{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:42:30Z","timestamp":1791304950445,"version":"4.3.1"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,9,5]],"date-time":"2014-09-05T00:00:00Z","timestamp":1409875200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Clin Pathol"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/1472-6890-14-39","type":"journal-article","created":{"date-parts":[[2014,9,5]],"date-time":"2014-09-05T23:01:15Z","timestamp":1409958075000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Implant based differences in adverse local tissue reaction in failed total hip arthroplasties: a morphological and immunohistochemical study"],"prefix":"10.1186","volume":"14","author":[{"given":"Giorgio","family":"Perino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin F","family":"Ricciardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth A","family":"Jerabek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Martignoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle","family":"Wilner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Maass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R","family":"Goldring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P Edward","family":"Purdue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,9,5]]},"reference":[{"issue":"Suppl","key":"185_CR1","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.1097\/00003086-199608001-00003","volume":"329","author":"HC Amstutz","year":"1996","unstructured":"Amstutz HC, Grigoris P: Metal on metal bearings in hip arthroplasty. Clin Orthop Relat Res. 1996, 329 (Suppl): S11-S34.","journal-title":"Clin Orthop Relat Res"},{"key":"185_CR2","doi-asserted-by":"publisher","first-page":"214","DOI":"10.5435\/JAAOS-20-04-214","volume":"20","author":"A Srinivasan","year":"2012","unstructured":"Srinivasan A, Jung E, Levine BR: Modularity of the femoral component in total hip arthroplasty. J Am Acad Orthop Surg. 2012, 20: 214-222. 10.5435\/JAAOS-20-04-214.","journal-title":"J Am Acad Orthop Surg"},{"key":"185_CR3","doi-asserted-by":"publisher","first-page":"e1410","DOI":"10.1136\/bmj.e1410","volume":"344","author":"D Cohen","year":"2012","unstructured":"Cohen D: How safe are metal-on-metal hip implants?. BMJ. 2012, 344: e1410-10.1136\/bmj.e1410.","journal-title":"BMJ"},{"key":"185_CR4","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1016\/j.arth.2008.09.009","volume":"24","author":"AM Kop","year":"2009","unstructured":"Kop AM, Swarts E: Corrosion of a hip stem with a modular neck taper junction: a retrieval study of 16 cases. J Arthroplasty. 2009, 24: 1019-1023. 10.1016\/j.arth.2008.09.009.","journal-title":"J Arthroplasty"},{"key":"185_CR5","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.actbio.2008.07.032","volume":"5","author":"M Huber","year":"2009","unstructured":"Huber M, Reinisch G, Trettenhahn G, Zweym\u00fcller K, Lintner F: Presence of corrosion products and hypersensitivity-associated reactions in periprosthetic tissue after aseptic loosening of total hip replacements with metal bearing surfaces. Acta Biomater. 2009, 5: 172-180. 10.1016\/j.actbio.2008.07.032.","journal-title":"Acta Biomater"},{"key":"185_CR6","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1302\/0301-620X.94B6.28373","volume":"94","author":"BH Bosker","year":"2012","unstructured":"Bosker BH, Ettema HB, Boomsma MF, Kollen BJ, Maas M, Verheyen CC: High incidence of pseudotumour formation after large-diameter metal-on-metal total hip replacement: a prospective cohort study. J Bone Joint Surg Br. 2012, 94: 755-761.","journal-title":"J Bone Joint Surg Br"},{"key":"185_CR7","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1302\/0301-620X.94B2.27247","volume":"94","author":"R Chana","year":"2012","unstructured":"Chana R, Esposito C, Campbell PA, Walter WK, Walter WL: Mixing and matching causing taper wear: corrosion associated with pseudotumour formation. J Bone Joint Surg Br. 2012, 94: 281-286.","journal-title":"J Bone Joint Surg Br"},{"key":"185_CR8","doi-asserted-by":"publisher","first-page":"e1009","DOI":"10.3928\/01477447-20120621-12","volume":"35","author":"D Fabi","year":"2012","unstructured":"Fabi D, Levine B, Paprosky W, Della Valle C, Sporer S, Klein G, Levine H, Hartzband M: Metal-on-metal total hip arthroplasty: causes and high incidence of early failure. Orthopedics. 