{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T20:10:29Z","timestamp":1776283829520,"version":"3.50.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,5,20]],"date-time":"2012-05-20T00:00:00Z","timestamp":1337472000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Complement Altern Med"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1186\/1472-6882-12-65","type":"journal-article","created":{"date-parts":[[2012,5,20]],"date-time":"2012-05-20T15:54:08Z","timestamp":1337529248000},"source":"Crossref","is-referenced-by-count":28,"title":["Antioxidant and gastric cytoprotective prostaglandins properties of Cassia sieberiana roots bark extract as an anti-ulcerogenic agent"],"prefix":"10.1186","volume":"12","author":[{"given":"Edmund T","family":"Nartey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Ofosuhene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Kudzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caleb M","family":"Agbale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,5,20]]},"reference":[{"key":"1069_CR1","doi-asserted-by":"publisher","first-page":"118","DOI":"10.3362\/9781780443737.007","volume-title":"Useful plants of Ghana","author":"DK Abbiw","year":"1990","unstructured":"Abbiw DK: Portions and Medicine. Useful plants of Ghana. 1990, Intermediate Technology Publications, London, 118-205."},{"key":"1069_CR2","first-page":"53","volume":"14","author":"ET Nartey","year":"2009","unstructured":"Nartey ET, Addo PG, Ofosuhene M, Okine LK, Nyarko AK: The effect of Cassia sieberiana roots bark extract on various experimental gastric ulcer models in rats. J Phytomed Ther. 2009, 14: 53-59.","journal-title":"J Phytomed Ther"},{"issue":"9","key":"1069_CR3","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1248\/bpb.25.1151","volume":"25","author":"W Toma","year":"2002","unstructured":"Toma W, Graciosa JS, Andrade FDP, Hiruma-Lima CA, Vilegas W, Souza-Brito ARM: Antiulcerogenic activity of four extracts from the bark of Quassia amora L. (Simaroubaceae). Biol Pharm Bull. 2002, 25 (9): 1151-1155. 10.1248\/bpb.25.1151.","journal-title":"Biol Pharm Bull"},{"issue":"8\u20139","key":"1069_CR4","doi-asserted-by":"publisher","first-page":"2227","DOI":"10.1016\/j.fct.2010.05.053","volume":"48","author":"I G\u00fcl\u00e7in","year":"2010","unstructured":"G\u00fcl\u00e7in I, Bursal E, Sehito\u011flu MH, Bilsel M, G\u00f6ren AC: Polyphenol contents and antioxidant activity of lyophilized aqueous extract of propolis from Erzurum, Turkey. Food Chem Toxicol. 2010, 48 (8\u20139): 2227-2238.","journal-title":"Food Chem Toxicol"},{"key":"1069_CR5","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1006\/phrs.1998.0343","volume":"38","author":"L Rastogi","year":"1998","unstructured":"Rastogi L, Patnaik GK, Dikshit M: Free radicals and antioxidants status following pylorus ligation induced gastric mucosal injury in rats. Pharm Res. 1998, 38: 125-132. 10.1006\/phrs.1998.0343.","journal-title":"Pharm Res"},{"key":"1069_CR6","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/BF00936440","volume":"125","author":"D Das","year":"1993","unstructured":"Das D, Banerjee RK: Effect of stress on the antioxidant enzymes and gastric ulceration. Mol Cell Biochem. 1993, 125: 115-125. 10.1007\/BF00936440.","journal-title":"Mol Cell Biochem"},{"key":"1069_CR7","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1136\/gut.38.6.826","volume":"38","author":"F Karmeli","year":"1996","unstructured":"Karmeli F, Okon E, Rachmilewitz D: Sulphydryl blocker induced gastric damage is ameliorated by scavenging of free radicals. Gut. 1996, 38: 826-832. 