{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T06:15:36Z","timestamp":1778652936555,"version":"3.51.4"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,11,5]],"date-time":"2013-11-05T00:00:00Z","timestamp":1383609600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Complement Altern Med"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>The present study evaluates the effects of extract of <jats:italic>Musa sapientum<\/jats:italic> fruit (MSE) on ulcer index, blood glucose level and gastric mucosal cytokines, TNF-\u03b1 and IL-1\u03b2 and growth factor, TGF-\u03b1 (affected in diabetes and chronic ulcer) in acetic acid (AA)-induced gastric ulcer (GU) in diabetic (DR) rat.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>MSE (100\u00a0mg\/kg, oral), omeprazole (OMZ, 2.0\u00a0mg\/kg, oral), insulin (INS, 4 U\/kg, sc) or pentoxyphylline (PTX, 10\u00a0mg\/kg, oral) were given once daily for 10\u00a0days in 14\u00a0days post-streptozotocin (60\u00a0mg\/kg, intraperitoneal)-induced diabetic rats while, the normal\/diabetic rats received CMC for the same period after induction of GU with AA. Ulcer index was calculated based upon the product of length and width (mm<jats:sup>2<\/jats:sup>\/rat) of ulcers while, TNF-\u03b1, IL-1\u03b2 and TGF-\u03b1 were estimated in the gastric mucosal homogenate from the intact\/ulcer region. Phytochemical screening and HPTLC analysis of MSE was done following standard procedures.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>An increase in ulcer index, TNF-\u03b1 and IL-1\u03b2 were observed in normal (NR)-AA rat compared to NR-normal saline rat, which were further increased in DR-AA rat while, treatments of DR-AA rat with MSE, OMZ, INS and PTX reversed them, more so with MSE and PTX. Significant increase in TGF-\u03b1 was found in NR-AA rat which did not increase further in DR-AA rat. MSE and PTX tended to increase while, OMZ and INS showed little or no effect on TGF-\u03b1 in AA-DR rat. Phytochemical screening of MSE showed the presence of saponins, flavonoids, glycosides, steroids and alkaloids and HPTLC analysis indicated the presence of eight active compounds.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>MSE showed antidiabetic and better ulcer healing effects compared with OMZ (antiulcer) or INS (antidiabetic) in diabetic rat and could be more effective in diabetes with concurrent gastric ulcer.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1472-6882-13-305","type":"journal-article","created":{"date-parts":[[2013,11,6]],"date-time":"2013-11-06T00:01:31Z","timestamp":1383696091000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Healing effects of Musa sapientum var. paradisiaca in diabetic rats with co-occurring gastric ulcer: cytokines and growth factor by PCR amplification"],"prefix":"10.1186","volume":"13","author":[{"given":"Mohan","family":"Kumar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manish Kumar","family":"Gautam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raj Kumar","family":"Goel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,11,5]]},"reference":[{"key":"1545_CR1","first-page":"52","volume-title":"Current research in pharmacology in India (1975\u20131982)","author":"AK Sanyal","year":"1984","unstructured":"Sanyal AK, Goel RK: Pharmacology of gastrointestinal tract. 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