{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:15:05Z","timestamp":1790957705201,"version":"4.1.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T00:00:00Z","timestamp":1410739200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Complement Altern Med"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/1472-6882-14-337","type":"journal-article","created":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T07:01:17Z","timestamp":1410764477000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Sub-MICs of Carum copticum and Thymus vulgaris influence virulence factors and biofilm formation in Candida spp"],"prefix":"10.1186","volume":"14","author":[{"given":"Mohd SA","family":"Khan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iqbal","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swaranjit S","family":"Cameotra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francien","family":"Botha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,9,15]]},"reference":[{"key":"1913_CR1","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1128\/CMR.00029-06","volume":"20","author":"MA Pfaller","year":"2007","unstructured":"Pfaller MA, Diekema DJ: Epidemiology of invasive candidiasis: a persistent public health problem. Clin Microbiol Rev. 2007, 20: 133-163. 10.1128\/CMR.00029-06.","journal-title":"Clin Microbiol Rev"},{"key":"1913_CR2","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1086\/421946","volume":"39","author":"H Wisplinghoff","year":"2004","unstructured":"Wisplinghoff H, Bischoff T, Tallent SM, Seifert H, Wenzel RP, Edmond MB: Nosocomial bloodstream infections in US hospitals: Analysis of 24,179 cases from a prospective nationwide surveillance study. Clin Infect Dis. 2004, 39: 309-317. 10.1086\/421946.","journal-title":"Clin Infect Dis"},{"key":"1913_CR3","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1128\/CMR.12.1.80","volume":"12","author":"PL Fiedel Jr","year":"1999","unstructured":"Fiedel PL, Vazquez JA, Sobel JD: Candida glabrata: a review of epidemiology, pathogenesis, and clinical disease with comparison to C. albicans. Clin Microbiol Rev. 1999, 12: 80-96.","journal-title":"Clin Microbiol Rev"},{"key":"1913_CR4","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1046\/j.1439-0507.2002.00741.x","volume":"45","author":"GL Macphail","year":"2002","unstructured":"Macphail GL, Taylor GD, Buchanan-Chell M, Ross C, Wilson S, Kureishi A: Epidemiology, treatment and outcome of candidemia: a five-year review at three Can hospitals. Mycoses. 2002, 45: 141-145. 10.1046\/j.1439-0507.2002.00741.x.","journal-title":"Mycoses"},{"key":"1913_CR5","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/S0732-8893(97)00064-3","volume":"28","author":"MA Pfaller","year":"1997","unstructured":"Pfaller MA, Jones RN, Marshall SA, Coffman SL, Hollis RJ, Edmond MB, Wenzel RP: Inducible amp C beta-lactamase producing gram-negative bacilli from blood stream infections: frequency, antimicrobial susceptibility, and molecular epidemiology in a national surveillance program (SCOPE). Diag Microbiol Infect Dis. 1997, 28: 211-219. 10.1016\/S0732-8893(97)00064-3.","journal-title":"Diag Microbiol Infect Dis"},{"key":"1913_CR6","doi-asserted-by":"publisher","first-page":"670","DOI":"10.3855\/jidc.2623","volume":"7","author":"J Chander","year":"2013","unstructured":"Chander J, Singla N, Sidhu SK, Gombar S: Epidemiology of Candida blood stream infections: experience of a tertiary care centre in North India. J Infect Dev Ctries. 2013, 7: 670-675.","journal-title":"J Infect Dev Ctries"},{"key":"1913_CR7","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1007\/s100960050001","volume":"19","author":"JA Crump","year":"2000","unstructured":"Crump JA, Collignon PJ: Intravascular catheter-associated infections. Eur J Clin Microbiol Infect Dis. 2000, 19: 1318-1322.","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"1913_CR8","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/S0966-842X(02)00002-1","volume":"100","author":"LJ Douglas","year":"2003","unstructured":"Douglas LJ: Candida biofilms and their role in infection. Trends Microbiol. 