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Severely-ill Papua New Guinean children with mixed <jats:italic>P. falciparum\/P. vivax<\/jats:italic> infections are more likely to develop cerebral malaria and die than those with <jats:italic>P. falciparum<\/jats:italic> alone, possibly reflecting <jats:italic>P. vivax<\/jats:italic> sequestration. Nested PCR was performed on <jats:italic>post mortem<\/jats:italic> brain tissue from three such children dying from cerebral malaria due to mixed-species infections. No <jats:italic>P. vivax<\/jats:italic> DNA was detected. These findings do not support the hypothesis that <jats:italic>P. vivax<\/jats:italic> sequestration occurs in human brain.<\/jats:p>","DOI":"10.1186\/1475-2875-11-107","type":"journal-article","created":{"date-parts":[[2012,4,3]],"date-time":"2012-04-03T16:55:30Z","timestamp":1333472130000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["A histopathologic study of fatal paediatric cerebral malaria caused by mixed Plasmodium falciparum\/Plasmodium vivax infections"],"prefix":"10.1186","volume":"11","author":[{"given":"Laurens","family":"Manning","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Rosanas-Urgell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moses","family":"Laman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Edoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catriona","family":"McLean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Siba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy ME","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,4,3]]},"reference":[{"key":"2091_CR1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.4269\/ajtmh.2007.77.79","volume":"77","author":"RN Price","year":"2007","unstructured":"Price RN, Tjitra E, Guerra CA, Yeung S, White NJ, Anstey NM: Vivax malaria: neglected and not benign. 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