2012, 35: e1009-e1016. 10.3928\/01477447-20120621-12.","journal-title":"Orthopedics"},{"key":"185_CR9","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1302\/0301-620X.94B7.29122","volume":"94","author":"IP Gill","year":"2012","unstructured":"Gill IP, Webb J, Sloan K, Beaver RJ: Corrosion at the neck-stem junction as a cause of metal ion release and pseudotumour formation. J Bone Joint Surg Br. 2012, 94: 895-900.","journal-title":"J Bone Joint Surg Br"},{"key":"185_CR10","doi-asserted-by":"publisher","first-page":"3101","DOI":"10.1007\/s11999-012-2502-5","volume":"470","author":"H Meyer","year":"2012","unstructured":"Meyer H, Mueller T, Goldau G, Chamaon K, Ruetschi M, Lohmann CH: Corrosion at the cone\/taper interface leads to failure of large-diameter metal-on-metal total hip arthroplasties. Clin Orthop Relat Res. 2012, 470: 3101-3108. 10.1007\/s11999-012-2502-5.","journal-title":"Clin Orthop Relat Res"},{"key":"185_CR11","doi-asserted-by":"publisher","first-page":"865","DOI":"10.2106\/JBJS.L.01042","volume":"95","author":"HJ Cooper","year":"2013","unstructured":"Cooper HJ, Urban RM, Wixson RL, Meneghini RM, Jacobs JJ: Adverse local tissue reaction arising from corrosion at the femoral neck-body junction in a dual-taper stem with a cobalt-chromium modular neck. J Bone Joint Surg Am. 2013, 95: 865-872. 10.2106\/JBJS.L.01042.","journal-title":"J Bone Joint Surg Am"},{"key":"185_CR12","doi-asserted-by":"publisher","first-page":"543.e13","DOI":"10.1016\/j.arth.2012.07.026","volume":"28","author":"SD Werner","year":"2013","unstructured":"Werner SD, Bono JV, Nandi S, Ward DM, Talmo CT: Adverse tissue reactions in modular exchangeable neck implants: a report of two cases. J Arthroplasty. 2013, 28: 543.e13-5. 10.1016\/j.arth.2012.07.026.","journal-title":"J Arthroplasty"},{"key":"185_CR13","doi-asserted-by":"publisher","first-page":"18","DOI":"10.2106\/JBJS.C.00949","volume":"87","author":"AP Davies","year":"2005","unstructured":"Davies AP, Willert HG, Campbell PA, Learmonth ID, Case CP: An unusual lymphocytic perivascular infiltration in tissues around contemporary metal-on-metal joint replacements. J Bone Joint Surg Am. 2005, 87: 18-27. 10.2106\/JBJS.C.00949.","journal-title":"J Bone Joint Surg Am"},{"key":"185_CR14","doi-asserted-by":"publisher","first-page":"28","DOI":"10.2106\/JBJS.A.02039pp","volume":"87","author":"HG Willert","year":"2005","unstructured":"Willert HG, Buchhorn GH, Fayyazi A, Flury R, Windler M, K\u00f6ster G, Lohmann CH: Metal-on-metal bearings and hypersensitivity in patients with artificial hip joints. A clinical and histomorphological study. J Bone Joint Surg Am. 2005, 87: 28-36.","journal-title":"J Bone Joint Surg Am"},{"key":"185_CR15","doi-asserted-by":"publisher","first-page":"653","DOI":"10.3109\/17453670903473016","volume":"80","author":"G Mahendra","year":"2009","unstructured":"Mahendra G, Pandit H, Kliskey K, Murray D, Gill HS, Athanasou N: Necrotic and vinflammatory changes in metal-on-metal resurfacing hip arthroplasties. Acta Orthop. 2009, 80: 653-659. 10.3109\/17453670903473016.","journal-title":"Acta Orthop"},{"key":"185_CR16","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.1007\/s11999-010-1372-y","volume":"468","author":"P Campbell","year":"2010","unstructured":"Campbell P, Ebramzadeh E, Nelson S, Takamura K, De Smet K, Amstutz HC: Histological features of pseudotumor-like tissues from metal-on-metal hips. Clin Orthop Relat Res. 2010, 468: 2321-2327. 