{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:39:20Z","timestamp":1790383160127,"version":"4.1.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2003,11,13]],"date-time":"2003-11-13T00:00:00Z","timestamp":1068681600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Clin Pharmacol"],"DOI":"10.1186\/1472-6904-3-4","type":"journal-article","created":{"date-parts":[[2003,11,29]],"date-time":"2003-11-29T02:19:35Z","timestamp":1070072375000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["The safety of over-the-counter niacin. A randomized placebo-controlled trial [ISRCTN18054903]"],"prefix":"10.1186","volume":"3","author":[{"given":"Edward","family":"Mills","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Prousky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gannady","family":"Raskin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Gagnier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Rachlis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor M","family":"Montori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Juurlink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2003,11,13]]},"reference":[{"key":"16_CR1","unstructured":"FDA: . Center for Food Safety & Applied Nutrition. Dietary Supplements. Dec.10, 2002, [http:\/\/vm.cfsan.fda.gov\/~dms\/supplmnt.html]"},{"key":"16_CR2","unstructured":"HealthCanada.: Dept of Justice. Food and Drugs Act. ( R.S. 1985, c. F-27 )."},{"key":"16_CR3","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1046\/j.1365-2125.1998.00715.x","volume":"45","author":"J Barnes","year":"1998","unstructured":"Barnes J, Mills SY, Abbot NC, Willoughby M, Ernst E: Different standards for reporting ADRs to herbal remedies and conventional OTC medicines: face-to-face interviews with 515 users of herbal remedies. Br J Clin Pharmacol. 1998, 45: 496-500. 10.1046\/j.1365-2125.1998.00715.x.","journal-title":"Br J Clin Pharmacol"},{"key":"16_CR4","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1046\/j.1365-2125.1999.00060.x","volume":"48","author":"IA Eland","year":"1999","unstructured":"Eland IA, Belton KJ, van Grootheest AC, Meiners AP, Rawlins MD, Stricker BH: Attitudinal survey of voluntary reporting of adverse drug reactions. Br J Clin Pharmacol. 1999, 48: 623-627. 10.1046\/j.1365-2125.1999.00060.x.","journal-title":"Br J Clin Pharmacol"},{"key":"16_CR5","doi-asserted-by":"crossref","unstructured":"Improving ADR reporting. Lancet. 2002, 360: 1435-10.1016\/S0140-6736(02)11485-1.","DOI":"10.1016\/S0140-6736(02)11485-1"},{"key":"16_CR6","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1016\/S0735-1097(86)80293-5","volume":"8","author":"PL Canner","year":"1986","unstructured":"Canner PL, Berge KG, Wenger NK, Stamler J, Friedman L, Prineas RJ, Friedewald W: Fifteen year mortality in Coronary Drug Project patients: long-term benefit with niacin. J Am Coll Cardiol. 1986, 8: 1245-1255.","journal-title":"J Am Coll Cardiol"},{"key":"16_CR7","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1016\/S0002-9149(01)02338-4","volume":"89","author":"ML Kashyap","year":"2002","unstructured":"Kashyap ML, McGovern ME, Berra K, Guyton JR, Kwiterovich PO, Harper WL, Toth PD, Favrot LK, Kerzner B, Nash SD, Bays HE, Simmons PD: Long-term safety and efficacy of a once-daily niacin\/lovastatin formulation for patients with dyslipidemia. Am J Cardiol. 2002, 89: 672-678. 10.1016\/S0002-9149(01)02338-4.","journal-title":"Am J Cardiol"},{"key":"16_CR8","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1056\/NEJMoa011090","volume":"345","author":"BG Brown","year":"2001","unstructured":"Brown BG, Zhao XQ, Chait A, Fisher LD, Cheung MC, Morse JS, Dowdy AA, Marino EK, Bolson EL, Alaupovic P, Frohlich J, Albers JJ: Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med. 2001, 345: 1583-1592. 10.1056\/NEJMoa011090.","journal-title":"N Engl J Med"},{"key":"16_CR9","doi-asserted-by":"publisher","first-page":"E9050","DOI":"10.1161\/hc4901.103512","volume":"104","author":"R SoRelle","year":"2001","unstructured":"SoRelle R: Niacin-simvastatin combination benefits patients with coronary artery disease. Circulation. 2001, 104: E9050-60.","journal-title":"Circulation"},{"key":"16_CR10","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/0090-6980(89)90088-9","volume":"38","author":"JD Morrow","year":"1989","unstructured":"Morrow JD, Parsons W. G., 3rd, Roberts L. J., 2nd: Release of markedly increased quantities of prostaglandin D2 in vivo in humans following the administration of nicotinic acid. Prostaglandins. 1989, 38: 263-274. 10.1016\/0090-6980(89)90088-9.","journal-title":"Prostaglandins"},{"key":"16_CR11","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1111\/1523-1747.ep12499963","volume":"98","author":"JD Morrow","year":"1992","unstructured":"Morrow JD, Awad JA, Oates JA, Roberts L. J., 2nd: Identification of skin as a major site of prostaglandin D2 release following oral administration of niacin in humans. J Invest Dermatol. 1992, 98: 812-815.","journal-title":"J Invest Dermatol"},{"key":"16_CR12","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1046\/j.1525-1497.1997.07118.x","volume":"12","author":"PW Jungnickel","year":"1997","unstructured":"Jungnickel PW, Maloley PA, Vander Tuin EL, Peddicord TE, Campbell JR: Effect of two aspirin pretreatment regimens on niacin-induced cutaneous reactions. J Gen Intern Med. 1997, 12: 591-596. 