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With the current dengue virus transmission rate and incidences, the development of antiviral drugs is of vital need. The aim of this project was to evaluate the possibility of developing a local medicinal plant,<jats:italic>Phyllanthus<\/jats:italic>as an anti-dengue agent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cocktail (aqueous and methanolic) extracts were prepared from four species of<jats:italic>Phyllanthus<\/jats:italic>(<jats:italic>P.amarus, P.niruri, P.urinaria,<\/jats:italic>and<jats:italic>P.watsonii)<\/jats:italic>and their polyphenolic compounds were identified via HPLC and LC-MS\/MS analysis. MTS assay was then carried out to determine the maximal non-toxic dose (MNTD) of the extracts, followed by screening of the<jats:italic>in vitro<\/jats:italic>antiviral activity of aqueous cocktail extracts against DENV2 by means of time-of-addition (pre-, simultaneous and post-) using RT-qPCR. The differentially expressed proteins in the treated and infected cells were analysed with two dimensional gel electrophoresis experiments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Several active compounds including gallic acid, geraniin, syringin, and corilagen have been identified. The MNTD of both aqueous and methanolic extracts on Vero cells were 250.0\u00a0\u03bcg\/ml and 15.63\u00a0\u03bcg\/ml respectively.<jats:italic>Phyllanthus<\/jats:italic>showed strongest inhibitory activity against DENV2 with more than 90% of virus reduction in simultaneous treatment. Two-dimensional analysis revealed significantly altered levels of thirteen proteins, which were successfully identified by tandem MS (MS\/MS). These altered proteins were involved in several biological processes, including viral entry, viral transcription and translation regulations, cytoskeletal assembly, and cellular metabolisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>Phyllanthus<\/jats:italic>could be potentially developed as an anti-DENV agent.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1472-6882-13-192","type":"journal-article","created":{"date-parts":[[2013,7,26]],"date-time":"2013-07-26T18:17:29Z","timestamp":1374862649000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Effects of cocktail of four local Malaysian medicinal plants (Phyllanthus spp.) against dengue virus 2"],"prefix":"10.1186","volume":"13","author":[{"given":"Sau Har","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin Quan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anusyah","family":"Rathkrishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok Mui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kien Chai","family":"Ong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishya","family":"Manikam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bobby Joe","family":"Payne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indu Bala","family":"Jaganath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamala Devi","family":"Sekaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,7,26]]},"reference":[{"issue":"11","key":"1436_CR1","doi-asserted-by":"publisher","first-page":"e890","DOI":"10.1371\/journal.pntd.0000890","volume":"4","author":"ME Beatty","year":"2010","unstructured":"Beatty ME, Stone A, Fitzsimons DW, Hanna JN, Lam SK, Vong S, Guzman MG, Mendez-Galvan JF, Halstead SB, Letson GW: Best practices in dengue surveillance: a report from the Asia-Pacific and Americas Dengue Prevention Boards. 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