10.1007\/s11999-010-1372-y.","journal-title":"Clin Orthop Relat Res"},{"key":"185_CR17","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1136\/jclinpath-2011-200398","volume":"65","author":"S Natu","year":"2012","unstructured":"Natu S, Sidaginamale RP, Gandhi J, Langton DJ, Nargol AV: Adverse reactions to metal debris: histopathological features of periprosthetic soft tissue reactions seen in association with failed metal on metal hip arthroplasties. J Clin Pathol. 2012, 65: 409-418. 10.1136\/jclinpath-2011-200398.","journal-title":"J Clin Pathol"},{"key":"185_CR18","doi-asserted-by":"publisher","first-page":"e81","DOI":"10.2106\/JBJS.L.00775","volume":"95","author":"G Grammatopoulos","year":"2013","unstructured":"Grammatopoulos G, Pandit H, Kamali A, Maggiani F, Glyn-Jones S, Gill HS, Murray DW, Athanasou N: The correlation of wear with histological features after failed hip resurfacing arthroplasty. J Bone Joint Surg Am. 2013, 95: e81-10.2106\/JBJS.L.00568.","journal-title":"J Bone Joint Surg Am"},{"key":"185_CR19","doi-asserted-by":"publisher","first-page":"e63470","DOI":"10.1371\/journal.pone.0063470","volume":"8","author":"S Mittal","year":"2013","unstructured":"Mittal S, Revell M, Barone F, Hardie DL, Matharu GS, Davenport AJ, Martin RA, Grant M, Mosselmans F, Pynsent P, Sumathi VP, Addison O, Revell PA, Buckley CD: Lymphoid aggregates that resemble tertiary lymphoid organs define a specific pathological subset in metal-on-metal hip replacements. PLoS One. 2013, 8: e63470-10.1371\/journal.pone.0063470.","journal-title":"PLoS One"},{"key":"185_CR20","doi-asserted-by":"publisher","first-page":"2354","DOI":"10.1016\/j.actbio.2014.02.003","volume":"10","author":"J Gallo","year":"2014","unstructured":"Gallo J, Vaculova J, Goodman SB, Konttinen YT, Thyssen JP: Contributions of human tissue analysis to understanding the mechanisms of loosening and osteolysis in total hip replacement. Acta Biomater. 2014, 10: 2354-2366. 10.1016\/j.actbio.2014.02.003.","journal-title":"Acta Biomater"},{"key":"185_CR21","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.2106\/JBJS.K.01352","volume":"94","author":"HJ Cooper","year":"2012","unstructured":"Cooper HJ, Della Valle CJ, Berger RA, Tetreault M, Paprosky WG, Sporer SM, Jacobs JJ: Corrosion at the head-neck taper as a cause for adverse local tissue reactions after total hip arthroplasty. J Bone Joint Surg Am. 2012, 94: 1655-1661.","journal-title":"J Bone Joint Surg Am"},{"issue":"8 Suppl","key":"185_CR22","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.arth.2012.03.019","volume":"27","author":"KB Fricka","year":"2012","unstructured":"Fricka KB, Ho H, Peace WJ, Engh CA: Metal-on-metal local tissue reaction is associated with corrosion of the head taper junction. J Arthroplasty. 2012, 27 (8 Suppl): 26-31.e1.","journal-title":"J Arthroplasty"},{"key":"185_CR23","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1016\/j.arth.2012.10.017","volume":"28","author":"RM Dyrkacz","year":"2013","unstructured":"Dyrkacz RM, Brandt JM, Ojo OA, Turgeon TR, Wyss UP: The influence of head size on corrosion and fretting behaviour at the head-neck interface of artificial hip joints. J Arthroplasty. 2013, 28: 1036-1040. 10.1016\/j.arth.2012.10.017.","journal-title":"J Arthroplasty"},{"key":"185_CR24","doi-asserted-by":"publisher","first-page":"884","DOI":"10.2214\/AJR.11.8203","volume":"199","author":"CL Hayter","year":"2012","unstructured":"Hayter CL, Gold SL, Koff MF, Perino G, Nawabi DH, Miller TT, Potter HG: MRI findings in painful metal-on-metal hip arthroplasty. AJR Am J Roentgenol. 2012, 199: 884-893. 