{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T15:10:15Z","timestamp":1793286615372,"version":"4.5.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,7,17]],"date-time":"2014-07-17T00:00:00Z","timestamp":1405555200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Complement Altern Med"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/1472-6882-14-250","type":"journal-article","created":{"date-parts":[[2014,7,17]],"date-time":"2014-07-17T21:01:20Z","timestamp":1405630880000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Possible mechanism underlying the effect of Heshouwuyin, a tonifying kidney herb, on sperm quality in aging rats"],"prefix":"10.1186","volume":"14","author":[{"given":"Siyun","family":"Niu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingbo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingliang","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyue","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenshan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingze","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,7,17]]},"reference":[{"key":"1819_CR1","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1136\/bmj.305.6854.609","volume":"305","author":"E Carlsen","year":"1992","unstructured":"Carlsen E, Giwercman A, Keiding N, Skakkebaek NE: Evidence for decreasing quality of semen during past 50\u00a0years. Br Med J. 1992, 305: 609-613. 10.1136\/bmj.305.6854.609.","journal-title":"Br Med J"},{"key":"1819_CR2","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/S0022-5347(17)70101-2","volume":"54","author":"J MacLeod","year":"1945","unstructured":"MacLeod J, Heim LM: Characteristics and variations in semen specimens in 100 normal young men. J Urol. 1945, 54: 474-482.","journal-title":"J Urol"},{"key":"1819_CR3","volume-title":"WHO Laboratory Manual for the Examination and Processing of Human Semen","author":"World Health Organization","year":"2010","unstructured":"World Health Organization: WHO Laboratory Manual for the Examination and Processing of Human Semen. 2010, Geneva: World Health Organization, 5","edition":"5"},{"key":"1819_CR4","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.tem.2011.07.004","volume":"22","author":"A Bartke","year":"2011","unstructured":"Bartke A: Pleiotropic effects of growth hormone signaling in aging. Trends Endocrinol Metab. 2011, 22: 437-442. 10.1016\/j.tem.2011.07.004.","journal-title":"Trends Endocrinol Metab"},{"key":"1819_CR5","first-page":"682","volume":"82","author":"D Simon","year":"1997","unstructured":"Simon D, Charles M, Nahoul K, Orssaud G, Kremski J, Hully V, Joubert E, Papoz L, Eschwege E: Association between plasma total testosterone and cardiovascular risk factors in healthy adult men: the telecom study. J Clin Endocrinol Metab. 1997, 82: 682-685.","journal-title":"J Clin Endocrinol Metab"},{"key":"1819_CR6","first-page":"1026","volume":"34","author":"BO Saleh","year":"2013","unstructured":"Saleh BO, Majeed MJ: Andropause phenomenon by measurement of serum free testosterone concentration in Iraqi healthy men. Age related study. Sabdi Med J. 2013, 34: 1026-1029.","journal-title":"Sabdi Med J"},{"key":"1819_CR7","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1371\/annotation\/bccccb7e-48a7-4594-b3e6-ce8c9d2489a2","volume":"8","author":"TV Pollet","year":"2013","unstructured":"Pollet TV, Cobey KD, van der Meij L: Testosterone levels are negatively associated with childlessness in males, but positively related to offspring count in fathers. PLoS One. 2013, 8: 156-164.","journal-title":"PLoS One"},{"key":"1819_CR8","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1001\/archinte.161.9.1161","volume":"161","author":"MG Glazier","year":"2001","unstructured":"Glazier MG, Bowman MA: A review of the evidence for the use of phytoestrogen for traditional estrogen replacement therapy. Arch Intern Med. 2001, 161: 1161-1171. 10.1001\/archinte.161.9.1161.","journal-title":"Arch Intern Med"},{"key":"1819_CR9","first-page":"525","volume":"28","author":"YL Li","year":"2008","unstructured":"Li YL, Chu W, Guo WC, Yu XP, Gao J, Zhang DF, Gao FL: The effect of Heshouwu decoction on anti-oxidation and blood lipid of aging rats. Zhongguo Laonianxue Zazhi. 