{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:52:29Z","timestamp":1792018349982,"version":"4.4.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Malar J"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/1475-2875-13-264","type":"journal-article","created":{"date-parts":[[2014,7,9]],"date-time":"2014-07-09T17:01:19Z","timestamp":1404925279000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Surveillance of artemether-lumefantrine associated Plasmodium falciparum multidrug resistance protein-1 gene polymorphisms in Tanzania"],"prefix":"10.1186","volume":"13","author":[{"given":"Reginald A","family":"Kavishe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petro","family":"Paulo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D","family":"Kaaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akili","family":"Kalinga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"van Zwetselaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaffu","family":"Chilongola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cally","family":"Roper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Alifrangis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,7,9]]},"reference":[{"key":"3290_CR1","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1083\/jcb.113.5.1033","volume":"113","author":"AF Cowman","year":"1991","unstructured":"Cowman AF, Karcz S, Galatis D, Culvenor JG: A P-glycoprotein homologue of Plasmodium falciparum is localized on the digestive vacuole. J Cell Biol. 1991, 113: 1033-1042.","journal-title":"J Cell Biol"},{"key":"3290_CR2","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1017\/S0031182096008487","volume":"114","author":"MT Duraisingh","year":"1997","unstructured":"Duraisingh MT, Drakeley CJ, Muller O, Bailey R, Snounou G, Targett GA, Greenwood BM, Warhurst DC: Evidence for selection for the tyrosine-86 allele of the pfmdr 1 gene of Plasmodium falciparum by chloroquine and amodiaquine. Parasitology. 1997, 114: 205-211.","journal-title":"Parasitology"},{"key":"3290_CR3","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.actatropica.2011.08.013","volume":"120","author":"OA Folarin","year":"2011","unstructured":"Folarin OA, Bustamante C, Gbotosho GO, Sowunmi A, Zalis MG, Oduola AM, Happi CT: In vitro amodiaquine resistance and its association with mutations in pfcrt and pfmdr1 genes of Plasmodium falciparum isolates from Nigeria. Acta Trop. 2011, 120: 224-230.","journal-title":"Acta Trop"},{"key":"3290_CR4","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1111\/j.1365-3156.2007.01995.x","volume":"13","author":"H Tinto","year":"2008","unstructured":"Tinto H, Guekoun L, Zongo I, Guiguemde RT, D\u2019Alessandro U, Ouedraogo JB: Chloroquine-resistance molecular markers (Pfcrt T76 and Pfmdr-1 Y86) and amodiaquine resistance in Burkina Faso. Trop Med Int Health. 2008, 13: 238-240.","journal-title":"Trop Med Int Health"},{"key":"3290_CR5","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.molbiopara.2007.09.008","volume":"157","author":"JK Lekostaj","year":"2008","unstructured":"Lekostaj JK, Amoah LE, Roepe PD: A single S1034C mutation confers altered drug sensitivity to PfMDR1 ATPase activity that is characteristic of the 7G8 isoform. Mol Biochem Parasitol. 2008, 157: 107-111.","journal-title":"Mol Biochem Parasitol"},{"key":"3290_CR6","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1111\/j.1365-2958.2005.04729.x","volume":"57","author":"AB Sidhu","year":"2005","unstructured":"Sidhu AB, Valderramos SG, Fidock DA: Pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum. Mol Microbiol. 2005, 57: 913-926.","journal-title":"Mol Microbiol"},{"key":"3290_CR7","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1128\/AAC.00875-06","volume":"51","author":"GS Humphreys","year":"2007","unstructured":"Humphreys GS, Merinopoulos I, Ahmed J, Whitty CJ, Mutabingwa TK, Sutherland CJ, Hallett RL: Amodiaquine and artemether-lumefantrine select distinct alleles of the Plasmodium falciparum mdr1 gene in Tanzanian children treated for uncomplicated malaria. Antimicrob Agents Chemother. 