{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T22:01:33Z","timestamp":1793397693000,"version":"4.5.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,6,22]],"date-time":"2013-06-22T00:00:00Z","timestamp":1371859200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Complement Altern Med"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>The use of plants and their derived substances increases day by day for the discovery of therapeutic agents owing to their versatile applications. Current research is directed towards finding naturally-occurring antioxidants having anticancer properties from plant origin since oxidants play a crucial role in developing various human diseases. The present study was designed to investigate the antioxidant and anticancer properties of <jats:italic>Sygygium fruticosum<\/jats:italic> (Roxb.) (abbreviated as SF).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>The dried coarse powder of seeds of SF was exhaustively extracted with methanol and the resulting crude methanolic extract (CME) was successively fractionated with petroleum ether, chloroform and ethyl acetate to get petroleum ether (PEF), chloroform (CHF), ethyl acetate (EAF) and lastly aqueous (AQF) fraction. The antioxidant activities were determined by several assays: total antioxidant capacity assay, DPPH free radical scavenging assay, hydroxyl radical scavenging assay, ferrous reducing antioxidant capacity and lipid peroxidation inhibition assay. The <jats:italic>in vivo<\/jats:italic> anticancer activity of SF was determined on Ehrlich\u2019s Ascite cell (EAC) induced Swiss albino mice.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>All the extractives showed strong antioxidant activities related to the standard. The total antioxidant capacity (TAC) of the fractions was in the following order: EAF&gt;AQF&gt;CME&gt;PEF&gt;CHF. The TAC of EAF at 320 \u03bcg\/mL was 2.60\u00b10.005 which was significantly higher (<jats:italic>p<\/jats:italic> &lt; 0.01) than that of standard catechin (1.37 \u00b1 0.005). The ferrous reducing antioxidant capacity of the extracts was in the following order: EAF&gt;AQF&gt;CME&gt;AA&gt;CHF&gt;PEF. In DPPH free radical scavenging assay, the IC<jats:sub>50<\/jats:sub> value of EAF was 4.85 \u03bcg\/mL, whereas that of BHT was 9.85 \u03bcg\/mL. In hydroxyl radical scavenging assay and lipid peroxidation inhibition assay, the EAF showed the most potent inhibitory activity with IC<jats:sub>50<\/jats:sub> of 43.3 and 68.11 \u03bcg\/mL, respectively. The lipid peroxidation inhibition assay was positively correlated (<jats:italic>p<\/jats:italic> &lt; 0 .001) with both DPPH free radical scavenging and hydroxyl radical scavenging assay. The total phenolic contents of SF were also positively correlated (<jats:italic>p<\/jats:italic> &lt; 0 .001) with DPPH free radical scavenging, hydroxyl radical scavenging and lipid peroxidation inhibition assay. Based on antioxidant activity, EAF was selected for cytotoxic assay and it was found that EAF inhibited 67.36% (<jats:italic>p<\/jats:italic> &lt; 0.01) cell growth at a dose of 50 mg\/kg (ip) on day six of EAC cell incubation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Our results suggest that EAF of seeds of SF possess significant antioxidant and moderate anticancer properties. Seeds of SF may therefore be a good source for natural antioxidants and a possible pharmaceutical supplement.