{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:09:56Z","timestamp":1772165396811,"version":"3.50.1"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2009,6,6]],"date-time":"2009-06-06T00:00:00Z","timestamp":1244246400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Women's Health"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Premature menopause is a major concern of younger women undergoing adjuvant therapy for breast cancer. Hormone replacement therapy is contraindicated in women with a history of breast cancer. Non-hormonal medications show a range of bothersome side-effects. There is growing evidence that cognitive behavioral therapy (CBT) and physical exercise can have a positive impact on symptoms in naturally occurring menopause. The objective of this study is to investigate the efficacy of these interventions among women with breast cancer experiencing treatment-induced menopause.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods\/design<\/jats:title>\n                    <jats:p>In a randomized, controlled, multicenter trial, we are evaluating the effectiveness of CBT\/relaxation, of physical exercise and of these two program elements combined, in reducing menopausal symptoms, improving sexual functioning, reducing emotional distress, and in improving the health-related quality of life of younger breast cancer patients who experience treatment-induced menopause. 325 breast cancer patients (aged &lt; 50) are being recruited from hospitals in the Amsterdam region, and randomly allocated to one of the three treatment groups or a 'waiting list' control group. Self-administered questionnaires are completed by the patients at baseline, and at 12 weeks (T1) and 6 months (T2) post-study entry. Upon completion of the study, women assigned to the control group will be given the choice of undergoing either the CBT or physical exercise program.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Cognitive behavioral therapy and physical exercise are potentially useful treatments among women with breast cancer undergoing treatment-induced, premature menopause. For these patients, hormonal and non-hormonal therapies are contraindicated or have a range of bothersome side-effects. Hence, research into these interventions is needed, before dissemination and implementation in the current health care system can take place.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>The study is registered at the Netherlands Trial Register (NTR1165) and ClinicalTrials.gov (NCT00582244).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/1472-6874-9-15","type":"journal-article","created":{"date-parts":[[2009,6,6]],"date-time":"2009-06-06T14:21:18Z","timestamp":1244298078000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Cognitive behavioral therapy and physical exercise for climacteric symptoms in breast cancer patients experiencing treatment-induced menopause: design of a multicenter trial"],"prefix":"10.1186","volume":"9","author":[{"given":"Saskia FA","family":"Duijts","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hester SA","family":"Oldenburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"van Beurden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil K","family":"Aaronson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,6,6]]},"reference":[{"key":"156_CR1","volume-title":"Incidence of cancer in the Netherlands 1999\/2000: Eleventh report of the Netherlands Cancer Registry","author":"O Visser","year":"2003","unstructured":"Visser O, Siesling S, van Dijk J: Incidence of cancer in the Netherlands 1999\/2000: Eleventh report of the Netherlands Cancer Registry. 2003, Utrecht: Association of Integral Cancer Centers"},{"key":"156_CR2","unstructured":"American Cancer Society \u2013 Cancer Facts Figures \u2013 2000. 2003, Atlanta, GA: American Cancer Society"},{"issue":"5","key":"156_CR3","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1200\/JCO.1996.14.5.1718","volume":"14","author":"J Bines","year":"1996","unstructured":"Bines J, Oleske DM, Cobleigh MA: Ovarian function in premenopausal women treated with adjuvant chemotherapy for breast cancer. J Clin Oncol. 