{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T23:20:33Z","timestamp":1782948033525,"version":"3.54.5"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,5,10]],"date-time":"2013-05-10T00:00:00Z","timestamp":1368144000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Complement Altern Med"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>The aims of this study were to evaluate the antioxidant activity and to identify the antioxidant components of a traditional Chinese medicine formula consisting of a combination of Shanzha (the fruit of <jats:italic>Crataegus pinnatifida<\/jats:italic> Bge. var. <jats:italic>major<\/jats:italic> N.E.Br., SZ) and Danshen (the root of <jats:italic>Salvia miltiorrhiza<\/jats:italic> Bge., DS). This medicine is extensively used to treat cardiovascular disease.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Twelve samples extracted and fractionated from SZ, DS and the formula (SZ+DS) were analyzed. The concentrations of eight phenolic compounds were determined by high performance liquid chromatography. Oxygen radical absorbance capacity (ORAC) assay and 1,1-diphenyl-2-picrylhydrazyl assay were conducted to explore the antioxidant activities of the samples and of the 15 phenolic compounds detected. Correlation analysis of the antioxidant activity of herb samples and their phenolic components was performed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The main phenolic component in all SZ+DS samples was salvianolic acid B, which exhibited strong antioxidant activity (ORAC value: 16.73 \u00b1 2.53, IC50 value: 8.80 \u00b1 0.06 \u03bcM) compared with the other phenolic compounds. For all samples, there was a positive relationship between their total phenolic components and their antioxidant activities.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Phenolic compounds were the bioactive components of the herb samples, and salvianolic acid B was identified as the main bioactive compound in the SZ+DS formula.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1472-6882-13-99","type":"journal-article","created":{"date-parts":[[2013,5,10]],"date-time":"2013-05-10T16:17:06Z","timestamp":1368202626000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Antioxidant activity and components of a traditional chinese medicine formula consisting of Crataegus pinnatifida and Salvia miltiorrhiza"],"prefix":"10.1186","volume":"13","author":[{"given":"Cheng-Yu","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Nan","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Qing","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,5,10]]},"reference":[{"key":"1366_CR1","volume-title":"Shi Jin Mo Dui Yao","author":"JS Lv","year":"2005","unstructured":"Lv JS: Shi Jin Mo Dui Yao. 2005, Beijing: People\u2019s Military Medical Press"},{"key":"1366_CR2","volume-title":"Oxygen free radical and nature antioxidants","author":"BL Zhao","year":"1999","unstructured":"Zhao BL: Oxygen free radical and nature antioxidants. 1999, Beijing: Science Press"},{"key":"1366_CR3","first-page":"8","volume":"7","author":"J Xu","year":"2007","unstructured":"Xu J, Guo CJ, Wei JY, Yang JJ, Li YF: Studies on the effect of once administration different fruit juices by gavage on antioxidant capacity of rat peripheral blood. Journal of Chinese Institute of Food Science and Technology. 2007, 7: 8-21.","journal-title":"Journal of Chinese Institute of Food Science and Technology"},{"key":"1366_CR4","first-page":"15","volume":"5","author":"YL Chen","year":"2004","unstructured":"Chen YL, Huang WJ, Liu Q: Effect of Danshen Injection on oxidant\/antioxidant system of geriatric refractory heart failure. Practical Clinical Medicine. 2004, 5: 15-17.","journal-title":"Practical Clinical Medicine"},{"key":"1366_CR5","first-page":"1066","volume":"40","author":"GC Bai","year":"2005","unstructured":"Bai GC, Qiu SX, Yu BY, Liu RH: Study on scavenging activities for superoxide anion radicals and structure-activity relationship of polyphenolic compounds from leaves of Crataegus. Chinese Pharmaceutical Journal. 2005, 40: 1066-1069.","journal-title":"Chinese Pharmaceutical Journal"},{"key":"1366_CR6","first-page":"1085","volume":"27","author":"XH Xia","year":"2009","unstructured":"Xia XH, Liu M, Zhang ZM, Wu ZJ, Pan SY: Anti-oxidant activity of hydrophilic components of Danshen root in vitro. Chinese Archive of Traditional Chinese Medicine. 2009, 27: 1085-1087.","journal-title":"Chinese Archive of Traditional Chinese Medicine"},{"key":"1366_CR7","doi-asserted-by":"publisher","first-page":"4290","DOI":"10.1021\/jf0502698","volume":"53","author":"RL Prior","year":"2005","unstructured":"Prior RL, Wu XL, Schaich K: Standardized methods for the determination of antioxidant capacity and phenolics in foods and dietary supplements. Journal of Agriculture and Food Chemistry. 2005, 53: 4290-4302. 10.1021\/jf0502698.","journal-title":"Journal of Agriculture and Food Chemistry"},{"key":"1366_CR8","first-page":"2296","volume":"35","author":"HQ Dai","year":"2010","unstructured":"Dai HQ, Chen CY, Yang B: AAPH scavenging activities of 22 flavonoids and phenolic acids and 9 extracts of Chinese materia medica. China Journal of Chinese Materia Medica. 2010, 35: 2296-2302.","journal-title":"China Journal of Chinese Materia Medica"},{"key":"1366_CR9","first-page":"1695","volume":"34","author":"YN Yuan","year":"2004","unstructured":"Yuan YN, Chen CY, Yang B, Kusu F, Kotani A: DPPH radical scavenging activities of 31 flavonoids and phenolic acids and 10 extracts of Chinese materia medica. Chinese Journal of Chinese Materia Medica. 2004, 34: 1695-1700.","journal-title":"Chinese Journal of Chinese Materia Medica"},{"key":"1366_CR10","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1096\/fj.02-0527hyp","volume":"17","author":"BX Ou","year":"2003","unstructured":"Ou BX, Huang DJ, Hampsch-Woodill M, Flanagan JA: When east meets west: the relationship between yin-yang and antioxidation-oxidation. FASEB J. 2003, 17: 127-129. 10.1096\/fj.02-0527hyp.","journal-title":"FASEB J"},{"key":"1366_CR11","first-page":"1","volume-title":"eCAM Advance Access","author":"H Liao","year":"2007","unstructured":"Liao H, Banbury LK, Leach DN, Liao H, Banbury LK, Leach DN: Antioxidant activity of 45 Chinese herbs and the relationship with their TCM characteristics. eCAM Advance Access. 2007, 1-6."},{"key":"1366_CR12","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.fct.2007.06.034","volume":"46","author":"GR Zhao","year":"2008","unstructured":"Zhao GR, Xiang ZJ, Ye TX, Xiang ZJ, Yuan YJ, Guo JX, Zhao LB: Characterization of the radical scavenging and antioxidant activities of danshensu and salvianolic acid B. Food Chem Toxicol. 2008, 46: 73-81. 10.1016\/j.fct.2007.06.034.","journal-title":"Food Chem Toxicol"}],"container-title":["BMC Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6882-13-99.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1472-6882-13-99\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6882-13-99","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6882-13-99.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T23:58:31Z","timestamp":1630540711000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccomplementalternmed.biomedcentral.com\/articles\/10.1186\/1472-6882-13-99"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,10]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["1366"],"URL":"https:\/\/doi.org\/10.1186\/1472-6882-13-99","relation":{},"ISSN":["1472-6882"],"issn-type":[{"value":"1472-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,10]]},"assertion":[{"value":"21 December 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 May 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"99"}}