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1472-6882-13-142","type":"journal-article","created":{"date-parts":[[2013,6,22]],"date-time":"2013-06-22T06:15:04Z","timestamp":1371881704000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Evaluation of antioxidant and anticancer properties of the seed extracts of Syzygium fruticosum Roxb. growing in Rajshahi, Bangladesh"],"prefix":"10.1186","volume":"13","author":[{"given":"Shafiqul","family":"Islam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samima","family":"Nasrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Ali","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ASM Sakhawat","family":"Hossain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhadul","family":"Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Proma","family":"Khandokhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Nurul Haque","family":"Mollah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamunur","family":"Rashid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Golam","family":"Sadik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Aziz Abdur","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AHM Khurshid","family":"Alam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,6,22]]},"reference":[{"key":"1385_CR1","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/S0378-8741(01)00413-5","volume":"79","author":"A Braca","year":"2002","unstructured":"Braca A, Sortino C, Politi M, Morelli I, Mendez J: Antioxidant activity of flavonoids from Licania licaniaeflora. J Ethno. 2002, 79: 379-381. 10.1016\/S0378-8741(01)00413-5.","journal-title":"J Ethno"},{"key":"1385_CR2","doi-asserted-by":"publisher","first-page":"345","DOI":"10.2165\/00003495-199549030-00003","volume":"49","author":"SR Maxwell","year":"1995","unstructured":"Maxwell SR: Prospects for the use of antioxidant therapies. Drugs. 1995, 49: 345-361. 10.2165\/00003495-199549030-00003.","journal-title":"Drugs"},{"key":"1385_CR3","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1126\/science.1071055","volume":"296","author":"WC Willett","year":"2002","unstructured":"Willett WC: Balancing life-style and genomics research for disease prevention. Science. 2002, 296: 695-698. 10.1126\/science.1071055.","journal-title":"Science"},{"key":"1385_CR4","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1016\/S0002-8223(96)00273-8","volume":"96","author":"KA Steinmetz","year":"1996","unstructured":"Steinmetz KA, Potter DJ: Vegetables, fruit, and cancer prevention: a review. J Am Diet Asso. 1996, 96: 1027-1039. 10.1016\/S0002-8223(96)00273-8.","journal-title":"J Am Diet Asso"},{"key":"1385_CR5","doi-asserted-by":"publisher","first-page":"3954","DOI":"10.1021\/jf990146l","volume":"47","author":"MP Kahkonen","year":"1999","unstructured":"Kahkonen MP, Hopia AI, Vuorela HJ, Rauha JP, Pihlaja K, Kujala KS: Heinonen: Antioxidant activity of plant extracts containing phenolic compounds. J Agr Food Chem. 1999, 47: 3954-3962. 10.1021\/jf990146l.","journal-title":"J Agr Food Chem"},{"key":"1385_CR6","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.foodchem.2003.05.007","volume":"85","author":"G Miliauskas","year":"2004","unstructured":"Miliauskas G, Venskutonis PR, Beek TAV: Screening of radical scavenging activity of some medicinal and aromatic plant extracts. Food Chem. 2004, 85: 231-237. 10.1016\/j.foodchem.2003.05.007.","journal-title":"Food Chem"},{"key":"1385_CR7","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.foodchem.2005.07.042","volume":"99","author":"N Balasundram","year":"2006","unstructured":"Balasundram N, Sundram K, Samman S: Phenolic compounds in plants and agri-industrial by-products: Antioxidant activity, occurrence, and potential uses. Food Chem. 2006, 99: 191-203. 10.1016\/j.foodchem.2005.07.042.","journal-title":"Food Chem"},{"key":"1385_CR8","first-page":"160","volume-title":"Encyclopaedia of Australian plants suitable for cultivation, volume 9","author":"RW Elliot","year":"2010","unstructured":"Elliot RW, Jones DL, Blake T, 2010: Encyclopaedia of Australian plants suitable for cultivation, volume 9. 2010, Australia: Port Melbourne: Lothian Press, 160-161."},{"key":"1385_CR9","doi-asserted-by":"publisher","first-page":"2545","DOI":"10.3390\/molecules13102545","volume":"13","author":"PZ Ruan","year":"2008","unstructured":"Ruan PZ, Zhang LL, Lin MY: Evaluation of the antioxidant activity of Syzygium cumini leaves. Mole. 2008, 13: 2545-2556. 