{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T09:27:34Z","timestamp":1758274054200,"version":"3.37.3"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,10,27]],"date-time":"2013-10-27T00:00:00Z","timestamp":1382832000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Inform Decis Mak"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>As the amount of information in electronic health care systems increases, data operations get more complicated and time-consuming. Intensive Care platforms require a timely processing of data retrievals to guarantee the continuous display of recent data of patients. Physicians and nurses rely on this data for their decision making. Manual optimization of query executions has become difficult to handle due to the increased amount of queries across multiple sources. Hence, a more automated management is necessary to increase the performance of database queries. The autonomic computing paradigm promises an approach in which the system adapts itself and acts as self-managing entity, thereby limiting human interventions and taking actions. Despite the usage of autonomic control loops in network and software systems, this approach has not been applied so far for health information systems.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We extend the COSARA architecture, an infection surveillance and antibiotic management service platform for the Intensive Care Unit (ICU), with self-managed components to increase the performance of data retrievals. We used real-life ICU COSARA queries to analyse slow performance and measure the impact of optimizations. Each day more than 2 million COSARA queries are executed. Three control loops, which monitor the executions and take action, have been proposed: reactive, deliberative and reflective control loops. We focus on improvements of the execution time of microbiology queries directly related to the visual displays of patients\u2019 data on the bedside screens.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The results show that autonomic control loops are beneficial for the optimizations in the data executions in the ICU. The application of reactive control loop results in a reduction of 8.61% of the average execution time of microbiology results. The combined application of the reactive and deliberative control loop results in an average query time reduction of 10.92% and the combination of reactive, deliberative and reflective control loops provides a reduction of 13.04%.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>We found that by controlled reduction of queries\u2019 executions the performance for the end-user can be improved. The implementation of autonomic control loops in an existing health platform, COSARA, has a positive effect on the timely data visualization for the physician and nurse.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1472-6947-13-120","type":"journal-article","created":{"date-parts":[[2013,10,27]],"date-time":"2013-10-27T15:30:44Z","timestamp":1382887844000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Autonomic care platform for optimizing query performance"],"prefix":"10.1186","volume":"13","author":[{"given":"Kristof","family":"Steurbaut","sequence":"first","affiliation":[]},{"given":"Steven","family":"Latr\u00e9","sequence":"additional","affiliation":[]},{"given":"Johan","family":"Decruyenaere","sequence":"additional","affiliation":[]},{"given":"Filip De","family":"Turck","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2013,10,27]]},"reference":[{"key":"899_CR1","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1109\/MC.2003.1160055","volume":"36","author":"JO Kephart","year":"2003","unstructured":"Kephart JO, Chess DM: The vision of autonomic computing. Computer. 2003, 36: 41-50. 10.1109\/MC.2003.1160055.http:\/\/dx.doi.org\/10.1109\/MC.2003.1160055,","journal-title":"Computer"},{"issue":"6","key":"899_CR2","doi-asserted-by":"publisher","first-page":"3765","DOI":"10.1007\/s10916-012-9849-8","volume":"36","author":"K Steurbaut","year":"2012","unstructured":"Steurbaut K, Colpaert K, Gadeyne B, Depuydt P, Vosters P, Danneels C, Benoit D, Decruyenaere J, De Turck F: COSARA: integrated service platform for infection surveillance and antibiotic management in the ICU. J Med Syst. 2012, 36 (6): 3765-3775. 