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The same natural compound and ethyl acetate extract inhibited oxidation induced by 2,2\u2032-azobis (2-amidinopropane) dihydrochloride in human chronic myelogenous leukemia cells with respectively 50% inhibitory concentration values of 0.225\u2009mg\/ml and 0.31\u2009mg\/ml, reflecting a significant antioxidant potential. The same two products inhibited the genotoxicity induced by hydroxyl radicals in the same human cell line (by 77.77% at a concentration of 800\u2009\u03bcg\/ml and by 80.55% at a concentration of 1000\u2009\u03bcg\/ml respectively).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>The <jats:bold>i<\/jats:bold> sorhamnetin 3- <jats:italic>o<\/jats:italic>-robinobioside and its original extract, the ethyl acetate extract, from <jats:italic>Nitraria retusa<\/jats:italic> leaves, have a great antioxidant and antigenotoxic potential on human chronic myelogenous leukemia cell line K562.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1472-6882-12-135","type":"journal-article","created":{"date-parts":[[2012,8,22]],"date-time":"2012-08-22T20:13:51Z","timestamp":1345666431000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Isorhamnetin 3-O-robinobioside from Nitraria retusa leaves enhance antioxidant and antigenotoxic activity in human chronic myelogenous leukemia cell line K562"],"prefix":"10.1186","volume":"12","author":[{"given":"Jihed","family":"Boubaker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Ben","family":"Sghaier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Skandrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamel","family":"Ghedira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Chekir-Ghedira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,8,22]]},"reference":[{"key":"1066_CR1","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/S0145-2126(02)00063-2","volume":"27","author":"L Cip\u00e1k","year":"2003","unstructured":"Cip\u00e1k L, Rauko P, Miadokov\u00e1 E, Cip\u00e1kov\u00e1 I, Novotn\u00fd L: Effects of flavonoids on cisplatin-induced apoptosis of HL-60 and L1210 leukemia cells. 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