{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:28:53Z","timestamp":1791293333524,"version":"4.1.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,11,13]],"date-time":"2013-11-13T00:00:00Z","timestamp":1384300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Malar J"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1186\/1475-2875-12-411","type":"journal-article","created":{"date-parts":[[2013,11,13]],"date-time":"2013-11-13T10:07:22Z","timestamp":1384337242000},"source":"Crossref","is-referenced-by-count":33,"title":["Optimal sampling designs for estimation of Plasmodium falciparum clearance rates in patients treated with artemisinin derivatives"],"prefix":"10.1186","volume":"12","author":[{"given":"Jennifer A","family":"Flegg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe J","family":"Gu\u00e9rin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Nosten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A","family":"Ashley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aung Pyae","family":"Phyo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjen M","family":"Dondorp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick M","family":"Fairhurst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duong","family":"Socheat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Borrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Bj\u00f6rkman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"M\u00e5rtensson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayfong","family":"Mayxay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul N","family":"Newton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delia","family":"Bethell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youry","family":"Se","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Noedl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahamadou","family":"Diakite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdoulaye A","family":"Djimde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tran T","family":"Hien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasia","family":"Stepniewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,11,13]]},"reference":[{"key":"3027_CR1","volume-title":"Guidelines for the treatment of malaria","author":"World Health Organization","year":"2010","unstructured":"World Health Organization: Guidelines for the treatment of malaria. 2010, Geneva: WHO, 2","edition":"2"},{"key":"3027_CR2","volume-title":"Am J Trop Med Hyg","author":"JA Flegg","year":"2013","unstructured":"Flegg JA, Metcalf CJE, Gharbi M, Venkatesan M, Shewchuk T, Sibley CH, Guerin PJ: Trends in antimalarial drug use in Africa. Am J Trop Med Hyg. 2013, Epub ahead of print"},{"key":"3027_CR3","doi-asserted-by":"publisher","first-page":"e82","DOI":"10.1086\/657120","volume":"51","author":"H Noedl","year":"2010","unstructured":"Noedl H, Se Y, Sriwichai S, Schaecher K, Teja-Isavadharm P, Smith B, Rutvisuttinunt W, Bethell D, Surasri S, Fukuda MM, Socheat D, Chan Thap L: Artemisinin resistance in Cambodia: a clinical trial designed to address an emerging problem in Southeast Asia. Clin Infect Dis. 2010, 51: e82-e89. 10.1086\/657120.","journal-title":"Clin Infect Dis"},{"key":"3027_CR4","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1056\/NEJMoa0808859","volume":"361","author":"AM Dondorp","year":"2009","unstructured":"Dondorp AM, Nosten F, Yi P, Das D, Phyo AP, Tarning J, Lwin KM, Ariey F, Hanpithakpong W, Lee SJ, Ringwald P, Silamut K, Imwong M, Chotivanich K, Lim P, Herdman T, An SS, Yeung S, Singhasivanon P, Day NP, Lindegardh N, Socheat D, White NJ: Artemisinin resistance in Plasmodium falciparum malaria. N Engl J Med. 2009, 361: 455-467. 