10.1007\/s10916-012-9849-8.http:\/\/dx.doi.org\/10.1007\/s10916-012-9849-8,","journal-title":"J Med Syst"},{"key":"899_CR3","first-page":"130","volume-title":"Computational Intelligence for Modelling, Control and Automation, 2006 and International Conference on Intelligent Agents, Web Technologies and Internet Commerce, International Conference on","author":"G Pour","year":"2006","unstructured":"Pour G: Prospects for expanding telehealth: multi-agent autonomic architectures. Computational Intelligence for Modelling, Control and Automation, 2006 and International Conference on Intelligent Agents, Web Technologies and Internet Commerce, International Conference on. 2006, Sydney: IEEE, 130-130.http:\/\/dx.doi.org\/10.1109\/CIMCA.2006.166,"},{"key":"899_CR4","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1109\/ICDCSW.2006.17","volume-title":"26th IEEE International Conference on Distributed Computing Systems Workshops (ICDCSW'06)","author":"S Strowes","year":"2006","unstructured":"Strowes S, Badr N, Heeps S, Lupu E, Sloman M: An event service supporting Autonomic Management of Ubiquitous Systems for e-Health. 26th IEEE International Conference on Distributed Computing Systems Workshops (ICDCSW'06). 2006, Lisbon: IEEE, 22-22.http:\/\/dx.doi.org\/10.1109\/ICDCSW.2006.17,"},{"issue":"3","key":"899_CR5","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1002\/cpe.1194","volume":"20","author":"E Lupu","year":"2008","unstructured":"Lupu E, Dulay N, Sloman M, Sventek J, Heeps S, Strowes S, Twidle K, Keoh SL, Filho AS: AMUSE: Autonomic Management of Ubiquitous e-Health Systems. Concurr Comput Pract Exper. 2008, 20 (3): 277-295. 10.1002\/cpe.1194.http:\/\/dx.doi.org\/10.1002\/cpe.v20:3,","journal-title":"Concurr Comput Pract Exper"},{"key":"899_CR6","first-page":"1","volume-title":"Proceedings of the 3d International ICST Conference on Pervasive Computing Technologies for Healthcare","author":"Y Zhu","year":"2009","unstructured":"Zhu Y, Sloman M, Lupu E, Loong Keoh S: Vesta: A secure and autonomic system for pervasive healthcare. Proceedings of the 3d International ICST Conference on Pervasive Computing Technologies for Healthcare. 2009, London: ICST, 1-8.http:\/\/dx.doi.org\/10.4108\/ICST.PERVASIVEHEALTH2009.5939,"},{"key":"899_CR7","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1109\/EASE.2007.7","volume-title":"Fourth IEEE International Workshop on Engineering of Autonomic and Autonomous Systems (EASe'07)","author":"WM Omar","year":"2007","unstructured":"Omar WM, Samir K, Taleb-Bendiab A: Autonomic model for managing complex healthcare applications. Fourth IEEE International Workshop on Engineering of Autonomic and Autonomous Systems (EASe'07). 2007, Newcastle-under-Lyme: IEEE, 94-98.http:\/\/dx.doi.org\/10.1109\/EASE.2007.7,"},{"key":"899_CR8","first-page":"52","volume-title":"HEALTHINF","author":"S Almomen","year":"2011","unstructured":"Almomen S, Menasc\u00e9 DA: An autonomic computing framework for self-managed emergency departments. HEALTHINF. Edited by: Traver V, Fred ALN, Filipe J, Gamboa H, Traver V, Fred ALN, Gamboa H. 2011, Rome: SciTePress, 52-60. [http:\/\/dblp.uni-trier.de\/rec\/bibtex\/conf\/biostec\/AlmomenM11],"},{"key":"899_CR9","first-page":"102","volume-title":"HEALTHINF Volume 6155 of Lecture Notes in Computer Science","author":"P Arozarena","year":"2010","unstructured":"Arozarena P, Toribio R, Kielthy J, Quinn K, Zach M: Probabilistic fault diagnosis in the MAGNETO autonomic control loop mechanisms for autonomous management of networks and services. HEALTHINF Volume 6155 of Lecture Notes in Computer Science. 2010, Berlin, Heidelberg: Springer Berlin \/ Heidelberg, 102-105.http:\/\/dx.doi.org\/10.1007\/978-3-642-13986-4_14,"},{"issue":"2","key":"899_CR10","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1109\/SURV.2011.042711.00078","volume":"14","author":"Z Movahedi","year":"2012","unstructured":"Movahedi Z, Ayari M, Langar R, Pujolle G: A survey of autonomic network architectures and evaluation criteria. Commun Surv Tutorials, IEEE. 2012, 14 (2): 464-490.http:\/\/dx.doi.org\/10.1109\/SURV.2011.042711.00078,","journal-title":"Commun Surv Tutorials, IEEE"},{"key":"899_CR11","first-page":"5","volume-title":"Communications Surveys & Tutorials, IEEE, SpringerBriefs in Computer Science","author":"CC Marquezan","year":"2012","unstructured":"Marquezan CC, Granville LZ: State of the art self-* and P2P for network management. Communications Surveys & Tutorials, IEEE, SpringerBriefs in Computer Science. 