{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:02:22Z","timestamp":1761058942454},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2009,6,30]],"date-time":"2009-06-30T00:00:00Z","timestamp":1246320000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Women's Health"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>For many women finding the right contraceptive method can be challenging and consistent and correct use over a lifetime is difficult. Even remembering to take a birth control pill every day can be a challenge. The primary objective of this study was to evaluate women's experience with a weekly ethinylestradiol\/norelgestromin contraceptive patch (EE\/NGMN patch), given new technologies recently developed in hormonal contraception to increase women's options in avoiding daily dosing.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>In 24 Italian sites, 207 women received the EE\/NGMN patch for up to 6 cycles. At study end, overall satisfaction and preference, as well as compliance, efficacy and safety, were evaluated.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>175 women (84.5%) completed the study. The overall satisfaction rate was 88%; convenience and once-a-week frequency of the patch were especially appreciated. At baseline, 82 women (39.4%) were using a contraceptive method, mainly oral contraceptives and barrier methods, but only 45.1% were very satisfied\/satisfied; after 6 months with the patch, 86.3% of this subset was very satisfied\/satisfied. Considering the method used in the 3 months before the study entry, 78.1% strongly preferred\/preferred the patch, for convenience (53.9%), ease of use\/simplicity (28.9%), fewer (9.2%) and less severe (2.6%) side effects. Compliance was very high: 1034\/1110 cycles (93.2%) were completed with perfect compliance and the mean subject's compliance score was 90%. One on-therapy pregnancy occurred. The patch was safe and well tolerated: adverse events frequency was low, with predominantly single reports of each event. Most of them started and subsided during cycle 1.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>This study demonstrated that the EE\/NGMN patch is associated with high satisfaction levels and excellent compliance. At study end, the majority of women indicated that they would continue using the patch.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1472-6874-9-18","type":"journal-article","created":{"date-parts":[[2009,6,30]],"date-time":"2009-06-30T18:20:58Z","timestamp":1246386058000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Satisfaction and compliance in hormonal contraception: the result of a multicentre clinical study on women's experience with the ethinylestradiol\/norelgestromin contraceptive patch in Italy"],"prefix":"10.1186","volume":"9","author":[{"given":"Pier Giorgio","family":"Crosignani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmine","family":"Nappi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Ronsini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzina","family":"Bruni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Marelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Sonnino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The Italian EVRA Contrast Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,6,30]]},"reference":[{"key":"159_CR1","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1056\/NEJMcp030751","volume":"349","author":"DB Petitti","year":"2003","unstructured":"Petitti DB: Combination estrogen-progestin oral contraceptives. NEJM. 2003, 349: 1443-50. 10.1056\/NEJMcp030751.","journal-title":"NEJM"},{"key":"159_CR2","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1016\/S0140-6736(00)03269-4","volume":"356","author":"A Kubba","year":"2000","unstructured":"Kubba A, Guillebaud J, Anderson RA, MacGregor EA: Contraception. The Lancet. 2000, 356: 1913-1919. 