{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T16:57:03Z","timestamp":1787936223215,"version":"build-2784847793"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Malar J"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>\n            <jats:italic>Plasmodium knowlesi<\/jats:italic> is a potentially life-threatening zoonotic malaria parasite due to its relatively short erythrocytic cycle. Microscopic identification of <jats:italic>P<\/jats:italic>. <jats:italic>knowlesi<\/jats:italic> is difficult, with \u201ccompacted parasite cytoplasm\u201d being one of the important identifying keys. This report is about a case of hyperparasitaemic human <jats:italic>P<\/jats:italic>. <jats:italic>knowlesi<\/jats:italic> infection (27% parasitaemia) with atypical amoeboid morphology. A peninsular Malaysian was admitted to the hospital with malaria. He suffered anaemia and acute kidney function impairment. Microscopic examination, assisted by nested PCR and sequencing confirmed as <jats:italic>P<\/jats:italic>. <jats:italic>knowlesi<\/jats:italic> infection. With anti-malarial treatment and several medical interventions, patient survived and recovered. One-month medical follow-up was performed after recovery and no recrudescence was noted. This case report highlights the extreme hyperparasitaemic setting, the atypical morphology of <jats:italic>P<\/jats:italic>. <jats:italic>knowlesi<\/jats:italic> in the patient\u2019s erythrocytes, as well as the medical interventions involved in this successfully treated case.<\/jats:p>","DOI":"10.1186\/1475-2875-12-88","type":"journal-article","created":{"date-parts":[[2013,3,6]],"date-time":"2013-03-06T13:14:23Z","timestamp":1362575663000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Hyperparasitaemic human Plasmodium knowlesi infection with atypical morphology in peninsular Malaysia"],"prefix":"10.1186","volume":"12","author":[{"given":"Wenn-Chyau","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pek-Woon","family":"Chin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yee-Ling","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lit-Chein","family":"Chin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mun-Yik","family":"Fong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chee-Jiek","family":"Yap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond Raj","family":"Supramaniam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohela","family":"Mahmud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,3,6]]},"reference":[{"key":"2684_CR1","first-page":"357","volume":"3","author":"JA Sinton","year":"1932","unstructured":"Sinton JA, Mulligan HW: A critical review of the literature relating to the identification of the malarial parasites recorded from monkeys of the family Ceropithecidae and Colobidae. 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