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Animals were randomly divided into two groups: a) non-treatment group (NT) (n\u2009=\u200918): animals received 1mL of vehicle; b) <jats:italic>C. verbenacea<\/jats:italic> group (C.v.) (n\u2009=\u200918): animals received 5mg\/Kg of essential oils isolated from <jats:italic>C. verbenacea.<\/jats:italic> The therapies were administered topically 3 times daily for 11 days. Then, the specimens were processed for morphometric analysis of bone loss. The ligatures were used for microbiological assessment of the presence of <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic>, <jats:italic>Tannerella forsythia<\/jats:italic> and <jats:italic>Porphyromonas gingivalis<\/jats:italic> using PCR. The gingival tissue was collected to Elisa assay of interleukin (IL)-1\u03b1 and IL-10 levels.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Bone loss was inhibited by <jats:italic>C. verbenacea<\/jats:italic> when compared to the NT group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). A decrease in the levels of IL-1\u03b1 and increase in the IL-10 amounts was observed in the C.v. group as compared to NT group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). A lower frequency of <jats:italic>P. gingivalis<\/jats:italic> was found in C.v. group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>\n              <jats:italic>C. verbenacea<\/jats:italic> essential oil topically administered diminished alveolar bone resorption, promoting a positive local imbalance in the pro\/anti-inflammatory system and reducing the frequency of detection of <jats:italic>P. gingivalis<\/jats:italic>.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1472-6882-12-224","type":"journal-article","created":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T19:14:00Z","timestamp":1353525240000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Protective effect of topical Cordia verbenacea in a rat periodontitis model: immune-inflammatory, antibacterial and morphometric assays"],"prefix":"10.1186","volume":"12","author":[{"given":"Suzana Peres","family":"Pimentel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme Emerson","family":"Barrella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato Corr\u00eaa Viana","family":"Casarin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiano Ribeiro","family":"Cirano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcio Zaffalon","family":"Casati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Ann","family":"Foglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glyn Mara","family":"Figueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Vieira","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,11,21]]},"reference":[{"issue":"Suppl 6","key":"1173_CR1","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1111\/j.1600-051X.2005.00822.x","volume":"32","author":"MS Tonetti","year":"2005","unstructured":"Tonetti MS, Claffey N, European Workshop in Periodontology group C: Advances in the progression of periodontitis and proposal of definitions of a periodontitis case and disease progression for use in risk factor research. 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