{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T09:53:57Z","timestamp":1775210037628,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,10,25]],"date-time":"2010-10-25T00:00:00Z","timestamp":1287964800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Educ"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Computer-based teaching (CBT) is a well-known educational device, but it has never been applied systematically to the teaching of a complex, rare, genetic disease, such as Hunter disease (MPS II).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Aim<\/jats:title>\n            <jats:p>To develop interactive teaching software functioning as a virtual clinic for the management of MPS II.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Implementation and Results<\/jats:title>\n            <jats:p>The <jats:italic>Hunter disease eClinic<\/jats:italic>, a self-training, user-friendly educational software program, available at the Lysosomal Storage Research Group (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.lysosomalstorageresearch.ca\" ext-link-type=\"uri\">http:\/\/www.lysosomalstorageresearch.ca<\/jats:ext-link>), was developed using the Adobe Flash multimedia platform. It was designed to function both to provide a realistic, interactive virtual clinic and instantaneous access to supporting literature on Hunter disease. The <jats:italic>Hunter disease eClinic<\/jats:italic> consists of an <jats:italic>eBook<\/jats:italic> and an <jats:italic>eClinic<\/jats:italic>. The <jats:italic>eClinic<\/jats:italic> is the interactive virtual clinic component of the software. Within an environment resembling a real clinic, the trainee is instructed to perform a medical history, to examine the patient, and to order appropriate investigation. The program provides clinical data derived from the management of actual patients with Hunter disease. The <jats:italic>eBook<\/jats:italic> provides instantaneous, electronic access to a vast collection of reference information to provide detailed background clinical and basic science, including relevant biochemistry, physiology, and genetics. In the <jats:italic>eClinic<\/jats:italic>, the trainee is presented with quizzes designed to provide immediate feedback on both trainee effectiveness and efficiency. User feedback on the merits of the program was collected at several seminars and formal clinical rounds at several medical centres, primarily in Canada. In addition, online usage statistics were documented for a 2-year period. Feedback was consistently positive and confirmed the practical benefit of the program. The online English-language version is accessed daily by users from all over the world; a Japanese translation of the program is also available.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>The Hunter disease <jats:italic>eClinic<\/jats:italic> employs a CBT model providing the trainee with realistic clinical problems, coupled with comprehensive basic and clinical reference information by instantaneous access to an electronic textbook, the <jats:italic>eBook<\/jats:italic>. The program was rated highly by attendees at national and international presentations. It provides a potential model for use as an educational approach to other rare genetic diseases.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1472-6920-10-72","type":"journal-article","created":{"date-parts":[[2010,10,26]],"date-time":"2010-10-26T06:16:00Z","timestamp":1288073760000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Hunter disease eClinic:interactive, computer-assisted, problem-based approach to independent learning about a rare genetic disease"],"prefix":"10.1186","volume":"10","author":[{"given":"Fatma","family":"Al-Jasmi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Moldovan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joe TR","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,10,25]]},"reference":[{"key":"421_CR1","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1016\/j.jpeds.2004.01.049","volume":"144","author":"WR Wilcox","year":"2004","unstructured":"Wilcox WR: Lysosomal storage disorders: the need for better pediatric recognition and comprehensive care. 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