{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:18:02Z","timestamp":1791559082096,"version":"4.3.4"},"reference-count":71,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Diabetol"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Endoplasmic reticulum (ER) stress is considered one of the mechanisms contributing to reactive oxygen species (ROS)- mediated cell apoptosis. In diabetic cardiomyopathy (DCM), cell apoptosis is generally accepted as the etiological factor and closely related to cardiac ROS generation. ER stress is proposed the link between ROS and cell apoptosis; however, the signaling pathways and their roles in participating ER stress- induced apoptosis in DCM are still unclear.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>In this study, we investigated the signaling transductions in ROS- dependent ER stress- induced cardiomocyte apoptosis in animal model of DCM. Moreover, in order to clarify the roles of IRE1 (inositol - requiring enzyme-1), PERK (protein kinase RNA (PKR)- like ER kinase) and ATF6 (activating transcription factor-6) in conducting apoptotic signal in ROS- dependent ER stress- induced cardiomocyte apoptosis, we further investigated apoptosis in high- glucose incubated cardiomyocytes with IRE1, ATF6 and PERK- knocked down respectively.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>we demonstrated that the ER stress sensors, referred as PERK, IRE1 and ATF6, were activated in ROS- mediated ER stress- induced cell apoptosis in rat model of DCM which was characterized by cardiac pump and electrical dysfunctions. The deletion of PERK in myocytes exhibited stronger protective effect against apoptosis induced by high- glucose incubation than deletion of ATF6 or IRE in the same myocytes. By subcellular fractionation, rather than ATF6 and IRE1, in primary cardiomyocytes, PERK was found a component of MAMs (mitochondria-associated endoplasmic reticulum membranes) which was the functional and physical contact site between ER and mitochondria.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>ROS- stimulated activation of PERK signaling pathway takes the major responsibility rather than IRE1 or ATF6 signaling pathways in ROS- medicated ER stress- induced myocyte apoptosis in DCM.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1475-2840-12-158","type":"journal-article","created":{"date-parts":[[2013,11,2]],"date-time":"2013-11-02T07:02:32Z","timestamp":1383375752000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":198,"title":["Protein kinase RNA- like endoplasmic reticulum kinase (PERK) signaling pathway plays a major role in reactive oxygen species (ROS)- mediated endoplasmic reticulum stress- induced apoptosis in diabetic cardiomyopathy"],"prefix":"10.1186","volume":"12","author":[{"given":"Zhong-Wei","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Tao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun-Lun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Hong","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,11,2]]},"reference":[{"issue":"25","key":"745_CR1","doi-asserted-by":"publisher","first-page":"3213","DOI":"10.1161\/CIRCULATIONAHA.106.679597","volume":"115","author":"S Boudina","year":"2007","unstructured":"Boudina S, Abel ED: Diabetic cardiomyopathy revisited. Circulation. 2007, 115 (25): 3213-3223.","journal-title":"Circulation"},{"issue":"1","key":"745_CR2","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s11154-010-9131-7","volume":"11","author":"S Boudina","year":"2010","unstructured":"Boudina S, Abel ED: Diabetic cardiomyopathy, causes and effects. Rev Endocr Metab Disord. 