2007, 51: 991-997.","journal-title":"Antimicrob Agents Chemother"},{"key":"3290_CR8","doi-asserted-by":"publisher","first-page":"2418","DOI":"10.1128\/AAC.47.8.2418-2423.2003","volume":"47","author":"AL Pickard","year":"2003","unstructured":"Pickard AL, Wongsrichanalai C, Purfield A, Kamwendo D, Emery K, Zalewski C, Kawamoto F, Miller RS, Meshnick SR: Resistance to antimalarials in Southeast Asia and genetic polymorphisms in pfmdr1. Antimicrob Agents Chemother. 2003, 47: 2418-2423.","journal-title":"Antimicrob Agents Chemother"},{"key":"3290_CR9","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1038\/35002615","volume":"403","author":"MB Reed","year":"2000","unstructured":"Reed MB, Saliba KJ, Caruana SR, Kirk K, Cowman AF: Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum. Nature. 2000, 403: 906-909.","journal-title":"Nature"},{"key":"3290_CR10","doi-asserted-by":"publisher","first-page":"5069","DOI":"10.1128\/AAC.00638-09","volume":"53","author":"L Mwai","year":"2009","unstructured":"Mwai L, Kiara SM, Abdirahman A, Pole L, Rippert A, Diriye A, Bull P, Marsh K, Borrmann S, Nzila A: In vitro activities of piperaquine, lumefantrine, and dihydroartemisinin in Kenyan Plasmodium falciparum isolates and polymorphisms in pfcrt and pfmdr1. Antimicrob Agents Chemother. 2009, 53: 5069-5073.","journal-title":"Antimicrob Agents Chemother"},{"key":"3290_CR11","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1093\/infdis\/jir486","volume":"204","author":"FN Baliraine","year":"2011","unstructured":"Baliraine FN, Rosenthal PJ: Prolonged selection of pfmdr1 polymorphisms after treatment of falciparum malaria with artemether-lumefantrine in Uganda. J Infect Dis. 2011, 204: 1120-1124.","journal-title":"J Infect Dis"},{"key":"3290_CR12","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1128\/AAC.00968-08","volume":"53","author":"CT Happi","year":"2009","unstructured":"Happi CT, Gbotosho GO, Folarin OA, Sowunmi A, Hudson T, O\u2019Neil M, Milhous W, Wirth DF, Oduola AM: Selection of Plasmodium falciparum multidrug resistance gene 1 alleles in asexual stages and gametocytes by artemether-lumefantrine in Nigerian children with uncomplicated falciparum malaria. Antimicrob Agents Chemother. 2009, 53: 888-895.","journal-title":"Antimicrob Agents Chemother"},{"key":"3290_CR13","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1475-2875-7-4","volume":"7","author":"JD Njau","year":"2008","unstructured":"Njau JD, Goodman CA, Kachur SP, Mulligan J, Munkondya JS, McHomvu N, Abdulla S, Bloland P, Mills A: The costs of introducing artemisinin-based combination therapy: evidence from district-wide implementation in rural Tanzania. Malar J. 2008, 7: 4-","journal-title":"Malar J"},{"key":"3290_CR14","doi-asserted-by":"publisher","first-page":"979","DOI":"10.4269\/ajtmh.2011.11-0071","volume":"85","author":"TT Thomsen","year":"2011","unstructured":"Thomsen TT, Ishengoma DS, Mmbando BP, Lusingu JP, Vestergaard LS, Theander TG, Lemnge MM, Bygbjerg IC, Alifrangis M: Prevalence of single nucleotide polymorphisms in the Plasmodium falciparum multidrug resistance gene (Pfmdr-1) in Korogwe District in Tanzania before and after introduction of artemisinin-based combination therapy. Am J Trop Med Hyg. 2011, 85: 979-983.","journal-title":"Am J Trop Med Hyg"},{"key":"3290_CR15","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/1475-2875-11-58","volume":"11","author":"E Kamugisha","year":"2012","unstructured":"Kamugisha E, Jing S, Minde M, Kataraihya J, Kongola G, Kironde F, Swedberg G: Efficacy of artemether-lumefantrine in treatment of malaria among under-fives and prevalence of drug resistance markers in Igombe-Mwanza, north-western Tanzania. Malar J. 2012, 11: 58-","journal-title":"Malar