10.2214\/AJR.11.8203.","journal-title":"AJR Am J Roentgenol"},{"key":"185_CR25","doi-asserted-by":"publisher","first-page":"895","DOI":"10.2106\/JBJS.K.01476","volume":"95","author":"DH Nawabi","year":"2013","unstructured":"Nawabi DH, Hayter CL, Su EP, Koff MF, Perino G, Gold SL, Koch KM, Potter HG: Magnetic resonance imaging findings in symptomatic versus asymptomatic subjects following metal-on-metal hip resurfacing arthroplasty. J Bone Joint Surg Am. 2013, 95: 895-902. 10.2106\/JBJS.K.01476.","journal-title":"J Bone Joint Surg Am"},{"key":"185_CR26","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1007\/s11999-013-2788-y","volume":"472","author":"DH Nawabi","year":"2014","unstructured":"Nawabi DH, Gold S, Lyman S, Fields K, Padgett DE, Potter HG: MRI Predicts ALVAL and tissue damage in metal-on-metal hip arthroplasty. Clin Orthop Relat Res. 2014, 472: 471-481. 10.1007\/s11999-013-2788-y.","journal-title":"Clin Orthop Relat Res"},{"key":"185_CR27","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1007\/s11999-013-3199-9","volume":"472","author":"DH Nawabi","year":"2014","unstructured":"Nawabi DH, Nassif NA, Do HT, Stoner K, Elpers M, Su EP, Wright T, Potter HG, Padgett DE: What causes unexplained pain in patients with metal-on metal hip devices? A retrieval, histologic, and imaging analysis. Clin Orthop Relat Res. 2014, 472: 543-554. 10.1007\/s11999-013-3199-9.","journal-title":"Clin Orthop Relat Res"},{"key":"185_CR28","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1002\/jbm.820110202","volume":"11","author":"HG Willert","year":"1977","unstructured":"Willert HG, Semlisch M: Reactions of the articular capsule to wear products of artificial joint prostheses. J Biomed Mater Res. 1977, 11: 157-164. 10.1002\/jbm.820110202.","journal-title":"J Biomed Mater Res"},{"key":"185_CR29","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1182\/blood.V81.6.1607.1607","volume":"81","author":"CL Holness","year":"1993","unstructured":"Holness CL, Simmons DL: Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins. Blood. 1993, 81: 1607-1613.","journal-title":"Blood"},{"key":"185_CR30","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1136\/jclinpath-2012-201286","volume":"66","author":"FQ Wang","year":"2013","unstructured":"Wang FQ, Chen G, Zhu JY, Zhang W, Ren JG, Liu H, Sun ZJ, Jia J, Zhao YF: M2-polarised macrophages in infantile haemangiomas: correlation with promoted angiogenesis. J Clin Pathol. 2013, 66: 1058-1064. 10.1136\/jclinpath-2012-201286.","journal-title":"J Clin Pathol"},{"key":"185_CR31","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/S0092-8674(00)80240-8","volume":"89","author":"W Zheng","year":"1997","unstructured":"Zheng W, Flavell RA: The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell. 1997, 89: 587-596. 10.1016\/S0092-8674(00)80240-8.","journal-title":"Cell"},{"key":"185_CR32","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/S0092-8674(00)80702-3","volume":"100","author":"SJ Szabo","year":"2000","unstructured":"Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman CG, Glimcher LH: A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell. 2000, 100: 655-669. 10.1016\/S0092-8674(00)80702-3.","journal-title":"Cell"},{"key":"185_CR33","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1126\/science.1079490","volume":"299","author":"S Hori","year":"2003","unstructured":"Hori S, Nomura T, Sakaguchi S: Control of regulatory T cell development by the transcription factor Foxp3. Science. 2003, 299: 1057-1061. 10.1126\/science.1079490.","journal-title":"Science"},{"key":"185_CR34","first-page":"321","volume":"144","author":"A Iemura","year":"1994","unstructured":"Iemura A, Tsai M, Ando A, Wershil BK, Galli SJ: The c-kit ligand, stem cell factor, promotes mast cell survival by suppressing apoptosis. Am J Pathol. 