2003, 100: 30-36.","journal-title":"Trends Microbiol"},{"key":"1913_CR9","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1007\/s002530100822","volume":"58","author":"M Gupte","year":"2002","unstructured":"Gupte M, Kulkarni P, Ganguli BN: Antifungal antibiotics. Appl Microbiol Biotechnol. 2002, 58: 46-57. 10.1007\/s002530100822.","journal-title":"Appl Microbiol Biotechnol"},{"key":"1913_CR10","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S0378-8741(00)00335-4","volume":"74","author":"I Ahmad","year":"2001","unstructured":"Ahmad I, Beg AZ: Antimicrobial and phytochemical studies on 45 Indian medicinal plants against multi-drug resistant human pathogens. J Ethnopharcol. 2001, 74: 113-123. 10.1016\/S0378-8741(00)00335-4.","journal-title":"J Ethnopharcol"},{"key":"1913_CR11","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1111\/j.1365-2672.2006.02862.x","volume":"100","author":"C Cavaleiro","year":"2006","unstructured":"Cavaleiro C, Pinto E, Goncalves MJ, Salgueiro L: Antifungal activity of Juniperus essential oils against dermatophyte, Aspergillus and Candida strains. J Appl Microbiol. 2006, 100: 1333-1338. 10.1111\/j.1365-2672.2006.02862.x.","journal-title":"J Appl Microbiol"},{"key":"1913_CR12","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.jep.2008.06.012","volume":"119","author":"AC Tavares","year":"2008","unstructured":"Tavares AC, Goncalves MJ, Cavaleiro C, Cruz MT, Lopes MC, Canhoto J, Salgueiro LR: Essential oil of Daucuscarota subsp. halophilus: composition, antifungal activity and cytotoxicity. J Ethnopharmacol. 2008, 119: 129-134. 10.1016\/j.jep.2008.06.012.","journal-title":"J Ethnopharmacol"},{"key":"1913_CR13","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1590\/S0074-02762008000500006","volume":"103","author":"AG Tempone","year":"2008","unstructured":"Tempone AG, Sartorelli P, Teixeira D, Prado FO, Calixto IA, Lorenzi H, Melhem MS: Brazilian flora extracts as source of novel antileishmanial and antifungal compounds. Mem Inst Osw Cruz. 2008, 103: 443-449. 10.1590\/S0074-02762008000500006.","journal-title":"Mem Inst Osw Cruz"},{"key":"1913_CR14","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1002\/ptr.1594","volume":"18","author":"R Giordani","year":"2004","unstructured":"Giordani R, Regli P, Kaloustian J, Mika\u00efl C, Abou L, Portugal H: Antifungal effect of various essential oils against Candidaalbicans. Potentiation of antifungal action of amphotericin B by essential oil from Thymus vulgaris. Phytother Res. 2004, 18: 990-995. 10.1002\/ptr.1594.","journal-title":"Phytother Res"},{"key":"1913_CR15","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1111\/j.1468-3083.2004.00886.x","volume":"18","author":"C Pina-Vaz","year":"2004","unstructured":"Pina-Vaz C, Rodrigues AG, Pinto E, Costa-de-Oliveira S, Tavares C, Salgueiro L, Cavaleiro C, Goncalves MJ, Martinez-de-Oliveira J: Antifungal activity of Thymus oils and their major compounds. Europ Acad Dermatol Venereol. 2004, 18: 73-78. 10.1111\/j.1468-3083.2004.00886.x.","journal-title":"Europ Acad Dermatol Venereol"},{"key":"1913_CR16","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1099\/jmm.0.46443-0","volume":"55","author":"E Pinto","year":"2006","unstructured":"Pinto E, Pina-Vaz C, Salgueiro L, Goncalves MJ, Costa-de-Oliveira S, Cavaleiro C, Palmeira A, Rodrigues A, Martinez-de-Oliveira J: Antifungal activity of the essential oil of Thymus pulegioides on Candida, Aspergillus and dermatophyte species. J Med Microbiol. 2006, 55: 1367-137. 