2010, 11 (1): 31-39.","journal-title":"Rev Endocr Metab Disord"},{"issue":"10","key":"745_CR3","doi-asserted-by":"publisher","first-page":"2791","DOI":"10.2337\/diacare.26.10.2791","volume":"26","author":"AG Bertoni","year":"2003","unstructured":"Bertoni AG, Tsai A, Kasper EK, Brancati FL: Diabetes and idiopathic cardiomyopathy: a nationwide case\u2013control study. Diabetes Care. 2003, 26 (10): 2791-2795.","journal-title":"Diabetes Care"},{"issue":"9","key":"745_CR4","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.2337\/diacare.24.9.1614","volume":"24","author":"GA Nichols","year":"2001","unstructured":"Nichols GA, Hillier TA, Erbey JR, Brown JB: Congestive heart failure in type 2 diabetes: prevalence, incidence, and risk factors. Diabetes Care. 2001, 24 (9): 1614-1619.","journal-title":"Diabetes Care"},{"issue":"3","key":"745_CR5","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1385\/CT:3:3:219","volume":"3","author":"L Cai","year":"2003","unstructured":"Cai L, Kang YJ: Cell death and diabetic cardiomyopathy. Cardiovasc Toxicol. 2003, 3 (3): 219-228.","journal-title":"Cardiovasc Toxicol"},{"issue":"3","key":"745_CR6","doi-asserted-by":"publisher","first-page":"H1303","DOI":"10.1152\/ajpheart.00053.2004","volume":"287","author":"D Engel","year":"2004","unstructured":"Engel D, Peshock R, Armstong RC, Sivasubramanian N, Mann DL: Cardiac myocyte apoptosis provokes adverse cardiac remodeling in transgenic mice with targeted TNF overexpression. Am J Physiol Heart Circ Physiol. 2004, 287 (3): H1303-H1311.","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"1","key":"745_CR7","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3164\/jcbn.2007008","volume":"41","author":"Z Li","year":"2007","unstructured":"Li Z, Zhang T, Dai H, Liu G, Wang H, Sun Y, Zhang Y, Ge Z: Involvement of endoplasmic reticulum stress in myocardial apoptosis of streptozocin-induced diabetic rats. J Clin Biochem Nutr. 2007, 41 (1): 58-67.","journal-title":"J Clin Biochem Nutr"},{"issue":"6","key":"745_CR8","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1161\/01.CIR.0000083716.82622.FD","volume":"108","author":"LA Barouch","year":"2003","unstructured":"Barouch LA, Berkowitz DE, Harrison RW, O\u2019Donnell CP, Hare JM: Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice. Circulation. 2003, 108 (6): 754-759.","journal-title":"Circulation"},{"issue":"4","key":"745_CR9","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1016\/j.bbrc.2004.04.138","volume":"318","author":"LE Wold","year":"2004","unstructured":"Wold LE, Ren J: Streptozotocin directly impairs cardiac contractile function in isolated ventricular myocytes via a p38 map kinase-dependent oxidative stress mechanism. Biochem Biophys Res Commun. 2004, 318 (4): 1066-1071.","journal-title":"Biochem Biophys Res Commun"},{"issue":"6","key":"745_CR10","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/j.freeradbiomed.2006.06.007","volume":"41","author":"L Cai","year":"2006","unstructured":"Cai L: Suppression of nitrative damage by metallothionein in diabetic heart contributes to the prevention of cardiomyopathy. Free Radic Biol Med. 2006, 41 (6): 851-861.","journal-title":"Free Radic Biol Med"},{"issue":"3","key":"745_CR11","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.niox.2006.12.001","volume":"16","author":"RM Saraiva","year":"2007","unstructured":"Saraiva RM, Minhas KM, Zheng M, Pitz E, Treuer A, Gonzalez D, Schuleri KH, Vandegaer KM, Barouch LA, Hare JM: Reduced neuronal nitric oxide synthase expression contributes to cardiac oxidative stress and nitroso-redox imbalance in ob\/ob mice. Nitric Oxide : Biology and Chemistry \/ Official Journal of the Nitric Oxide Society. 2007, 16 (3): 331-338.","journal-title":"Nitric Oxide : Biology and Chemistry \/ Official Journal of the Nitric Oxide Society"},{"issue":"6","key":"745_CR12","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/S0022-2828(03)00084-1","volume":"35","author":"SH Kwon","year":"2003","unstructured":"Kwon SH, Pimentel DR, Remondino A, Sawyer DB, Colucci WS: H(2)O(2) regulates cardiac myocyte phenotype via concentration-dependent activation of distinct kinase pathways. J Mol Cell Cardiol. 