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(\n                      <jats:italic>PF<\/jats:italic>\n                      ) leaf extract in the streptozotocin induced diabetic rats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Single intraperitoneal injection (IP) of streptozotocin (60\u00a0mg\/kg body weight) was used for induction of diabetes is swiss albino (wistar strain) rats. The induction of diabetes was confirmed after 3\u00a0days as noticing the increase in blood sugar level of tested rats.\n                      <jats:italic>PF<\/jats:italic>\n                      at a once a daily dose of 100\u00a0mg\/kg, 250\u00a0mg\/kg, 500\u00a0mg\/kg, p.o. along with glibenclamide 10\u00a0mg\/kg, p.o. was also given for 28\u00a0days. On the 28\n                      <jats:sup>th<\/jats:sup>\n                      day rats from all the groups fasted overnight fasted and the blood was collected from the puncturing the retro orbit of the eye under mild anesthetic condition. There collected blood sample was used to determine the antihyperlipidemic, hypoglycemic and antioxidant parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The oral acute toxicity studies did not show any toxic effect till the dose at 2000\u00a0mg\/kg. While oral glucose tolerance test showed better glucose tolerance in tested rats. The statistical data indicated that the different dose of the\n                      <jats:italic>PF<\/jats:italic>\n                      significantly increased the body weight, hexokinase, plasma insulin, high density lipoprotein cholesterol, superoxide dismutase, catalase and glutathione peroxides. It also decreases the level of fasting blood glucose, total cholesterol, triglycerides, low density lipoprotein cholesterol, very low density lipoprotein cholesterol, malonaldehyde, glucose-6-phosphate, fructose-1-6-biphosphate and glycated hemoglobin in STZ induced diabetic rats. The histopathology of STZ induce diabetic rats, as expected the test dose of\n                      <jats:italic>PF<\/jats:italic>\n                      extract considerably modulates the pathological condition of various vital organ viz. heart, kidney, liver, pancreas as shown in the histopathology examinations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our investigation has clearly indicated that the leaf extract of\n                      <jats:italic>Paederia foetida<\/jats:italic>\n                      Linn. showed remarkable antihyperglycemic activity due to its possible systematic effect involving in the pancreatic and extra pancreatic mechanism. Forever, the antihyperlipidemic activity was exerted possible by lowering the higher level of lipid profile and decreasing the intercalated disc space in the heart. The antioxidant activity of extract was due to inhibition of lipid peroxidation and increasing the SOD, GPx and CAT. It was corroborate that the extract shown the\n                      <jats:italic>Paederia foetida<\/jats:italic>\n                      Linn leaves potential to be act as antidiabetic, antihyperlipidemic and antioxidant properties.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/1472-6882-14-76","type":"journal-article","created":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T23:01:22Z","timestamp":1393282882000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["RETRACTED ARTICLE:Paederia foetida Linn. leaf extract: an antihyperlipidemic, antihyperglycaemic and antioxidant activity"],"prefix":"10.1186","volume":"14","author":[{"given":"Vikas","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firoz","family":"Anwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danish","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amita","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aftab","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoheir A","family":"Damanhouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vatsala","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pramod W","family":"Ramteke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakash Chandra","family":"Bhatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd","family":"Mujeeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,2,25]]},"reference":[{"issue":"4","key":"1668_CR1","doi-asserted-by":"publisher","first-page":"114","DOI":"10.4239\/wjd.v4.i4.114","volume":"4","author":"O Ali","year":"2013","unstructured":"Ali O: Genetics of type 2 diabetes. 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