10.1136\/gut.38.6.826.","journal-title":"Gut"},{"key":"1069_CR8","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1136\/gut.35.9.1181","volume":"35","author":"D Rachmilewitz","year":"1994","unstructured":"Rachmilewitz D, Karmeli F, Okon E, Samuni A: A novel anti-ulcerogenic stable radical prevents gastric mucosal lesions in rats. Gut. 1994, 35: 1181-1188. 10.1136\/gut.35.9.1181.","journal-title":"Gut"},{"issue":"1","key":"1069_CR9","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.ifset.2009.07.002","volume":"11","author":"\u0130 G\u00fcl\u00e7in","year":"2010","unstructured":"G\u00fcl\u00e7in \u0130: Antioxidant properties of resveratrol: a structure\u2013activity insight. Innov Food Sci Emerg Technol. 2010, 11 (1): 210-218. 10.1016\/j.ifset.2009.07.002.","journal-title":"Innov Food Sci Emerg Technol"},{"key":"1069_CR10","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1177\/153537020623100202","volume":"231","author":"GR Martin","year":"2006","unstructured":"Martin GR, Wallace JL: Gastrointestinal inflammation: a central component of mucosal defense and repair. Exp Biol Med. 2006, 231: 130-137.","journal-title":"Exp Biol Med"},{"key":"1069_CR11","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1152\/physrev.00004.2008","volume":"88","author":"JL Wallace","year":"2008","unstructured":"Wallace JL: Prostaglandins, NSAIDs, and gastric mucosal protection: why doesn\u2019t the stomach digest itself?. Physiol Rev. 2008, 88: 1547-1565. 10.1152\/physrev.00004.2008.","journal-title":"Physiol Rev"},{"key":"1069_CR12","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1111\/j.1365-2125.1991.tb05616.x","volume":"32","author":"AB Hawthorne","year":"1991","unstructured":"Hawthorne AB, Mahida YR, Cole AT, Hawkey CJ: Aspirin induced gastric mucosal damage: prevention by enteric-coating and relation to prostaglandin synthesis. Br J Clin Pharmacol. 1991, 32: 77-83. 10.1111\/j.1365-2125.1991.tb05616.x.","journal-title":"Br J Clin Pharmacol"},{"key":"1069_CR13","first-page":"1014","volume":"89","author":"SJ Sontag","year":"1994","unstructured":"Sontag SJ, Schnell TG, Budiman-Mak E, Adelman K, Fleischmann R, Cohen S, Roth SH, Ipe D, Schwartz KE: Healing of NSAID-induced gastric ulcers with a synthetic prostaglandin analog (enprostil). Am J Gastroenterol. 1994, 89: 1014-1020.","journal-title":"Am J Gastroenterol"},{"key":"1069_CR14","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/S1388-1981(02)00182-8","volume":"1582","author":"A Sturm","year":"2002","unstructured":"Sturm A, Dignass AU: Modulation of gastrointestinal wound repair and inflammation by phospholipids. Biochim Biophys Acta. 2002, 1582: 282-288. 10.1016\/S1388-1981(02)00182-8.","journal-title":"Biochim Biophys Acta"},{"key":"1069_CR15","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/0167-4781(92)90460-H","volume":"1130","author":"J Dimberg","year":"1992","unstructured":"Dimberg J, Gustafson-Svard C, Westrom B, Tagesson C, Soderkvist P: Group I phospholipase A2 mRNA expression in rat glandular stomach and pancreas. Ontogenic development and effects of cortisone acetate. Biochim Biophys Acta. 1992, 1130: 47-51. 10.1016\/0167-4781(92)90460-H.","journal-title":"Biochim Biophys Acta"},{"key":"1069_CR16","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1111\/j.1476-5381.1993.tb13851.x","volume":"110","author":"RJ Evans","year":"1993","unstructured":"Evans RJ, Surprenant A: Effects of phospholipase A2 inhibitors on coupling of alpha 2-adrenoceptors to inwardly rectifying potassium currents in guinea-pig submucosal neurones. Br J Pharmacol. 