10.1046\/j.1525-1497.1997.07118.x.","journal-title":"J Gen Intern Med"},{"key":"16_CR13","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1097\/00045391-199506000-00006","volume":"2","author":"RT Dunn","year":"1995","unstructured":"Dunn RT, Ford MA, Rindone JP, Kwiecinski FA: Low-Dose Aspirin and Ibuprofen Reduce the Cutaneous Reactions Following Niacin Administration. Am J Ther. 1995, 2: 478-480.","journal-title":"Am J Ther"},{"key":"16_CR14","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1001\/jama.1994.03510330050033","volume":"271","author":"JM McKenney","year":"1994","unstructured":"McKenney JM, Proctor JD, Harris S, Chinchili VM: A comparison of the efficacy and toxic effects of sustained- vs immediate-release niacin in hypercholesterolemic patients. Jama. 1994, 271: 672-677. 10.1001\/jama.271.9.672.","journal-title":"Jama"},{"key":"16_CR15","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1097\/00004836-198710000-00022","volume":"9","author":"GL Clementz","year":"1987","unstructured":"Clementz GL, Holmes AW: Nicotinic acid-induced fulminant hepatic failure. J Clin Gastroenterol. 1987, 9: 582-584.","journal-title":"J Clin Gastroenterol"},{"key":"16_CR16","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1046\/j.1563-258X.2002.01112.x","volume":"152","author":"E Ernst","year":"2002","unstructured":"Ernst E, Pittler MH: Risks associated with herbal medicinal products. Wien Med Wochenschr. 2002, 152: 183-189. 10.1046\/j.1563-258X.2002.01112.x.","journal-title":"Wien Med Wochenschr"},{"key":"16_CR17","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1046\/j.1472-8206.2002.00066.x","volume":"16","author":"JK Aronson","year":"2002","unstructured":"Aronson JK, Derry S, Loke YK: Adverse drug reactions: keeping up to date. Fundam Clin Pharmacol. 2002, 16: 49-56. 10.1046\/j.1472-8206.2002.00066.x.","journal-title":"Fundam Clin Pharmacol"},{"key":"16_CR18","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1136\/bmj.312.7028.442b","volume":"312","author":"R Bracchi","year":"1996","unstructured":"Bracchi R: Drug companies should report side effects in terms of frequency. Bmj. 1996, 312: 442-","journal-title":"Bmj"},{"key":"16_CR19","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/S0885-3924(99)00093-7","volume":"18","author":"JE Edwards","year":"1999","unstructured":"Edwards JE, McQuay HJ, Moore RA, Collins SL: Reporting of adverse effects in clinical trials should be improved: lessons from acute postoperative pain. J Pain Symptom Manage. 1999, 18: 427-437. 10.1016\/S0885-3924(99)00093-7.","journal-title":"J Pain Symptom Manage"},{"key":"16_CR20","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1471-2288-1-7","volume":"1","author":"S Derry","year":"2001","unstructured":"Derry S, Kong Loke Y, Aronson JK: Incomplete evidence: the inadequacy of databases in tracing published adverse drug reactions in clinical trials. BMC Med Res Methodol. 2001, 1: 7-10.1186\/1471-2288-1-7.","journal-title":"BMC Med Res Methodol"},{"key":"16_CR21","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1046\/j.1365-2753.2001.00295.x","volume":"7","author":"A Figueiras","year":"2001","unstructured":"Figueiras A, Tato F, Fontainas J, Takkouche B, Gestal-Otero JJ: Physicians' attitudes towards voluntary reporting of adverse drug events. J Eval Clin Pract. 2001, 7: 347-354. 10.1046\/j.1365-2753.2001.00295.x.","journal-title":"J Eval Clin Pract"},{"key":"16_CR22","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1345\/aph.1C161","volume":"37","author":"BT Yim","year":"2003","unstructured":"Yim BT, Chong PH: Niacin-ER and lovastatin treatment of hypercholesterolemia and mixed dyslipidemia. Ann Pharmacother. 2003, 37: 106-115. 10.1345\/aph.1C161.","journal-title":"Ann Pharmacother"},{"key":"16_CR23","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1016\/S0002-9149(03)00318-7","volume":"91","author":"DM Capuzzi","year":"2003","unstructured":"Capuzzi DM, Morgan JM, Weiss RJ, Chitra RR, Hutchinson HG, Cressman MD: Beneficial effects of rosuvastatin alone and in combination with extended-release niacin in patients with a combined hyperlipidemia and low high-density lipoprotein cholesterol levels. Am J Cardiol. 2003, 91: 1304-1310. 10.1016\/S0002-9149(03)00318-7.","journal-title":"Am J Cardiol"}],"container-title":["BMC Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6904-3-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1472-6904-3-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6904-3-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6904-3-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T12:05:51Z","timestamp":1726229151000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/1472-6904-3-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,11,13]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2003,12]]}},"alternative-id":["16"],"URL":"https:\/\/doi.org\/10.1186\/1472-6904-3-4","relation":{},"ISSN":["1472-6904"],"issn-type":[{"value":"1472-6904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,11,13]]},"assertion":[{"value":"31 July 2003","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2003","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2003","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"4"}}