1996, 14 (5): 1718-29.","journal-title":"J Clin Oncol"},{"issue":"26","key":"156_CR4","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.1056\/NEJM200106283442607","volume":"344","author":"CL Shapiro","year":"2001","unstructured":"Shapiro CL, Recht A: Side effects of adjuvant treatment of breast cancer. N Engl J Med. 2001, 344 (26): 1997-2008. 10.1056\/NEJM200106283442607.","journal-title":"N Engl J Med"},{"issue":"8","key":"156_CR5","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1200\/JCO.1999.17.8.2365","volume":"17","author":"PJ Goodwin","year":"1999","unstructured":"Goodwin PJ, Ennis M, Pritchard KI, Trudeau M, Hood N: Risk of menopause during the first year after breast cancer diagnosis. J Clin Oncol. 1999, 17 (8): 2365-70.","journal-title":"J Clin Oncol"},{"issue":"4","key":"156_CR6","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1002\/pon.744","volume":"13","author":"NE Avis","year":"2004","unstructured":"Avis NE, Crawford S, Manuel J: Psychosocial problems among younger women with breast cancer. Psychooncology. 2004, 13 (4): 295-308.","journal-title":"Psychooncology"},{"issue":"1","key":"156_CR7","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S0378-5122(03)00087-2","volume":"45","author":"N Biglia","year":"2003","unstructured":"Biglia N, Cozzarella M, Cacciari F, Ponzone R, Roagna R, Maggiorotto F, et al: Menopause after breast cancer: a survey on breast cancer survivors. Maturitas. 2003, 45 (1): 29-38. 10.1016\/S0378-5122(03)00087-2.","journal-title":"Maturitas"},{"issue":"11","key":"156_CR8","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1200\/JCO.1995.13.11.2737","volume":"13","author":"RJ Couzi","year":"1995","unstructured":"Couzi RJ, Helzlsouer KJ, Fetting JH: Prevalence of menopausal symptoms among women with a history of breast cancer and attitudes toward estrogen replacement therapy. J Clin Oncol. 1995, 13 (11): 2737-44.","journal-title":"J Clin Oncol"},{"issue":"2","key":"156_CR9","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1200\/JCO.1998.16.2.501","volume":"16","author":"PA Ganz","year":"1998","unstructured":"Ganz PA, Rowland JH, Desmond K, Meyerowitz BE, Wyatt GE: Life after breast cancer: understanding women's health-related quality of life and sexual functioning. J Clin Oncol. 1998, 16 (2): 501-14.","journal-title":"J Clin Oncol"},{"issue":"6","key":"156_CR10","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/S0885-3924(02)00395-0","volume":"509;23","author":"PF Harris","year":"2002","unstructured":"Harris PF, Remington PL, Trentham-Dietz A, Allen CI, Newcomb PA: Prevalence and treatment of menopausal symptoms among breast cancer survivors. J Pain Symptom Manage. 2002, 509;23 (6): 501-10.1016\/S0885-3924(02)00395-0.","journal-title":"J Pain Symptom Manage"},{"issue":"3","key":"156_CR11","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1677\/erc.1.00783","volume":"11","author":"N Angelopoulos","year":"2004","unstructured":"Angelopoulos N, Barbounis V, Livadas S, Kaltsas D, Tolis G: Effects of estrogen deprivation due to breast cancer treatment. Endocr Relat Cancer. 2004, 11 (3): 523-35. 10.1677\/erc.1.00783.","journal-title":"Endocr Relat Cancer"},{"issue":"3","key":"156_CR12","first-page":"174","volume":"13","author":"AY Rostom","year":"2001","unstructured":"Rostom AY: The management of menopausal sequelae in patients with breast cancer. Clin Oncol (R Coll Radiol). 2001, 13 (3): 174-80.","journal-title":"Clin Oncol (R Coll Radiol)"},{"issue":"4","key":"156_CR13","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1097\/00002820-199608000-00007","volume":"19","author":"S Young-McCaughan","year":"1996","unstructured":"Young-McCaughan S: Sexual functioning in women with breast cancer after treatment with adjuvant therapy. Cancer Nurs. 1996, 19 (4): 308-19. 10.1097\/00002820-199608000-00007.","journal-title":"Cancer Nurs"},{"issue":"3","key":"156_CR14","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1002\/pon.794","volume":"13","author":"JR Bloom","year":"2004","unstructured":"Bloom JR, Stewart SL, Chang S, Banks PJ: Then and now: quality of life of young breast cancer survivors. Psychooncology. 2004, 13 (3): 147-60. 10.1002\/pon.794.","journal-title":"Psychooncology"},{"issue":"8","key":"156_CR15","first-page":"1311","volume":"26","author":"JS Carpenter","year":"1999","unstructured":"Carpenter JS, Andrykowski MA: Menopausal symptoms in breast cancer survivors. Oncol Nurs Forum. 