{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:55:03Z","timestamp":1789836903725,"version":"4.0.1"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Gen Hosp Psychiatry"],"DOI":"10.1186\/1475-2832-3-2","type":"journal-article","created":{"date-parts":[[2004,2,17]],"date-time":"2004-02-17T07:21:33Z","timestamp":1077002493000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":111,"title":["Fluoxetine: a review on evidence based medicine"],"prefix":"10.1186","volume":"3","author":[{"given":"Andrea","family":"Rossi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Barraco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Donda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2004,2,12]]},"reference":[{"key":"170_CR1","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/0024-3205(95)00209-O","volume":"57","author":"DT Wong","year":"1995","unstructured":"Wong DT, Bymaster FP, Engleman EA: Minireview: Prozac (Fluoxetine, Lilly 110140), the first selective selective serotonin uptake inhibitor and an antidepressant drug: twenty years since its first publication. Life Sci. 1995, 57: 411-441. 10.1016\/0024-3205(95)00209-O.","journal-title":"Life Sci"},{"key":"170_CR2","first-page":"49","volume":"38","author":"BH Guze","year":"1994","unstructured":"Guze BH, Gitlin M: New antidepressants and the treatment of depression. J Fam Pract. 1994, 38: 49-57.","journal-title":"J Fam Pract"},{"key":"170_CR3","first-page":"32","volume-title":"In: Drugs used in mood disorders. Drug evaluation subscription","author":"American Medical Association","year":"1992","unstructured":"American Medical Association: Psychopharmacologic drugs. In: Drugs used in mood disorders. Drug evaluation subscription. 1992, Chicago Ill, 1: 32-"},{"key":"170_CR4","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3102\/0013189X005010003","volume":"5","author":"GV Glass","year":"1976","unstructured":"Glass GV: Primary, secondary and meta-analysis of research. Educ Res. 1976, 5: 3-9.","journal-title":"Educ Res"},{"issue":"1","key":"170_CR5","doi-asserted-by":"publisher","first-page":"81","DOI":"10.2165\/00003495-200161010-00010","volume":"61","author":"SM Cheer","year":"2001","unstructured":"Cheer SM, Goa KL: Fluoxetine: A review of its therapeutic potential in the treatment of depression associated with physical illness. Drugs. 2001, 61 (1): 81-110.","journal-title":"Drugs"},{"issue":"4","key":"170_CR6","doi-asserted-by":"publisher","first-page":"301","DOI":"10.2165\/00023210-200014040-00005","volume":"14","author":"K Simpson","year":"2000","unstructured":"Simpson K, Noble S: Fluoxetine: A review of its use in women's health. CNS Drugs. 2000, 14 (4): 301-328.","journal-title":"CNS Drugs"},{"issue":"5","key":"170_CR7","doi-asserted-by":"publisher","first-page":"543","DOI":"10.2165\/00019053-199813050-00007","volume":"13","author":"MI Wilde","year":"1998","unstructured":"Wilde MI, Benfield P: Fluoxetine: A pharmacoeconomic review of its use in depression. PharmacoEconomics. 1998, 13 (5): 543-561.","journal-title":"PharmacoEconomics"},{"issue":"5","key":"170_CR8","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1016\/S0149-2918(97)80066-5","volume":"19","author":"PE Stokes","year":"1997","unstructured":"Stokes PE, Holtz A: Fluoxetine tenth anniversary update: The progress continues. Clinical Therapeutics. 1997, 19 (5): 1135-1150. 10.1016\/S0149-2918(97)80066-5.","journal-title":"Clinical Therapeutics"},{"issue":"4","key":"170_CR9","first-page":"173","volume":"3","author":"LV Scott","year":"1997","unstructured":"Scott LV: Fluoxetine: A review of its pharmacology and clinical applications. Journal of Serotonin Research. 1997, 3 (4): 173-191.","journal-title":"Journal of Serotonin Research"},{"issue":"3","key":"170_CR10","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1034\/j.1600-0447.2002.02255.x","volume":"106","author":"A Bakker","year":"2002","unstructured":"Bakker A, Van Balkom AJLM, Spinhoven P: SSRIs vs. TCAs in the treatment of panic disorder: A meta-analysis. Acta Psychiatrica Scandinavica. 