J"},{"key":"3290_CR16","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1186\/1475-2875-12-103","volume":"12","author":"M Malmberg","year":"2013","unstructured":"Malmberg M, Ngasala B, Ferreira PE, Larsson E, Jovel I, Hjalmarsson A, Petzold M, Premji Z, Gil JP, Bjorkman A, Martensson A: Temporal trends of molecular markers associated with artemether-lumefantrine tolerance\/resistance in Bagamoyo district, Tanzania. Malar J. 2013, 12: 103-","journal-title":"Malar J"},{"key":"3290_CR17","doi-asserted-by":"publisher","first-page":"536","DOI":"10.4269\/ajtmh.12-0525","volume":"88","author":"TT Thomsen","year":"2013","unstructured":"Thomsen TT, Madsen LB, Hansson HH, Tomas EV, Charlwood D, Bygbjerg IC, Alifrangis M: Rapid selection of Plasmodium falciparum chloroquine resistance transporter gene and multidrug resistance gene-1 haplotypes associated with past chloroquine and present artemether-lumefantrine use in Inhambane District, southern Mozambique. Am J Trop Med Hyg. 2013, 88: 536-541.","journal-title":"Am J Trop Med Hyg"},{"key":"3290_CR18","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1093\/infdis\/jis747","volume":"207","author":"M Malmberg","year":"2013","unstructured":"Malmberg M, Ferreira PE, Tarning J, Ursing J, Ngasala B, Bjorkman A, Martensson A, Gil JP: Plasmodium falciparum drug resistance phenotype as assessed by patient antimalarial drug levels and its association with pfmdr1 polymorphisms. J Infect Dis. 2013, 207: 842-847.","journal-title":"J Infect Dis"},{"key":"3290_CR19","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/nature12876","volume":"505","author":"F Ariey","year":"2014","unstructured":"Ariey F, Witkowski B, Amaratunga C, Beghain J, Langlois AC, Khim N, Kim S, Duru V, Bouchier C, Ma L, Lim P, Leang R, Duong S, Sreng S, Suon S, Chuor CM, Bout DM, Menard S, Rogers WO, Genton B, Fandeur T, Miotto O, Ringwald P, Le BJ, Berry A, Barale JC, Fairhurst RM, Benoit-Vical F, Mercereau-Puijalon O: A molecular marker of artemisinin-resistant Plasmodium falciparum malaria. Nature. 2014, 505: 50-55.","journal-title":"Nature"},{"key":"3290_CR20","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1136\/mp.51.4.215","volume":"51","author":"JM Polski","year":"1998","unstructured":"Polski JM, Kimzey S, Percival RW, Grosso LE: Rapid and effective processing of blood specimens for diagnostic PCR using filter paper and Chelex-100. Mol Pathol. 1998, 51: 215-217.","journal-title":"Mol Pathol"},{"key":"3290_CR21","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1046\/j.1365-2958.2000.01914.x","volume":"36","author":"MT Duraisingh","year":"2000","unstructured":"Duraisingh MT, Roper C, Walliker D, Warhurst DC: Increased sensitivity to the antimalarials mefloquine and artemisinin is conferred by mutations in the pfmdr1 gene of Plasmodium falciparum. Mol Microbiol. 2000, 36: 955-961.","journal-title":"Mol Microbiol"},{"key":"3290_CR22","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.1086\/375419","volume":"187","author":"JG Kublin","year":"2003","unstructured":"Kublin JG, Cortese JF, Njunju EM, Mukadam RA, Wirima JJ, Kazembe PN, Djimde AA, Kouriba B, Taylor TE, Plowe CV: Reemergence of chloroquine-sensitive Plasmodium falciparum malaria after cessation of chloroquine use in Malawi. J Infect Dis. 2003, 187: 1870-1875.","journal-title":"J Infect Dis"},{"key":"3290_CR23","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1056\/NEJMoa062032","volume":"355","author":"MK Laufer","year":"2006","unstructured":"Laufer MK, Thesing PC, Eddington ND, Masonga R, Dzinjalamala FK, Takala SL, Taylor TE, Plowe CV: Return of chloroquine antimalarial efficacy in Malawi. N Engl J Med. 2006, 355: 1959-1966.","journal-title":"N Engl J Med"},{"key":"3290_CR24","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1186\/1475-2875-12-415","volume":"12","author":"A Mohammed","year":"2013","unstructured":"Mohammed A, Ndaro A, Kalinga A, Manjurano A, Mosha JF, Mosha DF, van-Zwetselaar