1999, 26 (8): 1311-7.","journal-title":"Oncol Nurs Forum"},{"issue":"9","key":"156_CR16","doi-asserted-by":"publisher","first-page":"1682","DOI":"10.1002\/(SICI)1097-0142(19980501)82:9<1682::AID-CNCR14>3.0.CO;2-0","volume":"82","author":"JS Carpenter","year":"1998","unstructured":"Carpenter JS, Andrykowski MA, Cordova M, Cunningham L, Studts J, McGrath P, et al: Hot flashes in postmenopausal women treated for breast carcinoma: prevalence, severity, correlates, management, and relation to quality of life. Cancer. 1998, 82 (9): 1682-91. 10.1002\/(SICI)1097-0142(19980501)82:9<1682::AID-CNCR14>3.0.CO;2-0.","journal-title":"Cancer"},{"issue":"11","key":"156_CR17","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1002\/pon.793","volume":"13","author":"MS Hunter","year":"2004","unstructured":"Hunter MS, Grunfeld EA, Mittal S, Sikka P, Ramirez AJ, Fentiman I, et al: Menopausal symptoms in women with breast cancer: prevalence and treatment preferences. Psychooncology. 2004, 13 (11): 769-78. 10.1002\/pon.793.","journal-title":"Psychooncology"},{"issue":"11","key":"156_CR18","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.4065\/77.11.1207","volume":"77","author":"TD Shanafelt","year":"2002","unstructured":"Shanafelt TD, Barton DL, Adjei AA, Loprinzi CL: Pathophysiology and treatment of hot flashes. Mayo Clin Proc. 2002, 77 (11): 1207-18. 10.4065\/77.11.1207.","journal-title":"Mayo Clin Proc"},{"issue":"3","key":"156_CR19","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/BF00846541","volume":"10","author":"L Gannon","year":"1987","unstructured":"Gannon L, Hansel S, Goodwin J: Correlates of menopausal hot flashes. J Behav Med. 1987, 10 (3): 277-85. 10.1007\/BF00846541.","journal-title":"J Behav Med"},{"issue":"5","key":"156_CR20","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1037\/0278-6133.9.5.529","volume":"9","author":"LC Swartzman","year":"1990","unstructured":"Swartzman LC, Edelberg R, Kemmann E: Impact of stress on objectively recorded menopausal hot flushes and on flush report bias. Health Psychol. 1990, 9 (5): 529-45. 10.1037\/0278-6133.9.5.529.","journal-title":"Health Psychol"},{"key":"156_CR21","volume-title":"Oral oestrogen replacement therapy versus placebo for hot flushes (Cochrane Review)","author":"A MacLennan","year":"2004","unstructured":"MacLennan A, Lester S, Moore V: Oral oestrogen replacement therapy versus placebo for hot flushes (Cochrane Review). 2004"},{"issue":"9407","key":"156_CR22","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/S0140-6736(04)15493-7","volume":"363","author":"L Holmberg","year":"2004","unstructured":"Holmberg L, Anderson H: HABITS (hormonal replacement therapy after breast cancer \u2013 is it safe?), a randomised comparison: trial stopped. Lancet. 2004, 363 (9407): 453-5. 10.1016\/S0140-6736(04)15493-7.","journal-title":"Lancet"},{"issue":"9","key":"156_CR23","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1345\/aph.1D610","volume":"38","author":"SE Fugate","year":"2004","unstructured":"Fugate SE, Church CO: Nonestrogen treatment modalities for vasomotor symptoms associated with menopause. Ann Pharmacother. 2004, 38 (9): 1482-99. 10.1345\/aph.1D610.","journal-title":"Ann Pharmacother"},{"issue":"10","key":"156_CR24","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1177\/106002809302701012","volume":"27","author":"CF Caley","year":"1993","unstructured":"Caley CF, Weber SS: Paroxetine: a selective serotonin reuptake inhibiting antidepressant. Ann Pharmacother. 1993, 27 (10): 1212-22.","journal-title":"Ann Pharmacother"},{"issue":"9207","key":"156_CR25","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/S0140-6736(99)11381-3","volume":"355","author":"JM Kent","year":"2000","unstructured":"Kent JM: SNaRIs, NaSSAs, and NaRIs: new agents for the treatment of depression. Lancet. 2000, 355 (9207): 911-8. 10.1016\/S0140-6736(99)11381-3.","journal-title":"Lancet"},{"issue":"5","key":"156_CR26","first-page":"583","volume":"60","author":"LR Laufer","year":"1982","unstructured":"Laufer LR, Erlik Y, Meldrum DR, Judd HL: Effect of clonidine on hot flashes in postmenopausal women. Obstet Gynecol. 1982, 60 (5): 583-6.","journal-title":"Obstet Gynecol"},{"issue":"3","key":"156_CR27","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/0002-9378(87)90050-0","volume":"156","author":"M Nagamani","year":"1987","unstructured":"Nagamani M, Kelver ME, Smith ER: Treatment of menopausal hot flashes with transdermal administration of clonidine. Am J Obstet Gynecol. 