{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:50:59Z","timestamp":1760122259055},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T00:00:00Z","timestamp":1371513600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Complement Altern Med"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Soshiho-tang (SH; Chinese name, Xiao-Chai-Hu-Tang; Japanese name, Shosaiko-to) is a traditional Korean, Chinese, and Japanese medicine, which has been used to treat various conditions, including hepatitis, liver cirrhosis, and chronic and acute liver disease. SH consists of seven herbal components, of which <jats:italic>Scutellaria baicalensis<\/jats:italic> Georgi and <jats:italic>Zingiber officinale<\/jats:italic> Roscoe, are reported to have antithrombotic and antiplatelet activities. We investigated the antithrombotic activity of SH, including <jats:italic>S. baicalensis<\/jats:italic> and <jats:italic>Z. officinale<\/jats:italic>, as an integrative therapy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>To identify the antithrombotic activity of SH, we used a FeCl<jats:sub>3<\/jats:sub>-induced thrombus formation model. The mechanism of SH-mediated antithrombotic activity was assessed by determining platelet aggregation and coagulation times <jats:italic>ex vivo<\/jats:italic>, washed platelet aggregation, serotonin secretion, and thromboxane B<jats:sub>2<\/jats:sub> formation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>SH prolonged the occlusion time of thrombus formation when applied in a FeCl<jats:sub>3<\/jats:sub>-induced thrombus formation model. SH also inhibited collagen-induced platelet aggregation <jats:italic>ex vivo<\/jats:italic> in a concentration-dependent manner; however, it did not affect coagulation. Hence, to identify the antiplatelet effect of SH, we investigated washed platelet aggregations <jats:italic>in vitro<\/jats:italic>. SH significantly inhibited various agonist-induced platelet aggregations, and it completely inhibited serotonin secretion and thromboxane B<jats:sub>2<\/jats:sub> formation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>The findings suggest that SH inhibited FeCl<jats:sub>3<\/jats:sub>-induced thrombus formation through antiplatelet activity, including inhibition of platelet aggregation, and serotonin and TXB<jats:sub>2<\/jats:sub> production. Thus, SH may be useful as an integrative herbal formula for the treatment of thrombosis.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1472-6882-13-137","type":"journal-article","created":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T03:54:44Z","timestamp":1371527684000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Antithrombotic and antiplatelet activities of Soshiho-tang extract"],"prefix":"10.1186","volume":"13","author":[{"given":"Jung-Jin","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taesoo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won-Kyung","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Yeul","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,6,18]]},"reference":[{"issue":"6","key":"1380_CR1","doi-asserted-by":"publisher","first-page":"399","DOI":"10.2165\/00129784-200505060-00007","volume":"5","author":"SR Steinhubl","year":"2005","unstructured":"Steinhubl SR, Moliterno DJ: The role of the platelet in the pathogenesis of atherothrombosis. 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