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The role of pro- and anti-inflammatory cytokines in psychiatric disorders has been the focus of great research attention in recent years. In the present study, we detected the antidepressant effect of soyo-san in the ovariectomized and repeated stressed female rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was designed to evaluate the antidepressant-like effect of soyo-san on the forced swimming test (FST). The rats were randomly divided into the following groups: the nonoperated and nonstressed group (non-op), the nonoperated and stressed group (non-op\u2009+\u2009ST), the ovariectomized and stress group (OVX) and sham operated and stressed group (sham), the ovariectomized and stressed group (OVX\u2009+\u2009ST), the ovariectomized, stressed and soyo-san 100\u00a0mg\/kg treated group (SOY100) and the ovariectomized, stressed and soyo-san 400\u00a0mg\/kg treated group (SOY400). The rats were exposed to immobilization stress (IMO) for 14day (2\u00a0h\/14day), and soyo-san (100\u00a0mg\/kg and 400\u00a0mg\/kg) was administrated during the same time. In the same animals, the levels of corticosterone and interleukin-1-beta (IL-1\u03b2) were examined in the serum. Also, the change of IL-1\u03b2 expression in brain regions was examined after behavior test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the FST, the lower dose (100\u00a0mg\/kg) of extract was effective in reducing immobility, along with an increase in swimming time. The serum levels of corticosterone and IL-1\u03b2 in the SOY groups were significantly lower than those in the control group. In the brain, the expression of IL-1\u03b2 positive neurons in the control group were significantly increased in the paraventricular nucleus (PVN) and hippocampus compared to the non-op. However, soyo-san groups significantly reduced the IL-1\u03b2-ir neurons in the PVN and hippocampal regions compared to the control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present results demonstrated that soyo-san effectively reduced behavioral and patho-physiological depression-like responses. Trial registration: Our results suggest that soyo-san may be useful for immune regulator in repeated stress-induced ovariectomized female rats.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1472-6882-14-34","type":"journal-article","created":{"date-parts":[[2014,1,21]],"date-time":"2014-01-21T02:01:35Z","timestamp":1390269695000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Soyo-san reduces depressive-like behavior and proinflammatory cytokines in ovariectomized female rats"],"prefix":"10.1186","volume":"14","author":[{"given":"Hyun-Jung","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Soo","family":"Shim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Yong","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Hee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Insop","family":"Shim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,1,21]]},"reference":[{"key":"1640_CR1","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1111\/j.1749-6632.2000.tb05454.x","volume":"917","author":"FS Dhabhar","year":"2000","unstructured":"Dhabhar FS: Acute stress enhances while chronic stress suppresses skin immunity. 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