M, Koenderink JB, Mosha FW, Alifrangis M, Reyburn H, Roper C, Kavishe RA: Trends in chloroquine resistance marker, Pfcrt-K76T mutation ten years after chloroquine withdrawal in Tanzania. Malar J. 2013, 12: 415-","journal-title":"Malar J"},{"key":"3290_CR25","doi-asserted-by":"publisher","first-page":"e4569","DOI":"10.1371\/journal.pone.0004569","volume":"4","author":"S Gesase","year":"2009","unstructured":"Gesase S, Gosling RD, Hashim R, Ord R, Naidoo I, Madebe R, Mosha JF, Joho A, Mandia V, Mrema H, Mapunda E, Savael Z, Lemnge M, Mosha FW, Greenwood B, Roper C, Chandramohan D: High resistance of Plasmodium falciparum to sulphadoxine\/pyrimethamine in northern Tanzania and the emergence of dhps resistance mutation at Codon 581. PLoS One. 2009, 4: e4569-","journal-title":"PLoS One"},{"key":"3290_CR26","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.pt.2013.08.002","volume":"29","author":"I Naidoo","year":"2013","unstructured":"Naidoo I, Roper C: Mapping \u2018partially resistant\u2019, \u2018fully resistant\u2019, and \u2018super resistant\u2019 malaria. Trends Parasitol. 2013, 29: 505-515.","journal-title":"Trends Parasitol"},{"key":"3290_CR27","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3201\/eid1909.130133","volume":"19","author":"DT Minja","year":"2013","unstructured":"Minja DT, Schmiegelow C, Mmbando B, Bostrom S, Oesterholt M, Magistrado P, Pehrson C, John D, Salanti A, Luty AJ, Lemnge M, Theander T, Lusingu J, Alifrangis M: Plasmodium falciparum mutant haplotype infection during pregnancy associated with reduced birthweight, Tanzania. Emerg Infect Dis. 2013, 19: 9-","journal-title":"Emerg Infect Dis"},{"key":"3290_CR28","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1186\/1475-2875-13-152","volume":"13","author":"SI Matondo","year":"2014","unstructured":"Matondo SI, Temba GS, Kavishe AA, Kauki JS, Kalinga A, van-Zwetselaar M, Reyburn H, Kavishe RA: High levels of sulphadoxine-pyrimethamine resistance Pfdhfr-Pfdhps quintuple mutations: a cross sectional survey of six regions in Tanzania. Malar J. 2014, 13: 152-","journal-title":"Malar J"},{"key":"3290_CR29","doi-asserted-by":"crossref","first-page":"523","DOI":"10.4269\/ajtmh.2009.80.523","volume":"80","author":"M Alifrangis","year":"2009","unstructured":"Alifrangis M, Lusingu JP, Mmbando B, Dalgaard MB, Vestergaard LS, Ishengoma D, Khalil IF, Theander TG, Lemnge MM, Bygbjerg IC: Five-year surveillance of molecular markers of Plasmodium falciparum antimalarial drug resistance in Korogwe District, Tanzania: accumulation of the 581G mutation in the P. falciparum dihydropteroate synthase gene. Am J Trop Med Hyg. 2009, 80: 523-527.","journal-title":"Am J Trop Med Hyg"},{"key":"3290_CR30","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1186\/1475-2875-10-198","volume":"10","author":"W Yavo","year":"2011","unstructured":"Yavo W, Faye B, Kuete T, Djohan V, Oga SA, Kassi RR, Diatta M, Ama MV, Tine R, Ndiaye JL, Evi JB, Same-Ekobo A, Faye O, Kone M: Multicentric assessment of the efficacy and tolerability of dihydroartemisinin-piperaquine compared to artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in sub-Saharan Africa. Malar J. 2011, 10: 198-","journal-title":"Malar J"},{"key":"3290_CR31","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/S1567-1348(01)00021-1","volume":"1","author":"AG Schneider","year":"2002","unstructured":"Schneider AG, Premji Z, Felger I, Smith T, Abdulla S, Beck HP, Mshinda H: A point mutation in codon 76 of pfcrt of P. falciparum is positively selected for by Chloroquine treatment in Tanzania. Infect Genet Evol. 2002, 1: 183-189.","journal-title":"Infect Genet Evol"},{"key":"3290_CR32","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1186\/1475-2875-10-238","volume":"10","author":"FM Ringsted","year":"2011","unstructured":"Ringsted FM, Massawe IS, Lemnge MM, Bygbjerg IC: Saleability of anti-malarials in private drug shops in Muheza, Tanzania: a