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This approach is applied to data on Type 2 diabetes screening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Good convergence of estimations is demonstrated. In contrast to previous Markov models, the major advantage of our proposed method is that integrating the prevalence pool equation (that the numbers entering the prevalence pool is equal to the number leaving it) into the likelihood function not only simplifies the likelihood function but makes estimation of parameters stable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This approach may be useful in quantifying the progression of a variety of chronic diseases.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1472-6947-7-34","type":"journal-article","created":{"date-parts":[[2007,11,9]],"date-time":"2007-11-09T07:13:25Z","timestamp":1194592405000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Estimation of progression of multi-state chronic disease using the Markov model and prevalence pool concept"],"prefix":"10.1186","volume":"7","author":[{"given":"Hui-Chuan","family":"Shih","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pesus","family":"Chou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Ming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao-Hsin","family":"Tung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,11,9]]},"reference":[{"key":"165_CR1","doi-asserted-by":"publisher","first-page":"307","DOI":"10.2307\/2988469","volume":"45","author":"HH Chen","year":"1996","unstructured":"Chen HH, Duffy SW, Tabar L: A Markov chain method to estimate the tumour progression rate from preclinical to clinical phase, sensitivity and positive predictive value for mammography in breast cancer screening. 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