by-count":94,"title":["Current practice of glucocorticoid replacement therapy and patient-perceived health outcomes in adrenal insufficiency - a worldwide patient survey"],"prefix":"10.1186","volume":"12","author":[{"given":"M","family":"Forss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Batcheller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Skrtic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Johannsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,6,13]]},"reference":[{"key":"127_CR1","doi-asserted-by":"publisher","first-page":"4849","DOI":"10.1210\/jc.2006-0076","volume":"91","author":"R Bergthorsdottir","year":"2006","unstructured":"Bergthorsdottir R, Leonsson-Zachrisson M, Od\u00e9n A, Johannsson G: Premature mortality in patients with Addison's disease: a population-based study. J Clin Endocrinol Metab. 2006, 91: 4849-4853. 10.1210\/jc.2006-0076.","journal-title":"J Clin Endocrinol Metab"},{"key":"127_CR2","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1111\/j.1365-2265.2008.03340.x","volume":"69","author":"S Bensing","year":"2008","unstructured":"Bensing S, Brandt L, Tabaro F, Sj\u00f6berg O, Nilsson B, Ekbom A, Blomqvist P, K\u00e4mpe O: Increased death risk and altered cancer incidence pattern in patients with isolated or combined autoimmune primary adrenocortical insufficiency. Clin Endocrinol (Oxf). 2008, 69: 697-704. 10.1111\/j.1365-2265.2008.03340.x.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"127_CR3","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.jpeds.2003.12.036","volume":"144","author":"JL Mills","year":"2004","unstructured":"Mills JL, Schonberger LB, Wysowski DK, Brown P, Durako SJ, Cox C, Kong F, Fradkin JE: Long-term mortality in the United States cohort of pituitary-derived growth hormone recipients. J Pediat. 2004, 144: 430-436. 10.1016\/j.jpeds.2003.12.036.","journal-title":"J Pediat"},{"key":"127_CR4","doi-asserted-by":"publisher","first-page":"3954","DOI":"10.1210\/jc.2006-0524","volume":"91","author":"H Filipsson","year":"2006","unstructured":"Filipsson H, Monson JP, Koltowska-H\u00e4ggstr\u00f6m M, Mattsson A, Johannsson G: The impact of glucocorticoid replacement regimens on metabolic outcome and comorbidity in hypopituitary patients. Clin Endocrinol Metab. 2006, 91: 3954-3961. 10.1210\/jc.2006-0524.","journal-title":"Clin Endocrinol Metab"},{"key":"127_CR5","volume-title":"A survey among patients with Addison\u2019s disease, Cushing\u2019s syndrome or congenital adrenal Hyperplasia (CAH)","author":"J Holleman","year":"2006","unstructured":"Holleman J: Illness, healthcare, and the quality of life. A survey among patients with Addison\u2019s disease, Cushing\u2019s syndrome or congenital adrenal Hyperplasia (CAH). 2006, Dutch Addison and Cushing Society: NVACP, the Netherlands, (English version: November 2007)"},{"key":"127_CR6","doi-asserted-by":"publisher","first-page":"207","DOI":"10.7326\/0003-4819-120-3-199402010-00005","volume":"120","author":"PM Zelissen","year":"1994","unstructured":"Zelissen PM, Croughs RJ, van Rijk PP, Raymakers JA: Effect of glucocorticoid replacement therapy on bone mineral density in patients with Addison disease. Ann Intern Med. 1994, 120: 207-210.","journal-title":"Ann Intern Med"},{"key":"127_CR7","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1530\/EJE-08-0880","volume":"160","author":"K L\u00f8v\u00e5s","year":"2009","unstructured":"L\u00f8v\u00e5s K, Gjesdal CG, Christensen M, Wolff AB, Alm\u00e5s B, Svartberg J, Fougner K, Syversen U, Bollerslev J, Falch JA, Hunt PJ, Chatterjee VKK, Husebye ES: Glucocorticoid replacement therapy and pharmacogenetics in Addison's disease: effects on bone. Eur J Endocrinol. 2009, 160: 993-1002. 10.1530\/EJE-08-0880.","journal-title":"Eur J Endocrinol"},{"key":"127_CR8","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1136\/bmj.294.6575.798","volume":"294","author":"JP Devogelaer","year":"1987","unstructured":"Devogelaer JP, Crabb\u00e9 J, Nagant de Deuxchaisnes C: Bone mineral density in Addison's disease: evidence for an effect of adrenal androgens on bone mass. Br Med J (Clin Res Ed). 