2003, 35 (6): 615-621.","journal-title":"J Mol Cell Cardiol"},{"issue":"6","key":"745_CR13","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.2337\/diabetes.54.6.1615","volume":"54","author":"M Brownlee","year":"2005","unstructured":"Brownlee M: The pathobiology of diabetic complications: a unifying mechanism. Diabetes. 2005, 54 (6): 1615-1625.","journal-title":"Diabetes"},{"issue":"6","key":"745_CR14","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/j.semcdb.2007.09.003","volume":"18","author":"JD Malhotra","year":"2007","unstructured":"Malhotra JD, Kaufman RJ: The endoplasmic reticulum and the unfolded protein response. Semin Cell Dev Biol. 2007, 18 (6): 716-731.","journal-title":"Semin Cell Dev Biol"},{"key":"745_CR15","doi-asserted-by":"publisher","first-page":"827971","DOI":"10.1155\/2012\/827971","volume":"2012","author":"J Xu","year":"2012","unstructured":"Xu J, Zhou Q, Xu W, Cai L: Endoplasmic reticulum stress and diabetic cardiomyopathy. Exp Diabetes Res. 2012, 2012: 827971.","journal-title":"Exp Diabetes Res"},{"issue":"6765","key":"745_CR16","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1038\/47513","volume":"403","author":"T Nakagawa","year":"2000","unstructured":"Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, Yuan J: Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature. 2000, 403 (6765): 98-103.","journal-title":"Nature"},{"issue":"12","key":"745_CR17","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1089\/ars.2007.1782","volume":"9","author":"JD Malhotra","year":"2007","unstructured":"Malhotra JD, Kaufman RJ: Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword?. Antioxid Redox Signal. 2007, 9 (12): 2277-2293.","journal-title":"Antioxid Redox Signal"},{"key":"745_CR18","doi-asserted-by":"publisher","first-page":"e518","DOI":"10.1038\/cddis.2013.44","volume":"4","author":"XF Qi","year":"2013","unstructured":"Qi XF, Zheng L, Lee KJ, Kim DH, Kim CS, Cai DQ, Wu Z, Qin JW, Yu YH, Kim SK: HMG-CoA reductase inhibitors induce apoptosis of lymphoma cells by promoting ROS generation and regulating Akt, Erk and p38 signals via suppression of mevalonate pathway. Cell Death & Disease. 2013, 4: e518.","journal-title":"Cell Death & Disease"},{"issue":"3","key":"745_CR19","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.bbrc.2012.01.037","volume":"418","author":"W Ding","year":"2012","unstructured":"Ding W, Yang L, Zhang M, Gu Y: Reactive oxygen species-mediated endoplasmic reticulum stress contributes to aldosterone-induced apoptosis in tubular epithelial cells. Biochem Biophys Res Commun. 2012, 418 (3): 451-456.","journal-title":"Biochem Biophys Res Commun"},{"issue":"8","key":"745_CR20","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1016\/j.cellsig.2012.03.011","volume":"24","author":"A Higa","year":"2012","unstructured":"Higa A, Chevet E: Redox signaling loops in the unfolded protein response. Cell Signal. 2012, 24 (8): 1548-1555.","journal-title":"Cell Signal"},{"issue":"1","key":"745_CR21","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1096\/fj.09-135087","volume":"24","author":"CE Senkal","year":"2010","unstructured":"Senkal CE, Ponnusamy S, Bielawski J, Hannun YA, Ogretmen B: Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6\/CHOP arm of ER-stress-response pathways. FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 2010, 24 (1): 296-308.","journal-title":"FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology"},{"issue":"3","key":"745_CR22","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1677\/JOE-07-0230","volume":"196","author":"Z Li","year":"2008","unstructured":"Li Z, Zhang T, Dai H, Liu G, Wang H, Sun Y, Zhang Y, Ge Z: Endoplasmic reticulum stress is involved in myocardial apoptosis of streptozocin-induced diabetic rats. J Endocrinol. 