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Their haemolytic activity and <jats:italic>in vitro<\/jats:italic> cytoxicity were evaluated. The chromatographic profiles of active fractions were also established.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The plant extract and fractions revealed anti-plasmodial activity (IC<jats:sub>50<\/jats:sub> &lt; 5 \u03bcg\/mL) with no toxicity (Selectivity indexes &gt;10). The dichloromethane fraction showed stronger anti-plasmodial activity than the total extract.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Anti-plasmodial activity and toxicity of <jats:italic>I. senegalensis<\/jats:italic> are reported for the first time and showed promising results in malaria field research.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1475-2875-10-85","type":"journal-article","created":{"date-parts":[[2011,4,13]],"date-time":"2011-04-13T06:16:36Z","timestamp":1302675396000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Icacina senegalensis (Icacinaceae), traditionally used for the treatment of malaria, inhibits in vitro Plasmodium falciparum growth without host cell toxicity"],"prefix":"10.1186","volume":"10","author":[{"given":"Serigne O","family":"Sarr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Perrotey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahima","family":"Fall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sa\u00efd","family":"Ennahar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjie","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y\u00e9rim M","family":"Diop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ermanno","family":"Candolfi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Marchioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,4,11]]},"reference":[{"key":"1677_CR1","volume-title":"World Malaria Report","author":"WHO","year":"2010","unstructured":"WHO: World Malaria Report. 2010, [http:\/\/www.rbm.who.int]"},{"key":"1677_CR2","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/S1471-4922(02)02249-3","volume":"18","author":"JF Trape","year":"2002","unstructured":"Trape JF, Pison G, Spiegel A, Enel C, Rogier C: Combating malaria in Africa. 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