2012, London: Springer London, 5-25.http:\/\/dx.doi.org\/10.1007\/978-1-4471-4201-0_2,"},{"key":"899_CR12","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1109\/COMPSACW.2010.72","volume-title":"Computer Software and Applications Conference Workshops (COMPSACW) 2010 IEEE 34th Annual","author":"D Smith","year":"2010","unstructured":"Smith D, Guan Q, Fu S: An anomaly detection framework for autonomic management of compute cloud systems. Computer Software and Applications Conference Workshops (COMPSACW) 2010 IEEE 34th Annual. 2010, IEEE, 376-381.http:\/\/dx.doi.org\/10.1109\/COMPSACW.2010.72,"},{"issue":"3","key":"899_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1145\/1541880.1541882","volume":"41","author":"V Chandola","year":"2009","unstructured":"Chandola V, Banerjee A, Kumar V: Anomaly detection: a survey. ACM Comput Surv. 2009, 41 (3): 1-72.http:\/\/dx.doi.org\/10.1145\/1541880.1541882,","journal-title":"ACM Comput Surv"},{"issue":"6","key":"899_CR14","doi-asserted-by":"publisher","first-page":"7003","DOI":"10.1016\/j.eswa.2010.12.014","volume":"38","author":"J Rabatel","year":"2011","unstructured":"Rabatel J, Bringay S, Poncelet P: Anomaly detection in monitoring sensor data for preventive maintenance. Expert Syst with Appl. 2011, 38 (6): 7003-7015. 10.1016\/j.eswa.2010.12.014.http:\/\/dx.doi.org\/10.1016\/j.eswa.2010.12.014,","journal-title":"Expert Syst with Appl"},{"key":"899_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1109\/ICUMT.2009.5345533","volume-title":"Ultra Modern Telecommunications &amp; Workshops, 2009, ICUMT. International Conference on","author":"J Strassner","year":"2009","unstructured":"Strassner J, Hong JWK, van der Meer S: The design of an autonomic element for managing emerging networks and services. Ultra Modern Telecommunications &amp; Workshops, 2009, ICUMT. International Conference on. 2009, Saint-Petersburg: IEEE, 1-8.http:\/\/dx.doi.org\/10.1109\/ICUMT.2009.5345533,"},{"key":"899_CR16","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1109\/NOMS.2012.6212036","volume-title":"Network Operations and Management Symposium (NOMS) 2012 IEEE","author":"SS Kim","year":"2012","unstructured":"Kim SS, Seo S s, Kang JM, Hong JWK: Autonomic fault management based on cognitive control loops. Network Operations and Management Symposium (NOMS) 2012 IEEE. 2012, Maui: IEEE, 1104-1110.http:\/\/dx.doi.org\/10.1109\/NOMS.2012.6212036,"},{"key":"899_CR17","first-page":"114","volume-title":"Modelling Autonomic Communications Environments Volume 5276 of Lecture Notes in Computer Science","author":"JA Lozano","year":"2008","unstructured":"Lozano JA, Castro A, Gonz\u00e1lez JM, L\u00f3pez de Vergara JE, Villagr\u00e1 VA, Olmedo V: Autonomic Provisioning Model for Digital Home Services Modelling Autonomic Communications Environments. Modelling Autonomic Communications Environments Volume 5276 of Lecture Notes in Computer Science. Edited by: Meer S, Burgess M, Denazis S. 2008, Berlin, Heidelberg: Springer, Berlin \/ Heidelberg, 114-119.http:\/\/dx.doi.org\/10.1007\/978-3-540-87355-6_11,"},{"key":"899_CR18","volume-title":"In Proceedings of the 1997 European Conference on Arti Life (ECAL-97)","author":"A Sloman","year":"1997","unstructured":"Sloman A: Designing human-like minds. In Proceedings of the 1997 European Conference on Arti Life (ECAL-97). 1997, Brighton, Heidelberg: Springer Berlin, [http:\/\/citeseerx.ist.psu.edu\/viewdoc\/summary?doi=10.1.1.210.3370],"},{"issue":"4","key":"899_CR19","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1002\/nem.805","volume":"22","author":"J Famaey","year":"2012","unstructured":"Famaey J, Latr\u00e9 S, Strassner J, Turck FD: Semantic context dissemination and service matchmaking in future network management. Int J Netw Manag. 2012, 22 (4): 285-310. 