2008, 196 (3): 565-572.","journal-title":"J Endocrinol"},{"issue":"6","key":"745_CR23","doi-asserted-by":"publisher","first-page":"e38051","DOI":"10.1371\/journal.pone.0038051","volume":"7","author":"I Downs","year":"2012","unstructured":"Downs I, Liu J, Aw TY, Adegboyega PA, Ajuebor MN: The ROS scavenger, NAC, regulates hepatic Valpha14iNKT cells signaling during Fas mAb-dependent fulminant liver failure. PLoS One. 2012, 7 (6): e38051.","journal-title":"PLoS One"},{"issue":"3","key":"745_CR24","doi-asserted-by":"publisher","first-page":"e17750","DOI":"10.1371\/journal.pone.0017750","volume":"6","author":"L Bocchi","year":"2011","unstructured":"Bocchi L, Savi M, Graiani G, Rossi S, Agnetti A, Stillitano F, Lagrasta C, Baruffi S, Berni R, Frati C: Growth factor-induced mobilization of cardiac progenitor cells reduces the risk of arrhythmias, in a rat model of chronic myocardial infarction. PLoS One. 2011, 6 (3): e17750.","journal-title":"PLoS One"},{"issue":"6","key":"745_CR25","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1016\/S1734-1140(12)70945-3","volume":"64","author":"H Soraya","year":"2012","unstructured":"Soraya H, Khorrami A, Garjani A, Maleki-Dizaji N: Acute treatment with metformin improves cardiac function following isoproterenol induced myocardial infarction in rats. Pharmacological Reports : PR. 2012, 64 (6): 1476-1484.","journal-title":"Pharmacological Reports : PR"},{"issue":"8","key":"745_CR26","doi-asserted-by":"publisher","first-page":"e23116","DOI":"10.1371\/journal.pone.0023116","volume":"6","author":"L Zuo","year":"2011","unstructured":"Zuo L, Youtz DJ, Wold LE: Particulate matter exposure exacerbates high glucose-induced cardiomyocyte dysfunction through ROS generation. PLoS One. 2011, 6 (8): e23116.","journal-title":"PLoS One"},{"key":"745_CR27","volume-title":"Journal of Nutrition & Food Sciences","author":"Y Jiang","year":"2011","unstructured":"Jiang Y, Zhang Y, Wark L, Ortiz E, Lim S, He H, Wang W, Medeiros D, Lin D: Wolfberry Water Soluble Phytochemicals Down-Regulate ER Stress Biomarkers and Modulate Multiple Signaling Pathways Leading To Inhibition of Proliferation and Induction of Apoptosis in Jurkat Cells. Journal of Nutrition & Food Sciences. 2011, S2."},{"issue":"7","key":"745_CR28","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/j.bbagen.2012.02.010","volume":"1820","author":"S Kumar","year":"2012","unstructured":"Kumar S, Kain V, Sitasawad SL: High glucose-induced Ca2+ overload and oxidative stress contribute to apoptosis of cardiac cells through mitochondrial dependent and independent pathways. Biochimica Biophysica Acta. 2012, 1820 (7): 907-920.","journal-title":"Biochimica Biophysica Acta"},{"issue":"11","key":"745_CR29","doi-asserted-by":"publisher","first-page":"1880","DOI":"10.1038\/cdd.2012.74","volume":"19","author":"T Verfaillie","year":"2012","unstructured":"Verfaillie T, Rubio N, Garg AD, Bultynck G, Rizzuto R, Decuypere JP, Piette J, Linehan C, Gupta S, Samali A: PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress. Cell Death Differ. 2012, 19 (11): 1880-1891.","journal-title":"Cell Death Differ"},{"issue":"24","key":"745_CR30","doi-asserted-by":"publisher","first-page":"15525","DOI":"10.1128\/JVI.79.24.15525-15536.2005","volume":"79","author":"S Griffin","year":"2005","unstructured":"Griffin S, Clarke D, McCormick C, Rowlands D, Harris M: Signal peptide cleavage and internal targeting signals direct the hepatitis C virus p7 protein to distinct intracellular membranes. J Virol. 2005, 79 (24): 15525-15536.","journal-title":"J Virol"},{"issue":"4","key":"745_CR31","doi-asserted-by":"publisher","first-page":"377","DOI":"10.7150\/ijms.5224","volume":"10","author":"Y Li","year":"2013","unstructured":"Li Y, Zhang Y, Liu DB, Liu HY, Hou WG, Dong YS: Curcumin attenuates diabetic neuropathic pain by downregulating TNF-alpha in a rat model. Int J Med Sci. 2013, 10 (4): 377-381.","journal-title":"Int J Med Sci"},{"issue":"9","key":"745_CR32","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.2337\/diacare.21.9.1414","volume":"21","author":"H King","year":"1998","unstructured":"King H, Aubert RE, Herman WH: Global burden of diabetes, 1995\u20132025: prevalence, numerical estimates, and projections. Diabetes Care. 1998, 21 (9): 1414-1431.","journal-title":"Diabetes Care"},{"key":"745_CR33","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/1475-2840-12-20","volume":"12","author":"G Papa","year":"2013","unstructured":"Papa G, Degano C, Iurato MP, Licciardello C, Maiorana R, Finocchiaro C: Macrovascular complication phenotypes in type 2 diabetic patients. Cardiovasc Diabetol. 