1987, 294: 798-800. 10.1136\/bmj.294.6575.798.","journal-title":"Br Med J (Clin Res Ed)"},{"key":"127_CR9","first-page":"52","volume":"107","author":"CM Florkowski","year":"1994","unstructured":"Florkowski CM, Holmes SJ, Elliot JR, Donald RA, Espiner EA: Bone mineral density is reduced in female but not male subjects with Addison's disease. N Z Med J. 1994, 107: 52-53.","journal-title":"N Z Med J"},{"key":"127_CR10","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1111\/j.1365-2265.2011.04174.x","volume":"76","author":"O Ragnarsson","year":"2012","unstructured":"Ragnarsson O, Nystr\u00f6m HF, Johannsson G: Glucocorticoid replacement therapy is independently associated with reduced bone mineral density in women with hypopituitarism. Clin Endocrinol (Oxf). 2012, 76: 246-252. 10.1111\/j.1365-2265.2011.04174.x.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"127_CR11","volume-title":"International Addison\u2019s survey 2003","author":"J Wass","year":"2005","unstructured":"Wass J, White K, Elliott A, Baker S, Arlt W, Chatterjee K, Croxson M, Gurnell E, Hunt P, Howlett T: Medication management and quality of life in patients with primary adrenal insufficiency. International Addison\u2019s survey 2003. 2005, Poster presentation in Harrogate 2005. [\n                    http:\/\/www.addisons.org.uk\/comms\/meetings\/harrogateposter2005.pdf\n                    \n                  ]"},{"key":"127_CR12","volume-title":"North American survey of individuals with Addison's disease","author":"PL Margulies","year":"1997","unstructured":"Margulies PL, Mullen J, National Adrenal Diseases Foundation, National Adrenal Diseases Foundation: North American survey of individuals with Addison's disease. 1997,\n                    http:\/\/www.nadf.us\/news\/survey1997_text.pdf\n                    \n                  ,"},{"key":"127_CR13","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1046\/j.1365-2265.2002.01466.x","volume":"56","author":"K L\u00f8v\u00e5s","year":"2002","unstructured":"L\u00f8v\u00e5s K, Loge JH, Husebye ES: Subjective health status in Norwegian patients with Addison's disease. Clin Endocrinol (Oxf). 2002, 56: 581-588. 10.1046\/j.1365-2265.2002.01466.x.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"127_CR14","doi-asserted-by":"publisher","first-page":"3912","DOI":"10.1210\/jc.2007-0685","volume":"92","author":"S Hahner","year":"2007","unstructured":"Hahner S, Loeffler M, Fassnacht M, Weismann D, Koschker AC, Quinkler M, Decker O, Arlt W, Allolio B: Impaired subjective health status in 256 patients with adrenal insufficiency on standard therapy based on cross-sectional analysis. J Clin Endocrinol Metab. 2007, 92: 3912-3922. 10.1210\/jc.2007-0685.","journal-title":"J Clin Endocrinol Metab"},{"key":"127_CR15","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1210\/jc.2007-1134","volume":"93","author":"EM Gurnell","year":"2008","unstructured":"Gurnell EM, Hunt PJ, Curran SE, Conway CL, Pullenayegum EM, Huppert FA, Compston JE, Herbert J, Chatterjee VKK: Long-term DHEA replacement in primary adrenal insufficiency: a randomized, controlled trial. J Clin Endocrinol Metab. 2008, 93: 400-409. 10.1210\/jc.2007-1134.","journal-title":"J Clin Endocrinol Metab"},{"key":"127_CR16","doi-asserted-by":"publisher","first-page":"4882","DOI":"10.1210\/jc.2009-1368","volume":"94","author":"MM Erichsen","year":"2009","unstructured":"Erichsen MM, L\u00f8v\u00e5s K, Skinningsrud B, Wolff AB, Undlien DE, Svartberg J, Fougner KJ, Berg TJ, Bollerslev J, Mella B, Carlson JA, Erlich H, Husebye ES: Clinical, immunological, and genetic features of autoimmune primary adrenal insufficiency: observations from a Norwegian registry. J Clin Endocrinol Metab. 2009, 94: 4882-4890. 