{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:45:02Z","timestamp":1792633502198,"version":"4.5.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Complement Altern Med"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/1472-6882-14-118","type":"journal-article","created":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T03:38:36Z","timestamp":1396323516000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["The ameliorating effects of long-term electroacupuncture on cardiovascular remodeling in spontaneously hypertensive rats"],"prefix":"10.1186","volume":"14","author":[{"given":"Ze-Jun","family":"Huo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui-Hua","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Man","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Hong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Shui","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You-Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan-She","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Gang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Yan","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,4,1]]},"reference":[{"issue":"9455","key":"1714_CR1","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/S0140-6736(05)70151-3","volume":"365","author":"PM Kearney","year":"2005","unstructured":"Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J: Global burden of hypertension: analysis of worldwide data. Lancet. 2005, 365 (9455): 217-223. 10.1016\/S0140-6736(05)17741-1.","journal-title":"Lancet"},{"issue":"9","key":"1714_CR2","doi-asserted-by":"publisher","first-page":"2227","DOI":"10.1111\/j.1582-4934.2012.01536.x","volume":"16","author":"WB Zhang","year":"2012","unstructured":"Zhang WB, Du QJ, Li H, Sun AJ, Qiu ZH, Wu CN, Zhao G, Gong H, Hu K, Zou YZ, Ge JB: The therapeutic effect of Rosuvastatin on cardiac remodeling from hypertrophy to fibrosis during the end-stage hypertension in rats. J Cell Mol Med. 2012, 16 (9): 2227-2237. 10.1111\/j.1582-4934.2012.01536.x.","journal-title":"J Cell Mol Med"},{"issue":"6","key":"1714_CR3","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.jash.2011.08.006","volume":"5","author":"F Cacciapuoti","year":"2011","unstructured":"Cacciapuoti F: Molecular mechanisms of left ventricular hypertrophy (LVH) in systemic hypertension (SH)-possible therapeutic perspectives. J Am Soc Hypertens. 2011, 5 (6): 449-455. 10.1016\/j.jash.2011.08.006.","journal-title":"J Am Soc Hypertens"},{"issue":"Suppl 1","key":"1714_CR4","doi-asserted-by":"publisher","first-page":"S25","DOI":"10.1097\/01.hjh.0000388491.35836.d2","volume":"28","author":"AU Shahbaz","year":"2010","unstructured":"Shahbaz AU, Sun Y, Bhattacharya SK, Ahokas RA, Gerling IC, McGee JE, Weber KT: Fibrosis in hypertensive heart disease: molecular pathways and cardioprotective strategies. J Hypertens. 2010, 28 (Suppl 1): S25-S32. 10.1097\/01.hjh.0000388491.35836.d2.","journal-title":"J Hypertens"},{"issue":"1","key":"1714_CR5","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.cardiores.2003.10.019","volume":"61","author":"HJ Hong","year":"2004","unstructured":"Hong HJ, Chan P, Liu JC, Juan SH, Huang MT, Lin JG, Cheng TH: Angiotensin II induces endothelin-1 gene expression via extracellular signal-regulated kinase pathway in rat aortic smooth muscle cells. Cardiovasc Res. 2004, 61 (1): 159-168. 10.1016\/j.cardiores.2003.10.019.","journal-title":"Cardiovasc Res"},{"issue":"11","key":"1714_CR6","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1161\/CIRCRESAHA.110.217737","volume":"106","author":"A Leask","year":"2010","unstructured":"Leask A: Potential therapeutic targets for cardiac fibrosis: TGFbeta, angiotensin, endothelin, CCN2, and PDGF, partners in fibroblast activation. Circ Res. 2010, 106 (11): 1675-1680. 10.1161\/CIRCRESAHA.110.217737.","journal-title":"Circ Res"},{"issue":"1\u20132","key":"1714_CR7","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s11010-009-0219-x","volume":"333","author":"S Umar","year":"2010","unstructured":"Umar S, van der Laarse A: Nitric oxide and nitric oxide synthase isoforms in the normal, hypertrophic, and failing heart. Mol Cell Biochem. 2010, 333 (1\u20132): 191-201.","journal-title":"Mol Cell Biochem"},{"issue":"3","key":"1714_CR8","doi-asserted-by":"publisher","first-page":"H1070","DOI":"10.1152\/ajpheart.00940.2003","volume":"286","author":"F Ichinose","year":"2004","unstructured":"Ichinose F, Bloch KD, Wu JC, Hataishi R, Aretz HT, Picard MH, Scherrer-Crosbie M: Pressure overload-induced LV hypertrophy and dysfunction in mice are exacerbated by congenital NOS3 deficiency. Am J Physiol Heart Circ Physiol. 