2013, 12: 20.","journal-title":"Cardiovasc Diabetol"},{"issue":"7","key":"745_CR34","doi-asserted-by":"publisher","first-page":"997","DOI":"10.2165\/00003495-200767070-00005","volume":"67","author":"S Coccheri","year":"2007","unstructured":"Coccheri S: Approaches to prevention of cardiovascular complications and events in diabetes mellitus. Drugs. 2007, 67 (7): 997-1026.","journal-title":"Drugs"},{"issue":"4","key":"745_CR35","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1210\/er.2003-0012","volume":"25","author":"ZY Fang","year":"2004","unstructured":"Fang ZY, Prins JB, Marwick TH: Diabetic cardiomyopathy: evidence, mechanisms, and therapeutic implications. Endocr Rev. 2004, 25 (4): 543-567.","journal-title":"Endocr Rev"},{"issue":"2","key":"745_CR36","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1177\/1074248409356557","volume":"15","author":"A Baraka","year":"2010","unstructured":"Baraka A, AbdelGawad H: Targeting apoptosis in the heart of streptozotocin-induced diabetic rats. J Cardiovasc Pharmacol Ther. 2010, 15 (2): 175-181.","journal-title":"J Cardiovasc Pharmacol Ther"},{"issue":"12","key":"745_CR37","doi-asserted-by":"publisher","first-page":"e52013","DOI":"10.1371\/journal.pone.0052013","volume":"7","author":"W Yu","year":"2012","unstructured":"Yu W, Wu J, Cai F, Xiang J, Zha W, Fan D, Guo S, Ming Z, Liu C: Curcumin alleviates diabetic cardiomyopathy in experimental diabetic rats. PLoS One. 2012, 7 (12): e52013.","journal-title":"PLoS One"},{"key":"745_CR38","volume-title":"Biochim Biophys Acta","author":"HK Gaggin","year":"2013","unstructured":"Gaggin HK, Januzzi JL: Biomarkers and diagnostics in heart failure. Biochim Biophys Acta. 2013"},{"key":"745_CR39","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/1475-2840-12-44","volume":"12","author":"S Nunes","year":"2013","unstructured":"Nunes S, Soares E, Fernandes J, Viana S, Carvalho E, Pereira FC, Reis F: Early cardiac changes in a rat model of prediabetes: brain natriuretic peptide overexpression seems to be the best marker. Cardiovasc Diabetol. 2013, 12: 44.","journal-title":"Cardiovasc Diabetol"},{"key":"745_CR40","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1475-2840-11-8","volume":"11","author":"ZC Chen","year":"2012","unstructured":"Chen ZC, Cheng YZ, Chen LJ, Cheng KC, Li Y, Cheng J: Increase of ATP-sensitive potassium (K(ATP)) channels in the heart of type-1 diabetic rats. Cardiovasc Diabetol. 2012, 11: 8.","journal-title":"Cardiovasc Diabetol"},{"key":"745_CR41","doi-asserted-by":"publisher","first-page":"122","DOI":"10.3389\/fphys.2012.00122","volume":"3","author":"S Smith","year":"2012","unstructured":"Smith S, Curran J, Hund TJ, Mohler PJ: Defects in cytoskeletal signaling pathways, arrhythmia, and sudden cardiac death. Front Physiol. 2012, 3: 122.","journal-title":"Front Physiol"},{"issue":"3","key":"745_CR42","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1385\/CT:1:3:181","volume":"1","author":"L Cai","year":"2001","unstructured":"Cai L, Kang YJ: Oxidative stress and diabetic cardiomyopathy: a brief review. Cardiovasc Toxicol. 2001, 1 (3): 181-193.","journal-title":"Cardiovasc Toxicol"},{"issue":"6","key":"745_CR43","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1023\/A:1013715704835","volume":"15","author":"M Neuss","year":"2001","unstructured":"Neuss M, Crow MT, Chesley A, Lakatta EG: Apoptosis in cardiac disease\u2013what is it\u2013how does it occur. Cardiovascular Drugs and Therapy \/ Sponsored by the International Society of Cardiovascular Pharmacotherapy. 