{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T15:37:52Z","timestamp":1774453072695,"version":"3.50.1"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Malar J"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Sabang Municipality, in Aceh Province, Indonesia, plans to initiate a malaria elimination programme in 2013. A baseline survey of the distribution of malaria in the municipality was conducted to lay the foundations for an evidence-based programme and to assess the island\u2019s readiness to begin the elimination process.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>The entire population of the municipality was screened for malaria infection and G6PD deficiency. Specimens collected included blood slides, blots and tubes for selected households.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results and Discussion<\/jats:title>\n            <jats:p>Samples were collected from 16,229 residents. Microscopic examination of the blood smears revealed 12 malaria infections; 10 with <jats:italic>Plasmodium falciparum<\/jats:italic> and 2 with <jats:italic>Plasmodium vivax<\/jats:italic>. To confirm the parasite prevalence, polymerase chain reaction (PCR) diagnosis was performed on the entire positive cases by microscopy and randomized 10% of the microscopically negative blood samples. PCR revealed an additional 11 subjects with malaria; one <jats:italic>P. falciparum<\/jats:italic> infection from the village of Paya Keunekai, and nine <jats:italic>P. vivax<\/jats:italic> infections and one mixed <jats:italic>P. falciparum<\/jats:italic>\/<jats:italic>P. vivax<\/jats:italic> infection from the village of Batee Shok. The overall slide positivity rate was 0.074% (CI 95%: 0.070 \u2013 0.078) and PCR corrected prevalence 0,590% (CI 95%: 0.582 \u2013 0.597). Analysis of 937 blood samples for G6PD deficiency revealed two subjects (0.2%) of deficient G6PD. Analysis of several genes of the parasite, such as <jats:italic>Pfdhfr<\/jats:italic>, <jats:italic>Pfdhps<\/jats:italic>, <jats:italic>Pfmdr1<\/jats:italic>, <jats:italic>Pfcrt<\/jats:italic>, <jats:italic>Pfmsp1<\/jats:italic>, <jats:italic>Pfmsp2<\/jats:italic>, <jats:italic>Pvdhfr<\/jats:italic>, <jats:italic>Pvdhps<\/jats:italic>, <jats:italic>Pvmdr1<\/jats:italic> and host gene, such as G6PD gene revealed that both <jats:italic>P. falciparum<\/jats:italic> and <jats:italic>P. vivax<\/jats:italic> carried the mutation associated with chloroquine resistance.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Malariometric and host genetic analysis indicated that there is a low prevalence of both malaria and G6PD deficiency in the population of Sabang Municipality. Nevertheless, malaria cases were clustered in three rural villages and efforts for malaria elimination in Sabang should be particularly focused on those three villages.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1475-2875-11-291","type":"journal-article","created":{"date-parts":[[2012,8,21]],"date-time":"2012-08-21T12:14:43Z","timestamp":1345551283000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The baseline distribution of malaria in the initial phase of elimination in Sabang Municipality, Aceh Province, Indonesia"],"prefix":"10.1186","volume":"11","author":[{"given":"Puji BS","family":"Asih","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismail E","family":"Rozi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Herdiana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nandha R","family":"Pratama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anggi PN","family":"Hidayati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvia S","family":"Marantina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sully","family":"Kosasih","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krisin","family":"Chand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suradi","family":"Wangsamuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faisal A","family":"Rusdjy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria E","family":"Sumiwi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Imran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Titik","family":"Yuniarti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tahi","family":"Sianturi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamilah","family":"Nur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Asnita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Bukhari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cut","family":"Barussanah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Yani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cut","family":"Ainun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurnia","family":"Jamil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cut","family":"Mariam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon P","family":"Sengkerij","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferdinand J","family":"Laihad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Hawley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Din","family":"Syafruddin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,8,21]]},"reference":[{"key":"2425_CR1","volume-title":"Buletin Penelitian Kesehatan","author":"Ministry of health, Indonesia","year":"1984","unstructured":"Ministry of health, Indonesia: Buletin Penelitian Kesehatan. 1984, \u2009, Jakarta"},{"key":"2425_CR2","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1865-1380-5-11","volume":"5","author":"D Muriuki","year":"2012","unstructured":"Muriuki D, Hahn S, Hexom B, Allan R: Cross-sectional survey of malaria prevalence in tsunami-affected districts of Aceh Province, Indonesia. 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