10.1016\/S0140-6736(00)03269-4.","journal-title":"The Lancet"},{"key":"159_CR3","unstructured":"Frost JJ, Darroch JE, Remez L: Improving contraceptive use in the United States. Brief. 2008, New York: Guttmacher Institute, 1"},{"key":"159_CR4","doi-asserted-by":"publisher","first-page":"89","DOI":"10.2307\/2991665","volume":"30","author":"MJ Rosenberg","year":"1998","unstructured":"Rosenberg MJ, Waugh MS, Burnhill MS: Compliance, counseling and satisfaction with oral contraceptives: a prospective evaluation. Fam Plann Perspect. 1998, 30: 89-92. 10.2307\/2991665.","journal-title":"Fam Plann Perspect"},{"key":"159_CR5","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/0010-7824(95)00074-K","volume":"51","author":"MJ Rosenberg","year":"1995","unstructured":"Rosenberg MJ, Waugh MS, Meehan TE: Use and misuse of oral contraceptives: risk indicators for poor pill taking and discontinuation. Contraception. 1995, 51: 283-8. 10.1016\/0010-7824(95)00074-K.","journal-title":"Contraception"},{"issue":"Suppl 4","key":"159_CR6","first-page":"S1","volume":"89","author":"O Suwanmalee","year":"2006","unstructured":"Suwanmalee O, Taneepanichskul S: A clinical study of transdermal contraceptive patch in Thai women. J Med Assoc Thai. 2006, 89 (Suppl 4): S1-4.","journal-title":"J Med Assoc Thai"},{"issue":"2","key":"159_CR7","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1038\/nrd1304","volume":"3","author":"MR Prausnitz","year":"2004","unstructured":"Prausnitz MR, Mitragotri S, Langer R: Current status and future potential of transdermal drug delivery. Nature Rev Drug Discov. 2004, 3 (2): 115-24. 10.1038\/nrd1304.","journal-title":"Nature Rev Drug Discov"},{"issue":"6","key":"159_CR8","doi-asserted-by":"publisher","first-page":"359","DOI":"10.2165\/00024677-200605060-00004","volume":"5","author":"A Graziottin","year":"2006","unstructured":"Graziottin A: A review of transdermal hormonal contraception. Focus on the ethinylestradiol\/norelgestromin contraceptive patch. Treat Endocrinol. 2006, 5 (6): 359-65. 10.2165\/00024677-200605060-00004.","journal-title":"Treat Endocrinol"},{"key":"159_CR9","volume-title":"Am J Obstet Gynecol","author":"R Burkman","year":"2007","unstructured":"Burkman R: Transdermal hormonal contraception: benefits and risks. Am J Obstet Gynecol. 2007, 197: 134.e1-6"},{"issue":"2 Suppl 2","key":"159_CR10","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1016\/S0015-0282(01)03261-7","volume":"77","author":"LS Abrams","year":"2002","unstructured":"Abrams LS, Skee DM, Natarajan J, Wong FA: Pharmacokinetic overview of Ortho Evra\u2122\/Evra\u2122. Fertil Steril. 2002, 77 (2 Suppl 2): S3-12. 10.1016\/S0015-0282(01)03261-7.","journal-title":"Fertil Steril"},{"issue":"Suppl 1","key":"159_CR11","doi-asserted-by":"publisher","first-page":"S7","DOI":"10.1016\/j.maturitas.2003.09.014","volume":"46","author":"AE Schindler","year":"2003","unstructured":"Schindler AE, Campagnoli C, Druckmann R, Huber J, Pasqualini JR, Schweppe KW, Thijssen JH: Classification and pharmacology of progestins. Maturitas. 2003, 46 (Suppl 1): S7-16. 10.1016\/j.maturitas.2003.09.014.","journal-title":"Maturitas"},{"issue":"4 Pt 2","key":"159_CR12","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1016\/S0002-9378(12)90410-X","volume":"167","author":"A Phillips","year":"1992","unstructured":"Phillips A, Hahn DW, McGuire JL: Preclinical evaluation of norgestimate, a progestin with minimal androgenic activity. Am J Obstet Gynecol. 1992, 167 (4 Pt 2): 1191-6.","journal-title":"Am J Obstet Gynecol"},{"issue":"6","key":"159_CR13","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.1016\/j.ajog.2005.02.067","volume":"192","author":"T White","year":"2005","unstructured":"White T, Jain JK, Stanczyk FZ: Effect of oral versus transdermal steroidal contraceptives on androgenic markers. Am J Obstet Gynecol. 2005, 192 (6): 2055-9. 