{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T12:40:59Z","timestamp":1775479259955,"version":"3.50.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2009,11,27]],"date-time":"2009-11-27T00:00:00Z","timestamp":1259280000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Clin Pathol"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1186\/1472-6890-9-10","type":"journal-article","created":{"date-parts":[[2009,11,28]],"date-time":"2009-11-28T00:11:50Z","timestamp":1259367110000},"source":"Crossref","is-referenced-by-count":25,"title":["Ex-vivo changes in amino acid concentrations from blood stored at room temperature or on ice: implications for arginine and taurine measurements"],"prefix":"10.1186","volume":"9","author":[{"given":"Joshua S","family":"Davis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christabelle J","family":"Darcy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Piera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvette R","family":"McNeil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tonia","family":"Woodberry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas M","family":"Anstey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,11,27]]},"reference":[{"key":"71_CR1","doi-asserted-by":"crossref","first-page":"1650S","DOI":"10.1093\/jn\/137.6.1650S","volume":"137","author":"RH Boger","year":"2007","unstructured":"Boger RH: The pharmacodynamics of L-arginine. J Nutr. 2007, 137: 1650S-1655S.","journal-title":"J Nutr"},{"key":"71_CR2","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.1161\/01.CIR.0000089507.19675.F9","volume":"108","author":"P Ganz","year":"2003","unstructured":"Ganz P, Vita JA: Testing endothelial vasomotor function: nitric oxide, a multipotent molecule. Circulation. 2003, 108: 2049-2053. 10.1161\/01.CIR.0000089507.19675.F9.","journal-title":"Circulation"},{"key":"71_CR3","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1038\/ni1001-907","volume":"2","author":"C Bogdan","year":"2001","unstructured":"Bogdan C: Nitric oxide and the immune response. Nat Immunol. 2001, 2: 907-916. 10.1038\/ni1001-907.","journal-title":"Nat Immunol"},{"key":"71_CR4","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1097\/01.CCM.0000142939.81045.A0","volume":"32","author":"YC Luiking","year":"2004","unstructured":"Luiking YC, Poeze M, Dejong CH, Ramsay G, Deutz NE: Sepsis: an arginine deficiency state?. Crit Care Med. 2004, 32: 2135-2145. 10.1097\/01.CCM.0000142939.81045.A0.","journal-title":"Crit Care Med"},{"key":"71_CR5","doi-asserted-by":"publisher","first-page":"R155","DOI":"10.1186\/cc8055","volume":"13","author":"JS Davis","year":"2009","unstructured":"Davis JS, Yeo TW, Thomas JH, McMillan M, Darcy CJ, McNeil YR, Cheng AC, Celermajer DS, Stephens DP, Anstey NM: Sepsis-associated microvascular dysfunction measured by peripheral arterial tonometry: an observational study. Crit Care. 2009, 13: R155-10.1186\/cc8055.","journal-title":"Crit Care"},{"key":"71_CR6","doi-asserted-by":"publisher","first-page":"2693","DOI":"10.1084\/jem.20070819","volume":"204","author":"TW Yeo","year":"2007","unstructured":"Yeo TW, Lampah DA, Gitawati R, Tjitra E, Kenangalem E, McNeil YR, Darcy CJ, Granger DL, Weinberg JB, Lopansri BK, et al: Impaired nitric oxide bioavailability and L-arginine reversible endothelial dysfunction in adults with falciparum malaria. J Exp Med. 2007, 204: 2693-2704. 10.1084\/jem.20070819.","journal-title":"J Exp Med"},{"key":"71_CR7","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1097\/00000658-199111000-00013","volume":"214","author":"JB Ochoa","year":"1991","unstructured":"Ochoa JB, Udekwu AO, Billiar TR, Curran RD, Cerra FB, Simmons RL, Peitzman AB: Nitrogen oxide levels in patients after trauma and during sepsis. Ann Surg. 1991, 214: 621-626. 