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TPW was then evaluated against CCl\n                      <jats:sub>4<\/jats:sub>\n                      -induced liver toxicity in rats. Liver enzymes (AST, ALT, and ALP) and antioxidant markers were assessed. The effect of TPW on isolated hepatic cells, post-CCl\n                      <jats:sub>4<\/jats:sub>\n                      administration, was assessed by isolated mitochondrial membrane staining. The actions of TPW on apoptotic pathway in CCl\n                      <jats:sub>4<\/jats:sub>\n                      -treated Chang cells were also elucidated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      TPW was found to be safe at all doses tested in both\n                      <jats:italic>in vitro<\/jats:italic>\n                      and\n                      <jats:italic>in vivo<\/jats:italic>\n                      toxicity studies. TPW (400\u00a0mg\/kg, p.o.) significantly (*p &lt;0.05) improved liver enzyme activity as compared to CCl\n                      <jats:sub>4<\/jats:sub>\n                      . Also, it improved antioxidant status (GSH, GST, MDA and total thiol) and preserved hepatic cell architecture. TPW pre-treatment significantly attenuated the levels of phospho-p53, p53, cleaved caspase-3, phospho-Bad, Bad and cleaved PARP in CCl\n                      <jats:sub>4<\/jats:sub>\n                      -treated Chang cells, improving the viability considerably.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The findings support a protective role for\n                      <jats:italic>Terminalia paniculata<\/jats:italic>\n                      in pathologies involving oxidative stress.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/1472-6882-13-127","type":"journal-article","created":{"date-parts":[[2013,6,6]],"date-time":"2013-06-06T16:14:18Z","timestamp":1370535258000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Toxicological evaluation of Terminalia paniculata bark extract and its protective effect against CCl4-induced liver injury in rodents"],"prefix":"10.1186","volume":"13","author":[{"given":"Sahil","family":"Talwar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitesh V","family":"Jagani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawan G","family":"Nayak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitesh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anoop","family":"Kishore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Punit","family":"Bansal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rekha R","family":"Shenoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnadas","family":"Nandakumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,6,6]]},"reference":[{"key":"1378_CR1","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.jep.2009.11.014","volume":"127","author":"A Somasundaram","year":"2010","unstructured":"Somasundaram A, Karthikeyan R, Velmurugan V, Dhandapani B, Raja M: Evaluation of hepatoprotective activity of Kyllinga nemoralis (Hutch & Dalz) rhizomes. 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