{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:08:43Z","timestamp":1790622523345,"version":"4.1.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2002,11,11]],"date-time":"2002-11-11T00:00:00Z","timestamp":1036972800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Complement Altern Med"],"DOI":"10.1186\/1472-6882-2-10","type":"journal-article","created":{"date-parts":[[2002,11,28]],"date-time":"2002-11-28T12:08:34Z","timestamp":1038485314000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Impact of in utero exposure to EtOH on corpus callosum development and paw preference in rats: protective effects of silymarin"],"prefix":"10.1186","volume":"2","author":[{"given":"Nicol","family":"Moreland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"La Grange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Montoya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2002,11,11]]},"reference":[{"key":"22_CR1","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1111\/j.1530-0277.1988.tb00191.x","volume":"12","author":"B Zimmerberg","year":"1988","unstructured":"Zimmerberg B, Riley EP: Prenatal alcohol exposure alters behavioral laterality of adult offspring in rats. Alcohol Clin Exp Res. 1988, 12: 259-263.","journal-title":"Alcohol Clin Exp Res"},{"key":"22_CR2","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1017\/S0012162299001358","volume":"41","author":"R Riikonen","year":"1999","unstructured":"Riikonen R, Salonen I, Partaneu K, Verho S: Brain perfusion SPECT and MRI in foetal alcohol syndrome. Dev Med Child Neurol. 1999, 41: 652-659. 10.1017\/S0012162299001358.","journal-title":"Dev Med Child Neurol"},{"key":"22_CR3","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1111\/j.1469-8749.2001.tb00179.x","volume":"43","author":"SL Archibald","year":"2001","unstructured":"Archibald SL, Fennema-Notestine C, Gamst A, Riley EP, Mattson SN, Jernigan TL: Brain dysmorphology in individuals with severe prenatal alcohol exposure. Dev Med Child Neurol. 2001, 43: 148-154.","journal-title":"Dev Med Child Neurol"},{"key":"22_CR4","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1002\/tera.1044","volume":"64","author":"FL Bookstein","year":"2001","unstructured":"Bookstein FL, Sampson PD, Streissguth AP, Connor PD: Geometric morphometries of corpus callosum and subcortical structures in the fetal-alcohol-affected brain. Teratol. 2001, 64: 4-32. 10.1002\/tera.1044.","journal-title":"Teratol"},{"key":"22_CR5","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1136\/jnnp.42.2.134","volume":"42","author":"MA Jeeves","year":"1979","unstructured":"Jeeves MA, Simpson DA, Geffen G: Functional consequences of transcallosal removal of intraventricular tumor. J Neurol Neurosurg Psychiatry. 1979, 42: 134-142.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"22_CR6","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/S0006-8993(97)00533-7","volume":"766","author":"MW Miller","year":"1997","unstructured":"Miller MW: Effects of prenatal exposure to ethanol on callosal projective neurons in rat somatosensory cortex. Brain Res. 1997, 766: 121-128. 10.1016\/S0006-8993(97)00533-7.","journal-title":"Brain Res"},{"key":"22_CR7","first-page":"49","volume":"18","author":"SN Mattson","year":"1994","unstructured":"Mattson SN, Jernigen TL, Riley EP: MRI and prenatal alcohol exposure. Alcohol Health Res World. 1994, 18: 49-52.","journal-title":"Alcohol Health Res World"},{"key":"22_CR8","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1001\/archneur.1993.00540070083022","volume":"50","author":"CL Coulter","year":"1993","unstructured":"Coulter CL, Leech RW, Schaefer GB, Scheithauer BW, Brumback RA: Midline cerebral dysgenesis, dysfunction of the hypothalamic-pituitary axis, and fetal alcohol effects. Arch Neurol. 1993, 50: 771-775.","journal-title":"Arch Neurol"},{"key":"22_CR9","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/S0387-7604(87)80042-6","volume":"9","author":"JS Jeret","year":"1987","unstructured":"Jeret JS, Serur D, Wisniewski KE, Lubin RA: Clinicopathological findings associated with agenesis of the corpus callosum. Brain Dev. 1987, 9: 255-264.","journal-title":"Brain Dev"},{"key":"22_CR10","first-page":"631","volume":"8","author":"B Zimmerberg","year":"1986","unstructured":"Zimmerberg B, Riley EP: Side preference behavior in rats exposed to alcohol prenatally. Neurobehav Toxicol Teratol. 1986, 8: 631-635.","journal-title":"Neurobehav Toxicol Teratol"},{"key":"22_CR11","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/0741-8329(87)90044-9","volume":"4","author":"W London","year":"1987","unstructured":"London W: Cerebral laterality and the study of alcoholism. Alcohol. 1987, 4: 207-208. 