1987, 156 (3): 561-5.","journal-title":"Am J Obstet Gynecol"},{"key":"156_CR28","doi-asserted-by":"crossref","unstructured":"Hunter MS: Cognitive behavioural interventions for premenstrual and menopausal problems. J Reprod Infant Psychol. 2003, 183-93. 10.1080\/0264683031000155006. 21","DOI":"10.1080\/0264683031000155006"},{"issue":"4","key":"156_CR29","doi-asserted-by":"publisher","first-page":"202","DOI":"10.3109\/01674829609025684","volume":"17","author":"JH Irvin","year":"1996","unstructured":"Irvin JH, Domar AD, Clark C, Zuttermeister PC, Friedman R: The effects of relaxation response training on menopausal symptoms. J Psychosom Obstet Gynaecol. 1996, 17 (4): 202-7. 10.3109\/01674829609025684.","journal-title":"J Psychosom Obstet Gynaecol"},{"issue":"2","key":"156_CR30","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/S0378-5122(03)00187-7","volume":"48","author":"L Lindh-Astrand","year":"2004","unstructured":"Lindh-Astrand L, Nedstrand E, Wyon Y, Hammar M: Vasomotor symptoms and quality of life in previously sedentary postmenopausal women randomised to physical activity or estrogen therapy. Maturitas. 2004, 48 (2): 97-105. 10.1016\/S0378-5122(03)00187-7.","journal-title":"Maturitas"},{"key":"156_CR31","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1111\/j.2044-8287.1996.tb00496.x","volume":"1","author":"MS Hunter","year":"1996","unstructured":"Hunter MS, Liao KLM: Evaluation of a four session cognitive behavioural intervention for menopausal hot flushes. Br J Health Psychol. 1996, 1: 113-25.","journal-title":"Br J Health Psychol"},{"issue":"2","key":"156_CR32","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/S0002-9378(11)91425-2","volume":"167","author":"RR Freedman","year":"1992","unstructured":"Freedman RR, Woodward S: Behavioral treatment of menopausal hot flushes: evaluation by ambulatory monitoring. Am J Obstet Gynecol. 1992, 167 (2): 436-9.","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"156_CR33","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/0005-7916(83)90031-9","volume":"14","author":"DW Stevenson","year":"1983","unstructured":"Stevenson DW, Delprato DJ: Multiple component self-control program for menopausal hot flashes. J Behav Ther Exp Psychiatry. 1983, 14 (2): 137-40. 10.1016\/0005-7916(83)90031-9.","journal-title":"J Behav Ther Exp Psychiatry"},{"issue":"13","key":"156_CR34","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1093\/jnci\/92.13.1054","volume":"92","author":"PA Ganz","year":"2000","unstructured":"Ganz PA, Greendale GA, Petersen L, Zibecchi L, Kahn B, Belin TR: Managing menopausal symptoms in breast cancer survivors: results of a randomized controlled trial. J Natl Cancer Inst. 2000, 92 (13): 1054-64. 10.1093\/jnci\/92.13.1054.","journal-title":"J Natl Cancer Inst"},{"issue":"4","key":"156_CR35","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/S1462-3889(99)81335-0","volume":"3","author":"D Fenlon","year":"1999","unstructured":"Fenlon D: Relaxation therapy as an intervention for hot flushes in women with breast cancer. Eur J Oncol Nurs. 1999, 3 (4): 223-31. 10.1016\/S1462-3889(99)81335-0.","journal-title":"Eur J Oncol Nurs"},{"issue":"2","key":"156_CR36","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/S0378-5122(98)00004-8","volume":"29","author":"T Ivarsson","year":"1998","unstructured":"Ivarsson T, Spetz AC, Hammar M: Physical exercise and vasomotor symptoms in postmenopausal women. Maturitas. 1998, 29 (2): 139-46. 10.1016\/S0378-5122(98)00004-8.","journal-title":"Maturitas"},{"issue":"6","key":"156_CR37","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1016\/S0002-9378(03)00872-X","volume":"189","author":"C Li","year":"2003","unstructured":"Li C, Samsioe G, Borgfeldt C, Lidfeldt J, Agardh C, Nerbrand C: Menopause-related symptoms: What are the background factors? A prospective population-based cohort study of Swedish women (The Women's Health in Lund Area study). Am J Obstet Gynecol. 2003, 189 (6): 1646-53. 10.1016\/S0002-9378(03)00872-X.","journal-title":"Am J Obstet Gynecol"},{"issue":"5","key":"156_CR38","doi-asserted-by":"publisher","first-page":"143","DOI":"10.2114\/jpa.23.143","volume":"23","author":"M Ueda","year":"2004","unstructured":"Ueda M: A 12-week structured education and exercise program improved climacteric symptoms in middle-aged women. J Physiol Anthropol Appl Human Sci. 2004, 23 (5): 143-8. 