2008, 28: 525-526.","journal-title":"Zhongguo Laonianxue Zazhi"},{"key":"1819_CR10","first-page":"435","volume":"41","author":"KH Guo","year":"2010","unstructured":"Guo KH, Gao FL, Niu SY, Wang XJ, Chen L: Effect of Heshouwuyin on Rb\/p53 signal transduction pathway in aging rat testis tissue cells. Jiepou Xuebao. 2010, 41: 435-439.","journal-title":"Jiepou Xuebao"},{"key":"1819_CR11","first-page":"532","volume":"22","author":"XJ Wang","year":"2011","unstructured":"Wang XJ, Niu SY, Zhang YQ, Gao FL: Protective effect of HSWY on the reproductive functions of male aging rats. Shizhen guoyi guoyao. 2011, 22: 532-535.","journal-title":"Shizhen guoyi guoyao"},{"key":"1819_CR12","volume-title":"Pharmacology of Chinese materia medica","author":"CX Chen","year":"2006","unstructured":"Chen CX: Pharmacology of Chinese materia medica. 2006, Shanghai: Shanghai Science and Technology Press"},{"key":"1819_CR13","first-page":"371","volume":"14","author":"XY Wu","year":"2008","unstructured":"Wu XY, Wang WY, Wang RR, Fang ZX, Chen GR: Ginkgo biloba extract enhances testosterone synthesis of Leydig cells in type 2 diabetic rats. Zhonghua nankexue zazhi. 2008, 14: 371-376.","journal-title":"Zhonghua nankexue zazhi"},{"key":"1819_CR14","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1002\/jbt.18","volume":"5","author":"SA El-Maraghy","year":"2001","unstructured":"El-Maraghy SA, Gad MZ, Fahim AT, Hamdy MA: Effect of cadmium and aluminum intake on the antioxidant status and lipid peroxidation in rat tissues. J Biochem Mol Toxicol. 2001, 5: 207-214.","journal-title":"J Biochem Mol Toxicol"},{"key":"1819_CR15","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s00276-008-0330-9","volume":"30","author":"N Acer","year":"2008","unstructured":"Acer N, Sahin B, Usanmaz M, Tato\u011flu H, Irmak Z: Comparison of point counting and planimetry methods for the assessment of cerebellar volume in human using magnetic resonance imaging: a stereological study. Surg Radiol Anat. 2008, 30: 335-339. 10.1007\/s00276-008-0330-9.","journal-title":"Surg Radiol Anat"},{"key":"1819_CR16","first-page":"30","volume":"17","author":"F Aydin","year":"2007","unstructured":"Aydin F, Senturk N, Sahin B, Bek Y, Yuksel EP, Turanli AY: A practical method for the estimation of vitiligo surface area: a comparison between the point counting and digital planimetry techniques. Eur J Dermatol. 2007, 17: 30-32.","journal-title":"Eur J Dermatol"},{"key":"1819_CR17","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1073\/pnas.92.20.9363","volume":"92","author":"GP Dimri","year":"1995","unstructured":"Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, Medrano EE, Linskens M, Rubelj I, Pereira-Smith O: A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A. 1995, 92: 93-106.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1819_CR18","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1002\/cyto.990080411","volume":"8","author":"DT Sasaki","year":"1987","unstructured":"Sasaki DT, Dumas SE, Engleman EG: Discrimination of viable and nonviable cells using propidium iodide in two color immunofluorescence. Cytometry. 1987, 8: 413-420. 10.1002\/cyto.990080411.","journal-title":"Cytometry"},{"key":"1819_CR19","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.homp.2005.07.001","volume":"94","author":"DM Aziz","year":"2005","unstructured":"Aziz DM, Enbergs H: Stimulation of bovine sperm mitochondrial activity by homeopathic dilutions of monensin. Homeopathy. 2005, 94: 229-232. 10.1016\/j.homp.2005.07.001.","journal-title":"Homeopathy"},{"key":"1819_CR20","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0015-0282(16)47963-X","volume":"42","author":"RI Tejada","year":"1984","unstructured":"Tejada RI, Mitchell JC, Norman A, Marik JJ, Friedman S: A test for the practical evaluation of male fertility by acridine orange (AO) fluorescence. Fertil Steril. 