10.1099\/jmm.0.46443-0.","journal-title":"J Med Microbiol"},{"key":"1913_CR17","first-page":"85","volume":"5","author":"AG Pirbalouti","year":"2009","unstructured":"Pirbalouti AG, Bahmani M, Avijgan M: Anti-Candida activity of some of the Iranian medicinal plants. Elect J Biol. 2009, 5: 85-88.","journal-title":"Elect J Biol"},{"key":"1913_CR18","doi-asserted-by":"publisher","first-page":"167","DOI":"10.2515\/therapie\/2011019","volume":"66","author":"SS Hussain","year":"2011","unstructured":"Hussain SS, Agoumi A, Amghar S, Boukachabine K: Anticandida activity of the marketed essential oil of Thymus vulgaris L and its concomitant action with amphotericin B. Therapie. 2011, 66: 167-169. 10.2515\/therapie\/2011019.","journal-title":"Therapie"},{"key":"1913_CR19","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1002\/cbdv.201200041","volume":"9","author":"CA Jamali","year":"2012","unstructured":"Jamali CA, Bouzidi LE, Bekkouche K, Lahcen H, Markouk M, Wohlmuth H, Leach D, Abbad A: Chemical composition and antioxidant and anticandidal activities of essential oils from different wild moroccan Thymus species. Chem Biodiver. 2012, 9: 1188-1197. 10.1002\/cbdv.201200041.","journal-title":"Chem Biodiver"},{"key":"1913_CR20","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1055\/s-0032-1315153","volume":"78","author":"V Tullio","year":"2012","unstructured":"Tullio V, Mandras N, Allizond V, Nostro A, Roana J, Merlino C, Banche G, Scalas D, Cuffini AM: Positive interaction of thyme (red) essential oil with human polymorphonuclear granulocytes in eradicating intracellular Candida albicans. Planta Med. 2012, 78: 1633-1635.","journal-title":"Planta Med"},{"key":"1913_CR21","doi-asserted-by":"publisher","first-page":"T356","DOI":"10.1111\/1750-3841.12020","volume":"78","author":"G Kavoosi","year":"2013","unstructured":"Kavoosi G, Tafsiry A, Ebdam AA, Rowshan V: Evaluation of antioxidant and antimicrobial activities of essential oils from Carum copticum Seed and Ferula assafoetida Latex. J Food Scie. 2013, 78: T356-T361. 10.1111\/1750-3841.12020.","journal-title":"J Food Scie"},{"key":"1913_CR22","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1128\/MMBR.67.3.400-428.2003","volume":"67","author":"JR Naglik","year":"2003","unstructured":"Naglik JR, Challacombe SJ, Hube B: Candida albicans secreted aspartyl proteinases in virulence and pathogenesis. Microbiol Mol Biol Rev. 2003, 67: 400-428. 10.1128\/MMBR.67.3.400-428.2003.","journal-title":"Microbiol Mol Biol Rev"},{"key":"1913_CR23","volume-title":"Candida and candidosis","author":"FC Odds","year":"1988","unstructured":"Odds FC: Candida and candidosis. 1988, London: Bailliere Tindall"},{"key":"1913_CR24","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1128\/IAI.63.5.1993-1998.1995","volume":"63","author":"AS Ibrahim","year":"1995","unstructured":"Ibrahim AS, Mirbod F, Filler SG, Banno Y, Cole GT, Kitajima Y, Edwards JE, Nozawa Y, Ghannoum MA: Evidence implicating phospholipase as a virulence factor of Candida albicans. Infect Immun. 1995, 63: 1993-1998.","journal-title":"Infect Immun"},{"key":"1913_CR25","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/BF01575445","volume":"74","author":"L Hoegl","year":"1996","unstructured":"Hoegl L, Ollert M, Korting HC: The role of Candida albicans secreted aspartyl proteinase in the development of candidoses. J Mol Med. 1996, 74: 135-142. 10.1007\/BF01575445.","journal-title":"J Mol Med"},{"key":"1913_CR26","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1111\/j.1567-1364.2009.00570.x","volume":"9","author":"RS Almeida","year":"2009","unstructured":"Almeida RS, Wilson D, Hube B: Candida albicans iron acquisition within the host. FEMS Yeast Res. 2009, 9: 1000-1012. 10.1111\/j.1567-1364.2009.00570.x.","journal-title":"FEMS Yeast Res"},{"key":"1913_CR27","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1126\/science.283.5409.1837","volume":"283","author":"C Potera","year":"1999","unstructured":"Potera C: Forging a link between biofilms and disease. Science. 1999, 283: 1837-1839. 