2001, 15 (6): 507-523.","journal-title":"Cardiovascular Drugs and Therapy \/ Sponsored by the International Society of Cardiovascular Pharmacotherapy"},{"issue":"1\u20132","key":"745_CR44","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s11010-012-1395-7","volume":"370","author":"B Jie","year":"2012","unstructured":"Jie B, Zhang X, Wu X, Xin Y, Liu Y, Guo Y: Neuregulin-1 suppresses cardiomyocyte apoptosis by activating PI3K\/Akt and inhibiting mitochondrial permeability transition pore. Mol Cell Biochem. 2012, 370 (1\u20132): 35-43.","journal-title":"Mol Cell Biochem"},{"issue":"19","key":"745_CR45","first-page":"2360","volume":"122","author":"Z Zhang","year":"2009","unstructured":"Zhang Z, Yu B, Tao GZ: Apelin protects against cardiomyocyte apoptosis induced by glucose deprivation. Chin Med J (Engl). 2009, 122 (19): 2360-2365.","journal-title":"Chin Med J (Engl)"},{"issue":"4","key":"745_CR46","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1002\/jbt.10081","volume":"17","author":"FM Ferreira","year":"2003","unstructured":"Ferreira FM, Palmeira CM, Seica R, Moreno AJ, Santos MS: Diabetes and mitochondrial bioenergetics: alterations with age. J Biochem Mol Toxicol. 2003, 17 (4): 214-222.","journal-title":"J Biochem Mol Toxicol"},{"issue":"2","key":"745_CR47","doi-asserted-by":"publisher","first-page":"H768","DOI":"10.1152\/ajpheart.00038.2005","volume":"289","author":"S Ghosh","year":"2005","unstructured":"Ghosh S, Pulinilkunnil T, Yuen G, Kewalramani G, An D, Qi D, Abrahani A, Rodrigues B: Cardiomyocyte apoptosis induced by short-term diabetes requires mitochondrial GSH depletion. Am J Physiol Heart Circ Physiol. 2005, 289 (2): H768-776.","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"21","key":"745_CR48","first-page":"2580","volume":"122","author":"CJ Li","year":"2009","unstructured":"Li CJ, Zhang QM, Li MZ, Zhang JY, Yu P, Yu DM: Attenuation of myocardial apoptosis by alpha-lipoic acid through suppression of mitochondrial oxidative stress to reduce diabetic cardiomyopathy. Chin Med J (Engl). 2009, 122 (21): 2580-2586.","journal-title":"Chin Med J (Engl)"},{"issue":"5","key":"745_CR49","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.yjmcc.2004.07.008","volume":"37","author":"F Fiordaliso","year":"2004","unstructured":"Fiordaliso F, Bianchi R, Staszewsky L, Cuccovillo I, Doni M, Laragione T, Salio M, Savino C, Melucci S, Santangelo F: Antioxidant treatment attenuates hyperglycemia-induced cardiomyocyte death in rats. J Mol Cell Cardiol. 2004, 37 (5): 959-968.","journal-title":"J Mol Cell Cardiol"},{"issue":"9","key":"745_CR50","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1038\/sj.embor.7400779","volume":"7","author":"E Szegezdi","year":"2006","unstructured":"Szegezdi E, Logue SE, Gorman AM, Samali A: Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep. 2006, 7 (9): 880-885.","journal-title":"EMBO Rep"},{"issue":"3","key":"745_CR51","doi-asserted-by":"publisher","first-page":"e32972","DOI":"10.1371\/journal.pone.0032972","volume":"7","author":"I Moserova","year":"2012","unstructured":"Moserova I, Kralova J: Role of ER stress response in photodynamic therapy: ROS generated in different subcellular compartments trigger diverse cell death pathways. PLoS One. 2012, 7 (3): e32972.","journal-title":"PLoS One"},{"issue":"7","key":"745_CR52","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/nrm2199","volume":"8","author":"D Ron","year":"2007","unstructured":"Ron D, Walter P: Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol. 2007, 8 (7): 519-529.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"12","key":"745_CR53","doi-asserted-by":"publisher","first-page":"2792","DOI":"10.1161\/ATVBAHA.111.224881","volume":"31","author":"CM Scull","year":"2011","unstructured":"Scull CM, Tabas I: Mechanisms of ER stress-induced apoptosis in atherosclerosis. Arterioscler Thromb Vasc Biol. 2011, 31 (12): 2792-2797.