{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T22:41:10Z","timestamp":1778539270608,"version":"3.51.4"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,3,14]],"date-time":"2014-03-14T00:00:00Z","timestamp":1394755200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Complement Altern Med"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>\n              <jats:italic>Artemisia capillaries<\/jats:italic> Thunb. (AC) has been used to treat inflammatory and hepatic disorders such as hepatic injury, hepatic fibrosis and hepatitis. However, the efficacy of AC against atopic dermatitis (AD), an inflammatory disease, has not been examined. In the present study, AC was evaluated for anti-inflammatory and anti-AD effects using both <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> systems.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>The contents of six compounds (chlorogenic acid, caffeic acid, isochlorogenic acid A, hyperoside, isoquercitrin and scoparone) in AC were simultaneously assayed using HPLC system. To evaluate the anti-inflammatory effect of AC, NO production was measured in RAW264.7 cell stimulated with 1\u00a0\u03bcg\/mL LPS. Histamine levels were assayed in MC\/9 cells stimulated with 50 nM PMA and 1\u00a0\u03bcM A23187. To examine the role of AC <jats:italic>in vivo<\/jats:italic>, AC (10\u00a0mg\/mouse\/day) was topically applied for four weeks the back and ears of <jats:italic>Dermatophagoides farinae<\/jats:italic>-sensitized Nc\/Nga mice. Protopic ointment (0.1% tacrolimus) was used as a positive control.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The contents of the six components in AC range from 0.44 to 43.14\u00a0mg\/g. Chlorogenic acid (21.06\u2009\u00b1\u20090.08\u00a0mg\/g) and isochlorogenic acid A (43.14\u2009\u00b1\u20090.12\u00a0mg\/g) were major components in AC. AC inhibited NO and histamine production in cells respectively. In <jats:italic>D. farinae<\/jats:italic>-sensitized Nc\/Nga mice, the topical application of AC reduced dermatitis scores, hemorrhage, hypertrophy and hyperkeratosis of the epidermis in the dorsal skin and ear. The treatment of AC also reduced the plasma levels of histamine (1.5 fold) and IgE (1.4 fold).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Our results suggest that AC should be explored as a potential therapeutic agent to treat atopic dermatitis and analysis by HPLC will help to improve the quality of AC.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1472-6882-14-100","type":"journal-article","created":{"date-parts":[[2014,3,14]],"date-time":"2014-03-14T06:01:39Z","timestamp":1394776899000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Artemisia capillaris inhibits atopic dermatitis-like skin lesions in Dermatophagoides farinae-sensitized Nc\/Nga mice"],"prefix":"10.1186","volume":"14","author":[{"given":"Hyekyung","family":"Ha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoyoung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Seob","family":"Seo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye-Sun","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun Kyoung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mee-Young","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeunkyoo","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,3,14]]},"reference":[{"key":"2108_CR1","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1254\/jphs.09R02FM","volume":"110","author":"T Terui","year":"2009","unstructured":"Terui T: Analysis of the mechanism for the development of allergic skin inflammation and the application for its treatment: overview of the pathophysiology of atopic dermatitis. J Pharmacol Sci. 2009, 110: 232-236. 10.1254\/jphs.09R02FM.","journal-title":"J Pharmacol Sci"},{"key":"2108_CR2","doi-asserted-by":"publisher","first-page":"35","DOI":"10.2332\/allergolint.55.35","volume":"55","author":"H Nagai","year":"2006","unstructured":"Nagai H, Teramachi H, Tuchiya T: Recent advances in the development of anti-allergic drugs. Allergol Int. 2006, 55: 35-42. 