10.3390\/molecules13102545.","journal-title":"Mole"},{"key":"1385_CR10","doi-asserted-by":"publisher","first-page":"124","DOI":"10.5138\/ijpm.2010.0975.0185.02019","volume":"2","author":"A Jain","year":"2010","unstructured":"Jain A, Sharma S, Goyal M, Dubey S, Jain S, Sahu J, Sharma A, Kaushik A: Anti-inflammatory activity of Syzygium cumini leaves. Int J Phytomed. 2010, 2: 124-126. 10.5138\/ijpm.2010.0975.0185.02019.","journal-title":"Int J Phytomed"},{"key":"1385_CR11","first-page":"861","volume":"45","author":"N Singh","year":"2007","unstructured":"Singh N, Gupta M: Effects of ethanolic extract of Syzygium cumini (L.) seed powder on pancreatic islet of alloxan diabetic rats. Ind J Exp Bio. 2007, 45: 861-867.","journal-title":"Ind J Exp Bio"},{"key":"1385_CR12","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1089\/1096620041224067","volume":"7","author":"K Ravi","year":"2004","unstructured":"Ravi K, Sivagnanam K, Subramanjan S: Antidiabetic activity of Eugenia jambolana seed kernels on streptozotocin induced diabetic rats. J Med Food. 2004, 7: 187-191. 10.1089\/1096620041224067.","journal-title":"J Med Food"},{"key":"1385_CR13","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1016\/j.fct.2005.04.004","volume":"43","author":"R Kasiappan","year":"2005","unstructured":"Kasiappan R, Subbaih R, Subramanian S: Antihyperlipidemic effect of Eugenia jambolana seed kernel on streptozotocin induced diabetes rats. Food Chem Toxicol. 2005, 43: 1433-1439. 10.1016\/j.fct.2005.04.004.","journal-title":"Food Chem Toxicol"},{"key":"1385_CR14","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/S0367-326X(00)00325-7","volume":"72","author":"S Muruganandan","year":"2001","unstructured":"Muruganandan S, Srinivasan K, Chandra S, Tandan SK, Lal J, Raviprakash V: Anti-inflammatory activity of Syzygium cumini bark. Fitoterapia. 2001, 72: 369-375. 10.1016\/S0367-326X(00)00325-7.","journal-title":"Fitoterapia"},{"key":"1385_CR15","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/1756-0500-6-24","volume":"6","author":"MA Khan","year":"2013","unstructured":"Khan MA, Rahman AA, Islam S, Khandokhar P, Parvin S, Islam MB, Hossain M, Rashid M, Sadik G, Nasrin S, Mollah MN, Alam AHMK: A comparative study on the antioxidant activity of methanolic extracts from different parts of Morus alba L. (Moraceae). BMC Res Notes. 2013, 6: 24-10.1186\/1756-0500-6-24. doi:10.1186\/1756-0500-6-24","journal-title":"BMC Res Notes"},{"key":"1385_CR16","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1021\/jf020782a","volume":"51","author":"K Wolfe","year":"2003","unstructured":"Wolfe K, Wu X, Liu RH: Antioxidant activity of apple peels. J Agr Food Chem. 2003, 51: 609-614. 10.1021\/jf020782a.","journal-title":"J Agr Food Chem"},{"key":"1385_CR17","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/j.foodchem.2005.05.024","volume":"97","author":"AAL Ordonez","year":"2006","unstructured":"Ordonez AAL, Gomez JD, Vattuone MA, Isla MI: Antioxidant activities of Sechium edule (Jacq.) Swart extracts. Food Chem. 2006, 97: 452-458. 10.1016\/j.foodchem.2005.05.024.","journal-title":"Food Chem"},{"key":"1385_CR18","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.lwt.2005.09.011","volume":"40","author":"A Kumaran","year":"2007","unstructured":"Kumaran A, Karunakaran RJ: In vitro antioxidant activities of methanol extracts of Phyllanthus species from India. LWT- Food Sci Technol. 2007, 40: 344-352. 10.1016\/j.lwt.2005.09.011.","journal-title":"LWT- Food Sci Technol"},{"key":"1385_CR19","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/S0305-4179(97)00115-0","volume":"24","author":"JS Sun","year":"1998","unstructured":"Sun JS, Tsuang YW, Chen IJ, Huang WC, Hang YS, Lu FJ: An ultra-weak chemiluminescence study on oxidative stress in rabbits following acute thermal injury. Burns. 1998, 24: 225-231. 10.1016\/S0305-4179(97)00115-0.","journal-title":"Burns"},{"key":"1385_CR20","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1006\/abio.1999.4019","volume":"269","author":"P Prieto","year":"1999","unstructured":"Prieto P, Pineda M, Aguilar M: Spectrophotometric quantitation of antioxidant capacity through the formation of a phosphomolybdenum complex: specific application to the determination of vitamin E. Anal Bio. 1999, 269: 337-341. 