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"4","key":"745_CR54","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.ymeth.2004.10.010","volume":"35","author":"AS Lee","year":"2005","unstructured":"Lee AS: The ER chaperone and signaling regulator GRP78\/BiP as a monitor of endoplasmic reticulum stress. Methods (San Diego, Calif). 2005, 35 (4): 373-381.","journal-title":"Methods (San Diego, Calif)"},{"issue":"6","key":"745_CR55","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1007\/s00210-013-0852-5","volume":"386","author":"FH Shi","year":"2013","unstructured":"Shi FH, Cheng YS, Dai DZ, Peng HJ, Cong XD, Dai Y: Depressed calcium-handling proteins due to endoplasmic reticulum stress and apoptosis in the diabetic heart are attenuated by argirein. Naunyn Schmiedebergs Arch Pharmacol. 2013, 386 (6): 521-531.","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"1","key":"745_CR56","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.cellsig.2012.09.012","volume":"25","author":"QY Zheng","year":"2013","unstructured":"Zheng QY, Li PP, Jin FS, Yao C, Zhang GH, Zang T, Ai X: Ursolic acid induces ER stress response to activate ASK1-JNK signaling and induce apoptosis in human bladder cancer T24 cells. Cell Signal. 2013, 25 (1): 206-213.","journal-title":"Cell Signal"},{"issue":"11","key":"745_CR57","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1101\/gad.992302","volume":"16","author":"H Nishitoh","year":"2002","unstructured":"Nishitoh H, Matsuzawa A, Tobiume K, Saegusa K, Takeda K, Inoue K, Hori S, Kakizuka A, Ichijo H: ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes Dev. 2002, 16 (11): 1345-1355.","journal-title":"Genes Dev"},{"issue":"7","key":"745_CR58","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1101\/gad.12.7.982","volume":"12","author":"H Zinszner","year":"1998","unstructured":"Zinszner H, Kuroda M, Wang X, Batchvarova N, Lightfoot RT, Remotti H, Stevens JL, Ron D: CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev. 1998, 12 (7): 982-995.","journal-title":"Genes Dev"},{"issue":"4","key":"745_CR59","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/sj.cdd.4401373","volume":"11","author":"S Oyadomari","year":"2004","unstructured":"Oyadomari S, Mori M: Roles of CHOP\/GADD153 in endoplasmic reticulum stress. Cell Death Differ. 2004, 11 (4): 381-389.","journal-title":"Cell Death Differ"},{"issue":"4","key":"745_CR60","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1038\/sj.cdd.4401369","volume":"11","author":"T Gotoh","year":"2004","unstructured":"Gotoh T, Terada K, Oyadomari S, Mori M: hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria. Cell Death Differ. 2004, 11 (4): 390-402.","journal-title":"Cell Death Differ"},{"issue":"2","key":"745_CR61","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.biocel.2012.09.017","volume":"45","author":"AP Lakshmanan","year":"2013","unstructured":"Lakshmanan AP, Harima M, Suzuki K, Soetikno V, Nagata M, Nakamura T, Takahashi T, Sone H, Kawachi H, Watanabe K: The hyperglycemia stimulated myocardial endoplasmic reticulum (ER) stress contributes to diabetic cardiomyopathy in the transgenic non-obese type 2 diabetic rats: a differential role of unfolded protein response (UPR) signaling proteins. Int J Biochem Cell Biol. 2013, 45 (2): 438-447.","journal-title":"Int J Biochem Cell Biol"},{"issue":"6","key":"745_CR62","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1016\/S1097-2765(00)00133-7","volume":"6","author":"J Ye","year":"2000","unstructured":"Ye J, Rawson RB, Komuro R, Chen X, Dave UP, Prywes R, Brown MS, Goldstein JL: ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Mol Cell. 2000, 6 (6): 1355-1364.","journal-title":"Mol Cell"},{"issue":"10","key":"745_CR63","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1161\/CIRCRESAHA.107.161273","volume":"101","author":"CC Glembotski","year":"2007","unstructured":"Glembotski CC: Endoplasmic reticulum stress in the heart. Circ Res. 2007, 101 (10): 975-984.","journal-title":"Circ Res"},{"issue":"40","key":"745_CR64","doi-asserted-by":"publisher","first-page":"35227","DOI":"10.1074\/jbc.M111.233502","volume":"286","author":"N Morishima","year":"2011","unstructured":"Morishima N, Nakanishi K, Nakano A: Activating transcription factor-6 (ATF6) mediates apoptosis with reduction of myeloid cell leukemia sequence 1 (Mcl-1) protein via induction of WW domain binding protein 1. J Biol Chem. 2011, 286 (40): 35227-35235.","journal-title":"J Biol Chem"},{"issue":"14","key":"745_CR65","doi-asserted-by":"publisher","first-page":"12343","DOI":"10.1074\/jbc.M107988200","volume":"277","author":"T Gotoh","year":"2002","unstructured":"Gotoh T, Oyadomari S, Mori K, Mori M: Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP. J Biol Chem. 2002, 277 (14): 12343-12350.","journal-title":"J Biol Chem"},{"issue":"8","key":"745_CR66","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1016\/j.jacc.2006.07.022","volume":"48","author":"L Cai","year":"2006","unstructured":"Cai L, Wang Y, Zhou G, Chen T, Song Y, Li X, Kang YJ: Attenuation by metallothionein of early cardiac cell death via suppression of mitochondrial oxidative stress results in a prevention of diabetic cardiomyopathy. J Am Coll Cardiol. 2006, 48 (8): 1688-1697.","journal-title":"J Am Coll Cardiol"},{"key":"745_CR67","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/1475-2840-10-57","volume":"10","author":"PM Ku","year":"2011","unstructured":"Ku PM, Chen LJ, Liang JR, Cheng KC, Li YX, Cheng JT: Molecular role of GATA binding protein 4 (GATA-4) in hyperglycemia-induced reduction of cardiac contractility. Cardiovasc Diabetol. 2011, 10: 57.","journal-title":"Cardiovasc Diabetol"},{"issue":"8","key":"745_CR68","doi-asserted-by":"publisher","first-page":"4595","DOI":"10.1167\/iovs.12-9910","volume":"53","author":"M Wu","year":"2012","unstructured":"Wu M, Yang S, Elliott MH, Fu D, Wilson K, Zhang J, Du M, Chen J, Lyons T: Oxidative and endoplasmic reticulum stresses mediate apoptosis induced by modified LDL in human retinal Muller cells. Invest Ophthalmol Vis Sci. 2012, 53 (8): 4595-4604.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"745_CR69","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.bbamcr.2012.04.013","volume":"1833","author":"A Raturi","year":"2013","unstructured":"Raturi A, Simmen T: Where the endoplasmic reticulum and the mitochondrion tie the knot: the mitochondria-associated membrane (MAM). Biochim Biophys Acta. 2013, 1833 (1): 213-224.","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"745_CR70","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.tcb.2008.12.002","volume":"19","author":"T Hayashi","year":"2009","unstructured":"Hayashi T, Rizzuto R, Hajnoczky G, Su TP: MAM: more than just a housekeeper. Trends Cell Biol. 2009, 19 (2): 81-88.","journal-title":"Trends Cell Biol"},{"issue":"11","key":"745_CR71","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1038\/embor.2010.151","volume":"11","author":"C Cerqua","year":"2010","unstructured":"Cerqua C, Anesti V, Pyakurel A, Liu D, Naon D, Wiche G, Baffa R, Dimmer KS, Scorrano L: Trichoplein\/mitostatin regulates endoplasmic reticulum-mitochondria juxtaposition. EMBO Rep. 2010, 11 (11): 854-860.","journal-title":"EMBO Rep"}],"container-title":["Cardiovascular Diabetology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1475-2840-12-158.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T02:13:40Z","timestamp":1630548820000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardiab.biomedcentral.com\/articles\/10.1186\/1475-2840-12-158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,2]]},"references-count":71,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["745"],"URL":"https:\/\/doi.org\/10.1186\/1475-2840-12-158","relation":{},"ISSN":["1475-2840"],"issn-type":[{"value":"1475-2840","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,2]]},"assertion":[{"value":"15 July 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 November 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"158"}}