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The current study investigates the protective potential of Standardized Fruit Extract of <jats:italic>Punica granatum L<\/jats:italic> (PFE) [Ellagic acid (41.6%), Punicalagins (10%), Granatin (5.1%)] in Tibial &amp; Sural Nerve Transection (TST) induced neuropathic pain in rats.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>TST was performed by sectioning tibial and sural nerve portions of the sciatic nerve and leaving the common peroneal nerve intact. Acetone drop, pin-prick, hot plate, paint brush &amp; Walking Track tests were performed to assess cold allodynia; mechanical heat, hyperalgesia and dynamic mechanical allodynia &amp; tibial functional index respectively. The levels of TNF-\u03b1, TBARS, GSH and Nitrite were measured in the sciatic nerve as an index of inflammation &amp; oxidative stress.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>TST led to significant development of cold allodynia; mechanical and heat hyperalgesia; dynamic mechanical allodynia; functional deficit in walking along with rise in the levels of TBARS, TNF-\u03b1, GSH and Nitrite. Administrations of PFE (100 &amp; 300\u00a0mg\/kg oral), significantly attenuate TST induced behavioral &amp; biochemical changes. Pretreatments of BADGE (120\u00a0mg\/kg <jats:italic>IP<\/jats:italic>) a PPAR-\u03b3 antagonist and nitric oxide precursor L-arginine (100\u00a0mg\/kg <jats:italic>IP<\/jats:italic>) abolished the protective effect of PFE. Whereas, pretreatment of L-NAME (5\u00a0mg\/kg <jats:italic>IP<\/jats:italic>) a NOS inhibitor significantly potentiated PFE\u2019s protective effect of PFE.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>PFE shown to have attenuating effect in TST induced neuropathic pain which may be attributed to potential PPAR-gamma agonistic activity, nitric oxide inhibitory, anti-inflammatory and anti oxidative actions.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1472-6882-13-274","type":"journal-article","created":{"date-parts":[[2013,10,21]],"date-time":"2013-10-21T09:01:16Z","timestamp":1382346076000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Attenuating effect of standardized fruit extract of punica granatum L in rat model of tibial and sural nerve transection induced neuropathic pain"],"prefix":"10.1186","volume":"13","author":[{"given":"Vivek","family":"Jain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh","family":"Pareek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yashumati Ratan","family":"Bhardwaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirmal","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,10,21]]},"reference":[{"key":"1517_CR1","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1212\/01.wnl.0000282763.29778.59","volume":"70","author":"RD Treede","year":"2008","unstructured":"Treede RD, Jensen TS, Campbell JN, Cruccu G, Dostrovsky JO, Griffin JW, Hansson P, Hughes R, Nurmikko T, Serra J: Neuropathic pain: redefinition and a grading system for clinical and research purposes. 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