10.1056\/NEJMoa0808859.","journal-title":"N Engl J Med"},{"key":"3027_CR5","volume-title":"Global plan for artemisinin resistance containment (GPARC)","author":"World Health Organization","year":"2011","unstructured":"World Health Organization: Global plan for artemisinin resistance containment (GPARC). 2011, Geneva: WHO"},{"key":"3027_CR6","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1128\/AAC.01868-12","volume":"57","author":"B Witkowski","year":"2013","unstructured":"Witkowski B, Khim N, Chim P, Kim S, Ke S, Kloeung N, Chy S, Duong S, Leang R, Ringwald P, Dondorp AM, Tripura R, Benoit-Vical F, Berry A, Gorgette O, Ariey F, Barale JC, Mercereau-Puijalon O, Menard D: Reduced artemisinin susceptibility of Plasmodium falciparum ring stages in western Cambodia. Antimicrob Agents Chemother. 2013, 57: 914-923. 10.1128\/AAC.01868-12.","journal-title":"Antimicrob Agents Chemother"},{"key":"3027_CR7","volume-title":"Lancet Infect Dis","author":"B Witkowski","year":"2013","unstructured":"Witkowski B, Amaratunga C, Khim N, Sreng S, Chim P, Kim S, Lim P, Mao S, Sopha C, Sam B, Anderson JM, Duong S, Chuor CM, Taylor WR, Suon S, Mercereau-Puijalon O, Fairhurst RM, Menard D: Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies. Lancet Infect Dis. 2013, 10.1016\/S1473-3099(13)70252-4. [Epub ahead of print]"},{"key":"3027_CR8","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.1056\/NEJMc0805011","volume":"359","author":"H Noedl","year":"2008","unstructured":"Noedl H, Se Y, Schaecher K, Smith BL, Socheat D, Fukuda MM: Evidence of artemisinin-resistant malaria in western Cambodia. N Engl J Med. 2008, 359: 2619-2620. 10.1056\/NEJMc0805011.","journal-title":"N Engl J Med"},{"key":"3027_CR9","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/1475-2875-8-10","volume":"8","author":"W Rogers","year":"2009","unstructured":"Rogers W, Sem R, Tero T, Chim P, Lim P, Muth S, Socheat D, Ariey F, Wongsrichanalai C: Failure of artesunate-mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria in southern Cambodia. Malar J. 2009, 8: 10-10.1186\/1475-2875-8-10.","journal-title":"Malar J"},{"key":"3027_CR10","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1128\/AAC.41.7.1413","volume":"41","author":"NJ White","year":"1997","unstructured":"White NJ: Assessment of the pharmacodynamic properties of antimalarial drugs in vivo. Antimicrob Agents Chemother. 1997, 41: 1413-1422.","journal-title":"Antimicrob Agents Chemother"},{"key":"3027_CR11","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1186\/1475-2875-8-253","volume":"8","author":"NJ White","year":"2009","unstructured":"White NJ, Pongtavornpinyo W, Maude RJ, Saralamba S, Aguas R, Stepniewska K, Lee SJ, Dondorp AM, White LJ, Day NP: Hyperparasitaemia and low dosing are an important source of anti-malarial drug resistance. Malar J. 2009, 8: 253-10.1186\/1475-2875-8-253.","journal-title":"Malar J"},{"key":"3027_CR12","doi-asserted-by":"crossref","first-page":"4694","DOI":"10.1182\/blood.V88.12.4694.bloodjournal88124694","volume":"88","author":"NP Day","year":"1996","unstructured":"Day NP, Pham TD, Phan TL, Dinh XS, Pham PL, Ly VC, Tran TH, Nguyen TH, Bethell DB, Nguyan HP, White NJ: Clearance kinetics of parasites and pigment-containing leukocytes in severe malaria. Blood. 1996, 88: 4694-4700.","journal-title":"Blood"},{"key":"3027_CR13","doi-asserted-by":"publisher","first-page":"3414","DOI":"10.1128\/AAC.44.12.3414-3424.2000","volume":"44","author":"JA Simpson","year":"2000","unstructured":"Simpson JA, Watkins ER, Price RN, Aarons L, Kyle DE, White NJ: Mefloquine pharmacokinetic-pharmacodynamic models: implications for dosing and resistance. Antimicrob Agents Chemother. 