10.1006\/abio.1999.4019.","journal-title":"Anal Bio"},{"key":"1385_CR21","doi-asserted-by":"publisher","first-page":"307","DOI":"10.5264\/eiyogakuzashi.44.307","volume":"44","author":"M Oyaizu","year":"1986","unstructured":"Oyaizu M: Studies on products of browning reactions: antioxidant activities of products of browning reaction prepared from glucose amine. Jap J Nut. 1986, 44: 307-315. 10.5264\/eiyogakuzashi.44.307.","journal-title":"Jap J Nut"},{"key":"1385_CR22","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1002\/1099-1573(200006)14:4<250::AID-PTR587>3.0.CO;2-J","volume":"14","author":"HY Choi","year":"2000","unstructured":"Choi HY, Jhun EJ, Lim BO: Application of flow injection-chemilumineacence to the study of radical scavenging activity in plants. Phytother Res. 2000, 14: 250-253. 10.1002\/1099-1573(200006)14:4<250::AID-PTR587>3.0.CO;2-J.","journal-title":"Phytother Res"},{"key":"1385_CR23","first-page":"6002","volume":"20","author":"SM Klein","year":"1981","unstructured":"Klein SM, Cohen G, Cederbaum : Production of formaldehyde during metabolism of dimethyl sulphoxide by hydroxyl radical generating system. Biochem. 1981, 20: 6002-6012.","journal-title":"Biochem"},{"key":"1385_CR24","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/S0024-3205(99)00643-8","volume":"66","author":"F Liu","year":"2000","unstructured":"Liu F, Nagaki TB: Antioxidative and free radical scavenging activities of selected medicinal herbs. J Life Sci. 2000, 66: 725-735. 10.1016\/S0024-3205(99)00643-8.","journal-title":"J Life Sci"},{"key":"1385_CR25","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1055\/s-2006-959427","volume":"60","author":"P Sur","year":"1994","unstructured":"Sur P, Ganguly DK: Tea Plant Root Extract (TRE) as an Antineoplastic Agent. Planta Med. 1994, 60: 106-109. 10.1055\/s-2006-959427.","journal-title":"Planta Med"},{"key":"1385_CR26","doi-asserted-by":"publisher","first-page":"4484","DOI":"10.1016\/j.biortech.2007.07.067","volume":"99","author":"GK Jayaprakasha","year":"2008","unstructured":"Jayaprakasha GK, Girennavar B, Patil BS: Radical scavenging activities of Rio Red grapefruits and Sour orangefruit extracts in different in vitro model systems. Biores Tech. 2008, 99: 4484-4494. 10.1016\/j.biortech.2007.07.067.","journal-title":"Biores Tech"},{"key":"1385_CR27","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/j.foodchem.2003.07.003","volume":"85","author":"N Singh","year":"2004","unstructured":"Singh N, Rajini PS: Free radical scavenging activity of an aqueous extract of potato peel. Food Chem. 2004, 85: 611-616. 10.1016\/j.foodchem.2003.07.003.","journal-title":"Food Chem"},{"key":"1385_CR28","doi-asserted-by":"publisher","first-page":"759","DOI":"10.3390\/12040759","volume":"12","author":"X Duan","year":"2007","unstructured":"Duan X, Wu G, Jiang Y: Evaluation of the antioxidant properties of litchi fruit phenolics in relation to pericarp browning prevention. Mole. 2007, 12: 759-771. 10.3390\/12040759.","journal-title":"Mole"},{"key":"1385_CR29","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.foodchem.2008.05.111","volume":"112","author":"H Li","year":"2009","unstructured":"Li H, Wang X, Li Y, Li P, Wang H: Polyphenolic compounds and antioxidant properties of selected China wines. Food Chem. 2009, 112: 454-460. 10.1016\/j.foodchem.2008.05.111.","journal-title":"Food Chem"},{"key":"1385_CR30","doi-asserted-by":"publisher","first-page":"R1","DOI":"10.1007\/BF00506554","volume":"307","author":"J Baumann","year":"1979","unstructured":"Baumann J, Wurn G, Bruchlausen FV: Prostaglandin synthetase inhibiting O-2 radical scavenging properties of some flavonoids and related phenolic compounds. Deutsche Pharmakologische Gesellschaft Abstracts of the 20th spring meeting, Naunyn-Schmiedebergs Abstract No: R27 cited in. Arch Pharmacol. 