10.2114\/jpa.23.143.","journal-title":"J Physiol Anthropol Appl Human Sci"},{"issue":"4","key":"156_CR39","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1097\/01.GME.0000113932.56832.27","volume":"11","author":"EJ Aiello","year":"2004","unstructured":"Aiello EJ, Yasui Y, Tworoger SS, Ulrich CM, Irwin ML, Bowen D, et al: Effect of a yearlong, moderate-intensity exercise intervention on the occurrence and severity of menopause symptoms in postmenopausal women. Menopause. 2004, 11 (4): 382-8. 10.1097\/01.GME.0000113932.56832.27.","journal-title":"Menopause"},{"issue":"4","key":"156_CR40","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1097\/01.GME.0000134181.75710.52","volume":"11","author":"VM Rice","year":"2004","unstructured":"Rice VM: Effect of moderate-intensity exercise in alleviating menopausal symptoms. Menopause. 2004, 11 (4): 372-4. 10.1097\/01.GME.0000134181.75710.52.","journal-title":"Menopause"},{"issue":"2","key":"156_CR41","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1023\/A:1006263818115","volume":"55","author":"LJ Fallowfield","year":"1999","unstructured":"Fallowfield LJ, Leaity SK, Howell A, Benson S, Cella D: Assessment of quality of life in women undergoing hormonal therapy for breast cancer: validation of an endocrine symptom subscale for the FACT-B. Breast Cancer Res Treat. 1999, 55 (2): 189-99. 10.1023\/A:1006263818115.","journal-title":"Breast Cancer Res Treat"},{"key":"156_CR42","volume-title":"Statistical power analysis for the behavioral sciences","author":"J Cohen","year":"1988","unstructured":"Cohen J: Statistical power analysis for the behavioral sciences. 1988, Hilsdale, NJ: Lawrence Earlbaum Associates"},{"key":"156_CR43","first-page":"589","volume":"34","author":"JB Madalinska","year":"2005","unstructured":"Madalinska JB, Hollenstein J, Bleiker EMA, van Beurden M, Valdimarsdottir HB, Massuger LF, et al: The quality of life effects of prophylactic salpingo-oophorectomy versus gynecologic screening among women at increased risk of hereditary ovarian cancer. J Clin Oncol. 2005, 34: 589-99.","journal-title":"J Clin Oncol"},{"key":"156_CR44","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1111\/j.2044-8260.1995.tb01493.x","volume":"34","author":"MS Hunter","year":"1995","unstructured":"Hunter MS, Liao KLM: A psychological analysis of menopausal hot flushes. Br J Clin Psychol. 1995, 34: 589-99.","journal-title":"Br J Clin Psychol"},{"issue":"1","key":"156_CR45","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.ajog.2003.12.027","volume":"191","author":"ST Brookes","year":"2004","unstructured":"Brookes ST, Donovan JL, Wright M, Jackson S, Abrams P: Then and now: quality of life of young breast cancer survivors. Am J Obstet Gynecol. 2004, 191 (1): 73-82. 10.1016\/j.ajog.2003.12.027.","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"156_CR46","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/BF00435972","volume":"5","author":"K Thirlaway","year":"1996","unstructured":"Thirlaway K, Fallowfield L, Cuzick J: The Sexual Activity Questionnaire: a measure of women's sexual functioning. Qual Life Res. 1996, 5 (1): 81-90. 10.1007\/BF00435972.","journal-title":"Qual Life Res"},{"issue":"1","key":"156_CR47","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1200\/JCO.2001.19.7.1885","volume":"19","author":"L Fallowfield","year":"2001","unstructured":"Fallowfield L, Fleissig A, Edwards R, West A, Powles TJ, Howell A, et al: Tamoxifen for the prevention of breast cancer: psychosocial impact on women participating in two randomized controlled trials. J Clin Oncol. 2001, 19 (1): 1885-92.","journal-title":"J Clin Oncol"},{"issue":"1","key":"156_CR48","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1093\/jnci\/94.1.39","volume":"94","author":"PA Ganz","year":"2002","unstructured":"Ganz PA, Desmond KA, Leedham B, Rowland JH, Meyerowitz BE, Belin TR: Quality of life in long-term, disease-free survivors of breast cancer: a follow-up study. J Natl Cancer Inst. 2002, 94 (1): 39-49.","journal-title":"J Natl Cancer Inst"},{"issue":"22","key":"156_CR49","doi-asserted-by":"publisher","first-page":"4184","DOI":"10.1200\/JCO.2003.04.196","volume":"21","author":"PA Ganz","year":"2003","unstructured":"Ganz PA, Greendale GA, Petersen L, Kahn B, Bower JE: Breast cancer in younger women: reproductive and late health effects of treatment. J Clin Oncol. 