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A significantly lower MALT1 and A20 expression level was found in T cells from patients with AML compared with healthy controls (<jats:italic>p<\/jats:italic>\u2009=\u20090.045,<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001); however, the expression level of MALT1-V1 (variant 1) was significantly higher in the AML group than in the healthy control group (<jats:italic>p<\/jats:italic>\u2009=\u20090.006), and the expression level of NF-\u03baB was increased in the AML group. In conclusion, the characteristics of the expression pattern of MALT1-A20-NF-\u03baB and the distribution of MALT1 variants in T cells from AML were first characterized. Overall, low TCR-CD3 signaling is related to low MALT1 expression, which may related to T cell immunodeficiency, while the up-regulation of MALT1-V1 may play a role in overcoming the T cell activity by downregulating A20 in patients with AML, which may be related to a specific response to AML-associated antigens.<\/jats:p>","DOI":"10.1186\/1475-2867-13-37","type":"journal-article","created":{"date-parts":[[2013,4,30]],"date-time":"2013-04-30T06:14:41Z","timestamp":1367302481000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Changes in the MALT1-A20-NF-\u03baB expression pattern may be related to T cell dysfunction in AML"],"prefix":"10.1186","volume":"13","author":[{"given":"Li","family":"Shi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaohua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuli","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangqiu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,4,30]]},"reference":[{"key":"411_CR1","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/1756-8722-4-36","volume":"4","author":"S Takahashi","year":"2011","unstructured":"Takahashi S: Current findings for recurring mutations in acute myeloid leukemia. 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