10.1097\/00000658-199111000-00013.","journal-title":"Ann Surg"},{"key":"71_CR8","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1146\/annurev.pharmtox.41.1.79","volume":"41","author":"RH Boger","year":"2001","unstructured":"Boger RH, Bode-Boger SM: The clinical pharmacology of L-arginine. Annu Rev Pharmacol Toxicol. 2001, 41: 79-99. 10.1146\/annurev.pharmtox.41.1.79.","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"71_CR9","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1097\/TA.0b013e31814b2b17","volume":"63","author":"A Bernard","year":"2007","unstructured":"Bernard A, Meier C, Lopez N, May J, Chang P, Boulanger B, Kearney P: Packed red blood cell-associated arginine depletion is mediated by arginase. J Trauma. 2007, 63: 1108-1112. 10.1097\/TA.0b013e31814b2b17.","journal-title":"J Trauma"},{"key":"71_CR10","doi-asserted-by":"crossref","first-page":"2820S","DOI":"10.1093\/jn\/134.10.2820S","volume":"134","author":"M Mori","year":"2004","unstructured":"Mori M, Gotoh T: Arginine metabolic enzymes, nitric oxide and infection. J Nutr. 2004, 134: 2820S-2825S.","journal-title":"J Nutr"},{"key":"71_CR11","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1097\/00024382-200116020-00005","volume":"16","author":"HA Prins","year":"2001","unstructured":"Prins HA, Houdijk AP, Nijveldt RJ, Teerlink T, Huygens P, Thijs LG, van Leeuwen PA: Arginase release from red blood cells: possible link in transfusion induced immune suppression?. Shock. 2001, 16: 113-115. 10.1097\/00024382-200116020-00005.","journal-title":"Shock"},{"key":"71_CR12","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1126\/science.281.5380.1191","volume":"281","author":"DH Munn","year":"1998","unstructured":"Munn DH, Zhou M, Attwood JT, Bondarev I, Conway SJ, Marshall B, Brown C, Mellor AL: Prevention of allogeneic fetal rejection by tryptophan catabolism. Science. 1998, 281: 1191-1193. 10.1126\/science.281.5380.1191.","journal-title":"Science"},{"key":"71_CR13","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1042\/bj2120835","volume":"212","author":"MS Ardawi","year":"1983","unstructured":"Ardawi MS, Newsholme EA: Glutamine metabolism in lymphocytes of the rat. Biochem J. 1983, 212: 835-842.","journal-title":"Biochem J"},{"key":"71_CR14","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1111\/j.2042-7158.1994.tb03895.x","volume":"46","author":"PP Stapleton","year":"1994","unstructured":"Stapleton PP, Mahon TM, Nowlan P, Bloomfield FJ: Effects of in-vivo administration of taurine and HEPES on the inflammatory response in rats. J Pharm Pharmacol. 1994, 46: 745-750.","journal-title":"J Pharm Pharmacol"},{"key":"71_CR15","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s726-002-8200-9","volume":"22","author":"J Muhling","year":"2002","unstructured":"Muhling J, Fuchs M, Fleck C, Sablotzki A, Krull M, Dehne MG, Gonter J, Weiss S, Engel J, Hempelmann G: Effects of arginine, L-alanyl-L-glutamine or taurine on neutrophil (PMN) free amino acid profiles and immune functions in vitro. Amino Acids. 2002, 22: 39-53. 10.1007\/s726-002-8200-9.","journal-title":"Amino Acids"},{"key":"71_CR16","first-page":"221","volume":"43","author":"B Hainque","year":"1985","unstructured":"Hainque B, Gerbet D, Roisin JP, Le Moel G, Troupel S, Galli A: [Course of the concentration of serum free amino acids as a function of time and the method of preservation]. Ann Biol Clin (Paris). 1985, 43: 221-226.","journal-title":"Ann Biol Clin (Paris)"},{"key":"71_CR17","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/0009-8981(87)90067-2","volume":"164","author":"A Schaefer","year":"1987","unstructured":"Schaefer A, Piquard F, Haberey P: Plasma amino-acids analysis: effects of delayed samples preparation and of storage. Clin Chim Acta. 1987, 164: 163-169. 