1984, 42: 87-91.","journal-title":"Fertil Steril"},{"key":"1819_CR21","first-page":"1389","volume":"26","author":"ZB Zhang","year":"2006","unstructured":"Zhang ZB, Yang QT, Yang JQ, Zheng JH, Zhou DR: Comparative studies on protective effects on reproduction of Icariin and the substance extracted from the semen cuscutae in rats with partial androgen deficiency. Zhonghua Lao Nian Yi Xue Za Zhi. 2006, 26: 1389-1391.","journal-title":"Zhonghua Lao Nian Yi Xue Za Zhi"},{"key":"1819_CR22","first-page":"294","volume":"9","author":"BR She","year":"2003","unstructured":"She BR, Qing DN, Wang S, She YC: Effects of flavonoids from herba epimedii on the reproductive system in male rats. Zhonghua Nan Ke Xue. 2003, 9: 294-296.","journal-title":"Zhonghua Nan Ke Xue"},{"key":"1819_CR23","first-page":"29","volume":"36","author":"XW Wang","year":"2001","unstructured":"Wang XW, Jiang XY, Wu LY, Wang XF, AY : Scavenging effects of glycosides of Cistanche on free radicals and its protection against OH\u2009\u00b7\u20092 induced DNA damage in vitro. Zhongguo Yao Xue Za Zhi. 2001, 36: 29-32.","journal-title":"Zhongguo Yao Xue Za Zhi"},{"key":"1819_CR24","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.jep.2006.12.012","volume":"111","author":"WC Hou","year":"2007","unstructured":"Hou WC, Tsay HS, Liang HJ, Lee TY, Wang GJ, Liu DZ: Improving abnormal hemorheological parameters in aging guinea pigs by water-soluble extracts of Salvia miltiorrhiza Bunge. J Ethnopharmacol. 2007, 111: 483-489. 10.1016\/j.jep.2006.12.012.","journal-title":"J Ethnopharmacol"},{"key":"1819_CR25","first-page":"52","volume":"5","author":"L Yu","year":"2003","unstructured":"Yu L, Xu XD, Wu JD, Hu Y: Experimental studies of Wolfiporia extensa retard skin aging in rats. Liaoning Zhongyi Xueyuan Xuebao. 2003, 5: 52-53.","journal-title":"Liaoning Zhongyi Xueyuan Xuebao"},{"key":"1819_CR26","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1089\/152308603770310202","volume":"5","author":"D Harman","year":"2003","unstructured":"Harman D: The free radical theory of aging. Antioxid Redoxsignal. 2003, 5: 557-561.","journal-title":"Antioxid Redoxsignal"},{"key":"1819_CR27","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/j.biocel.2004.10.013","volume":"37","author":"I Ben-porath","year":"2005","unstructured":"Ben-porath I, Weinberg RA: The signals and pathways activating cellular senescence. Int J Biochem Cell Biol. 2005, 37: 961-976. 10.1016\/j.biocel.2004.10.013.","journal-title":"Int J Biochem Cell Biol"},{"key":"1819_CR28","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/978-1-4419-8997-0_14","volume":"543","author":"W Droge","year":"2003","unstructured":"Droge W: Oxidative stress and aging. Adv Exp Med Biol. 2003, 543: 191-200. 10.1007\/978-1-4419-8997-0_14.","journal-title":"Adv Exp Med Biol"},{"key":"1819_CR29","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.1210\/jc.2012-3695","volume":"98","author":"KL Hildreth","year":"2013","unstructured":"Hildreth KL, Barry DW, Moreau KL, Vande Griend J, Meacham RB, Nakamura T, Wolfe P, Kohrt WM, Ruscin JM, Kittelson J, Cress ME, Ballard R, Schwartz RS: Effects of testosterone and progressive resistance exercise in healthy, highly functioning older men with low-normal testosterone levels. J Clin Endocrinol Metab. 2013, 98: 1891-1900. 10.1210\/jc.2012-3695.","journal-title":"J Clin Endocrinol Metab"}],"container-title":["BMC Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6882-14-250.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1472-6882-14-250\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6882-14-250","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6882-14-250.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T04:53:57Z","timestamp":1630558437000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccomplementalternmed.biomedcentral.com\/articles\/10.1186\/1472-6882-14-250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,17]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["1819"],"URL":"https:\/\/doi.org\/10.1186\/1472-6882-14-250","relation":{},"ISSN":["1472-6882"],"issn-type":[{"value":"1472-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,17]]},"assertion":[{"value":"18 September 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"250"}}