1994, 144: 321-328.","journal-title":"Am J Pathol"},{"key":"185_CR35","first-page":"94","volume":"319","author":"JJ Jacobs","year":"1995","unstructured":"Jacobs JJ, Urban RM, Gilbert JL, Skipor AK, Black J, Jasty M, Galante JO: Local and distant products from modularity. Clin Orthop Relat Res. 1995, 319: 94-105.","journal-title":"Clin Orthop Relat Res"},{"key":"185_CR36","doi-asserted-by":"crossref","first-page":"268","DOI":"10.2106\/00004623-199802000-00015","volume":"80","author":"JJ Jacobs","year":"1998","unstructured":"Jacobs JJ, Gilbert JL, Urban RM: Corrosion of metal orthopaedic implants. J Bone Joint Surg Am. 1998, 80: 268-282.","journal-title":"J Bone Joint Surg Am"},{"key":"185_CR37","first-page":"0","volume":"5","author":"JR Berstock","year":"2014","unstructured":"Berstock JR, Baker RP, Bannister GC, Case CP: Histology of failed metal-on-metal hip arthroplasty; three distinct sub-types. Hip Int. 2014, 5: 0-","journal-title":"Hip Int"},{"key":"185_CR38","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1302\/0301-620X.93B2.25099","volume":"93","author":"DJ Langton","year":"2011","unstructured":"Langton DJ, Joyce TJ, Jameson SS, Lord J, Van Orsouw M, Holland JP, Nargol AV, De Smet KA: Adverse reaction to metal debris following hip resurfacing: the influence of component type, orientation and volumetric wear. J Bone Joint Surg Br. 2011, 93: 164-171.","journal-title":"J Bone Joint Surg Br"},{"key":"185_CR39","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1302\/0301-620X.93B10.27645","volume":"93","author":"JU Lindgren","year":"2011","unstructured":"Lindgren JU, Brismar BH, Wikstrom AC: Adverse reaction to metal release from a modular metal-on-polyethylene hip prosthesis. J Bone Joint Surg Br. 2011, 93: 1427-1430.","journal-title":"J Bone Joint Surg Br"},{"key":"185_CR40","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/1741-7015-9-113","volume":"9","author":"A Hinsch","year":"2011","unstructured":"Hinsch A, Vettorazzi E, Morlock MM, R\u00fcther W, Amling M, Zustin J: Sex differences in the morphological failure patterns following hip resurfacing arthroplasty. BMC Med. 2011, 9: 113-10.1186\/1741-7015-9-113.","journal-title":"BMC Med"},{"key":"185_CR41","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1016\/j.nano.2011.08.002","volume":"7","author":"Z Xia","year":"2011","unstructured":"Xia Z, Kwon YM, Mehmood S, Downing C, Jurkschat K, Murray DW: Characterization of metal-wear nanoparticles in pseudotumor following metal-on-metal hip resurfacing. Nanomedicine. 2011, 7: 674-681. 10.1016\/j.nano.2011.08.002.","journal-title":"Nanomedicine"},{"key":"185_CR42","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1002\/jor.22411","volume":"31","author":"MS Caicedo","year":"2013","unstructured":"Caicedo MS, Samelko L, McAllister K, Jacobs JJ, Hallab NJ: Increasing both CoCrMo-alloy particle size and surface irregularity induces increased macrophage inflammasome activation in vitro potentially through lysosomal destabilization mechanisms. J Orthop Res. 2013, 31: 1633-1642. 10.1002\/jor.22411.","journal-title":"J Orthop Res"},{"key":"185_CR43","doi-asserted-by":"publisher","first-page":"2704","DOI":"10.1007\/s11999-010-1259-y","volume":"468","author":"DG Campbell","year":"2010","unstructured":"Campbell DG, Field JR, Callary SA: Second-generation highly cross-linked X3\u2122 polyethylene wear: a preliminary radiostereometric analysis study. Clin Orthop Relat Res. 2010, 468: 2704-2709. 10.1007\/s11999-010-1259-y.","journal-title":"Clin Orthop Relat Res"},{"key":"185_CR44","doi-asserted-by":"publisher","first-page":"3596","DOI":"10.1007\/s11999-013-3188-z","volume":"471","author":"SA Callary","year":"2013","unstructured":"Callary SA, Field JR, Campbell DG: Low wear of a second-generation highly crosslinked polyethylene liner: a 5-year radiostereometric analysis study. Clin Orthop Relat Res. 2013, 471: 3596-3600. 