10.2332\/allergolint.55.35.","journal-title":"Allergol Int"},{"key":"2108_CR3","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1111\/j.1365-2133.1995.tb02691.x","volume":"133","author":"H Aoyama","year":"1995","unstructured":"Aoyama H, Tabata N, Tanaka M, Uesugi Y, Tagami H: Successful treatment of resistant facial lesions of atopic dermatitis with 0.1% FK506 ointment. Br J Dermatol. 1995, 133: 494-496. 10.1111\/j.1365-2133.1995.tb02691.x.","journal-title":"Br J Dermatol"},{"key":"2108_CR4","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.jaad.2003.08.003","volume":"50","author":"JM Hanifin","year":"2004","unstructured":"Hanifin JM, Cooper KD, Ho VC, Kang S, Krafchik BR, Margolis DJ, Schachner LA, Sidbury R, Whitmore SE, Sieck CK, Van Voorhees AS: Guidelines of care for atopic dermatitis, developed in accordance with the American Academy of Dermatology (AAD)\/American Academy of Dermatology Association \u201cAdministrative Regulations for Evidence-Based Clinical Practice Guidelines\u201d. J Am Acad Dermatol. 2004, 50: 391-404. 10.1016\/j.jaad.2003.08.003.","journal-title":"J Am Acad Dermatol"},{"issue":"4 Pt 1","key":"2108_CR5","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/S0091-6749(98)70281-7","volume":"102","author":"M Boguniewicz","year":"1998","unstructured":"Boguniewicz M, Fiedler VC, Raimer S, Lawrence ID, Leung DY, Hanifin JM: A randomized, vehicle-controlled trial of tacrolimus ointment for treatment of atopic dermatitis in children. Pediatric Tacrolimus Study Group. J Allergy Clin Immunol. 1998, 102 (4 Pt 1): 637-644.","journal-title":"J Allergy Clin Immunol"},{"key":"2108_CR6","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/S0738-081X(02)00367-X","volume":"21","author":"NS Tomi","year":"2003","unstructured":"Tomi NS, Luger TA: The treatment of atopic dermatitis with topical immunomodulators. Clin Dermatol. 2003, 21: 215-224. 10.1016\/S0738-081X(02)00367-X.","journal-title":"Clin Dermatol"},{"key":"2108_CR7","doi-asserted-by":"publisher","first-page":"T207","DOI":"10.1111\/j.1750-3841.2011.02385.x","volume":"76","author":"HI Lee","year":"2011","unstructured":"Lee HI, Seo KO, Yun KW, Kim MJ, Lee MK: Comparative study of the hepatoprotective efficacy of Artemisia iwayomogi and Artemisia capillaris on ethanol-administered mice. J Food Sci. 2011, 76: T207-211. 10.1111\/j.1750-3841.2011.02385.x.","journal-title":"J Food Sci"},{"key":"2108_CR8","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1080\/08820130902936307","volume":"38","author":"JD Cha","year":"2009","unstructured":"Cha JD, Moon SE, Kim HY, Lee JC, Lee KY: The essential oil isolated from Artemisia capillaris prevents LPS-induced production of NO and PGE(2) by inhibiting MAPK-mediated pathways in RAW 264.7 macrophages. Immunol Invest. 2009, 38: 483-497. 10.1080\/08820130902936307.","journal-title":"Immunol Invest"},{"key":"2108_CR9","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1089\/jmf.2008.1240","volume":"12","author":"JH Hong","year":"2009","unstructured":"Hong JH, Hwang EY, Kim HJ, Jeong YJ, Lee IS: Artemisia capillaris inhibits lipid accumulation in 3\u00a0T3-L1 adipocytes and obesity in C57BL\/6\u00a0J mice fed a high fat diet. J Med Food. 2009, 12: 736-745. 