2002, 106 (3): 163-167. 10.1034\/j.1600-0447.2002.02255.x.","journal-title":"Acta Psychiatrica Scandinavica"},{"issue":"2-3","key":"170_CR11","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/S0165-0327(01)00354-8","volume":"68","author":"A Khan","year":"2002","unstructured":"Khan A, Leventhal RM, Khan S, Brown WA: Suicide risk in patients with anxiety disorders: A meta-analysis of the FDA database. Journal of Affective Disorders. 2002, 68 (2-3): 183-190. 10.1016\/S0165-0327(01)00354-8.","journal-title":"Journal of Affective Disorders"},{"issue":"2","key":"170_CR12","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/S0165-0327(00)00254-8","volume":"65","author":"TA Furukawa","year":"2001","unstructured":"Furukawa TA, Streiner DL, Young LT: Is antidepressant\u2013benzodiazepine combination therapy clinically more useful? A meta-analytic study. Journal of Affective Disorders. 2001, 65 (2): 173-177. 10.1016\/S0165-0327(00)00254-8.","journal-title":"Journal of Affective Disorders"},{"issue":"SUPPL. 2","key":"170_CR13","doi-asserted-by":"publisher","first-page":"S15","DOI":"10.1097\/00004850-200008002-00004","volume":"15","author":"GJH Van der Linden","year":"2000","unstructured":"Van der Linden GJH, Stein DJ, Van Balkom AJLM: The efficacy of the selective serotonin reuptake inhibitors for social anxiety disorder (social phobia): A meta-analysis of randomized controlled trials. International Clinical Psychopharmacology. 2000, 15 (SUPPL. 2): S15-S23.","journal-title":"International Clinical Psychopharmacology"},{"issue":"6","key":"170_CR14","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1017\/S0033291799001324","volume":"29","author":"MS De Lima","year":"1999","unstructured":"De Lima MS, Hotoph M, Wessely S: The efficacy of drug treatments for dysthymia: A systematic review and meta-analysis. Psychological Medicine. 1999, 29 (6): 1273-1289. 10.1017\/S0033291799001324.","journal-title":"Psychological Medicine"},{"issue":"2","key":"170_CR15","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1007\/BF02908299","volume":"21","author":"LA Rossy","year":"1999","unstructured":"Rossy LA, Buckelew SP, Dorr N, Hagglund KJ, Thayer JF, McIntosh MJ, Hewett JE, Johnson JC: A meta-analysis of fibromyalgia treatment interventions. Annals of Behavioral Medicine. 1999, 21 (2): 180-191.","journal-title":"Annals of Behavioral Medicine"},{"issue":"1","key":"170_CR16","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/S0005-7894(99)80049-5","volume":"30","author":"MC Whittal","year":"1999","unstructured":"Whittal MC, Agras WS, Gould RA: Bulimia nervosa: A meta-analysis of psychosocial and pharmacological treatments. Behavior Therapy. 1999, 30 (1): 117-135.","journal-title":"Behavior Therapy"},{"issue":"SUPPL 1","key":"170_CR17","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1002\/(SICI)1520-6394(1998)7:1+<11::AID-DA4>3.0.CO;2-I","volume":"7","author":"IM Anderson","year":"1998","unstructured":"Anderson IM: SSRIS versus tricyclic antidepressants in depressed inpatients: A meta-analysis of efficacy and tolerability. Depression and Anxiety. 1998, 7 (SUPPL 1): 11-17. 10.1002\/(SICI)1520-6394(1998)7:1+<11::AID-DA4>3.3.CO;2-O.","journal-title":"Depression and Anxiety"},{"issue":"2","key":"170_CR18","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/S0272-7358(01)00089-7","volume":"22","author":"KD Michael","year":"2002","unstructured":"Michael KD, Crowley SL: How effective are treatments for child and adolescent depression? A meta-analytic review. Clinical Psychology Review. 2002, 22 (2): 247-269. 