10.1016\/0741-8329(87)90044-9.","journal-title":"Alcohol"},{"key":"22_CR12","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/0165-3806(89)90291-5","volume":"46","author":"B Zimmerberg","year":"1989","unstructured":"Zimmerberg B, Reuter JM: Sexually dimorphic behavioral and brain asymmetries in neonatal rats: effects of prenatal alcohol exposure. Brain Res Dev Brain Res. 1989, 46: 281-290. 10.1016\/0165-3806(89)90291-5.","journal-title":"Brain Res Dev Brain Res"},{"key":"22_CR13","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/j.1572-0241.1998.00139.x","volume":"93","author":"K Flora","year":"1998","unstructured":"Flora K, Hahn M, Rosen H, Benner K: Milk thistle (Silybum marianum) for the therapy of liver disease. Am Gastroenterol. 1998, 93: 139-143. 10.1016\/S0002-9270(97)00082-8.","journal-title":"Am Gastroenterol"},{"key":"22_CR14","first-page":"369","volume-title":"Plant Flavonoids in Biology and Medicine II: Biochemical, Cellular, and Medicinal Properties.","author":"J Sonnenbichler","year":"1999","unstructured":"Sonnenbichler J, Zetle I: Plant Flavonoids in Biology and Medicine II: Biochemical, Cellular, and Medicinal Properties. Edited by: Alan R Liss. 1999, New York, 369-374."},{"key":"22_CR15","first-page":"236","volume":"48","author":"R Locher","year":"1997","unstructured":"Locher R, Suter PM, Weyhenmeyer R, Vetter W: Inhibitory action of silibinin on low density lipoprotein oxidation. Arzneimittelforschung. 1997, 48: 236-239.","journal-title":"Arzneimittelforschung"},{"key":"22_CR16","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1016\/0006-2952(85)90421-6","volume":"34","author":"A Valenzuela","year":"1985","unstructured":"Valenzuela A, Lagos C, Schmidt K, Videla L: Silymarin protection against hepatic peroxidation induced by acute ethanol intoxication in the rat. Biochem Pharmacol. 1985, 34: 2209-2212. 10.1016\/0006-2952(85)90421-6.","journal-title":"Biochem Pharmacol"},{"key":"22_CR17","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1002\/hep.510230415","volume":"22","author":"C Dehmlow","year":"1996","unstructured":"Dehmlow C, Erhard J, de Groot H: Inhibition of Kupffer cell functions as an explanation for hepatoprotective properties of silibinin. Hepatology. 1996, 22: 749-754.","journal-title":"Hepatology"},{"key":"22_CR18","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1002\/1099-1573(200011)14:7<517::AID-PTR654>3.0.CO;2-W","volume":"14","author":"J Edwards","year":"2000","unstructured":"Edwards J, La Grange L, Wang M, Reyes E: Fetoprotectivity of the flavanolignan compound Siliphos against ethanol-induced toxicity. Phytother Res. 2000, 14: 517-521. 10.1002\/1099-1573(200011)14:7<517::AID-PTR654>3.0.CO;2-W.","journal-title":"Phytother Res"},{"key":"22_CR19","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0378-8741(98)00144-5","volume":"65","author":"L La Grange","year":"1999","unstructured":"La Grange L, Wang M, Watkins R, Ortiz D, Sanchez ME, Konst J, Lee C, Reyes E: Protective effects of the flavonoid mixture silymarin on fetal rat brain and liver. J Ethnopharm. 1999, 65: 53-61. 10.1016\/S0378-8741(98)00144-5.","journal-title":"J Ethnopharm"},{"key":"22_CR20","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1080\/J157v02n01_06","volume":"2","author":"A Busby","year":"2002","unstructured":"Busby A, La Grange L, Edwards J, King J: The use of a silymarin\/phospholipid compound as a fetoprotectant from ethanol-induced behavioral deficits. J Herbal Pharmacother. 2002, 2: 39-47. 10.1300\/J157v02n01_06.","journal-title":"J Herbal Pharmacother"},{"key":"22_CR21","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1055\/s-1999-14085","volume":"65","author":"C Reid","year":"1999","unstructured":"Reid C, Edwards J, Wang M, Manybeads Y, Mike L, Martinez N, La Grange L, Reyes E: Prevention by a silymarin\/phospholipid compound of ethanol-induced social learning deficits in rats. Planta Med. 1999, 65: 421-424. 10.1055\/s-1999-14085.","journal-title":"Planta Med"},{"key":"22_CR22","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1212\/WNL.57.2.235","volume":"57","author":"E Sowell","year":"2001","unstructured":"Sowell E, Mattson S, Thompson P, Jemigan T, Riley E, Toga A: Mapping callosal morphology and cognitive correlates: effects of heavy prenatal alcohol exposure. Neurology. 2001, 57: 235-244.","journal-title":"Neurology"},{"key":"22_CR23","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1515\/JBCPP.2002.13.1.41","volume":"13","author":"S Pence","year":"2002","unstructured":"Pence S: Paw preference in rats. J Basic Clin Physiol Pharmacol. 