{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T21:51:22Z","timestamp":1717192282245},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,9,17]],"date-time":"2012-09-17T00:00:00Z","timestamp":1347840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Complement Altern Med"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Abnormal Savda Munziq (ASMq), a traditional uyghur medicine, has shown anti-tumour properties <jats:italic>in vitro<\/jats:italic>. This study attempts to confirm these effects <jats:italic>in vivo<\/jats:italic> and measure effects on the immune system.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Kunming mice transplanted with Sarcoma 180 cells were treated with ASMq (2\u20138\u2009g\/kg\/day) by intra-gastric administration compared to model and cyclophosphamide (20\u2009mg\/kg\/day). After the 14th day post tumour implant, thymus, liver, spleen and tumours were removed, weighed, and processed for histopathological analysis. Blood samples were also taken for haematological and biochemical analyses including TNF-\u03b1 , IL-1 \u03b2 and IL-2. Splenic lymphocyte function was measured with MTT; lymphocyte subpopulations were measured by flow cytometry.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>ASMq treated animals had reduced tumour volume compared to model and increased concentrations of TNF-\u03b1, IL-1\u03b2 and IL-2 compared to untreated and to cyclophosphamide-treated animals. No histopathological alterations were observed. The absence of viable S180 cells and the presence of necrotic cells and granulation tissue were observed in tumour tissue of treated animals. The effect on T lymphocytes was unclear.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>ASMq confirmed in vivo anti-tumour effects observed in vitro, which may be at least in part mediated by increased immune activity.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1472-6882-12-157","type":"journal-article","created":{"date-parts":[[2012,9,17]],"date-time":"2012-09-17T06:14:00Z","timestamp":1347862440000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Immunomodulatory and antitumour effects of abnormal Savda Munziq on S180 tumour-bearing mice"],"prefix":"10.1186","volume":"12","author":[{"given":"Ainiwaer","family":"Aikemu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anwar","family":"Umar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdiryim","family":"Yusup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halmurat","family":"Upur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9n\u00e9dicte","family":"Berk\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"B\u00e9gaud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,9,17]]},"reference":[{"issue":"4","key":"1109_CR1","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1111\/j.1472-8206.2004.00249.x","volume":"18","author":"A Yusup","year":"2004","unstructured":"Yusup A, Upur H, Umar A, Moore N: Protective effects of Munziq and Mushil of abnormal Savda to mitochondrial oxidative damage. Fundam Clin Pharmacol. 2004, 18 (4): 471-476. 10.1111\/j.1472-8206.2004.00249.x.","journal-title":"Fundam Clin Pharmacol"},{"key":"1109_CR2","doi-asserted-by":"publisher","first-page":"152015","DOI":"10.1093\/ecam\/nep059","volume":"2011","author":"A Yusup","year":"2011","unstructured":"Yusup A, Upur H, Umar A, Berke B, Yimit D, Lapham JC, Moore N, Cassand P: Abnormal Savda Munziq, an Herbal Preparation of Traditional Uyghur Medicine, may Prevent 1,2-dimethylhydrazine-induced Rat Colon Carcinogenesis. Evid Based Complement Alternat Med. 2011, 2011: 152015-","journal-title":"Evid Based Complement Alternat Med"},{"key":"1109_CR3","first-page":"34","volume":"16","author":"A Yusup","year":"2000","unstructured":"Yusup A, Upur H, Umar A: Effects of Munziq and Mushil of Abnormal Savda on oxidative and radiation-induced DNA damage in vitro. Zhong Yao Yao Li Yu Lin Chuang Za Zhi. 2000, 16: 34-36.","journal-title":"Zhong Yao Yao Li Yu Lin Chuang Za Zhi"},{"issue":"4","key":"1109_CR4","doi-asserted-by":"publisher","first-page":"483","DOI":"10.2515\/therapie:2004083","volume":"59","author":"H Upur","year":"2004","unstructured":"Upur H, Yusup A, Umar A, Moore N: Uyghur traditional medicine syndrome of Abnormal Savda in men is associated with oxidative stress, which can be improved by Munziq and Mushil of Abnormal Savda. Therapie. 2004, 59 (4): 483-484. 10.2515\/therapie:2004083.","journal-title":"Therapie"},{"issue":"4","key":"1109_CR5","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1111\/j.1472-8206.2005.00342.x","volume":"19","author":"A Yusup","year":"2005","unstructured":"Yusup A, Upur H, Baudrimont I, Umar A, Kader T, Begaud B, Creppy EE, Moore N: Cytotoxicity of abnormal Savda Munziq aqueous extract in human hepatoma (HepG2) cells. Fundam Clin Pharmacol. 2005, 19 (4): 465-472. 