2004, 286 (3): H1070-H1075.","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"7","key":"1714_CR9","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1161\/01.RES.0000264081.78659.45","volume":"100","author":"P Zhang","year":"2007","unstructured":"Zhang P, Xu X, Hu X, van Deel ED, Zhu G, Chen Y: Inducible nitric oxide synthase deficiency protects the heart from systolic overload-induced ventricular hypertrophy and congestive heart failure. Circ Res. 2007, 100 (7): 1089-1098. 10.1161\/01.RES.0000264081.78659.45.","journal-title":"Circ Res"},{"key":"1714_CR10","doi-asserted-by":"publisher","first-page":"130529","DOI":"10.1093\/ecam\/nen064","volume":"2011","author":"HS Hwang","year":"2011","unstructured":"Hwang HS, Kim YS, Ryu YH, Lee JE, Lee YS, Yang EJ, Choi SM, Lee MS: Electroacupuncture delays hypertension development through enhancing NO\/NOS activity in spontaneously hypertensive rats. Evid Based Complement Alternat Med. 2011, 2011: 130529-","journal-title":"Evid Based Complement Alternat Med"},{"issue":"7","key":"1714_CR11","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1080\/10739680600885210","volume":"13","author":"DD Kim","year":"2006","unstructured":"Kim DD, Pica AM, Dur\u00e1n RG, Dur\u00e1n WN: Acupuncture reduces experimental renovascular hypertension through mechanisms involving nitric oxide synthases. Microcirculation. 2006, 13 (7): 577-585. 10.1080\/10739680600885210.","journal-title":"Microcirculation"},{"issue":"6","key":"1714_CR12","first-page":"393","volume":"34","author":"WN Liu","year":"2009","unstructured":"Liu WN, Jin LW, Han DW, Ren XX, Zhu J, Zhang LF: Effect of electroacupuncture of different acupoints on blood pressure, plasma angiotensin II, aldosterone and atrial natriuretic peptide in spontaneous hypertension rats. Zhen Ci Yan Jiu. 2009, 34 (6): 393-397.","journal-title":"Zhen Ci Yan Jiu"},{"issue":"3\u20134","key":"1714_CR13","doi-asserted-by":"publisher","first-page":"263","DOI":"10.3727\/036012905815901235","volume":"30","author":"YL Huang","year":"2005","unstructured":"Huang YL, Fan MX, Wang J, Li L, Lu N, Cao YX, Shen LL, Zhu DN: Effects of acupuncture on nNOS and iNOS expression in the rostral ventrolateral medulla of stress-induced hypertensive rats. Acupunct Electrother Res. 2005, 30 (3\u20134): 263-273.","journal-title":"Acupunct Electrother Res"},{"issue":"1","key":"1714_CR14","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.jcm.2008.07.003","volume":"8","author":"J Zhang","year":"2009","unstructured":"Zhang J, Ng D, Sau A: Effects of electrical stimulation of acupuncture points on blood pressure. J Chiropr Med. 2009, 8 (1): 9-14. 10.1016\/j.jcm.2008.07.003.","journal-title":"J Chiropr Med"},{"issue":"1","key":"1714_CR15","doi-asserted-by":"publisher","first-page":"698","DOI":"10.3390\/ijms13010698","volume":"13","author":"OH Lee","year":"2012","unstructured":"Lee OH, Kim KI, Han CK, Kim YC, Hong HD: Effects of acidic polysaccharides from gastrodia rhizome on systolic blood pressure and serum lipid concentrations in spontaneously hypertensive rats fed a high-fat diet. Int J Mol Sci. 2012, 13 (1): 698-709.","journal-title":"Int J Mol Sci"},{"issue":"6","key":"1714_CR16","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1161\/01.CIR.58.6.1072","volume":"58","author":"DJ Sahn","year":"1978","unstructured":"Sahn DJ, DeMaria A, Kisslo J, Weyman A: Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. Circulation. 1978, 58 (6): 1072-1083. 10.1161\/01.CIR.58.6.1072.","journal-title":"Circulation"},{"issue":"2","key":"1714_CR17","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1248\/bpb.35.164","volume":"35","author":"Y Chen","year":"2012","unstructured":"Chen Y, Wu X, Yu S, Fauzee NJ, Wu J, Li L, Zhao J, Zhao Y: Neuroprotective capabilities of Tanshinone IIA against cerebral ischemia\/reperfusion injury via anti-apoptotic pathway in rats. Biol Pharm Bull. 2012, 35 (2): 164-170. 10.1248\/bpb.35.164.","journal-title":"Biol Pharm Bull"},{"issue":"4","key":"1714_CR18","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1007\/s00418-008-0541-5","volume":"131","author":"Y Xia","year":"2009","unstructured":"Xia Y, Lee K, Li N, Corbett D, Mendoza L, Frangogiannis NG: Characterization of the inflammatory and fibrotic response in a mouse model of cardiac pressure overload. Histochem Cell Biol. 2009, 131 (4): 471-481. 