10.1089\/jmf.2008.1240.","journal-title":"J Med Food"},{"issue":"34","key":"2108_CR10","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1007\/s12272-011-0919-0","volume":"2011","author":"OS Kwon","year":"2011","unstructured":"Kwon OS, Choi JS, Islam MN, Kim YS, Kim HP: Inhibition of 5-lipoxygenase and skin inflammation by the aerial parts of Artemisia capillaris and its constituents. Arch Pharm Res. 2011, 2011 (34): 1561-1569.","journal-title":"Arch Pharm Res"},{"key":"2108_CR11","first-page":"535","volume":"19","author":"EK Kim","year":"2007","unstructured":"Kim EK, Kwon KB, Han MJ, Song MY, Lee JH, LV N, Choi KB, Ryu DG, Kim KS, Park JW, Park BH: Inhibitory effect of Artemisia capillaris extract on cytokine-induced nitric oxide formation and cytotoxicity of RINm5F cells. Int J Mol Med. 2007, 19: 535-540.","journal-title":"Int J Mol Med"},{"key":"2108_CR12","first-page":"743075","volume-title":"Evid Based Complement Alternat Med","author":"H Lee","year":"2012","unstructured":"Lee H, Lee JK, Ha H, Lee MY, Seo CS, Shin HK: Angelicae Dahuricae Radix inhibits dust mite extract-induced atopic dermatitis-like skin lesions in Nc\/Nga mice. Evid Based Complement Alternat Med. 2012, 743075-doi:10.1155\/2012\/743075"},{"key":"2108_CR13","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.1007\/s12272-012-1213-5","volume":"35","author":"KM Park","year":"2012","unstructured":"Park KM, Li Y, Kim B, Zhang H, Hwangbo K, Piao DG, Chi MJ, Woo MH, Choi JS, Lee JH, Moon DC, Chang HW, Kim JR, Son JK: High-performance liquid chromatographic analysis for quantitation of marker compounds of Artemisia capillaris Thunb. Arch Pharm Res. 2012, 35: 2153-2162. 10.1007\/s12272-012-1213-5.","journal-title":"Arch Pharm Res"},{"key":"2108_CR14","first-page":"233","volume":"16","author":"SW Kim","year":"2010","unstructured":"Kim SW, Kim HW, Woo MH, Lee JH, Choi JS, Min BS: Quantitative determination of bioactive compounds in some Artemisia capillaris by high-performance liquid chromatography. Nat Prod Sci. 2010, 16: 233-238.","journal-title":"Nat Prod Sci"},{"key":"2108_CR15","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/S0021-9673(01)00513-1","volume":"911","author":"SJ Sheu","year":"2001","unstructured":"Sheu SJ, Chieh CL, Weng WC: Capillary electrophoretic determination of the constituents of Artemisiae Capillaris Herba. J Chromatogr A. 2001, 911: 285-293. 10.1016\/S0021-9673(01)00513-1.","journal-title":"J Chromatogr A"},{"key":"2108_CR16","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/S0968-0896(00)00225-X","volume":"9","author":"TS Wu","year":"2001","unstructured":"Wu TS, Tsang ZJ, Wu PL, Lin FW, Li CY, Teng CM, Lee KH: New constituents and antiplatelet aggregation and anti-HIV principles of Artemisia capillaris. Bioorg Med Chem. 2001, 9: 77-83. 10.1016\/S0968-0896(00)00225-X.","journal-title":"Bioorg Med Chem"},{"key":"2108_CR17","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1002\/biof.5520310105","volume":"31","author":"JH Hong","year":"2007","unstructured":"Hong JH, Lee JW, Park JH, Lee IS: Antioxidative and cytoprotective effects of Artemisia capillaris fractions. Biofactors. 2007, 31: 43-53. 10.1002\/biof.5520310105.","journal-title":"Biofactors"},{"key":"2108_CR18","first-page":"302","volume":"43","author":"A Nugroho","year":"2012","unstructured":"Nugroho A, Lim SC, Park HJ: Qualitative Analysis of Phenolic Substances in Artemisia capillaris by LC-MS. Kor J Pharmacogn. 2012, 43: 302-307.","journal-title":"Kor J Pharmacogn"},{"key":"2108_CR19","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1055\/s-2005-837790","volume":"71","author":"JD Cha","year":"2005","unstructured":"Cha JD, Jeong MR, Jeong SI, Moon SE, Kim JY, Kil BS, Song YH: Chemical composition and antimicrobial activity of the essential oils of Artemisia scoparia and A. capillaris. Planta Med. 2005, 71: 186-190. 10.1055\/s-2005-837790.","journal-title":"Planta Med"},{"key":"2108_CR20","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.jep.2012.09.003","volume":"144","author":"BJ Hao","year":"2012","unstructured":"Hao BJ, Wu YH, Wang JG, Hu SQ, Keil DJ, Hu HJ, Lou JD, Zhao Y: Hepatoprotective and antiviral properties of isochlorogenic acid A from Laggera alata against hepatitis B virus infection. J Ethnopharmacol. 2012, 144: 190-194. 