baseline study in an era of assumed artemisinin combination therapy (ACT). Malar J. 2011, 10: 238-","journal-title":"Malar J"},{"key":"3290_CR33","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1093\/infdis\/jiu141","volume":"210","author":"MD Conrad","year":"2014","unstructured":"Conrad MD, Leclair N, Arinaitwe E, Wanzira H, Kakuru A, Bigira V, Muhindo M, Kamya MR, Tappero JW, Greenhouse B, Dorsey G, Rosenthal PJ: Comparative impacts over 5 years of artemisinin-based combination therapies on P. falciparum polymorphisms that modulate drug sensitivity in Ugandan children. J Infect Dis. 2014, 210: 344-353.","journal-title":"J Infect Dis"},{"key":"3290_CR34","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1186\/1475-2875-12-377","volume":"12","author":"NO Duah","year":"2013","unstructured":"Duah NO, Matrevi SA, de Souza DK, Binnah DD, Tamakloe MM, Opoku VS, Onwona CO, Narh CA, Quashie NB, Abuaku B, Duplessis C, Kronmann KC, Koram KA: Increased pfmdr1 gene copy number and the decline in pfcrt and pfmdr1 resistance alleles in Ghanaian Plasmodium falciparum isolates after the change of anti-malarial drug treatment policy. Malar J. 2013, 12: 377-","journal-title":"Malar J"},{"key":"3290_CR35","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1186\/1475-2875-12-255","volume":"12","author":"NB Gadalla","year":"2013","unstructured":"Gadalla NB, Abdallah TM, Atwal S, Sutherland CJ, Adam I: Selection of pfdhfr\/pfdhps alleles and declining artesunate\/sulphadoxine-pyrimethamine efficacy against Plasmodium falciparum eight years after deployment in eastern Sudan. Malar J. 2013, 12: 255-","journal-title":"Malar J"},{"key":"3290_CR36","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1186\/1475-2875-12-263","volume":"12","author":"K Na-Bangchang","year":"2013","unstructured":"Na-Bangchang K, Muhamad P, Ruaengweerayut R, Chaijaroenkul W, Karbwang J: Identification of resistance of Plasmodium falciparum to artesunate-mefloquine combination in an area along the Thai-Myanmar border: integration of clinico-parasitological response, systemic drug exposure, and in vitro parasite sensitivity. Malar J. 2013, 12: 263-","journal-title":"Malar J"},{"key":"3290_CR37","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1186\/1475-2875-12-441","volume":"12","author":"TD Van","year":"2013","unstructured":"Van TD, Dieye B, Valim C, Daniels RF, Sene PD, Lukens AK, Ndiaye M, Bei AK, Ndiaye YD, Hamilton EJ, Ndir O, Mboup S, Volkman SK, Wirth DF, Ndiaye D: Changes in drug sensitivity and anti-malarial drug resistance mutations over time among Plasmodium falciparum parasites in Senegal. Malar J. 2013, 12: 441-","journal-title":"Malar J"},{"key":"3290_CR38","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1086\/651949","volume":"201","author":"S Vinayak","year":"2010","unstructured":"Vinayak S, Alam MT, Sem R, Shah NK, Susanti AI, Lim P, Muth S, Maguire JD, Rogers WO, Fandeur T, Barnwell JW, Escalante AA, Wongsrichanalai C, Ariey F, Meshnick SR, Udhayakumar V: Multiple genetic backgrounds of the amplified Plasmodium falciparum multidrug resistance (pfmdr1) gene and selective sweep of 184\u00a0F mutation in Cambodia. J Infect Dis. 2010, 201: 1551-1560.","journal-title":"J Infect Dis"}],"container-title":["Malaria Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1475-2875-13-264.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T01:16:18Z","timestamp":1548119778000},"score":1,"resource":{"primary":{"URL":"https:\/\/malariajournal.biomedcentral.com\/articles\/10.1186\/1475-2875-13-264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,9]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["3290"],"URL":"https:\/\/doi.org\/10.1186\/1475-2875-13-264","relation":{},"ISSN":["1475-2875"],"issn-type":[{"value":"1475-2875","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,9]]},"assertion":[{"value":"23 April 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"264"}}