10.1126\/science.283.5409.1837.","journal-title":"Science"},{"key":"1913_CR28","doi-asserted-by":"publisher","first-page":"33","DOI":"10.3109\/13693786.2011.582890","volume":"50","author":"MSA Khan","year":"2012","unstructured":"Khan MSA, Malik A, Ahmad I: Anti-candidal activity of essential oils alone and in combination with amphotericin B and fluconazole against multi-drug resistant isolates of Candida albicans. Med Mycol. 2012, 50: 33-42. 10.3109\/13693786.2011.582890.","journal-title":"Med Mycol"},{"key":"1913_CR29","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/S0934-8840(11)80437-8","volume":"273","author":"S Aoki","year":"1990","unstructured":"Aoki S, Itokuwa S, Nakamura Y, Nasuhara T: Comparative pathogenicity of wild type strains and respiratory mutants of Candida albicans in mice. Zent Bakteriol. 1990, 273: 332-343. 10.1016\/S0934-8840(11)80437-8.","journal-title":"Zent Bakteriol"},{"key":"1913_CR30","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1046\/j.0902-0055.2002.00100.x","volume":"18","author":"T Kuriyama","year":"2003","unstructured":"Kuriyama T, Williams DW, Lewis MAO: In vitro secreted aspartyl proteinase activity of Candida albicans isolated from oral diseases and healthy oral cavities. Oral Microbiol Immunol. 2003, 18: 405-407. 10.1046\/j.0902-0055.2002.00100.x.","journal-title":"Oral Microbiol Immunol"},{"key":"1913_CR31","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1099\/00222615-13-3-423","volume":"13","author":"F MacDonald","year":"1980","unstructured":"MacDonald F, Odds FC: Inducible proteinase of Candida albicans in diagnostic serology and in the pathogenesis of systemic candidosis. J Med Microbiol. 1980, 13: 423-435. 10.1099\/00222615-13-3-423.","journal-title":"J Med Microbiol"},{"key":"1913_CR32","doi-asserted-by":"publisher","first-page":"2971","DOI":"10.1128\/JCM.39.8.2971-2974.2001","volume":"39","author":"G Luo","year":"2001","unstructured":"Luo G, Samaranayake LP, Yau JYY: Candida species exhibit differential in vitro hemolytic activities. J Clin Microbiol. 2001, 39: 2971-2974. 10.1128\/JCM.39.8.2971-2974.2001.","journal-title":"J Clin Microbiol"},{"key":"1913_CR33","doi-asserted-by":"crossref","first-page":"5154","DOI":"10.1128\/IAI.62.11.5154-5156.1994","volume":"62","author":"JM Manns","year":"1994","unstructured":"Manns JM, Mosser DM, Buckley HR: Production of hemolytic factor by Candida albicans. Infect Immun. 1994, 62: 5154-5156.","journal-title":"Infect Immun"},{"key":"1913_CR34","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1111\/j.1574-6968.1980.tb05599.x","volume":"9","author":"M Rosenberg","year":"1980","unstructured":"Rosenberg M, Gutnick D, Rosenberg E: Adherence of bacteria to hydrocarbons: A simple method for measuring cell-surface hydrophobicity. FEMS Microbiol Lett. 1980, 9: 29-33. 10.1111\/j.1574-6968.1980.tb05599.x.","journal-title":"FEMS Microbiol Lett"},{"key":"1913_CR35","doi-asserted-by":"publisher","first-page":"2475","DOI":"10.1128\/AAC.45.9.2475-2479.2001","volume":"45","author":"G Ramage","year":"2001","unstructured":"Ramage G, Vande-Walle K, Wickes B, Lopez-Ribot JL: Standardized method for in vitro antifungal susceptibility testing of Candida albicans biofilms. Antimicrob Agents Chemother. 2001, 45: 2475-2479. 10.1128\/AAC.45.9.2475-2479.2001.","journal-title":"Antimicrob Agents Chemother"},{"key":"1913_CR36","first-page":"259","volume-title":"Capillary gas Chromatography in Essential Oil Analysis","author":"T Shibamoto","year":"1987","unstructured":"Shibamoto T: Retention indices in essential oil analysis. Capillary gas Chromatography in Essential Oil Analysis. Edited by: Sandra P, Bicchi C. 1987, New York: HuethigVerlag, 259-274."},{"key":"1913_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0021-9673(01)81487-4","volume":"503","author":"NW Davies","year":"1990","unstructured":"Davies NW: Gas chromatographic retention indices of monoterpenes and sesquiterpenes on methyl silicone and carbowax 20 M phases. J Chromatogr A. 1990, 503: 1-24.","journal-title":"J Chromatogr A"},{"key":"1913_CR38","volume-title":"Identification of essential oil components by gas chromatography\/quadrupole mass spectroscopy","author":"RP Adams","year":"2001","unstructured":"Adams RP: Identification of essential oil components by gas chromatography\/quadrupole mass spectroscopy. 