10.1016\/S0272-7358(01)00089-7.","journal-title":"Clinical Psychology Review"},{"issue":"10","key":"170_CR19","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1097\/00005053-199410000-00003","volume":"182","author":"RP Greenberg","year":"1994","unstructured":"Greenberg RP, Bornstein RF, Zborowski MJ, Fisher S, Greenberg MD: A meta-analysis of fluoxetine outcome in the treatment of depression. Journal of Nervous and Mental Disease. 1994, 182 (10): 547-551.","journal-title":"Journal of Nervous and Mental Disease"},{"issue":"7","key":"170_CR20","doi-asserted-by":"crossref","first-page":"404","DOI":"10.5694\/j.1326-5377.1994.tb127518.x","volume":"161","author":"GD Burrows","year":"1994","unstructured":"Burrows GD, Norman TR: Suicide, violent behaviour and fluoxetine: Meta-analysis of clinical trials shows that fluoxetine does not cause or increase suicidal behaviour or violent acts. Medical Journal of Australia. 1994, 161 (7): 404-405.","journal-title":"Medical Journal of Australia"},{"issue":"6804","key":"170_CR21","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1136\/bmj.303.6804.685","volume":"303","author":"CM Beasley Jr","year":"1991","unstructured":"Beasley CM, Dornseif BE, Bosomworth JC, Sayler ME, Rampey AH, Heiligenstein JH, Thompson VL, Murphy DJ, Masica DN: Fluoxetine and suicide: a meta-analysis of controlled trials of treatment for depression. BMJ. 1991, 303 (6804): 685-92.","journal-title":"BMJ"},{"key":"170_CR22","first-page":"247","volume":"57","author":"AE Falsetti","year":"2002","unstructured":"Falsetti AE: Fluoxetine\u2013induced suicidal ideation: An examination of the medical literature, case law, and the legal liability of drug manufacturers. Food and Drug Law J. 2002, 57: 247-267.","journal-title":"Food and Drug Law J"},{"issue":"4","key":"170_CR23","first-page":"569","volume":"30","author":"M Jarema","year":"1996","unstructured":"Jarema M: The use of meta\u2013analysis in the evaluation of antidepressive effects of fluoxetine. Psychiatria Polska. 1996, 30 (4): 569-581.","journal-title":"Psychiatria Polska"},{"issue":"4","key":"170_CR24","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1345\/aph.1A265","volume":"36","author":"R Carr Roxane","year":"2002","unstructured":"Carr Roxane R, Ensom Mary HH: Fluoxetine in the treatment of premenstrual dysphoric disorder. The annals of pharmacotherapy. 2002, 36 (4): 713-7.","journal-title":"The annals of pharmacotherapy"},{"key":"170_CR25","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1093\/bmb\/57.1.161","volume":"57","author":"IM Anderson","year":"2001","unstructured":"Anderson IM: Meta\u2013analytical studies on new antidepressants. British Medical Bulletin. 2001, 57: 161-178. 10.1093\/bmb\/57.1.161.","journal-title":"British Medical Bulletin"},{"key":"170_CR26","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1097\/00004714-199004000-00008","volume":"10","author":"MA Jenike","year":"1990","unstructured":"Jenike MA, Bear L, Greist JH: Clomipramine versus fluoxetine in obsessive-compulsive disorder: A retrospective comparison of side effects and efficacy. Journal of Clinical Psychopharmacology. 1990, 10: 122-124.","journal-title":"Journal of Clinical Psychopharmacology"},{"issue":"10","key":"170_CR27","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1001\/archpsyc.1984.01790210041006","volume":"41","author":"JK Myers","year":"1984","unstructured":"Myers JK, Weissman MM, Tischler GL, Holzer CE, Leaf PJ, Orvaschel H, Anthony JC, Boyd JH, Burke JD, Kramer M, et al: Six-month prevalence of psychiatric disorders in three communities 1980 to 1982. Archives of General Psychiatry. 1984, 41 (10): 959-67.","journal-title":"Archives of General Psychiatry"},{"issue":"5","key":"170_CR28","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1111\/j.1532-5415.1986.tb04316.x","volume":"34","author":"S Borson","year":"1986","unstructured":"Borson S, Barnes RA, Kukull WA, Okimoto JT, Veith RC, Inui TS, Carter W, Raskind MA: Symptomatic depression in elderly medical outpatients. I. Prevalence, demography, and health service utilization. Journal of the American Geriatrics Society. 