10.1016\/0009-8981(87)90067-2.","journal-title":"Clin Chim Acta"},{"key":"71_CR18","first-page":"354","volume":"28","author":"KL Nuttall","year":"1998","unstructured":"Nuttall KL, Chen M, Komaromy-Hiller G: Delayed separation and the plasma amino acids arginine and ornithine. Ann Clin Lab Sci. 1998, 28: 354-359.","journal-title":"Ann Clin Lab Sci"},{"key":"71_CR19","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/S0021-9673(96)00891-6","volume":"763","author":"C van Wandelen","year":"1997","unstructured":"van Wandelen C, Cohen SA: Using quaternary high-performance liquid chromatography eluent systems for separating 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate-derivatized amino acid mixtures. J Chromatogr A. 1997, 763: 11-22. 10.1016\/S0021-9673(96)00891-6.","journal-title":"J Chromatogr A"},{"key":"71_CR20","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s00228-005-0015-9","volume":"62","author":"J Martens-Lobenhoffer","year":"2006","unstructured":"Martens-Lobenhoffer J, Bode-Boger SM: Measurement of asymmetric dimethylarginine (ADMA) in human plasma: from liquid chromatography estimation to liquid chrmoatgoraphy-mass spectrometry quantification. Eur J Clin Pharmacol. 2006, 62: 61-68. 10.1007\/s00228-005-0015-9.","journal-title":"Eur J Clin Pharmacol"},{"key":"71_CR21","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/0009-8981(85)90152-4","volume":"148","author":"S Sahai","year":"1985","unstructured":"Sahai S, Uhlhaas S: Stability of amino acids in human plasma. Clin Chim Acta. 1985, 148: 255-259. 10.1016\/0009-8981(85)90152-4.","journal-title":"Clin Chim Acta"},{"key":"71_CR22","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1097\/01.CCM.0000050291.37714.74","volume":"31","author":"Z Argaman","year":"2003","unstructured":"Argaman Z, Young VR, Noviski N, Castillo-Rosas L, Lu XM, Zurakowski D, Cooper M, Davison C, Tharakan JF, Ajami A, Castillo L: Arginine and nitric oxide metabolism in critically ill septic pediatric patients. Crit Care Med. 2003, 31: 591-597. 10.1097\/01.CCM.0000050291.37714.74.","journal-title":"Crit Care Med"},{"key":"71_CR23","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1097\/00024382-200115030-00009","volume":"15","author":"AC Bernard","year":"2001","unstructured":"Bernard AC, Mistry SK, Morris SM, O'Brien WE, Tsuei BJ, Maley ME, Shirley LA, Kearney PA, Boulanger BR, Ochoa JB: Alterations in arginine metabolic enzymes in trauma. Shock. 2001, 15: 215-219. 10.1097\/00024382-200115030-00009.","journal-title":"Shock"},{"key":"71_CR24","doi-asserted-by":"publisher","first-page":"11460","DOI":"10.1073\/pnas.93.21.11460","volume":"93","author":"L Castillo","year":"1996","unstructured":"Castillo L, Beaumier L, Ajami AM, Young VR: Whole body nitric oxide synthesis in healthy men determined from [15N] arginine-to-[15N]citrulline labeling. Proc Natl Acad Sci USA. 1996, 93: 11460-11465. 10.1073\/pnas.93.21.11460.","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["BMC Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1472-6890-9-10\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6890-9-10.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6890-9-10","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6890-9-10.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T07:01:49Z","timestamp":1548226909000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcclinpathol.biomedcentral.com\/articles\/10.1186\/1472-6890-9-10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11,27]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["71"],"URL":"https:\/\/doi.org\/10.1186\/1472-6890-9-10","relation":{},"ISSN":["1472-6890"],"issn-type":[{"value":"1472-6890","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11,27]]},"article-number":"10"}}