10.1016\/j.ajog.2005.02.067.","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"159_CR14","doi-asserted-by":"publisher","first-page":"223","DOI":"10.3109\/09513590009167685","volume":"14","author":"T Rabe","year":"2000","unstructured":"Rabe T, Kowald A, Ortmann J, Rehberger-Schneider S: Inhibition of skin 5 alpha-reductase by oral contraceptive progestins in vitro. Gynecol Endocrinol. 2000, 14 (4): 223-30.","journal-title":"Gynecol Endocrinol"},{"issue":"4","key":"159_CR15","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1080\/09513590701214414","volume":"23","author":"F Paris","year":"2007","unstructured":"Paris F, Rabeolina F, Balaguer P, Bacquet A, Sultan C: Antiandrogenic activity of norgestimate in a human androgen-dependent stable-transfected cell line. Gynecol Endocrinol. 2007, 23 (4): 193-7. 10.1080\/09513590701214414.","journal-title":"Gynecol Endocrinol"},{"issue":"5 Pt 1","key":"159_CR16","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1016\/S0029-7844(01)01534-4","volume":"98","author":"GH Smallwood","year":"2001","unstructured":"Smallwood GH, Meador ML, Lenihan JP, Shangold GA, Fisher AC, Creasy GW, for the ORTHO EVRA\/EVRA 002 Study Group: Efficacy and safety of a transdermal contraceptive system. Obstet Gynecol. 2001, 98 (5 Pt 1): 799-805. 10.1016\/S0029-7844(01)01534-4.","journal-title":"Obstet Gynecol"},{"issue":"18","key":"159_CR17","doi-asserted-by":"publisher","first-page":"2347","DOI":"10.1001\/jama.285.18.2347","volume":"285","author":"MC Audet","year":"2001","unstructured":"Audet MC, Moreau M, Koltun WD, Waldbaum AS, Shangold GA, Fisher AC, Creasy GW, for the ORTHO EVRA\/EVRA 004 Study Group: Evaluation of contraceptive efficacy and cycle control of a transdermal contraceptive patch vs an oral contraceptive: a randomized controlled trial. JAMA. 2001, 285 (18): 2347-54. 10.1001\/jama.285.18.2347.","journal-title":"JAMA"},{"issue":"2 Suppl 2","key":"159_CR18","doi-asserted-by":"publisher","first-page":"S13","DOI":"10.1016\/S0015-0282(01)03275-7","volume":"77","author":"M Zieman","year":"2002","unstructured":"Zieman M, Guillebaud J, Weisberg E, Shangold GA, Fisher AC, Creasy GW: Contraceptive efficacy and cycle control with the Ortho Evra\/Evra transdermal system: the analysis of pooled data. Fertil Steril. 2002, 77 (2 Suppl 2): S13-8. 10.1016\/S0015-0282(01)03275-7.","journal-title":"Fertil Steril"},{"issue":"1","key":"159_CR19","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/S0015-0282(03)00556-9","volume":"80","author":"RA Pierson","year":"2003","unstructured":"Pierson RA, Archer DF, Moreau M, Shangold GA, Fisher AC, Creasy GW, for the ORTHO EVRA\/EVRA 008 Study Group: Ortho Evra\/Evra versus oral contraceptives: follicular development and ovulation in normal cycles and after an intentional dosing error. Fertil Steril. 2003, 80 (1): 34-42. 10.1016\/S0015-0282(03)00556-9.","journal-title":"Fertil Steril"},{"issue":"2 Suppl 2","key":"159_CR20","doi-asserted-by":"publisher","first-page":"S27","DOI":"10.1016\/S0015-0282(01)03263-0","volume":"77","author":"DF Archer","year":"2002","unstructured":"Archer DF, Bigrigg A, Smallwood GH, Shangold GA, Creasy GW, Fisher AC: Assessment of compliance with a weekly contraceptive patch (Ortho Evra\/Evra) among North American women. Fertil Steril. 2002, 77 (2 Suppl 2): S27-31. 10.1016\/S0015-0282(01)03263-0.","journal-title":"Fertil Steril"},{"issue":"3","key":"159_CR21","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.contraception.2003.10.006","volume":"69","author":"DF Archer","year":"2004","unstructured":"Archer DF, Cullins V, Creasy GW, Fisher AC: The impact of improved compliance with a weekly contraceptive transdermal system (Ortho Evra) on contraceptive efficacy. Contraception. 2004, 69 (3): 189-95. 10.1016\/j.contraception.2003.10.006.","journal-title":"Contraception"},{"key":"159_CR22","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.jpag.2004.11.016","volume":"18","author":"Z Harel","year":"2005","unstructured":"Harel Z, Riggs S, Vaz R, Flanagan P, Dunn K, Harel D: Adolescents' experience with the combined estrogen and progestin transdemal contraceptive method Ortho Evra. J Pediatr Adolesc Gynecol. 