1993, 110: 591-596. 10.1111\/j.1476-5381.1993.tb13851.x.","journal-title":"Br J Pharmacol"},{"key":"1069_CR17","unstructured":"Official methods of analysis of the association of official analytical chemists. 1990, Association of Official Analytical Chemists,, Arlington, VA, 15"},{"key":"1069_CR18","doi-asserted-by":"publisher","first-page":"4083","DOI":"10.1021\/jf0103572","volume":"49","author":"A Yildirim","year":"2001","unstructured":"Yildirim A, Mavi A, Kara A: Determination of antioxidant and antimicrobial activities of Rumex crispus L. extracts. J Agric Food Chem. 2001, 49: 4083-4089. 10.1021\/jf0103572.","journal-title":"J Agric Food Chem"},{"key":"1069_CR19","doi-asserted-by":"publisher","first-page":"6929","DOI":"10.1021\/jf0206163","volume":"50","author":"QH Zhu","year":"2002","unstructured":"Zhu QH, Hackman RM, Ensunsa JL, Holt RR, Keen CL: Antioxidant activities of oolong tea. J Agric Food Chem. 2002, 50: 6929-6934. 10.1021\/jf0206163.","journal-title":"J Agric Food Chem"},{"key":"1069_CR20","doi-asserted-by":"publisher","first-page":"3206","DOI":"10.1021\/jf981351o","volume":"47","author":"YH Kuo","year":"1999","unstructured":"Kuo YH, Yeh DB, Pan BS: Rapid photometric assay evaluating antioxidative activity in edible plant material. J Agric Food Chem. 1999, 47: 3206-3209. 10.1021\/jf981351o.","journal-title":"J Agric Food Chem"},{"key":"1069_CR21","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/0003-2697(87)90222-3","volume":"165","author":"B Halliwell","year":"1987","unstructured":"Halliwell B, Gutteridge JMC, Arurma OI: The deoxyribose method: a simple \u201ctest-tube\u201d assay for determination of rate constants for reactions of hydroxyl radicals. Anal Bioch. 1987, 165: 215-219. 10.1016\/0003-2697(87)90222-3.","journal-title":"Anal Bioch"},{"key":"1069_CR22","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1006\/abbi.1994.1485","volume":"315","author":"TCP Dinis","year":"1994","unstructured":"Dinis TCP, Madeira VMC, Almeida LM: Action of phenolic derivatives (acetaminophen, salicylate, and 5-aminosalicylate) as inhibitors of membrane lipid peroxidation and as peroxyl radical scavengers. Arch Biochem Biophys. 1994, 315: 161-169. 10.1006\/abbi.1994.1485.","journal-title":"Arch Biochem Biophys"},{"issue":"1","key":"1069_CR23","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry OH, Rosebrough NJ, Farr AL, Randall RJ: Protein measurement with the Folin phenol reagent. J Biol Chem. 1951, 193 (1): 265-275.","journal-title":"J Biol Chem"},{"key":"1069_CR24","first-page":"128","volume-title":"Medicinal Plants and Traditional Medicine in Africa","author":"A Sofowora","year":"1982","unstructured":"Sofowora A: Screening for bioactive agents. Medicinal Plants and Traditional Medicine in Africa. 1982, Wiley, New York, 128-161."},{"issue":"1","key":"1069_CR25","first-page":"60","volume":"11","author":"L Wang","year":"2003","unstructured":"Wang L, Yen J-H, Liang H-H, Wu M-J: Antioxidant effects of methanol ectracts form lotus plumule and blossom (Nelumbo nucifera Gertn.). J Food Drug Anal. 2003, 11 (1): 60-66.","journal-title":"J Food Drug Anal"},{"key":"1069_CR26","doi-asserted-by":"publisher","first-page":"4241","DOI":"10.1021\/jf000167b","volume":"48","author":"CD Porto","year":"2000","unstructured":"Porto CD, Calligaris S, Cellotti E, Nicoli MC: Antiradical properties of commercial cognacs assessed by the DPPH test. J Agric Food Chem. 2000, 48: 4241-4245. 