2000, 44: 3414-3424. 10.1128\/AAC.44.12.3414-3424.2000.","journal-title":"Antimicrob Agents Chemother"},{"key":"3027_CR14","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1186\/1475-2875-10-339","volume":"10","author":"JA Flegg","year":"2011","unstructured":"Flegg JA, Guerin PJ, White NJ, Stepniewska K: Standardizing the measurement of parasite clearance in falciparum malaria: the parasite clearance estimator. Malar J. 2011, 10: 339-10.1186\/1475-2875-10-339.","journal-title":"Malar J"},{"key":"3027_CR15","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1186\/1475-2875-10-278","volume":"10","author":"NJ White","year":"2011","unstructured":"White NJ: The parasite clearance curve. Malar J. 2011, 10: 278-10.1186\/1475-2875-10-278.","journal-title":"Malar J"},{"key":"3027_CR16","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1093\/infdis\/jit165","volume":"208","author":"SC Nkhoma","year":"2013","unstructured":"Nkhoma SC, Stepniewska K, Nair S, Phyo AP, McGready R, Nosten F, Anderson TJ: Genetic evaluation of the performance of malaria parasite clearance rate metrics. J Infect Dis. 2013, 208: 346-350. 10.1093\/infdis\/jit165.","journal-title":"J Infect Dis"},{"key":"3027_CR17","unstructured":"Parasite Clearance Estimator (PCE). https:\/\/www.wwarn.org\/pce\/ ,"},{"key":"3027_CR18","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/S1473-3099(12)70181-0","volume":"12","author":"C Amaratunga","year":"2012","unstructured":"Amaratunga C, Sreng S, Suon S, Phelps ES, Stepniewska K, Lim P, Zhou C, Mao S, Anderson JM, Lindegardh N, Jiang H, Song J, Su XZ, White NJ, Dondorp AM, Anderson TJ, Fay MP, Mu J, Duong S, Fairhurst RM: Artemisinin-resistant Plasmodium falciparum in Pursat province, western Cambodia: a parasite clearance rate study. Lancet Infect Dis. 2012, 12: 851-858. 10.1016\/S1473-3099(12)70181-0.","journal-title":"Lancet Infect Dis"},{"key":"3027_CR19","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1093\/infdis\/jit082","volume":"207","author":"TM Lopera-Mesa","year":"2013","unstructured":"Lopera-Mesa TM, Doumbia S, Chiang S, Zeituni AE, Konate DS, Doumbouya M, Keita AS, Stepniewska K, Traore K, Diakite SA, Ndiaye D, Sa JM, Anderson JM, Fay MP, Long CA, Diakite M, Fairhurst RM: Plasmodium falciparum clearance rates in response to artesunate in Malian children with malaria: effect of acquired immunity. J Infect Dis. 2013, 207: 1655-1663. 10.1093\/infdis\/jit082.","journal-title":"J Infect Dis"},{"key":"3027_CR20","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.1016\/S0140-6736(12)60484-X","volume":"379","author":"AP Phyo","year":"2012","unstructured":"Phyo AP, Nkhoma S, Stepniewska K, Ashley EA, Nair S, McGready R, Al-Saai S, Dondorp AM, Lwin KM, Singhasivanon P, Day NP, White NJ, Anderson TJ, Nosten F: Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study. Lancet. 2012, 379: 1960-1966. 10.1016\/S0140-6736(12)60484-X.","journal-title":"Lancet"},{"key":"3027_CR21","doi-asserted-by":"publisher","first-page":"e48","DOI":"10.1093\/cid\/cis958","volume":"56","author":"D Das","year":"2013","unstructured":"Das D, Tripura R, Phyo AP, Lwin K, Tarning J, Lee SJ, Hanpithakpong W, Stepniewska K, Menard D, Ringwald P, Silamut K, Imwong M, Chotivanich K, Yi P, Day NP, Lindegardh N, Socheat D, Nguon C, White NJ, Nosten F, Dondorp AM: Effect of high-dose or split-dose artesunate on parasite clearance in artemisinin-resistant falciparum malaria. Clin Infect Dis. 2013, 56: e48-e58. 