10.1002\/nem.805.http:\/\/dx.doi.org\/10.1002\/nem.805,","journal-title":"Int J Netw Manag"},{"issue":"6","key":"899_CR20","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1109\/JCN.2011.6157472","volume":"13","author":"T Choi","year":"2011","unstructured":"Choi T, Lee TH, Kodirov N, Lee J, Kim D, Kang JM, Kim S, Strassner J, Hong JK: HiMang: Highly manageable network and service architecture for new generation. Commun Netw, J. 2011, 13 (6): 552-566.","journal-title":"Commun Netw, J"},{"key":"899_CR21","volume-title":"Int J Netw Manag","author":"S Kim","year":"2013","unstructured":"Kim S, Kang JM, Seo S s, Hong JWK: A cognitive model-based approach for autonomic fault management in OpenFlow networks. Int J Netw Manag. 2013. pre\u2013print,http:\/\/dx.doi.org\/10.1002\/nem.1839,"},{"key":"899_CR22","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/978-0-387-79361-0_7","volume-title":"Performance Modeling and Engineering","author":"T Abdelzaher","year":"2008","unstructured":"Abdelzaher T, Diao Y, Hellerstein J, Lu C, Zhu X: Introduction to control theory and its application to computing systems. Performance Modeling and Engineering. Edited by: Liu Z, Xia C. 2008, US: Springer, 185-215.http:\/\/dx.doi.org\/10.1007\/978-0-387-79361-0_7,"},{"issue":"3","key":"899_CR23","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1109\/MCS.2003.1200252","volume":"23","author":"T Abdelzaher","year":"2003","unstructured":"Abdelzaher T, Stankovic J, Lu C, Zhang R, Lu Y: Feedback performance control in software services. Control Syst IEEE. 2003, 23 (3): 74-90. 10.1109\/MCS.2003.1200252.","journal-title":"Control Syst IEEE"},{"issue":"9","key":"899_CR24","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1109\/TPDS.2006.123","volume":"17","author":"C Lu","year":"2006","unstructured":"Lu C, Lu Y, Abdelzaher T, Stankovic J, Son SH: Feedback control architecture and design methodology for service delay guarantees in web Servers. Parallel Distributed Syst IEEE Trans. 2006, 17 (9): 1014-1027.","journal-title":"Parallel Distributed Syst IEEE Trans"},{"issue":"3","key":"899_CR25","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1145\/1710115.1710123","volume":"37","author":"JL Hellerstein","year":"2010","unstructured":"Hellerstein JL, Morrison V, Eilebrecht E: Applying control theory in the real world: experience with building a controller for the.NET thread pool. SIGMETRICS Perform Eval Rev. 2010, 37 (3): 38-42. 10.1145\/1710115.1710123.http:\/\/doi.acm.org\/10.1145\/1710115.1710123,","journal-title":"SIGMETRICS Perform Eval Rev"},{"key":"899_CR26","first-page":"841","volume-title":"Integrated Network Management Proceedings, 2001, IEEE\/IFIP International Symposium on","author":"S Parekh","year":"2001","unstructured":"Parekh S, Gandhi N, Hellerstein J, Tilbury D, Jayram T, Bigus J: Using control theory to achieve service level objectives in performance management. Integrated Network Management Proceedings, 2001, IEEE\/IFIP International Symposium on. 2001, Seattle: IEEE, 841-854."},{"key":"899_CR27","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/S1389-1286(00)00151-1","volume":"35","author":"JL Hellerstein","year":"2001","unstructured":"Hellerstein JL, Zhang F, Shahabuddin P: A statistical approach to predictive detection. Comput Netw. 2001, 35: 77-95. 10.1016\/S1389-1286(00)00151-1. [http:\/\/www.sciencedirect.com\/science\/article\/pii\/S1389128600001511],","journal-title":"Comput Netw"},{"key":"899_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1109\/ICTTA.2008.4530359","volume-title":"Information and Communication Technologies: From Theory to Applications, 2008. ICTTA 2008. 3rd International Conference on","author":"A Hameurlain","year":"2008","unstructured":"Hameurlain A, Morvan F, El Samad M: Large scale data management in grid systems: a survey. Information and Communication Technologies: From Theory to Applications, 2008. ICTTA 2008. 3rd International Conference on. 2008, Damascus, 1-6."},{"key":"899_CR29","volume-title":"The VLDB J","author":"C Doulkeridis","year":"2013","unstructured":"Doulkeridis C, N\u00f8rv\u00e5g K: A survey of large-scale analytical query processing in MapReduce. The VLDB J. 2013. pre\u2013print,http:\/\/dx.doi.org\/10.1007\/s00778-013-0319-9,"},{"issue":"7","key":"899_CR30","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1016\/j.future.2011.08.014","volume":"28","author":"NW Paton","year":"2012","unstructured":"Paton NW, de Arag\u00e3o MA, Fernandes AA: Utility-driven adaptive query workload execution. Future Generat Comput Syst. 2012, 28 (7): 1070-1079. 