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The concept is claimed to be useful in predicting an individual\u2019s susceptibility to a particular disease, prognosis of that illness and selection of therapy. The present study was carried out to study if the platelet aggregatory response and its inhibition by aspirin varied in the different\n                      <jats:italic>prakriti<\/jats:italic>\n                      subtypes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      After obtaining Institutional Ethics Committee permission, normal healthy individuals of either sex between the age group 18 to 30 years were recruited in the study. Their p\n                      <jats:italic>rakriti<\/jats:italic>\n                      evaluation was done using a standardized validated questionnaire (TNMC\n                      <jats:italic>Prakriti<\/jats:italic>\n                      2004). Their Platelet Rich Plasma was incubated with either aspirin [2.5micro-mole (\u03bcM) and 5\u03bcM] or distilled water as control for three minutes after which the aggregatory response to 5\u03bcM Adenosine Diphosphate (ADP) was measured over a period of 7 minutes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We observed that in the study population of normal healthy participants (n= 137), ADP-induced maximal platelet aggregation (MPA) was highest among the\n                      <jats:italic>Vata-pitta prakriti<\/jats:italic>\n                      individuals [Median (range), 83.33% (52.33-96)] as compared to the other\n                      <jats:italic>prakriti<\/jats:italic>\n                      types and these individuals responded better to lower dose of aspirin compared to other\n                      <jats:italic>prakriti<\/jats:italic>\n                      types.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our results suggest that identifying the\n                      <jats:italic>prakriti<\/jats:italic>\n                      may help in individualising therapy or predicting proneness to a disease.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/1472-6882-12-248","type":"journal-article","created":{"date-parts":[[2012,12,10]],"date-time":"2012-12-10T10:14:34Z","timestamp":1355134474000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Prakriti (Ayurvedic concept of constitution) and variations in platelet aggregation"],"prefix":"10.1186","volume":"12","author":[{"given":"Supriya","family":"Bhalerao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tejashree","family":"Deshpande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urmila","family":"Thatte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,12,10]]},"reference":[{"key":"1248_CR1","first-page":"10","volume-title":"\u2018Historical survey of the evolution of Ayurveda\u2019, Chapter 2 in Ayurveda Revisited","author":"SA Dahanukar","year":"2000","unstructured":"Dahanukar SA, Thatte UM: \u2018Historical survey of the evolution of Ayurveda\u2019, Chapter 2 in Ayurveda Revisited. 2000, Popular Prakashan Mumbai, 10-27. reprint, 1","edition":"1"},{"key":"1248_CR2","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/1479-5876-6-48","volume":"6","author":"B Prasher","year":"2008","unstructured":"Prasher B, Negi S, Aggarwal S, Mandal AK, Sethi TP, Deshmukh SR, Purohit SG, Sengupta S, Khanna S, Mohammad F, Garg G, Brahmachari SK: Indian Genome Variation Consortium, Mukerji M; \u2018Whole genome expression and biochemical correlates of extreme constitutional types defined in Ayurveda\u2019. 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