2001, Carol Stream IL: Allured Publ Corp"},{"key":"1913_CR39","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1099\/jmm.0.47303-0","volume":"56","author":"CSP Tsang","year":"2007","unstructured":"Tsang CSP, Chu FCS, Leung WK, Jin LJ, Samaranayake LP, Siu SC: Phospholipase, proteinase and haemolytic activities of Candida albicans isolated from oral cavities of patients with type 2 diabetes mellitus. J Med Microbiol. 2007, 56: 1393-1398. 10.1099\/jmm.0.47303-0.","journal-title":"J Med Microbiol"},{"key":"1913_CR40","first-page":"559","volume":"35","author":"S Akcaglar","year":"2011","unstructured":"Akcaglar S, Ener B, Tore O: Acid proteinase enzyme activity in Candida albicans strains: a comparison of spectrophotometry and plate methods. Turk J Biol. 2011, 35: 559-567.","journal-title":"Turk J Biol"},{"key":"1913_CR41","doi-asserted-by":"publisher","first-page":"153","DOI":"10.14194\/ijmbr.1211","volume":"1","author":"CD Sachin","year":"2012","unstructured":"Sachin CD, Ruchi K, Santosh S: In vi tro evaluation of proteinase, phospholipase and haemolysin activities of Candida species isolated from clinical specimens. Int J Med Biomed Res. 2012, 1: 153-157. 10.14194\/ijmbr.1211.","journal-title":"Int J Med Biomed Res"},{"key":"1913_CR42","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/978-1-4615-5373-1_47","volume":"436","author":"B Hube","year":"1998","unstructured":"Hube B, Ruchel R, Monod M, Sanglard D, Odds FC: Functional aspects of secreted Candida proteinases. Adv Exp Med Biol. 1998, 436: 339-344. 10.1007\/978-1-4615-5373-1_47.","journal-title":"Adv Exp Med Biol"},{"key":"1913_CR43","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s11046-009-9232-6","volume":"169","author":"CR Costa","year":"2010","unstructured":"Costa CR, Jesu\u0131no RSA, Lemos JA, Fernandes OFL, e Souza LKH, Passos XS, Silva MRR: Effects of antifungal agents in Sap activity of Candida albicans isolates. Mycopathologia. 2010, 169: 91-98. 10.1007\/s11046-009-9232-6.","journal-title":"Mycopathologia"},{"key":"1913_CR44","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.funbio.2009.12.003","volume":"114","author":"R Kumar","year":"2010","unstructured":"Kumar R, Shukla PK: Amphotericin B resistance leads to enhanced proteinase and phospholipase activity and reduced germ tube formation in Candida albicans. Fung Biol. 2010, 114: 189-197. 10.1016\/j.funbio.2009.12.003.","journal-title":"Fung Biol"},{"key":"1913_CR45","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.fitote.2007.02.022","volume":"78","author":"PC Braga","year":"2007","unstructured":"Braga PC, Sasso MD, Culici M, Alfieri M: Eugenol and thymol, alone or in combination, induce morphological alterations in the envelope of Candida albicans. Fitoterapia. 2007, 78: 396-400. 10.1016\/j.fitote.2007.02.022.","journal-title":"Fitoterapia"}],"container-title":["BMC Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6882-14-337.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1472-6882-14-337\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6882-14-337","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6882-14-337.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T11:06:13Z","timestamp":1598267173000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccomplementalternmed.biomedcentral.com\/articles\/10.1186\/1472-6882-14-337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,15]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["1913"],"URL":"https:\/\/doi.org\/10.1186\/1472-6882-14-337","relation":{},"ISSN":["1472-6882"],"issn-type":[{"value":"1472-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,15]]},"assertion":[{"value":"23 April 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 September 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"337"}}