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Health promoting properties of this herb have been reported in pharmacognostical, phytochemical and pharmacological studies<jats:italic>.<\/jats:italic>However, studies on<jats:italic>C. sativum<\/jats:italic>have always focused on the aerial parts of the herb and scientific investigation on the root is limited. The aim of this research was to investigate the antioxidant and anticancer activities of<jats:italic>C. sativum<\/jats:italic>root, leaf and stem, including its effect on cancer cell migration, and its protection against DNA damage, with special focus on the roots.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Powdered roots, leaves and stems of<jats:italic>C. sativum<\/jats:italic>were extracted through sequential extraction using hexane, dichloromethane, ethyl acetate, methanol and water. Total phenolic content, FRAP and DPPH radical scavenging activities were measured. Anti-proliferative activitiy on the breast cancer cell line, MCF-7, was assayed using the MTT assay. Activities of the antioxidant enzymes, catalase, superoxide dismutase, glutathione peroxidase, and of the caspases-3, -8 and -9 were assayed on treatment with the extract. Cell cycle progression was analysed using flow cytometry. The scratch motility assay was used to assess inhibition of MCF-7 cell migration. DNA damage in 3\u00a0T3-L1 fibroblasts was evaluated by the comet assay. The components in the extract were identified by HPLC and GC-MS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The ethyl acetate extract of C<jats:italic>. sativum<\/jats:italic>roots showed the highest antiproliferative activity on MCF-7 cells (IC<jats:sub>50<\/jats:sub>\u2009=\u2009200.0\u2009\u00b1\u20092.6\u00a0\u03bcg\/mL) and had the highest phenolic content, FRAP and DPPH scavenging activities among the extracts.<jats:italic>C. sativum<\/jats:italic>root inhibited DNA damage and prevented MCF-7 cell migration induced by H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>, suggesting its potential in cancer prevention and inhibition of metastasis. The extract exhibited anticancer activity in MCF-7 cells by affecting antioxidant enzymes possibly leading to H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>accumulation, cell cycle arrest at the G<jats:sub>2<\/jats:sub>\/M phase and apoptotic cell death by the death receptor and mitochondrial apoptotic pathways.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study is the first report on the antioxidant and anticancer properties of<jats:italic>C. sativum<\/jats:italic>root. The herb shows potential in preventing oxidative stress-related diseases and would be useful as supplements used in combination with conventional drugs to enhance the treatment of diseases such as cancer.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1472-6882-13-347","type":"journal-article","created":{"date-parts":[[2013,12,9]],"date-time":"2013-12-09T20:01:10Z","timestamp":1386619270000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["Antioxidant activity of Coriandrum sativum and protection against DNA damage and cancer cell migration"],"prefix":"10.1186","volume":"13","author":[{"given":"Esther LH","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayakumar","family":"Rajarajeswaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin Yee","family":"Fung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MS","family":"Kanthimathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,12,9]]},"reference":[{"key":"1579_CR1","volume-title":"Evid-Based Compl Alt","author":"D DeSylvia","year":"2011","unstructured":"DeSylvia D, Stuber M, Fung CC, Bazargan-Hejazi S, Cooper E: The knowledge, attitudes and usage of complementary and alternative medicine of medical students. 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