10.1093\/cid\/cis958.","journal-title":"Clin Infect Dis"},{"key":"3027_CR22","volume-title":"Methods for surveillance of antimalarial drug efficacy","author":"World Health Organization","year":"2009","unstructured":"World Health Organization: Methods for surveillance of antimalarial drug efficacy. 2009, Geneva: WHO"},{"key":"3027_CR23","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1086\/650301","volume":"201","author":"K Stepniewska","year":"2010","unstructured":"Stepniewska K, Ashley E, Lee SJ, Anstey N, Barnes KI, Binh TQ, D\u2019Alessandro U, Day NP, de Vries PJ, Dorsey G, Guthmann J-P, Mayxay M, Newton PN, Olliaro P, Osorio L, Price RN, Rowland M, Smithuis F, Taylor WRJ, Nosten F, White NJ: In vivo parasitological measures of artemisinin susceptibility. J Infect Dis. 2010, 201: 570-579. 10.1086\/650301.","journal-title":"J Infect Dis"},{"key":"3027_CR24","doi-asserted-by":"publisher","first-page":"e19283","DOI":"10.1371\/journal.pone.0019283","volume":"6","author":"D Bethell","year":"2011","unstructured":"Bethell D, Se Y, Lon C, Tyner S, Saunders D, Sriwichai S, Darapiseth S, Teja-Isavadharm P, Khemawoot P, Schaecher K, Ruttvisutinunt W, Lin J, Kuntawungin W, Gosi P, Timmermans A, Smith B, Socheat D, Fukuda MM: Artesunate dose escalation for the treatment of uncomplicated malaria in a region of reported artemisinin resistance: a randomized clinical trial. PLoS One. 2011, 6: e19283-10.1371\/journal.pone.0019283.","journal-title":"PLoS One"},{"key":"3027_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1475-2875-11-355","volume":"11","author":"TT Hien","year":"2012","unstructured":"Hien TT, Thuy-Nhien NT, Phu NH, Boni MF, Thanh NV, Nha-Ca NT, Thai LH, Thai CQ, Van Toi P, Phung DT, Le TL, Le TD, Merson L, Dolecek C, Stepniewska K, Ringwald P, White NJ, Farrar J, Wolbers M: In vivo susceptibility of Plasmodium falciparum to artesunate in Binh Phuoc Province, Vietnam. Malar J. 2012, 11: 1-11. 10.1186\/1475-2875-11-1.","journal-title":"Malar J"},{"key":"3027_CR26","doi-asserted-by":"publisher","first-page":"24","DOI":"10.2307\/1907382","volume":"26","author":"J Tobin","year":"1958","unstructured":"Tobin J: Estimation of relationships of limited dependent variables. Econometrica. 1958, 26: 24-36. 10.2307\/1907382.","journal-title":"Econometrica"},{"key":"3027_CR27","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.2517-6161.1988.tb01731.x","volume":"50","author":"DV Hinkley","year":"1988","unstructured":"Hinkley DV: Bootstrap methods. J R Stat Soc Series B Stat Methodol. 1988, 50: 321-337.","journal-title":"J R Stat Soc Series B Stat Methodol"},{"key":"3027_CR28","volume-title":"Malar J","author":"KM Jamsen","year":"2013","unstructured":"Jamsen KM, Duffull SB, Tarning J, Price RN, Simpson JA: A robust design for identification of the parasite clearance estimator. Malar J. 2013, Accepted 2\/11\/2013"}],"container-title":["Malaria Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1475-2875-12-411.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1475-2875-12-411\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1475-2875-12-411.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,19]],"date-time":"2024-05-19T11:49:51Z","timestamp":1716119391000},"score":1,"resource":{"primary":{"URL":"https:\/\/malariajournal.biomedcentral.com\/articles\/10.1186\/1475-2875-12-411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,13]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["3027"],"URL":"https:\/\/doi.org\/10.1186\/1475-2875-12-411","relation":{},"ISSN":["1475-2875"],"issn-type":[{"value":"1475-2875","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,13]]},"article-number":"411"}}