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The total yield, total phenolic (TPC) and total flavonoid contents (TFC) of all the fractions were also determined. TLM was also subjected to preliminary phytochemical screening test for various constituents.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The total phenolic contents (TPC) (121.9\u00b13.1 mg GAE\/g extract) of TLM while total flavonoid contents (TFC) of TLE (60.9 \u00b12.2 mg RTE\/g extract) were found significantly higher as compared to other solvent fractions. Phytochemical screening of TLM revealed the presence of alkaloids, anthraquinones, cardiac glycosides, coumarins, flavonoids, saponins, phlobatannins, tannins and terpenoids. The EC\n                      <jats:sub>50<\/jats:sub>\n                      values based on the DPPH (41.0\u00b11 \u03bcg\/ml), ABTS (10.0\u00b10.9 \u03bcg\/ml) and phosphomolybdate (10.7\u00b12 \u03bcg\/ml) for TLB, hydroxyl radicals (8.0\u00b11 \u03bcg\/ml) for TLC, superoxide radicals (57.0\u00b10.3 \u03bcg\/ml) for TLM and hydrogen peroxide radicals (68.0\u00b12 \u03bcg\/ml) for TLE were generally lower showing potential antioxidant properties. A significant but marginal positive correlation was found between TPC and EC\n                      <jats:sub>50<\/jats:sub>\n                      values for DPPH, hydroxyl, phosphomolybdate and ABTS, whereas another weak and positive correlation was determined between TFC and EC\n                      <jats:sub>50<\/jats:sub>\n                      values for superoxide anion and hydroxyl radicals. Results of\n                      <jats:italic>in vivo<\/jats:italic>\n                      experiment revealed that administration of CCl\n                      <jats:sub>4<\/jats:sub>\n                      caused a significant increase in lipid peroxidation (TBARS) while decrease in GSH contents of liver. In contrast, TLM (200 mg\/kg bw) and silymarin (50 mg\/kg bw) co-treatment effectively prevented these alterations and maintained the antioxidant status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Data from present results revealed that\n                      <jats:italic>Torilis leptophylla<\/jats:italic>\n                      act as an antioxidant agent due to its free radical scavenging and cytoprotective activity.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/1472-6882-12-221","type":"journal-article","created":{"date-parts":[[2012,11,15]],"date-time":"2012-11-15T22:14:25Z","timestamp":1353017665000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":793,"title":["Antioxidant activity, total phenolic and total flavonoid contents of whole plant extracts Torilis leptophylla L"],"prefix":"10.1186","volume":"12","author":[{"given":"Naima","family":"Saeed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad R","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Shabbir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,11,16]]},"reference":[{"key":"1174_CR1","first-page":"77","volume":"2","author":"S Maqsood","year":"2010","unstructured":"Maqsood S, Singh P, Samoon MH, Balange AK: Effect of dietary chitosan on non-specific immune response and growth of Cyprinus carpio challenged with Aeromonas hydrophila. 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