10.1210\/jc.2009-1368.","journal-title":"J Clin Endocrinol Metab"},{"key":"127_CR17","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1530\/EJE-07-0052","volume":"157","author":"K L\u00f8v\u00e5s","year":"2007","unstructured":"L\u00f8v\u00e5s K, Husebye ES: Continuous subcutaneous hydrocortisone infusion in Addison's disease. Eur J Endocrinol. 2007, 157: 109-112. 10.1530\/EJE-07-0052.","journal-title":"Eur J Endocrinol"},{"key":"127_CR18","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1177\/014107688808100906","volume":"81","author":"RW Groves","year":"1988","unstructured":"Groves RW, Toms GC, Houghton BJ, Monson JP: Corticosteroid replacement therapy: twice or thrice daily?. J R Soc Med. 1988, 81: 514-516.","journal-title":"J R Soc Med"},{"key":"127_CR19","unstructured":"British Healthcare Business Intelligence Association (BHBIA): Legal and ethical guidelines for healthcare market research. , [http:\/\/www.bhbia.org.uk\/guidelines\/legalandethicalguidelines.aspx], October 2011"},{"key":"127_CR20","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1111\/j.1365-2265.2005.02421.x","volume":"64","author":"RM Reynolds","year":"2006","unstructured":"Reynolds RM, Stewart PM, Seckl JR, Padfield PL: Assessing the HPA axis in patients with pituitary disease: a UK survey. Clin Endocrinol (Oxf). 2006, 64: 82-85. 10.1111\/j.1365-2265.2005.02421.x.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"127_CR21","volume-title":"Adherence to long-term therapies: evidence for action","author":"World Health Organization","year":"2003","unstructured":"World Health Organization: Adherence to long-term therapies: evidence for action. 2003, Geneva, Switzerland,\n                    http:\/\/www.who.int\/chp\/knowledge\/publications\/adherence_full_report.pdf\n                    \n                  ,"},{"key":"127_CR22","doi-asserted-by":"publisher","first-page":"455","DOI":"10.2165\/11531290-000000000-00000","volume":"49","author":"N Simon","year":"2010","unstructured":"Simon N, Castinetti F, Ouliac F, Lesavre N, Brue T, Oliver C: Pharmacokinetic evidence for suboptimal treatment of adrenal insufficiency with currently available hydrocortisone tablets. Clin Pharmacokinet. 2010, 49: 455-463. 10.2165\/11531290-000000000-00000.","journal-title":"Clin Pharmacokinet"},{"key":"127_CR23","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1080\/00365510410004867","volume":"64","author":"J Blomgren","year":"2004","unstructured":"Blomgren J, Ekman B, Andersson PO, Arnqvist HJ: Non-physiological levels of circulating cortisol in growth hormone-treated hypopituitary adults after conventional cortisone substitution. Scand J Clin Lab Invest. 2004, 64: 132-139. 10.1080\/00365510410004867.","journal-title":"Scand J Clin Lab Invest"},{"key":"127_CR24","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/j.1365-2265.2012.04352.x","volume":"77","author":"B Ekman","year":"2012","unstructured":"Ekman B, Bachrach-Lindstr\u00f6m M, Lindstr\u00f6m T, Wahlberg J, Blomgren J, Arnqvist HJ: A randomized double blind crossover study comparing two and four dose hydrocortisone regimen with regard to quality of life, cortisol and ACTH profiles in patients with primary adrenal insufficiency. Clin Endocrinol (Oxf). 2012, 77: 18-25. 10.1111\/j.1365-2265.2012.04352.x.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"127_CR25","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1111\/j.1365-2265.2004.02106.x","volume":"61","author":"PM Mah","year":"2004","unstructured":"Mah PM, Jenkins RC, Rostami-Hodjegan A, Newell-Price J, Doane A, Ibbotson V, Tucker GT, Ross RJ: Weight-related dosing, timing and monitoring hydrocortisone replacement therapy in patients with adrenal insufficiency. Clin Endocrinol (Oxf). 2004, 61: 367-375. 10.1111\/j.1365-2265.2004.02106.x.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"127_CR26","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1002\/jps.2600711029","volume":"71","author":"RD Toothaker","year":"1982","unstructured":"Toothaker RD, Craig WA, Welling PG: Effect of dose size on the pharmacokinetics of oral hydrocortisone suspension. J Pharm Sci. 1982, 71: 1182-1185. 