10.1016\/j.future.2011.08.014. [http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0167739X11002123],","journal-title":"Future Generat Comput Syst"},{"key":"899_CR31","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.datak.2011.07.008","volume":"71","author":"HK Park","year":"2012","unstructured":"Park HK, Lee WS: Adaptive optimization for multiple continuous queries. Data Knowl Eng. 2012, 71: 29-46. 10.1016\/j.datak.2011.07.008. [http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0169023X11001054],","journal-title":"Data Knowl Eng"},{"key":"899_CR32","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1145\/342009.335420","volume-title":"Proceedings of the 2000 ACM SIGMOD International Conference on Management of Data, SIGMOD \u201900","author":"R Avnur","year":"2000","unstructured":"Avnur R, Hellerstein JM: Eddies: continuously adaptive query processing. Proceedings of the 2000 ACM SIGMOD International Conference on Management of Data, SIGMOD \u201900. 2000, New York: ACM, 261-272.http:\/\/doi.acm.org\/10.1145\/342009.335420,"},{"key":"899_CR33","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/0925-5273(93)90007-8","volume":"32","author":"V Suresh","year":"1993","unstructured":"Suresh V, Chaudhuri D: Dynamic scheduling\u2014a survey of research. Int J Production Econom. 1993, 32: 53-63. 10.1016\/0925-5273(93)90007-8. [http:\/\/www.sciencedirect.com\/science\/article\/pii\/0925527393900078],","journal-title":"Int J Production Econom"},{"key":"899_CR34","first-page":"419","volume-title":"Advances in Data and Web Management, Volume 4505 of Lecture Notes in Computer Science","author":"C Jiang","year":"2007","unstructured":"Jiang C, Wang C, Liu X, Zhao Y: A survey of job scheduling in grids. Advances in Data and Web Management, Volume 4505 of Lecture Notes in Computer Science. Edited by: Dong G, Lin X, Wang W, Yang Y, Yu J. 2007, Heidelberg: Springer Berlin, 419-427.http:\/\/dx.doi.org\/10.1007\/978-3-540-72524-4_44,"},{"key":"899_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1145\/1645164.1645167","volume-title":"Proceedings of the 4th Workshop on Workflows in Support of Large-Scale Science, WORKS '09","author":"S Bharathi","year":"2009:3","unstructured":"Bharathi S, Chervenak A: Scheduling data-intensive workflows on storage constrained resources. Proceedings of the 4th Workshop on Workflows in Support of Large-Scale Science, WORKS '09. 2009:3, New York: ACM, 1-3:10.http:\/\/doi.acm.org\/10.1145\/1645164.1645167,"},{"key":"899_CR36","volume-title":"18th Australasian Conference on Information Systems","author":"K Kerr","year":"2007","unstructured":"Kerr K, Norris T, Stockdale R: Data quality information and decision making: A Healthcare case study. 18th Australasian Conference on Information Systems. 2007, Melbourne: Association for Information Systems Research"},{"key":"899_CR37","volume-title":"Proceedings of the AMIA Annual Symposium","author":"A Rector","year":"2003","unstructured":"Rector A, Rogers J, Zanstra P, Van der Haring E: OpenGALEN: open source medical terminology and tools. Proceedings of the AMIA Annual Symposium. 2003, American Medical Informatics Association: Washington"}],"container-title":["BMC Medical Informatics and Decision Making"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6947-13-120.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1472-6947-13-120\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6947-13-120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1472-6947-13-120.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T20:08:23Z","timestamp":1630613303000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmedinformdecismak.biomedcentral.com\/articles\/10.1186\/1472-6947-13-120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,27]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["899"],"URL":"https:\/\/doi.org\/10.1186\/1472-6947-13-120","relation":{},"ISSN":["1472-6947"],"issn-type":[{"type":"electronic","value":"1472-6947"}],"subject":[],"published":{"date-parts":[[2013,10,27]]},"assertion":[{"value":"22 February 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 October 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"120"}}