10.1007\/s00418-008-0541-5.","journal-title":"Histochem Cell Biol"},{"issue":"3","key":"1714_CR19","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1161\/HYPERTENSIONAHA.111.182428","volume":"59","author":"HA Lee","year":"2012","unstructured":"Lee HA, Cho HM, Lee DY, Kim KC, Han HS, Kim IK: Tissue-specific upregulation of angiotensin-converting enzyme 1 in spontaneously hypertensive rats through histone code modifications. Hypertension. 2012, 59 (3): 621-626. 10.1161\/HYPERTENSIONAHA.111.182428.","journal-title":"Hypertension"},{"key":"1714_CR20","doi-asserted-by":"publisher","first-page":"812160","DOI":"10.1093\/ecam\/neq063","volume":"2011","author":"X Xiong","year":"2011","unstructured":"Xiong X, You C, Feng QC, Yin T, Chen ZB, Ball P, Wang LX: Pulse width modulation electro-acupuncture on cardiovascular remodeling and plasma nitric oxide in spontaneously hypertensive rats. Evid Based Complement Alternat Med. 2011, 2011: 812160-","journal-title":"Evid Based Complement Alternat Med"},{"key":"1714_CR21","doi-asserted-by":"publisher","first-page":"5118","DOI":"10.2741\/3590","volume":"14","author":"J Palomeque","year":"2009","unstructured":"Palomeque J, Delbridge L, Petroff MV: Angiotensin II: a regulator of cardiomyocyte function and survival. Front Biosci (Landmark Ed). 2009, 14: 5118-5133. 10.2741\/3590.","journal-title":"Front Biosci (Landmark Ed)"},{"issue":"1","key":"1714_CR22","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/S0025-6196(12)60017-2","volume":"68","author":"AA Khraibi","year":"1993","unstructured":"Khraibi AA, Heublein DM, Knox FG, Burnett JC: Increased plasma level of endothelin-1 in the Okamoto spontaneously hypertensive rat. Mayo Clin Proc. 1993, 68 (1): 42-46. 10.1016\/S0025-6196(12)60017-2.","journal-title":"Mayo Clin Proc"},{"issue":"1","key":"1714_CR23","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.cardiores.2003.10.019","volume":"61","author":"HJ Hong","year":"2004","unstructured":"Hong HJ, Chan P, Liu JC, Juan SH, Huang MT, Lin JG, Cheng TH: Angiotensin II induces endothelin-1 gene expression via extracellular signal-regulated kinase pathway in rat aortic smooth muscle cells. Cardiovas Res. 2004, 61 (1): 159-168. 10.1016\/j.cardiores.2003.10.019.","journal-title":"Cardiovas Res"},{"issue":"2","key":"1714_CR24","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1152\/physrev.00042.2007","volume":"89","author":"JL Balligand","year":"2009","unstructured":"Balligand JL, Feron O, Dessy C: eNOS activation by physical forces: from short-term regulation of contraction to chronic remodeling of cardiovascular tissues. Physiol Rev. 2009, 89 (2): 481-534. 10.1152\/physrev.00042.2007.","journal-title":"Physiol Rev"},{"key":"1714_CR25","first-page":"312","volume":"2","author":"FA Dias","year":"2010","unstructured":"Dias FA, Urboniene D, Yuzhakova MA, Biesiadecki BJ, Pena JR, Goldspink PH, Geenen DL, Wolska BM: Ablation of iNOS delays cardiac contractile dysfunction in chronic hypertension. Front Biosci (Elite Ed). 2010, 2: 312-324.","journal-title":"Front Biosci (Elite Ed)"},{"issue":"3","key":"1714_CR26","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/S0008-6363(99)00237-0","volume":"44","author":"N Kobayashi","year":"1999","unstructured":"Kobayashi N, Higashi T, Hara K, Shirataki H, Matsuoka H: Effects of imidapril on NOS expression and myocardial remodelling in failing heart of Dahl salt-sensitive hypertensive rats. Cardiovasc Res. 1999, 44 (3): 518-526. 10.1016\/S0008-6363(99)00237-0.","journal-title":"Cardiovasc Res"}],"container-title":["BMC Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6882-14-118.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1472-6882-14-118\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6882-14-118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6882-14-118.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T03:31:24Z","timestamp":1630553484000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccomplementalternmed.biomedcentral.com\/articles\/10.1186\/1472-6882-14-118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,1]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["1714"],"URL":"https:\/\/doi.org\/10.1186\/1472-6882-14-118","relation":{},"ISSN":["1472-6882"],"issn-type":[{"value":"1472-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,1]]},"assertion":[{"value":"3 December 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"118"}}