1986, 34 (5): 341-7.","journal-title":"Journal of the American Geriatrics Society"},{"issue":"3","key":"170_CR29","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1093\/geront\/27.3.281","volume":"27","author":"D Blazer","year":"1987","unstructured":"Blazer D, Hughes DC, George LK: The epidemiology of depression in an elderly community population. Gerontologist. 1987, 27 (3): 281-7.","journal-title":"Gerontologist"},{"issue":"1","key":"170_CR30","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0193-953X(18)30519-7","volume":"11","author":"GS Alexopoulos","year":"1988","unstructured":"Alexopoulos GS, Young RC, Meyers BS, Abrams RC, Shamoian CA: Late-onset depression. Psychiatric Clinics of North America. 1988, 11 (1): 101-15.","journal-title":"Psychiatric Clinics of North America"},{"issue":"4","key":"170_CR31","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/0165-0327(95)00030-Q","volume":"34","author":"DM Girling","year":"1995","unstructured":"Girling DM, Barkley C, Paykel ES, Gehlhaar E, Brayne C, Gill C, Mathewson D, Huppert FA: The prevalence of depression in a cohort of the very elderly. Journal of Affective Disorders. 1995, 34 (4): 319-29. 10.1016\/0165-0327(95)00030-Q.","journal-title":"Journal of Affective Disorders"},{"key":"170_CR32","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1001\/archpsyc.1977.01770240019001","volume":"34","author":"RE Markush","year":"1977","unstructured":"Markush RE, Schwab JJ, Farris MA, et al: Mortality and community mental health. Arch Gen Psychiatry. 1977, 34: 1393-1401.","journal-title":"Arch Gen Psychiatry"},{"issue":"2","key":"170_CR33","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1111\/j.1600-0447.1984.tb02471.x","volume":"69","author":"K Enzell","year":"1984","unstructured":"Enzell K: Mortality among persons with depressive symptoms and among responders and non-responders in a health check-up. An investigation of persons born in 1905 and followed up from age 66 to 75. Acta Psychiatrica Scandinavica. 1984, 69 (2): 89-102.","journal-title":"Acta Psychiatrica Scandinavica"},{"issue":"11","key":"170_CR34","doi-asserted-by":"publisher","first-page":"1796","DOI":"10.2105\/AJPH.84.11.1796","volume":"84","author":"ML Bruce","year":"1994","unstructured":"Bruce ML, Seeman TE, Merrill SS, Blazer DG: The impact of depressive symptomatology on physical disability: MacArthur Studies of Successful Aging. American Journal of Public Health. 1994, 84 (11): 1796-9.","journal-title":"American Journal of Public Health"},{"key":"170_CR35","unstructured":"xx x: Prozac (fluoxetine hydrocloride) Product Information. Dista Products Company, a division of the Eli Lilly industries, Inc., Carolina, Puerto Rico, a subdivision of Eli Lilly and Co., Indianapolis, Indiana. May 17, 1995"},{"issue":"1","key":"170_CR36","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1017\/S0033291799001270","volume":"30","author":"A Addis","year":"2000","unstructured":"Addis A, Koren G: Safety of fluoxetine during the first trimester of pregnancy: A meta\u2013analytical review of epidemiological studies. Psychological Medicine. 2000, 30 (1): 89-94. 10.1017\/S0033291799001270.","journal-title":"Psychological Medicine"},{"key":"170_CR37","doi-asserted-by":"crossref","unstructured":"Bacaltchuk J, Hay P: Antidepressants versus placebo for people with bulimia nervosa. The Cochrane Library. 2003, 1","DOI":"10.1002\/14651858.CD003391"},{"issue":"11","key":"170_CR38","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1016\/S0149-2918(00)83028-3","volume":"22","author":"CM Beasley Jr","year":"2000","unstructured":"Beasley CM, Koke SC, Nilsson ME, Gonzales JS: Adverse events and treatment discontinuations in clinical trials of fluoxetine in major depressive disorder: An updated meta-analysis. Clinical Therapeutics. 2000, 22 (11): 1319-1330. 