2005, 18: 85-90. 10.1016\/j.jpag.2004.11.016.","journal-title":"J Pediatr Adolesc Gynecol"},{"issue":"2 Suppl 2","key":"159_CR23","doi-asserted-by":"publisher","first-page":"S32","DOI":"10.1016\/S0015-0282(01)03262-9","volume":"77","author":"HA Zacur","year":"2002","unstructured":"Zacur HA, Hedon B, Mansour D, Shangold GA, Fisher AC, Creasy GW: Integrated summary of Ortho Evra\/Evra contraceptive patch adhesion in varied climates and conditions. Fertil Steril. 2002, 77 (2 Suppl 2): S32-5. 10.1016\/S0015-0282(01)03262-9.","journal-title":"Fertil Steril"},{"issue":"2 Suppl 2","key":"159_CR24","doi-asserted-by":"publisher","first-page":"S19","DOI":"10.1016\/S0015-0282(01)03264-2","volume":"77","author":"BM Sibai","year":"2002","unstructured":"Sibai BM, Odlind V, Meador ML, Shangold GA, Fisher AC, Creasy GW: A comparative and pooled analysis of the safety and tolerability of the contraceptive patch (Ortho Evra\/Evra). Fertil Steril. 2002, 77 (2 Suppl 2): S19-26. 10.1016\/S0015-0282(01)03264-2.","journal-title":"Fertil Steril"},{"issue":"1","key":"159_CR25","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.contraception.2007.03.003","volume":"76","author":"SS Jick","year":"2007","unstructured":"Jick SS, Kaye JA, Li L, Jick H: Further results on the risk of nonfatal venous thromboembolism in users of the contraceptive transdermal patch compared to users of oral contraceptives containing norgestimate and 35 microg of ethinyl estradiol. Contraception. 2007, 76 (1): 4-7. 10.1016\/j.contraception.2007.03.003.","journal-title":"Contraception"},{"issue":"2","key":"159_CR26","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1080\/13625180701300194","volume":"12","author":"F Martinez","year":"2007","unstructured":"Martinez F, Avecilla A: Combined hormonal contraception and venous thromboembolism. Eur J Contracept Reprod Health Care. 2007, 12 (2): 97-106. 10.1080\/13625180701300194.","journal-title":"Eur J Contracept Reprod Health Care"},{"issue":"2 Pt 1","key":"159_CR27","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1097\/01.AOG.0000250968.82370.04","volume":"109","author":"JA Cole","year":"2007","unstructured":"Cole JA, Norman H, Doherty M, Walker AM: Venous thromboembolism, myocardial infarction, and stroke among transdermal contraceptive system users. Obstet Gynecol. 2007, 109 (2 Pt 1): 339-46.","journal-title":"Obstet Gynecol"},{"key":"159_CR28","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.contraception.2006.01.001","volume":"73","author":"SS Jick","year":"2006","unstructured":"Jick SS, Kaye JA, Russmann S, Jick H: Risk of nonfatal venous thromboembolism in women using a contraceptive transdermal patch and oral contraceptives containing norgestimate and 35 microg of ethinyl estradiol. Contraception. 2006, 73: 223-8. 10.1016\/j.contraception.2006.01.001.","journal-title":"Contraception"},{"key":"159_CR29","unstructured":"ClinicalTrials.gov. [http:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT00511784]"},{"issue":"Suppl 1","key":"159_CR30","first-page":"P028","volume":"11","author":"A Jakimiuk","year":"2006","unstructured":"Jakimiuk A, Madalenet P, Chernev T, Cha'Ban K, Bergmans P, Preik M, Lee E: Transdermal contraception is associated with high levels of patient satisfaction and compliance [abstract]. Eur J Contracept Reprod Health Care. 2006, 11 (Suppl 1): P028-68\u20139","journal-title":"Eur J Contracept Reprod Health Care"},{"issue":"Suppl 1","key":"159_CR31","first-page":"P024","volume":"11","author":"A Jakimiuk","year":"2006","unstructured":"Jakimiuk A, Madalenet P, Chernev T, Cha'Ban K, Bergmans P, Preik M, Lee E: Efficacy and tolerability of transdermal hormonal contraception over 6 months[abstract]. Eur J Contracept Reprod Health Care. 2006, 11 (Suppl 1): P024-66\u20137","journal-title":"Eur J Contracept Reprod Health Care"},{"key":"159_CR32","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1097\/00005650-199603000-00003","volume":"34","author":"J Ware Jr","year":"1996","unstructured":"Ware J, Kosinski M, Keller SD: A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. Med Care. 1996, 34: 220-33. 