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In the present study, we investigated whether atrial natriuretic peptides (ANP) and renal ATPases play a role in the SAP<jats:italic>Aa<\/jats:italic> D- induced antidiuresis in rats.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>To evaluate the effect of SAP<jats:italic>Aa<\/jats:italic> D on furosemide-induced diuresis, Wistar rats (250-300\u2009g) were given an oral loading of physiological solution (0.9\u2009% NaCl, 4\u2009ml\/100\u2009g body weight) to impose a uniform water and salt state. The solution containing furosemide (Furo, 13\u2009mg\/kg) was given 30\u2009min after rats were orally treated with 50\u2009mg\/kg SAP<jats:italic>Aa<\/jats:italic> D (<jats:italic>SAPAaD\u2009+\u2009Furo<\/jats:italic>) or 0.5\u2009ml of 0.9\u2009% NaCl (<jats:italic>NaCl\u2009+\u2009Furo<\/jats:italic>). In the <jats:italic>SAPAaD\u2009+\u2009NaCl<\/jats:italic> group, rats were pretreated with SAP<jats:italic>Aa<\/jats:italic> D and 30\u2009min later they received the oral loading of physiological solution. Animals were individually housed in metabolic cages, and urine volume was measured every 30\u2009min throughout the experiment (3\u2009h). To investigate the role of ANP and renal Na<jats:sup>+<\/jats:sup> pumps on antidiuretic effects promoted by SAP<jats:italic>Aa<\/jats:italic> D, rats were given the physiological solution (as above) containing SAP<jats:italic>Aa<\/jats:italic> D (50\u2009mg\/kg). After 90\u2009min, samples of urine and blood from the last 30\u2009min were collected. Kidneys and atria were also removed after previous anesthesia. ANP was measured by radioimmunoassay (RIA) and renal cortical activities of Na<jats:sup>+<\/jats:sup>- and (Na<jats:sup>+<\/jats:sup>,K<jats:sup>+<\/jats:sup>)-ATPases were calculated from the difference between the [<jats:sup>32<\/jats:sup>P] Pi released in the absence and presence of 1\u2009mM furosemide\/2\u2009mM ouabain and in the absence and presence of 1\u2009mM ouabain, respectively.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>It was observed that SAP<jats:italic>Aa<\/jats:italic> D inhibited furosemide-induced diuresis (at 90\u2009min: from 10.0\u2009\u00b1\u20091.0\u2009mL, <jats:italic>NaCl\u2009+\u2009Furo<\/jats:italic> group, n\u2009=\u20095, to 5.9\u2009\u00b1\u20091.0\u2009mL, <jats:italic>SAPAaD\u2009+\u2009Furo<\/jats:italic> group n\u2009=\u20095, p\u2009&lt;\u20090.05), increased both Na<jats:sup>+<\/jats:sup>-ATPase (from 25.0\u2009\u00b1\u20095.9\u2009nmol Pi.mg<jats:sup>-1<\/jats:sup>.min<jats:sup>-1<\/jats:sup>, control, to 52.7\u2009\u00b1\u20098.9\u2009nmol Pi.mg<jats:sup>-1<\/jats:sup>.min<jats:sup>-1<\/jats:sup>, p\u2009&lt;\u20090.05) and (Na<jats:sup>+<\/jats:sup>,K<jats:sup>+<\/jats:sup>)-ATPase (from 47.8\u2009\u00b1\u200913.3\u2009nmol Pi.mg<jats:sup>-1<\/jats:sup>.min<jats:sup>-1<\/jats:sup>, control, to 79.8\u2009\u00b1\u20096.9\u2009nmol Pi .mg<jats:sup>-1<\/jats:sup>.min<jats:sup>-1<\/jats:sup>, p\u2009&lt;\u20090.05) activities in the renal cortex. SAP<jats:italic>Aa<\/jats:italic> D also lowered urine ANP (from 792\u2009\u00b1\u2009132\u2009pg\/mL, control, to 299\u2009\u00b1\u200988\u2009pg\/mL, p\u2009&lt;\u20090.01) and had no effect on plasma or atrial ANP.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>We concluded that the SAP<jats:italic>Aa<\/jats:italic> D antidiuretic effect may be due to an increase in the renal activities of Na<jats:sup>+<\/jats:sup>- and (Na<jats:sup>+<\/jats:sup>,K<jats:sup>+<\/jats:sup>)-ATPases and\/or a decrease in the renal ANP.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1472-6882-12-40","type":"journal-article","created":{"date-parts":[[2012,4,11]],"date-time":"2012-04-11T22:14:19Z","timestamp":1334182459000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The effect of saponins from Ampelozizyphus amazonicus Ducke on the renal Na+ pumps\u2019 activities and urinary excretion of natriuretic peptides"],"prefix":"10.1186","volume":"12","author":[{"given":"L\u00facio Ricardo Leite","family":"Diniz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviane Gomes","family":"Portella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1via Magalh\u00e3es","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aloa Machado","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celso","family":"Caruso-Neves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geovanni Dantas","family":"Cassali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adelina Martha","family":"dos Reis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MariadasGra\u00e7asLins","family":"Brand\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Aparecida Ribeiro","family":"Vieira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,4,11]]},"reference":[{"issue":"1","key":"1036_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jep.2007.07.023","volume":"114","author":"CI Wright","year":"2007","unstructured":"Wright CI, Van-Buren L, Kroner CI, Koning MM: Herbal medicines as diuretics: a review of the scientific evidence. 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