10.1111\/j.1472-8206.2005.00342.x.","journal-title":"Fundam Clin Pharmacol"},{"key":"1109_CR6","doi-asserted-by":"publisher","first-page":"251424","DOI":"10.1093\/ecam\/nen062","volume":"2011","author":"H Upur","year":"2011","unstructured":"Upur H, Yusup A, Baudrimont I, Umar A, Berke B, Yimit D, Lapham JC, Creppy EE, Moore N: Inhibition of cell growth and cellular protein, DNA and RNA synthesis in human hepatoma (HepG2) cells by ethanol extract of abnormal Savda Munziq of traditional Uyghur medicine. Evid Based Complement Alternat Med. 2011, 2011: 251424-","journal-title":"Evid Based Complement Alternat Med"},{"key":"1109_CR7","doi-asserted-by":"publisher","first-page":"926329","DOI":"10.1155\/2012\/926329","volume":"2012","author":"A Yusup","year":"2012","unstructured":"Yusup A, Upur H, Umar A, Berke B, Moore N: Ethanol Extract of Abnormal Savda Munziq, a Herbal Preparation of Traditional Uyghur Medicine, Inhibits Caco-2 Cells Proliferation via Cell Cycle Arrest and Apoptosis. Evid Based Complement Alternat Med. 2012, 2012: 926329-","journal-title":"Evid Based Complement Alternat Med"},{"key":"1109_CR8","first-page":"82","volume":"3","author":"A Yusup","year":"2010","unstructured":"Yusup A, Imam G, Rozi N, Aikemu A, Upur H: Effects of Immune Regulation of Abnormal Savda Munziq Granular on Immune Suppressed Mice. Science & Technology Review. 2010, 3: 82-86.","journal-title":"Science & Technology Review"},{"issue":"11","key":"1109_CR9","first-page":"1068","volume":"32","author":"A Yusup","year":"2007","unstructured":"Yusup A, Upur H, Tursun X, Berke B, Baudrimont I, Moore N: [Study on mechanism of abnormal savda munziq flavonoids in induction of apoptosis of Hep2 cells]. Zhongguo Zhong Yao Za Zhi. 2007, 32 (11): 1068-1071.","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"issue":"10","key":"1109_CR10","first-page":"2731","volume":"62","author":"S Man","year":"2002","unstructured":"Man S, Bocci G, Francia G, Green SK, Jothy S, Hanahan D, Bohlen P, Hicklin DJ, Bergers G, Kerbel RS: Antitumor effects in mice of low-dose (metronomic) cyclophosphamide administered continuously through the drinking water. Cancer Res. 2002, 62 (10): 2731-2735.","journal-title":"Cancer Res"},{"issue":"5","key":"1109_CR11","first-page":"379","volume":"26","author":"X Tao","year":"2003","unstructured":"Tao X, Tang D: [Advances in the study of tumor angiogenesis and anti-angiogenic Chinese herbal drugs]. Zhong Yao Cai. 2003, 26 (5): 379-381.","journal-title":"Zhong Yao Cai"},{"key":"1109_CR12","volume-title":"The pharmacology research method of traditional Chinese medicine","author":"Q Chen","year":"2006","unstructured":"Chen Q: The pharmacology research method of traditional Chinese medicine. 2006, Beijing: Public Health Publishing House"},{"issue":"2","key":"1109_CR13","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1211\/jpp.58.2.0011","volume":"58","author":"HI Magalhaes","year":"2006","unstructured":"Magalhaes HI, Veras ML, Torres MR, Alves AP, Pessoa OD, Silveira ER, Costa-Lotufo LV, de Moraes MO, Pessoa C: In-vitro and in-vivo antitumour activity of physalins B and D from Physalis angulata. J Pharm Pharmacol. 2006, 58 (2): 235-241.","journal-title":"J Pharm Pharmacol"},{"issue":"2","key":"1109_CR14","first-page":"182","volume":"30","author":"MA Indap","year":"1986","unstructured":"Indap MA, Gokhale SV: Combined effect of cyclophosphamide and extracts of Crotalaria and Senecio plants on experimental tumours. Indian J Physiol Pharmacol. 1986, 30 (2): 182-186.","journal-title":"Indian J Physiol Pharmacol"},{"issue":"1","key":"1109_CR15","first-page":"6","volume":"14","author":"S Jinghui","year":"2007","unstructured":"Jinghui S, Pengfei X, Fuyun G: Influence of Yudanrongxin Pills on immunoregulation in mice. Journal of Beijing University of Traditional Chinese Medicine:Clinical Medicine. 2007, 14 (1): 6-8.","journal-title":"Journal of Beijing University of Traditional Chinese Medicine:Clinical Medicine"},{"issue":"12","key":"1109_CR16","first-page":"1381","volume":"13","author":"Z Lianlong","year":"2008","unstructured":"Lianlong Z, Min D, Zhaoxiang M: Effects of ganoderma liciudm ploysaccharide\/seleno-k-carageenan syrup on immune function of immunosuppression mice. Chinese J Clin Pharmacology and Therapycology. 2008, 13 (12): 1381-1387.","journal-title":"Chinese J Clin Pharmacology and Therapycology"}],"container-title":["BMC Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6882-12-157.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1472-6882-12-157\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6882-12-157.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T20:13:31Z","timestamp":1630527211000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccomplementalternmed.biomedcentral.com\/articles\/10.1186\/1472-6882-12-157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,17]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["1109"],"URL":"https:\/\/doi.org\/10.1186\/1472-6882-12-157","relation":{},"ISSN":["1472-6882"],"issn-type":[{"value":"1472-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,17]]},"assertion":[{"value":"7 October 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2012","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2012","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"157"}}