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Pharmaceutical drugs treat liver disorders but cause further damage to it. Hence, herbal drugs are used worldwide and are becoming increasingly popular.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>The hepatoprotective activity of <jats:italic>Phyllanthus niruri<\/jats:italic> (PN) was evaluated against liver cirrhosis induced by thioacetamide (TAA) in male Sprague Dawley rats. Rats received intraperitoneal injections of thioacetamide (TAA, 200\u00a0mg\/kg, b.w. three times weekly) for eight weeks. Daily treatments with plant extract (200\u00a0mg\/kg) were administered orally for eight weeks. At the end of the study, hepatic damage was evaluated by monitoring transforming growth factor (TGF\u03b2), collagen \u03b11 (Coll\u03b11), matrix metalloproteinase-2 (MMP2) and tissue inhibitor of matrix metalloproteinase-1 (TIMP1) gene expression by real-time PCR. Moreover, different chromatographic techniques including column chromatography, thin layer chromatography, and Ultra Performance Liquid Chromatography (UPLC) with Liquid Chromatography\/Mass Spectrometry (LC\/MS) were used to isolate the active constituents of the plant.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The results revealed that treatment with PN significantly reduced the effect of thioacetamide toxicity and exhibited effective hepatoprotective activity. The mechanism of the hepatoprotective effect of PN is proposed to be by normalizing ROSs. Additionally, PN treatment regulated the expression of TGF\u03b2, Coll\u03b11, MMP2, and TIMP1 genes. In the active fraction of <jats:italic>P. niruri<\/jats:italic>, the isolated chemical constituents were 4-O-caffeoylquinic acid and quercetin 3-O-rhamnoside.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>The results of the present study indicate that PN ethanol extracts possess hepatoprotective activity that is most likely because of the isolated chemical constituents.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1472-6882-13-160","type":"journal-article","created":{"date-parts":[[2013,7,5]],"date-time":"2013-07-05T16:22:20Z","timestamp":1373041340000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Gene expression profiling reveals underlying molecular mechanism of hepatoprotective effect of Phyllanthus niruri on thioacetamide-induced hepatotoxicity in Sprague Dawley rats"],"prefix":"10.1186","volume":"13","author":[{"given":"Zahra A","family":"Amin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed A","family":"Alshawsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Kassim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hapipah M","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmood A","family":"Abdulla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,7,5]]},"reference":[{"issue":"1","key":"1402_CR1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/S0367-326X(98)00023-9","volume":"70","author":"H Ong","year":"1999","unstructured":"Ong H, Norzalina J: Malay herbal medicine in Gemencheh, Negri Sembilan, Malaysia. 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