10.1007\/s11999-013-3188-z.","journal-title":"Clin Orthop Relat Res"},{"key":"185_CR45","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1615\/CritRevImmunol.v32.i6.10","volume":"32","author":"CD Mills","year":"2012","unstructured":"Mills CD: M1 and M2 macrophages: oracles of health and disease. Crit Rev Immunol. 2012, 32: 463-488. 10.1615\/CritRevImmunol.v32.i6.10.","journal-title":"Crit Rev Immunol"},{"key":"185_CR46","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.rmed.2011.09.007","volume":"106","author":"K Amin","year":"2012","unstructured":"Amin K: The role of mast cells in allergic inflammation. Respir Med. 2012, 106: 9-14. 10.1016\/j.rmed.2011.09.007.","journal-title":"Respir Med"},{"key":"185_CR47","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1002\/jor.20826","volume":"27","author":"MS Caicedo","year":"2009","unstructured":"Caicedo MS, Desai R, McAllister K, Reddy A, Jacobs JJ, Hallab NJ: Soluble and particulate Co Cr-Mo alloy implant metals activate the inflammasome danger signaling pathway in human macrophages: a novel mechanism for implant debris reactivity. J Orthop Res. 2009, 27: 847-854. 10.1002\/jor.20826.","journal-title":"J Orthop Res"},{"key":"185_CR48","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/nrrheum.2011.128","volume":"7","author":"N Cobelli","year":"2011","unstructured":"Cobelli N, Scharf B, Crisi GM, Hardin J, Santambrogio L: Mediators of the inflammatory response to joint replacement devices. Nat Rev Rheumatol. 2011, 7: 600-608.","journal-title":"Nat Rev Rheumatol"},{"key":"185_CR49","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/cdd.2011.164","volume":"19","author":"N Vanlangenakker","year":"2012","unstructured":"Vanlangenakker N, Vanden Berghe T, Vandenabeele P: Many stimuli pull the necrotic trigger, an overview. Cell Death Differ. 2012, 19: 75-86. 10.1038\/cdd.2011.164.","journal-title":"Cell Death Differ"},{"key":"185_CR50","doi-asserted-by":"publisher","first-page":"e67127","DOI":"10.1371\/journal.pone.0067127","volume":"8","author":"L Samelko","year":"2013","unstructured":"Samelko L, Caicedo MS, Lim SJ, Della-Valle C, Jacobs J, Hallab NJ: Cobalt-alloy implant debris induce HIF-1\u03b1 hypoxia associated responses: a mechanism for metal-specific orthopedic implant failure. PLoS One. 2013, 8: e67127-10.1371\/journal.pone.0067127.","journal-title":"PLoS One"},{"key":"185_CR51","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1007\/s11999-010-1649-1","volume":"469","author":"T Fujishiro","year":"2011","unstructured":"Fujishiro T, Moojen DJ, Kobayashi N, Dhert WJ, Bauer TW: Perivascular and diffuse lymphocytic inflammation are not specific for failed metal-on-metal hip implants. Clin Orthop Relat Res. 2011, 469: 1127-1133. 10.1007\/s11999-010-1649-1.","journal-title":"Clin Orthop Relat Res"}],"container-title":["BMC Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6890-14-39.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1472-6890-14-39\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6890-14-39","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6890-14-39.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T03:30:36Z","timestamp":1598239836000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcclinpathol.biomedcentral.com\/articles\/10.1186\/1472-6890-14-39"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,5]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["185"],"URL":"https:\/\/doi.org\/10.1186\/1472-6890-14-39","relation":{},"ISSN":["1472-6890"],"issn-type":[{"value":"1472-6890","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,5]]},"assertion":[{"value":"13 May 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 September 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"39"}}