10.1021\/jf000167b.","journal-title":"J Agric Food Chem"},{"issue":"1","key":"1069_CR27","first-page":"83","volume":"50","author":"R Tandon","year":"2006","unstructured":"Tandon R, Mukherjee N, V. K, Dixit VK, R. Khanna R, Khanna HD: Lipid peroxidation levels in peptic ulcer and gastric carcinoma. Indian J Physiol Pharmacol. 2006, 50 (1): 83-86.","journal-title":"Indian J Physiol Pharmacol"},{"issue":"38","key":"1069_CR28","doi-asserted-by":"publisher","first-page":"5121","DOI":"10.3748\/wjg.v13.i38.5121","volume":"13","author":"SA Olaleye","year":"2007","unstructured":"Olaleye SA, Adaramoye OA, Erigbali PP, Adeniyi OS: Lead exposure increases oxidative stress in the gastric mucosa of HCL\/ethanol-exposed rats. World J Gastroenterol. 2007, 13 (38): 5121-5126.","journal-title":"World J Gastroenterol"},{"issue":"1","key":"1069_CR29","first-page":"39","volume":"14","author":"S Demir","year":"2003","unstructured":"Demir S, Yilmaz M, K\u00f6seo\u011flu M, Akalin N, Aslan D, Aydin A: Role of free radicals in peptic ulcer and gastritis. Turk J Gastroenterol. 2003, 14 (1): 39-43.","journal-title":"Turk J Gastroenterol"},{"issue":"9337","key":"1069_CR30","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/S0140-6736(02)11030-0","volume":"360","author":"FKL Chan","year":"2002","unstructured":"Chan FKL, Leung WK: Peptic-ulcer disease. Lancet. 2002, 360 (9337): 933-961. 10.1016\/S0140-6736(02)11030-0.","journal-title":"Lancet"},{"issue":"2","key":"1069_CR31","first-page":"88","volume":"30","author":"IM Siregar","year":"2011","unstructured":"Siregar IM, Miladiyah I: Protective effects of Cyclea barbata Miers leaves against aspirin-induced gastric ulcer in mice. Univ Med. 2011, 30 (2): 88-94.","journal-title":"Univ Med"},{"key":"1069_CR32","first-page":"619","volume-title":"The flavonoids-Advances in Research since 1986","author":"EJr Middleton","year":"1994","unstructured":"Middleton EJr, Kandaswami C: The impact of plant flovonoids on mammalian biology: implications for immunity, inflammation and cancer. The flavonoids-Advances in Research since 1986. Edited by: Harbourne JB. 1994, Chapman and Hall, Boca Raton, 619-652."},{"issue":"3","key":"1069_CR33","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/sj.bjp.0706201","volume":"145","author":"JL Wallace","year":"2005","unstructured":"Wallace JL, Devchand PR: Emerging roles for cyclooxygenase-2 in gastrointestinal mucosal defense. Br J Pharmacol. 2005, 145 (3): 275-282. 10.1038\/sj.bjp.0706201.","journal-title":"Br J Pharmacol"},{"issue":"20","key":"1069_CR34","doi-asserted-by":"publisher","first-page":"13243","DOI":"10.1073\/pnas.202392199","volume":"99","author":"L Ma","year":"2002","unstructured":"Ma L, del Soldato P, Wallace JL: Divergent effects of new cyclooxygenase inhibitors on gastric ulcer healing: Shifting the angiogenic balance. Proc Natl Acad Sci USA. 2002, 99 (20): 13243-13247. 10.1073\/pnas.202392199.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1069_CR35","doi-asserted-by":"crossref","first-page":"G903","DOI":"10.1152\/ajpgi.1992.262.5.G903","volume":"262","author":"H Asako","year":"1992","unstructured":"Asako H, Kubes P, Wallace J, Gaginella T, Wolf RE, Granger DN: Indomethacin-induced leukocyte adhesion in mesenteric venules: role of lipoxygenase products. Am J Physiol Gastrointest Liver Physiol. 1992, 262: G903-G908.