10.1016\/S0149-2918(00)83028-3.","journal-title":"Clinical Therapeutics"},{"issue":"10","key":"170_CR39","doi-asserted-by":"publisher","first-page":"722","DOI":"10.4088\/JCP.v61n1003","volume":"61","author":"CM Beasley Jr","year":"2000","unstructured":"Beasley CM, Nilsson ME, Koke SC, Gonzales JS: Efficacy, adverse events, and treatment discontinuations in fluoxetine clinical studies of major depression: A meta-analysis of the 20-mg\/day dose. Journal of Clinical Psychiatry. 2000, 61 (10): 722-728.","journal-title":"Journal of Clinical Psychiatry"},{"issue":"SUPPL. 6","key":"170_CR40","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1097\/00004850-199206006-00006","volume":"6","author":"CM Beasley Jr","year":"1992","unstructured":"Beasley CM, Dornseif BE, Bosomworth JC, Sayler ME, Rampey AH, Heiligenstein JH, Thompson VL, Murphy DJ, Masica DN: Fluoxetine and suicide: a meta\u2013analysis of controlled trials of treatment for depression. International Clinical Sychopharmacology. 1992, 6 (SUPPL. 6): 35-57.","journal-title":"International Clinical Sychopharmacology"},{"key":"170_CR41","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1192\/bjp.176.5.421","volume":"176","author":"P Bech","year":"2000","unstructured":"Bech P, Cialdella P, Haugh MC, Birkett MA, Hours A, Boissel JP, Tollefson GD: Meta-analysis of randomised controlled trials of fluoxetine v. placebo and tricyclic antidepressants in the short-term treatment of major depression. British Journal of Psychiatry. 2000, 176: 421-428. 10.1192\/bjp.176.5.421.","journal-title":"British Journal of Psychiatry"},{"issue":"2","key":"170_CR42","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/0005-7916(93)90043-V","volume":"24","author":"BJ Cox","year":"1993","unstructured":"Cox BJ, Swinson RP, Morrison B, Lee PS: Clomipramine, fluoxetine, and behavior therapy in the treatment of obsessive\u2013compulsive disorder: A meta\u2013analysis. Journal of Behavior Therapy and Experimental Psychiatry. 1993, 24 (2): 149-153. 10.1016\/0005-7916(93)90043-V.","journal-title":"Journal of Behavior Therapy and Experimental Psychiatry"},{"issue":"1","key":"170_CR43","first-page":"33","volume":"2","author":"S Hoog","year":"1999","unstructured":"Hoog S, Tepner R, Nilsson ME, Romano S, Kennedy JS: Changes in anxiety, agitation, and insomnia during treatment of depression for patients age 55 years and older: Analysis from fluoxetine double-blind, placebo-controlled trials. International Journal of Geriatric Psychopharmacology. 1999, 2 (1): 33-39.","journal-title":"International Journal of Geriatric Psychopharmacology"},{"issue":"4","key":"170_CR44","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1097\/00004850-199400940-00003","volume":"Winter 9","author":"GD Tollefson","year":"1994","unstructured":"Tollefson GD, Holman SL: How long to onset of antidepressant action: a meta-analysis of patients treated with fluoxetine or placebo. International Clinical Psychopharmacology. 1994, Winter 9 (4): 245-50.","journal-title":"International Clinical Psychopharmacology"}],"container-title":["Annals of General Hospital Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1475-2832-3-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T16:08:50Z","timestamp":1726243730000},"score":1,"resource":{"primary":{"URL":"https:\/\/annals-general-psychiatry.biomedcentral.com\/articles\/10.1186\/1475-2832-3-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,2,12]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2004,12]]}},"alternative-id":["170"],"URL":"https:\/\/doi.org\/10.1186\/1475-2832-3-2","relation":{},"ISSN":["1475-2832"],"issn-type":[{"value":"1475-2832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,2,12]]},"assertion":[{"value":"2 September 2003","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2004","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2004","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"2"}}