2002, 13: 41-49.","journal-title":"J Basic Clin Physiol Pharmacol"},{"key":"22_CR24","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/0006-8993(90)90347-E","volume":"537","author":"B Zimmerberg","year":"1990","unstructured":"Zimmerberg B, Mickus L: Sex differences in corpus callosum: influence of prenatal alcohol exposure and maternal under nutrition. Brain Res. 1990, 537: 115-222. 10.1016\/0006-8993(90)90347-E.","journal-title":"Brain Res"},{"key":"22_CR25","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1016\/0024-3205(85)90295-4","volume":"37","author":"RJ Handa","year":"1985","unstructured":"Handa RJ, McGivern RF, Noble ES, Gorski RA: Exposure to alcohol in utero alters adult pattern of luteinizing hormone secretion in male and female rats. Life Sci. 1985, 37: 1683-1690. 10.1016\/0024-3205(85)90295-4.","journal-title":"Life Sci"},{"key":"22_CR26","first-page":"126","volume":"8","author":"J Weinberg","year":"1984","unstructured":"Weinberg J, Clendenning S: Adrenocortical activity in females consuming alcohol during pregnancy. Alcohol Clin Exp Res. 1984, 8: 126-","journal-title":"Alcohol Clin Exp Res"},{"key":"22_CR27","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1111\/j.1530-0277.1988.tb00188.x","volume":"12","author":"RF McGivern","year":"1988","unstructured":"McGivern RF, Raum WJ, Salido E, Redei E: Lack of preinatal testosterone surge in fetal rats exposed to alcohol : alterations in testicular morphology and physiology. Alcohol Clin Exp Res. 1988, 12: 243-247.","journal-title":"Alcohol Clin Exp Res"},{"key":"22_CR28","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/0892-0362(91)90071-4","volume":"13","author":"J Dahlgren","year":"1991","unstructured":"Dahlgren J, Matuszczyk J, Hard E: Sexual orientation in male rats prenatally exposed to ethanol. Neurotoxicol Teratol. 1991, 13: 267-269. 10.1016\/0892-0362(91)90071-4.","journal-title":"Neurotoxicol Teratol"},{"key":"22_CR29","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1210\/jcem-64-1-153","volume":"64","author":"E Halmesm\u00e4ki","year":"1987","unstructured":"Halmesm\u00e4ki E, Autti I, Granstr\u00f6m M-L, Stenman U-H, Ylikorkala O: Estradiol, estriol, progesterone, prolactin, and human chorionic gonadotropin in pregnant women with alcohol abuse. J Clin Endocrinol Metab. 1987, 64: 153-156.","journal-title":"J Clin Endocrinol Metab"},{"key":"22_CR30","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1210\/endo.139.7.6101","volume":"139","author":"C Roselli","year":"1998","unstructured":"Roselli C, Klosterman S: Sexual differentiation of aromatase activity in the rat brain: effects of perinatal steroid exposure. Endocrinology. 1998, 139: 3193-3201.","journal-title":"Endocrinology"},{"key":"22_CR31","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1095\/biolreprod42.1.21","volume":"42","author":"F Naftolin","year":"1990","unstructured":"Naftolin F, Garcia-Segura LM, Keefe D, Levanth C, MacLusky NJ, Brown JR: Estrogen effects on the synaptology and neural membranes of the rat hypothalamic arcuate nucleus. Biol Reprod. 1990, 42: 21-28.","journal-title":"Biol Reprod"},{"key":"22_CR32","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/0006-8993(91)91584-N","volume":"542","author":"RH Fitch","year":"1991","unstructured":"Fitch RH, Cowell PE, Schrott LM, Denenberg VH: Corpus callosum: ovarian hormones and feminization. Brain Res. 1991, 542: 313-317. 10.1016\/0006-8993(91)91584-N.","journal-title":"Brain Res"},{"key":"22_CR33","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S0165-3806(00)00067-5","volume":"30","author":"HA Bimonte","year":"2000","unstructured":"Bimonte HA, Fitch RH, Denenberg VH: Neonatal estrogen blockade prevents normal callosal responsiveness to estradiol in adulthood. Brain Res Dev Brain Res. 2000, 30: 149-155.","journal-title":"Brain Res Dev Brain Res"}],"container-title":["BMC Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6882-2-10.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1472-6882-2-10\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6882-2-10","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6882-2-10.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T16:13:09Z","timestamp":1726243989000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccomplementalternmed.biomedcentral.com\/articles\/10.1186\/1472-6882-2-10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,11,11]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2002,12]]}},"alternative-id":["22"],"URL":"https:\/\/doi.org\/10.1186\/1472-6882-2-10","relation":{},"ISSN":["1472-6882"],"issn-type":[{"value":"1472-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,11,11]]},"assertion":[{"value":"18 July 2002","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2002","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2002","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"10"}}