2003, 21 (22): 4184-93. 10.1200\/JCO.2003.04.196.","journal-title":"J Clin Oncol"},{"issue":"10","key":"156_CR50","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1200\/JCO.1996.14.10.2756","volume":"14","author":"MA Sprangers","year":"1996","unstructured":"Sprangers MA, Groenvold M, Arraras JI, Franklin J, te Velde A, Muller M, et al: The European Organization for Research and Treatment of Cancer breast cancer-specific quality-of-life questionnaire module: first results from a three-country field study. J Clin Oncol. 1996, 14 (10): 2756-68.","journal-title":"J Clin Oncol"},{"issue":"6","key":"156_CR51","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","volume":"67","author":"AS Zigmond","year":"1983","unstructured":"Zigmond AS, Snaith RP: The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983, 67 (6): 361-70. 10.1111\/j.1600-0447.1983.tb09716.x.","journal-title":"Acta Psychiatr Scand"},{"issue":"6","key":"156_CR52","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1038\/sj.bjc.6601655","volume":"90","author":"GH de Bock","year":"2004","unstructured":"de Bock GH, Bonnema J, Zwaan RE, Velde van de CJ, Kievit J, Stiggelbout AM: Patient's needs and preferences in routine follow-up after treatment for breast cancer. Br J Cancer. 2004, 90 (6): 1144-50. 10.1038\/sj.bjc.6601655.","journal-title":"Br J Cancer"},{"issue":"5","key":"156_CR53","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1002\/pon.856","volume":"14","author":"J Turner","year":"2005","unstructured":"Turner J, Kelly B, Swanson C, Allison R, Wetzig N: Psychosocial impact of newly diagnosed advanced breast cancer. Psychooncology. 2005, 14 (5): 396-407. 10.1002\/pon.856.","journal-title":"Psychooncology"},{"issue":"2","key":"156_CR54","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1017\/S0033291796004382","volume":"27","author":"P Spinhoven","year":"1997","unstructured":"Spinhoven P, Ormel J, Sloekers PP, Kempen GI, Speckens AE, Van Hemert AM: A validation study of the Hospital Anxiety and Depression Scale (HADS) in different groups of Dutch subjects. Psychol Med. 1997, 27 (2): 363-70. 10.1017\/S0033291796004382.","journal-title":"Psychol Med"},{"issue":"6","key":"156_CR55","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1097\/00005650-199206000-00002","volume":"30","author":"JEJ Ware","year":"1992","unstructured":"Ware JEJ, Sherbourne CD: The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992, 30 (6): 473-83. 10.1097\/00005650-199206000-00002.","journal-title":"Med Care"},{"issue":"11","key":"156_CR56","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1016\/S0895-4356(98)00097-3","volume":"51","author":"NK Aaronson","year":"1998","unstructured":"Aaronson NK, Muller M, Cohen PD, Essink-Bot ML, Fekkes M, Sanderman R, et al: Translation, validation, and norming of the Dutch language version of the SF-36 Health Survey in community and chronic disease populations. J Clin Epidemiol. 1998, 51 (11): 1055-68. 10.1016\/S0895-4356(98)00097-3.","journal-title":"J Clin Epidemiol"}],"container-title":["BMC Women's Health"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6874-9-15.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1472-6874-9-15\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6874-9-15","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6874-9-15.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T04:55:51Z","timestamp":1630472151000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcwomenshealth.biomedcentral.com\/articles\/10.1186\/1472-6874-9-15"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6,6]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["156"],"URL":"https:\/\/doi.org\/10.1186\/1472-6874-9-15","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1166976.629077","asserted-by":"object"}]},"ISSN":["1472-6874"],"issn-type":[{"value":"1472-6874","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6,6]]},"assertion":[{"value":"5 March 2009","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2009","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2009","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"15"}}