10.1016\/j.jep.2012.09.003.","journal-title":"J Ethnopharmacol"},{"key":"2108_CR21","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/1472-6882-12-78","volume":"12","author":"K Tomimori","year":"2012","unstructured":"Tomimori K, Nakama S, Kimura R, Tamaki K, Ishikawa C, Mori N: Antitumor activity and macrophage nitric oxide producing action of medicinal herb, Crassocephalum crepidioides. BMC Complement Altern Med. 2012, 12: 78-10.1186\/1472-6882-12-78.","journal-title":"BMC Complement Altern Med"},{"key":"2108_CR22","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.jep.2011.04.067","volume":"136","author":"DA Chagas-Paula","year":"2011","unstructured":"Chagas-Paula DA, Oliveira RB, da Silva VC, Gobbo-Neto L, Gasparoto TH, Campanelli P, Faccioli LH, Da Costa FB: Chlorogenic acids from Tithonia diversifolia demonstrate better anti-inflammatory effect than indomethacin and its sesquiterpene lactones. J Ethnopharmacol. 2011, 136: 355-362. 10.1016\/j.jep.2011.04.067.","journal-title":"J Ethnopharmacol"},{"key":"2108_CR23","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.phytochem.2011.12.001","volume":"76","author":"N Huang","year":"2012","unstructured":"Huang N, Rizshsky L, Hauck CC, Nikolau BJ, Murphy PA, Birt DF: The inhibition of lipopolysaccharide-induced macrophage inflammation by 4 compounds in Hypericum perforatum extract is partially dependent on the activation of SOCS3. Phytochemistry. 2012, 76: 106-116.","journal-title":"Phytochemistry"},{"key":"2108_CR24","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1016\/j.jnutbio.2011.06.018","volume":"23","author":"N Yun","year":"2012","unstructured":"Yun N, Kang JW, Lee SM: Protective effects of chlorogenic acid against ischemia\/reperfusion injury in rat liver: molecular evidence of its antioxidant and anti-inflammatory properties. J Nutr Biochem. 2012, 23: 1249-1255. 10.1016\/j.jnutbio.2011.06.018.","journal-title":"J Nutr Biochem"},{"key":"2108_CR25","doi-asserted-by":"crossref","first-page":"217","DOI":"10.4014\/jmb.0904.04015","volume":"20","author":"HT Trinh","year":"2010","unstructured":"Trinh HT, Bae EA, Hyun YJ, Jang YA, Yun HK, Hong SS, Kim DH: Anti-allergic effects of fermented Ixeris sonchifolia and its constituent in mice. J Microbiol Biotechnol. 2010, 20: 217-223.","journal-title":"J Microbiol Biotechnol"},{"key":"2108_CR26","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1016\/S0161-5890(02)00013-5","volume":"38","author":"S Romagnani","year":"2002","unstructured":"Romagnani S: Cytokines and chemoattractants in allergic inflammation. Mol Immunol. 2002, 38: 881-885. 10.1016\/S0161-5890(02)00013-5.","journal-title":"Mol Immunol"},{"key":"2108_CR27","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.tox.2011.08.003","volume":"289","author":"T Fukuyama","year":"2011","unstructured":"Fukuyama T, Tajima Y, Hayashi K, Ueda H, Kosaka T: Prior or coinstantaneous oral exposure to environmental immunosuppressive agents aggravates mite allergen-induced atopic dermatitis-like immunoreaction in Nc\/Nga mice. Toxicology. 2011, 289: 132-140. 10.1016\/j.tox.2011.08.003.","journal-title":"Toxicology"}],"container-title":["BMC Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6882-14-100.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1472-6882-14-100\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6882-14-100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6882-14-100.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T17:54:06Z","timestamp":1630605246000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccomplementalternmed.biomedcentral.com\/articles\/10.1186\/1472-6882-14-100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,14]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["2108"],"URL":"https:\/\/doi.org\/10.1186\/1472-6882-14-100","relation":{},"ISSN":["1472-6882"],"issn-type":[{"value":"1472-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,14]]},"assertion":[{"value":"4 June 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 March 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"100"}}