1979, 307: R1-R77.","journal-title":"Arch Pharmacol"},{"key":"1385_CR31","first-page":"95","volume":"4","author":"C Scully","year":"1993","unstructured":"Scully C: Oral cancer: New insight into pathogenesis. Den Upd. 1993, 4: 95-98.","journal-title":"Den Upd"},{"key":"1385_CR32","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1289\/ehp.98106s1289","volume":"106","author":"XUY Klauning JE","year":"1998","unstructured":"Klauning JE XUY, Isenberg JS, Bachowski S, Kolaja KL, Jianga J, Stevenson DE, Waloorg EF: The role of oxidative stress in chemical carcinogenesis. Envir Heal Persp. 1998, 106: 289-333.","journal-title":"Envir Heal Persp"},{"key":"1385_CR33","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1093\/jnci\/85.18.1483","volume":"85","author":"WJ Blot","year":"1993","unstructured":"Blot WJ, Li JY, Taylor PR: Nutrition intervention trials in Linxian, China: supplementation with specific vitamin\/mineral combinations, cancer incidence, and disease-specific mortality in the general population. J Natl Cancer Inst. 1993, 85: 1483-1491. 10.1093\/jnci\/85.18.1483.","journal-title":"J Natl Cancer Inst"},{"key":"1385_CR34","doi-asserted-by":"publisher","first-page":"812","DOI":"10.2174\/092986710790712183","volume":"17","author":"D Lamoral-Theys","year":"2010","unstructured":"Lamoral-Theys D, Pottier L, Dufrasne F, Neve J, Dubois J, Kornienko A, Kiss R, Ingrassia L: Natural polyphenols that display anticancer properties through inhibition of kinase activity. Curr Med Chem. 2010, 17: 812-825. 10.2174\/092986710790712183.","journal-title":"Curr Med Chem"},{"key":"1385_CR35","doi-asserted-by":"publisher","first-page":"5165","DOI":"10.1021\/jf010697n","volume":"49","author":"W Zheng","year":"2001","unstructured":"Zheng W, Wang SY: Antioxidant activity and phenolic compounds in selected herbs. J Agr Food Chem. 2001, 49: 5165-5170. 10.1021\/jf010697n.","journal-title":"J Agr Food Chem"},{"key":"1385_CR36","first-page":"2916","volume":"57","author":"T Fotsis","year":"1997","unstructured":"Fotsis T, Pepper MS, Aktas E, Breit S, Rasku S, Adlercreutz H: Flavonoid, dietary-derived inhibitors of cell proliferation and in vitro angiogenesis. Can Res. 1997, 57: 2916-2921.","journal-title":"Can Res"},{"key":"1385_CR37","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1055\/s-2007-969188","volume":"5","author":"H Wagner","year":"1986","unstructured":"Wagner H, Geyer B, Yoshinobu K, Govind SR: Coumestans as the main active principles of liver drugs Eclipta alba and Wedelica calendulaceae. Planta Med. 1986, 5: 370-372.","journal-title":"Planta Med"},{"key":"1385_CR38","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1080\/1040869059096","volume":"45","author":"A Scalbert","year":"2005","unstructured":"Scalbert A, Manach C, Morand C, Remesy C: Dietary Polyphenols and the Prevention of Diseases. Cri Rev Food Sci Nut. 2005, 45: 287-306. 10.1080\/1040869059096.","journal-title":"Cri Rev Food Sci Nut"},{"key":"1385_CR39","first-page":"197","volume":"21","author":"T Ariga","year":"2004","unstructured":"Ariga T: The antioxidative function, preventive action on disease and utilization of proanthocyanidins. Bio Fact. 2004, 21: 197-201.","journal-title":"Bio Fact"}],"container-title":["BMC Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6882-13-142.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1472-6882-13-142\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6882-13-142","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6882-13-142.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T00:23:00Z","timestamp":1630542180000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccomplementalternmed.biomedcentral.com\/articles\/10.1186\/1472-6882-13-142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,22]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["1385"],"URL":"https:\/\/doi.org\/10.1186\/1472-6882-13-142","relation":{},"ISSN":["1472-6882"],"issn-type":[{"value":"1472-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,22]]},"assertion":[{"value":"5 March 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"142"}}