10.1097\/00005650-199603000-00003.","journal-title":"Med Care"},{"issue":"11","key":"159_CR33","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1016\/S0895-4356(98)00109-7","volume":"51","author":"B Gandek","year":"1998","unstructured":"Gandek B, Ware JE, Aaronson NK, Apolone G, Bjorner JB, Brazier JE, Bullinger M, Kaasa S, Leplege A, Prieto L, Sullivan M: Cross-validation of item selection and scoring for the SF-12 Health Survey in nine countries: results from the IQOLA project. J Clin Epidemiol. 1998, 51 (11): 1171-8. 10.1016\/S0895-4356(98)00109-7.","journal-title":"J Clin Epidemiol"},{"key":"159_CR34","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/1475-2891-7-21","volume":"7","author":"A Piccoli","year":"2008","unstructured":"Piccoli A, Crosignani P, Nappi C, Ronsini S, Bruni V, Marelli S, for the Italian Evra Contrast Study Group: Effect of the ethinylestradiol\/norelgestromin contraceptive patch on body composition. Results of bioelectrical impedance analysis in a population of Italian women. Nutrition Journal. 2008, 7: 21-10.1186\/1475-2891-7-21.","journal-title":"Nutrition Journal"},{"issue":"4","key":"159_CR35","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.contraception.2006.12.003","volume":"75","author":"GJ Wan","year":"2007","unstructured":"Wan GJ, Barnowski CE, Ambegaonkar BM, Bolge SC, McDonnell DD: Treatment satisfaction with a transdermal contraceptive patch or oral contraceptives. Contraception. 2007, 75 (4): 281-4. 10.1016\/j.contraception.2006.12.003.","journal-title":"Contraception"},{"issue":"4","key":"159_CR36","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/S1701-2163(16)30462-5","volume":"27","author":"F Weisberg","year":"2005","unstructured":"Weisberg F, Bouchard C, Moreau M, Audet MC, Mawdsley S, Dattani D, Dinniwell J, Horbay GLA, for the NRGEEP-CON-401 Study Group: Preference for and satisfaction of Canadian women with the transdermal contraceptive patch versus previous contraceptive method: an open-label, multicentre study. J Obstet Gynaecol Can. 2005, 27 (4): 350-9.","journal-title":"J Obstet Gynaecol Can"},{"issue":"2","key":"159_CR37","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.ejogrb.2005.01.021","volume":"121","author":"W Urdl","year":"2005","unstructured":"Urdl W, Apter D, Alperstein A, Koll P, Schonian S, Bringer J, Fisher AC, Preik M, for the ORTHO EVRA\/EVRA 003 Study Group: Contraceptive efficacy, compliance and beyond: factors related to satisfaction with once-weekly transdermal compared with oral contraception. Eur J Obstet Gynecol Reprod Biol. 2005, 121 (2): 202-10. 10.1016\/j.ejogrb.2005.01.021.","journal-title":"Eur J Obstet Gynecol Reprod Biol"}],"container-title":["BMC Women's Health"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6874-9-18.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1472-6874-9-18\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6874-9-18","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6874-9-18.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T08:57:17Z","timestamp":1630486637000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcwomenshealth.biomedcentral.com\/articles\/10.1186\/1472-6874-9-18"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6,30]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["159"],"URL":"https:\/\/doi.org\/10.1186\/1472-6874-9-18","relation":{},"ISSN":["1472-6874"],"issn-type":[{"type":"electronic","value":"1472-6874"}],"subject":[],"published":{"date-parts":[[2009,6,30]]},"assertion":[{"value":"31 October 2008","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2009","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2009","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"18"}}