10.1002\/jps.2600711029.","journal-title":"J Pharm Sci"},{"key":"127_CR27","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1210\/jc.2008-2380","volume":"94","author":"M Debono","year":"2009","unstructured":"Debono M, Ghobadi C, Rostami-Hodjegan A, Huatan H, Campbell MJ, Newell-Price J, Darzy K, Merke DP, Arlt W, Ross RJ: Modified-release hydrocortisone to provide circadian cortisol profiles. J Clin Endocrinol Metab. 2009, 94: 1548-1554. 10.1210\/jc.2008-2380.","journal-title":"J Clin Endocrinol Metab"},{"key":"127_CR28","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1210\/jc.2011-1926","volume":"97","author":"G Johannsson","year":"2012","unstructured":"Johannsson G, Nilsson AG, Bergthorsdottir R, Burman P, Dahlqvist P, Ekman B, Engstr\u00f6m BE, Olsson T, Ragnarsson O, Ryberg M, Wahlberg J, Biller BM, Monson JP, Stewart PM, Lennern\u00e4s H, Skrtic S: Improved cortisol exposure-time profile and outcome in patients with adrenal insufficiency: a prospective randomized trial of a novel hydrocortisone dual-release formulation. J Clin Endocrinol Metab. 2012, 97: 473-481. 10.1210\/jc.2011-1926.","journal-title":"J Clin Endocrinol Metab"},{"key":"127_CR29","volume-title":"Endocrine Abstracts 9 P142","author":"KG White","year":"2005","unstructured":"White KG, Wass JAHW, Elliott AE, Baker SJK: Medication management and quality of life in patients with primary adrenal insufficiency. British Endocrine Societies Joint Meeting. Endocrine Abstracts 9 P142. 2005,\n                    http:\/\/www.endocrine-abstracts.org\/ea\/0009\/ea0009p142.htm\n                    \n                  ,"},{"key":"127_CR30","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1210\/jc.2009-1711","volume":"95","author":"K L\u00f8v\u00e5s","year":"2010","unstructured":"L\u00f8v\u00e5s K, Curran S, Oksnes M, Husebye ES, Huppert FA, Chatterjee VK: Development of a disease-specific quality of life questionnaire in Addison's disease. J Clin Endocrinol Metab. 2010, 95: 545-551. 10.1210\/jc.2009-1711.","journal-title":"J Clin Endocrinol Metab"},{"key":"127_CR31","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1530\/EJE-09-0884","volume":"162","author":"S Hahner","year":"2010","unstructured":"Hahner S, Loeffler M, Bleicken B, Drechsler C, Milovanovic D, Fassnacht M, Ventz M, Quinkler M, Allolio B: Epidemiology of adrenal crisis in chronic adrenal insufficiency: the need for new prevention strategies. Eur J Endocrinol. 2010, 162: 597-602. 10.1530\/EJE-09-0884.","journal-title":"Eur J Endocrinol"},{"key":"127_CR32","doi-asserted-by":"publisher","first-page":"5110","DOI":"10.1210\/jc.2010-0917","volume":"95","author":"W Arlt","year":"2010","unstructured":"Arlt W, Willis DS, Wild SH, Krone N, Doherty EJ, Hahner S, Han TS, Carroll PV, Conway GS, Rees DA, Stimson RH, Walker BR, Connell JM, Ross RJ: United Kingdom Congenital Adrenal Hyperplasia Adult Study Executive (CaHASE): Health status of adults with congenital adrenal hyperplasia: a cohort study of 203 patients. J Clin Endocrinol Metab. 2010, 95: 5110-5121. 10.1210\/jc.2010-0917.","journal-title":"J Clin Endocrinol Metab"}],"container-title":["BMC Endocrine Disorders"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1472-6823-12-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6823-12-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6823-12-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6823-12-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T11:46:45Z","timestamp":1548157605000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcendocrdisord.biomedcentral.com\/articles\/10.1186\/1472-6823-12-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,13]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["127"],"URL":"https:\/\/doi.org\/10.1186\/1472-6823-12-8","relation":{},"ISSN":["1472-6823"],"issn-type":[{"value":"1472-6823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,13]]},"article-number":"8"}}