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"1069_CR36","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/0016-5085(92)91107-F","volume":"103","author":"H Asako","year":"1992","unstructured":"Asako H, Kubes P, Wallace J, Wolf RE, Granger DN: Modulation of leukocyte adhesion in rat mesenteric venules by aspirin and salicylate. Gastroenterology. 1992, 103: 146-152.","journal-title":"Gastroenterology"},{"key":"1069_CR37","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1093\/oxfordjournals.bmb.a072627","volume":"49","author":"VR Winrow","year":"1993","unstructured":"Winrow VR, Winyard PG, Morris CJ, Blake DR: Free radicals in inflammation: second messengers and mediators of tissue destruction. Brit Med Bull. 1993, 49: 506-522.","journal-title":"Brit Med Bull"},{"issue":"24","key":"1069_CR38","doi-asserted-by":"publisher","first-page":"16245","DOI":"10.1074\/jbc.M513874200","volume":"281","author":"Z Ni","year":"2006","unstructured":"Ni Z, Okeley NM, Smart BP, Gelb MH: Intracellular actions of group IIA secreted phospholipase A2 and group IVA cytosolic phospholipase A2 contribute to arachidonic acid release and prostaglandin production in rat gastric mucosal cells and transfected human embryonic kidney cells. J Biol Chem. 2006, 281 (24): 16245-16255. 10.1074\/jbc.M513874200.","journal-title":"J Biol Chem"},{"key":"1069_CR39","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1146\/annurev.pharmtox.39.1.175","volume":"39","author":"J Balsinde","year":"1999","unstructured":"Balsinde J, Balboa MA, Insel PA, Dennis EA: Regulation and inhibition of phospholipase A2. Annu Rev Pharmacol Toxicol. 1999, 39: 175-189. 10.1146\/annurev.pharmtox.39.1.175.","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"1069_CR40","volume-title":"Modulation of eicosanoids biosyntheses in vivo as a mechanism-based evaluation of putative anti-inflammatory plant extracts","author":"J Dadzie-Mensah","year":"2000","unstructured":"Dadzie-Mensah J: Modulation of eicosanoids biosyntheses in vivo as a mechanism-based evaluation of putative anti-inflammatory plant extracts. 2000, University of Ghana, Department of Biochemistry, MPhil Thesis"},{"key":"1069_CR41","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/0002-9610(89)90699-5","volume":"157","author":"T Otamiri","year":"1989","unstructured":"Otamiri T, Tagesson C: Role of phospholipase A2 and oxygenated free radicals in mucosal damage after small intestinal ischemia and reperfusion. Am J Surg. 1989, 157: 562-565. 10.1016\/0002-9610(89)90699-5.","journal-title":"Am J Surg"},{"key":"1069_CR42","first-page":"184","volume":"113","author":"M Boros","year":"1993","unstructured":"Boros M, Karacsony G, Kaszaki J, Nagy S: Reperfusion mucosal damage after complete intestinal ischemia in the dog: the effects of antioxidant and phospholipase A2 inhibitor therapy. Surgery. 1993, 113: 184-191.","journal-title":"Surgery"}],"container-title":["BMC Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1472-6882-12-65\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6882-12-65.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6882-12-65.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,16]],"date-time":"2022-01-16T00:19:03Z","timestamp":1642292343000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccomplementalternmed.biomedcentral.com\/articles\/10.1186\/1472-6882-12-65"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,20]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["1069"],"URL":"https:\/\/doi.org\/10.1186\/1472-6882-12-65","relation":{},"ISSN":["1472-6882"],"issn-type":[{"value":"1472-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,20]]},"article-number":"65"}}